Ion channels and disease: channelopathies
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
San Diego
Academic Press
©2000
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| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype Includes bibliographical references (pages 419-464) and index |
| Beschreibung: | 1 Online-Ressource (xxi, 481 pages) |
| ISBN: | 9780120653102 0120653109 9781435601123 1435601122 0080535216 9780080535210 |
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Datensatz im Suchindex
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| any_adam_object | |
| author | Ashcroft, Frances M. |
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| dewey-full | 616.07 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
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| discipline | Medizin |
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| isbn | 9780120653102 0120653109 9781435601123 1435601122 0080535216 9780080535210 |
| language | English |
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| spelling | Ashcroft, Frances M. Verfasser aut Ion channels and disease channelopathies Frances M. Ashcroft San Diego Academic Press ©2000 1 Online-Ressource (xxi, 481 pages) txt rdacontent c rdamedia cr rdacarrier Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype Includes bibliographical references (pages 419-464) and index MEDICAL / Pathology bisacsh MEDICAL / Pathophysiology bisacsh Ion channels fast Pathology, Molecular fast Kanalopathieën gtt Pathologie moléculaire ram Canaux ioniques ram Membrane cellulaire ram Ion Channels / physiology Genetic Diseases, Inborn / physiopathology Membrane Proteins / physiology Metabolism, Inborn Errors / physiopathology Medizin Ion channels Pathology, Molecular Ionenkanal (DE-588)4138699-1 gnd rswk-swf Funktionsstörung (DE-588)4126507-5 gnd rswk-swf Chronische Krankheit (DE-588)4010176-9 gnd rswk-swf Ionenkanal (DE-588)4138699-1 s Chronische Krankheit (DE-588)4010176-9 s 1\p DE-604 Funktionsstörung (DE-588)4126507-5 s 2\p DE-604 http://www.sciencedirect.com/science/book/9780120653102 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Ashcroft, Frances M. Ion channels and disease channelopathies MEDICAL / Pathology bisacsh MEDICAL / Pathophysiology bisacsh Ion channels fast Pathology, Molecular fast Kanalopathieën gtt Pathologie moléculaire ram Canaux ioniques ram Membrane cellulaire ram Ion Channels / physiology Genetic Diseases, Inborn / physiopathology Membrane Proteins / physiology Metabolism, Inborn Errors / physiopathology Medizin Ion channels Pathology, Molecular Ionenkanal (DE-588)4138699-1 gnd Funktionsstörung (DE-588)4126507-5 gnd Chronische Krankheit (DE-588)4010176-9 gnd |
| subject_GND | (DE-588)4138699-1 (DE-588)4126507-5 (DE-588)4010176-9 |
| title | Ion channels and disease channelopathies |
| title_auth | Ion channels and disease channelopathies |
| title_exact_search | Ion channels and disease channelopathies |
| title_full | Ion channels and disease channelopathies Frances M. Ashcroft |
| title_fullStr | Ion channels and disease channelopathies Frances M. Ashcroft |
| title_full_unstemmed | Ion channels and disease channelopathies Frances M. Ashcroft |
| title_short | Ion channels and disease |
| title_sort | ion channels and disease channelopathies |
| title_sub | channelopathies |
| topic | MEDICAL / Pathology bisacsh MEDICAL / Pathophysiology bisacsh Ion channels fast Pathology, Molecular fast Kanalopathieën gtt Pathologie moléculaire ram Canaux ioniques ram Membrane cellulaire ram Ion Channels / physiology Genetic Diseases, Inborn / physiopathology Membrane Proteins / physiology Metabolism, Inborn Errors / physiopathology Medizin Ion channels Pathology, Molecular Ionenkanal (DE-588)4138699-1 gnd Funktionsstörung (DE-588)4126507-5 gnd Chronische Krankheit (DE-588)4010176-9 gnd |
| topic_facet | MEDICAL / Pathology MEDICAL / Pathophysiology Ion channels Pathology, Molecular Kanalopathieën Pathologie moléculaire Canaux ioniques Membrane cellulaire Ion Channels / physiology Genetic Diseases, Inborn / physiopathology Membrane Proteins / physiology Metabolism, Inborn Errors / physiopathology Medizin Ionenkanal Funktionsstörung Chronische Krankheit |
| url | http://www.sciencedirect.com/science/book/9780120653102 |
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