Genetic diseases of the kidney:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier/Academic Press
2009
|
| Ausgabe: | 1st ed |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | Genetic Diseases of the Kidney identifies and analyzes genetic abnormalities causing renal diseases in human subjects. Although in a sense the genome contains all the instructions required for the formation of a phenotype, the information is encoded in an extremely complicated fashion. In primary genetic diseases, the genetic instruction specifies a phenotype clearly linked with a discreet lesion confined to the kidney. However, the genetic disturbance may be imbedded in a complicated physiologic ensemble, so that the nexus between the genetic disturbance and the phenotype may be obscured; in consequence, the causal sequence is extremely difficult to unravel. In many instances the renal disease is one component of a complicated systemic hereditary disease, either monogenic or polygenic. Indeed, renal disease may arise as the sum of minor inputs from many different, seemingly unrelated genes, so that the genetic contributions may be difficult to identify. Confounding the problem further are environmental influences, originating either in the chromosomal environment from modifier genes, or in the extra-chromosomal environmental from intrauterine or postnatal influences. These considerations have determined both the organization of the text as well as the detailed description of the genetic disorders and the physiologic derangements that emerge. * Lays the essential foundation of mammalian genetics principles for medical professionals with little to no background in genetics. Analyzes specific renal diseases - both monogenic disorders confined to the kidney as well as systemic diseases with renal involvement - and explains their genetic causes. World-renowned editors and authors offer expert frameworks for understanding the links between genes and complex clinical disorders (i.e., lupus, diabetes, HIV, and hypertension) Includes bibliographical references and index |
| Beschreibung: | 1 Online-Ressource (xiv, 829 p., [50] p. of plates) |
| ISBN: | 9780124498518 0124498515 9780080924274 0080924271 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV042302424 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 150129s2009 |||| o||u| ||||||eng d | ||
| 020 | |a 9780124498518 |9 978-0-12-449851-8 | ||
| 020 | |a 0124498515 |9 0-12-449851-5 | ||
| 020 | |a 9780080924274 |c electronic bk. |9 978-0-08-092427-4 | ||
| 020 | |a 0080924271 |c electronic bk. |9 0-08-092427-1 | ||
| 035 | |a (OCoLC)318327985 | ||
| 035 | |a (DE-599)BVBBV042302424 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-1046 | ||
| 082 | 0 | |a 616.61042 |2 22 | |
| 245 | 1 | 0 | |a Genetic diseases of the kidney |c edited by Richard P. Lifton ... [et al.] |
| 250 | |a 1st ed | ||
| 264 | 1 | |a Amsterdam |b Elsevier/Academic Press |c 2009 | |
| 300 | |a 1 Online-Ressource (xiv, 829 p., [50] p. of plates) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 500 | |a Genetic Diseases of the Kidney identifies and analyzes genetic abnormalities causing renal diseases in human subjects. Although in a sense the genome contains all the instructions required for the formation of a phenotype, the information is encoded in an extremely complicated fashion. In primary genetic diseases, the genetic instruction specifies a phenotype clearly linked with a discreet lesion confined to the kidney. However, the genetic disturbance may be imbedded in a complicated physiologic ensemble, so that the nexus between the genetic disturbance and the phenotype may be obscured; in consequence, the causal sequence is extremely difficult to unravel. In many instances the renal disease is one component of a complicated systemic hereditary disease, either monogenic or polygenic. Indeed, renal disease may arise as the sum of minor inputs from many different, seemingly unrelated genes, so that the genetic contributions may be difficult to identify. Confounding the problem further are environmental influences, originating either in the chromosomal environment from modifier genes, or in the extra-chromosomal environmental from intrauterine or postnatal influences. These considerations have determined both the organization of the text as well as the detailed description of the genetic disorders and the physiologic derangements that emerge. * Lays the essential foundation of mammalian genetics principles for medical professionals with little to no background in genetics. Analyzes specific renal diseases - both monogenic disorders confined to the kidney as well as systemic diseases with renal involvement - and explains their genetic causes. World-renowned editors and authors offer expert frameworks for understanding the links between genes and complex clinical disorders (i.e., lupus, diabetes, HIV, and hypertension) | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 7 | |a MEDICAL / Nephrology |2 bisacsh | |
| 650 | 7 | |a Kidneys / Diseases / Genetic aspects |2 fast | |
| 650 | 4 | |a Kidney Diseases / genetics | |
| 650 | 4 | |a Medizin | |
| 650 | 4 | |a Kidneys |x Diseases |x Genetic aspects | |
| 650 | 0 | 7 | |a Nierenkrankheit |0 (DE-588)4075399-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Genetik |0 (DE-588)4071711-2 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Nierenkrankheit |0 (DE-588)4075399-2 |D s |
| 689 | 0 | 1 | |a Genetik |0 (DE-588)4071711-2 |D s |
| 689 | 0 | |8 1\p |5 DE-604 | |
| 700 | 1 | |a Lifton, Richard P. |e Sonstige |4 oth | |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/book/9780124498518 |x Verlag |3 Volltext |
| 912 | |a ZDB-33-ESD |a ZDB-33-EBS | ||
| 940 | 1 | |q FAW_PDA_ESD | |
| 940 | 1 | |q FLA_PDA_ESD | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-027739416 | ||
| 883 | 1 | |8 1\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
Datensatz im Suchindex
| _version_ | 1804152882146050048 |
|---|---|
| any_adam_object | |
| building | Verbundindex |
| bvnumber | BV042302424 |
| collection | ZDB-33-ESD ZDB-33-EBS |
| ctrlnum | (OCoLC)318327985 (DE-599)BVBBV042302424 |
| dewey-full | 616.61042 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.61042 |
| dewey-search | 616.61042 |
| dewey-sort | 3616.61042 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 1st ed |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03676nmm a2200517zc 4500</leader><controlfield tag="001">BV042302424</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">150129s2009 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780124498518</subfield><subfield code="9">978-0-12-449851-8</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0124498515</subfield><subfield code="9">0-12-449851-5</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780080924274</subfield><subfield code="c">electronic bk.</subfield><subfield code="9">978-0-08-092427-4</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0080924271</subfield><subfield code="c">electronic bk.</subfield><subfield code="9">0-08-092427-1</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)318327985</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV042302424</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-1046</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.61042</subfield><subfield code="2">22</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Genetic diseases of the kidney</subfield><subfield code="c">edited by Richard P. Lifton ... [et al.]</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">1st ed</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Amsterdam</subfield><subfield code="b">Elsevier/Academic Press</subfield><subfield code="c">2009</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (xiv, 829 p., [50] p. of plates)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Genetic Diseases of the Kidney identifies and analyzes genetic abnormalities causing renal diseases in human subjects. Although in a sense the genome contains all the instructions required for the formation of a phenotype, the information is encoded in an extremely complicated fashion. In primary genetic diseases, the genetic instruction specifies a phenotype clearly linked with a discreet lesion confined to the kidney. However, the genetic disturbance may be imbedded in a complicated physiologic ensemble, so that the nexus between the genetic disturbance and the phenotype may be obscured; in consequence, the causal sequence is extremely difficult to unravel. In many instances the renal disease is one component of a complicated systemic hereditary disease, either monogenic or polygenic. Indeed, renal disease may arise as the sum of minor inputs from many different, seemingly unrelated genes, so that the genetic contributions may be difficult to identify. Confounding the problem further are environmental influences, originating either in the chromosomal environment from modifier genes, or in the extra-chromosomal environmental from intrauterine or postnatal influences. These considerations have determined both the organization of the text as well as the detailed description of the genetic disorders and the physiologic derangements that emerge. * Lays the essential foundation of mammalian genetics principles for medical professionals with little to no background in genetics. Analyzes specific renal diseases - both monogenic disorders confined to the kidney as well as systemic diseases with renal involvement - and explains their genetic causes. World-renowned editors and authors offer expert frameworks for understanding the links between genes and complex clinical disorders (i.e., lupus, diabetes, HIV, and hypertension)</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references and index</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">MEDICAL / Nephrology</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Kidneys / Diseases / Genetic aspects</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Kidney Diseases / genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medizin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Kidneys</subfield><subfield code="x">Diseases</subfield><subfield code="x">Genetic aspects</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Nierenkrankheit</subfield><subfield code="0">(DE-588)4075399-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Genetik</subfield><subfield code="0">(DE-588)4071711-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Nierenkrankheit</subfield><subfield code="0">(DE-588)4075399-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Genetik</subfield><subfield code="0">(DE-588)4071711-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="8">1\p</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lifton, Richard P.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.sciencedirect.com/science/book/9780124498518</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-33-ESD</subfield><subfield code="a">ZDB-33-EBS</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">FAW_PDA_ESD</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">FLA_PDA_ESD</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-027739416</subfield></datafield><datafield tag="883" ind1="1" ind2=" "><subfield code="8">1\p</subfield><subfield code="a">cgwrk</subfield><subfield code="d">20201028</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#cgwrk</subfield></datafield></record></collection> |
| id | DE-604.BV042302424 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:17:46Z |
| institution | BVB |
| isbn | 9780124498518 0124498515 9780080924274 0080924271 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027739416 |
| oclc_num | 318327985 |
| open_access_boolean | |
| owner | DE-1046 |
| owner_facet | DE-1046 |
| physical | 1 Online-Ressource (xiv, 829 p., [50] p. of plates) |
| psigel | ZDB-33-ESD ZDB-33-EBS FAW_PDA_ESD FLA_PDA_ESD |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Elsevier/Academic Press |
| record_format | marc |
| spelling | Genetic diseases of the kidney edited by Richard P. Lifton ... [et al.] 1st ed Amsterdam Elsevier/Academic Press 2009 1 Online-Ressource (xiv, 829 p., [50] p. of plates) txt rdacontent c rdamedia cr rdacarrier Genetic Diseases of the Kidney identifies and analyzes genetic abnormalities causing renal diseases in human subjects. Although in a sense the genome contains all the instructions required for the formation of a phenotype, the information is encoded in an extremely complicated fashion. In primary genetic diseases, the genetic instruction specifies a phenotype clearly linked with a discreet lesion confined to the kidney. However, the genetic disturbance may be imbedded in a complicated physiologic ensemble, so that the nexus between the genetic disturbance and the phenotype may be obscured; in consequence, the causal sequence is extremely difficult to unravel. In many instances the renal disease is one component of a complicated systemic hereditary disease, either monogenic or polygenic. Indeed, renal disease may arise as the sum of minor inputs from many different, seemingly unrelated genes, so that the genetic contributions may be difficult to identify. Confounding the problem further are environmental influences, originating either in the chromosomal environment from modifier genes, or in the extra-chromosomal environmental from intrauterine or postnatal influences. These considerations have determined both the organization of the text as well as the detailed description of the genetic disorders and the physiologic derangements that emerge. * Lays the essential foundation of mammalian genetics principles for medical professionals with little to no background in genetics. Analyzes specific renal diseases - both monogenic disorders confined to the kidney as well as systemic diseases with renal involvement - and explains their genetic causes. World-renowned editors and authors offer expert frameworks for understanding the links between genes and complex clinical disorders (i.e., lupus, diabetes, HIV, and hypertension) Includes bibliographical references and index MEDICAL / Nephrology bisacsh Kidneys / Diseases / Genetic aspects fast Kidney Diseases / genetics Medizin Kidneys Diseases Genetic aspects Nierenkrankheit (DE-588)4075399-2 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf Nierenkrankheit (DE-588)4075399-2 s Genetik (DE-588)4071711-2 s 1\p DE-604 Lifton, Richard P. Sonstige oth http://www.sciencedirect.com/science/book/9780124498518 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Genetic diseases of the kidney MEDICAL / Nephrology bisacsh Kidneys / Diseases / Genetic aspects fast Kidney Diseases / genetics Medizin Kidneys Diseases Genetic aspects Nierenkrankheit (DE-588)4075399-2 gnd Genetik (DE-588)4071711-2 gnd |
| subject_GND | (DE-588)4075399-2 (DE-588)4071711-2 |
| title | Genetic diseases of the kidney |
| title_auth | Genetic diseases of the kidney |
| title_exact_search | Genetic diseases of the kidney |
| title_full | Genetic diseases of the kidney edited by Richard P. Lifton ... [et al.] |
| title_fullStr | Genetic diseases of the kidney edited by Richard P. Lifton ... [et al.] |
| title_full_unstemmed | Genetic diseases of the kidney edited by Richard P. Lifton ... [et al.] |
| title_short | Genetic diseases of the kidney |
| title_sort | genetic diseases of the kidney |
| topic | MEDICAL / Nephrology bisacsh Kidneys / Diseases / Genetic aspects fast Kidney Diseases / genetics Medizin Kidneys Diseases Genetic aspects Nierenkrankheit (DE-588)4075399-2 gnd Genetik (DE-588)4071711-2 gnd |
| topic_facet | MEDICAL / Nephrology Kidneys / Diseases / Genetic aspects Kidney Diseases / genetics Medizin Kidneys Diseases Genetic aspects Nierenkrankheit Genetik |
| url | http://www.sciencedirect.com/science/book/9780124498518 |
| work_keys_str_mv | AT liftonrichardp geneticdiseasesofthekidney |