A Systems Biology Approach to Blood:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer
2014
|
| Schriftenreihe: | Advances in Experimental Medicine and Biology
844 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9781493920952 |
| DOI: | 10.1007/978-1-4939-2095-2 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804152844195987456 |
|---|---|
| adam_text | A SYSTEMS BIOLOGY APPROACH TO BLOOD
/
: 2014
TABLE OF CONTENTS / INHALTSVERZEICHNIS
PART I: BASIC COMPONENTS
SYSTEMS HEMATOLOGY: AN INTRODUCTION
QUANTIFICATION AND MODELING OF STEM CELL - NICHE INTERACTION
ANGIOGENESIS: A SYSTEMS BIOLOGY VIEW OF BLOOD VESSEL REMODELING
ERYTHROPOIESIS: FROM MOLECULAR PATHWAYS TO SYSTEM PROPERTIES
SYSTEMS BIOLOGY OF MEGAKARYOCYTES
SYSTEMS BIOLOGY OF PLATELET-VESSEL WALL INTERACTIONS
SYSTEMS APPROACH TO PHAGOYCTE PRODUCTION AND ACTIVATION: NEUTROPHILS AND
MONOCYTES
PART II: PHYSIOLOGICAL PROCESSES
STOCHASTICITY AND DETERMINISM IN MODELS OF HEMATOPOIESIS
SYSTEMS ANALYSIS OF HIGH–THROUGHPUT DATA
DEVELOPING A SYSTEMS-BASED UNDERSTANDING OF HEMATOPOIETIC STEM CELL
CYCLE CONTROL
A SYSTEMS BIOLOGY APPROACH TO IRON METABOLISM
INNATE IMMUNITY IN DISEASE - INSIGHTS FROM MATHEMATICAL MODELING AND
ANALYSIS
MODELING BIOMOLECULAR SITE DYNAMICS IN IMMUNORECEPTOR SIGNALING SYSTEMS
STRUCTURE AND FUNCTION OF PLATELET RECEPTORS INITIATING BLOOD CLOTTING
PART III: CLINICAL APPLICATIONS
UNDERSTANDING AND TREATING CYTOPENIA THROUGH MATHEMATICAL MODELING
DRUG RESISTANCE
ETIOLOGY AND TREATMENT OF HEMATOLOGICAL NEOPLASMS: STOCHASTIC
MATHEMATICAL MODELS
ASSESSING HEMATOPOIETIC (STEM-) CELL BEHAVIOR DURING REGENERATIVE
PRESSURE
ENGINEERED CELL-BASED THERAPIES: A VANGUARD OF DESIGN-DRIVEN MEDICINE
PART IV: EPILOGUE
A SYSTEMS APPROACH TO BLOOD DISORDERS
INDEX
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
A SYSTEMS BIOLOGY APPROACH TO BLOOD
/
: 2014
ABSTRACT / INHALTSTEXT
THE BLOOD SYSTEM IS MULTI-SCALE, FROM THE ORGANISM TO THE ORGANS TO
CELLS TO INTRACELLULAR SIGNALING PATHWAYS TO MACROMOLECULE INTERACTIONS.
BLOOD CONSISTS OF CIRCULATING CELLS, CELLULAR FRAGMENTS (PLATELETS AND
MICROPARTICLES), AND PLASMA MACROMOLECULES.BLOOD CELLS AND THEIR
FRAGMENTS RESULT FROM A HIGHLY-ORDERED PROCESS, HEMATOPOIESIS.
DEFINITIVE HEMATOPOIESIS OCCURS IN THE BONE MARROW, WHERE PLURIPOTENTIAL
STEM CELLS GIVE RISE TO MULTIPLE LINEAGES OF HIGHLY SPECIALIZED
CELLS.HIGHLY-PRODUCTIVE AND CONTINUOUSLY REGENERATIVE, HEMATOPOIESIS
REQUIRES A MICROENVIRONMENT OF MESENCHYMAL CELLS AND BLOOD VESSELS. A
SYSTEMS BIOLOGY APPROACH TO BLOOD IS DIVIDED INTO THREE MAIN SECTIONS:
BASIC COMPONENTS, PHYSIOLOGICAL PROCESSES, AND CLINICAL APPLICATIONS.
USING BLOOD AS A WINDOW, ONE CAN STUDY HEALTH AND DISEASE THROUGH THIS
UNIQUE TOOL BOX WITH REACTIVE BIOLOGICAL FLUIDS THAT MIRRORS THE
PREVAILING HEMODYNAMICS OF THE VESSEL WALLS AND THE VARIOUS BLOOD CELL
TYPES. MANY BLOOD DISEASES, RARE AND COMMON CAN AND HAVE BEEN EXPLOITED
USING SYSTEMS BIOLOGY APPROACHES WITH SUCCESSFUL RESULTS AND THEREFORE
IDEAL MODELS FOR SYSTEMS MEDICINE.MORE IMPORTANTLY, HEMATOPOIESIS
OFFERS ONE OF THE BEST STUDIED SYSTEMS WITH INSIGHT INTO STEM CELL
BIOLOGY, CELLULAR INTERACTION, DEVELOPMENT; LINAGE PROGRAMING AND
REPROGRAMING THAT ARE EVERY DAY INFLUENCED BY THE MOST MATURE AND
UNDERSTOOD REGULATORY NETWORKS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| series2 | Advances in Experimental Medicine and Biology |
| spelling | A Systems Biology Approach to Blood Seth Joel Corey, Marek Kimmel, Joshua N. Leonard, ed. New York, NY [u.a.] Springer 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Advances in Experimental Medicine and Biology 844 Medizin Medicine Hematology Biological models Biomedicine Corey, Seth Joel Sonstige oth Kimmel, Marek Sonstige oth Leonard, Joshua N. Sonstige oth Erscheint auch als Druckausgabe 978-1-4939-2094-5 Advances in Experimental Medicine and Biology 844 (DE-604)BV023059251 844 https://doi.org/10.1007/978-1-4939-2095-2 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027717312&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027717312&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | A Systems Biology Approach to Blood Advances in Experimental Medicine and Biology Medizin Medicine Hematology Biological models Biomedicine |
| title | A Systems Biology Approach to Blood |
| title_auth | A Systems Biology Approach to Blood |
| title_exact_search | A Systems Biology Approach to Blood |
| title_full | A Systems Biology Approach to Blood Seth Joel Corey, Marek Kimmel, Joshua N. Leonard, ed. |
| title_fullStr | A Systems Biology Approach to Blood Seth Joel Corey, Marek Kimmel, Joshua N. Leonard, ed. |
| title_full_unstemmed | A Systems Biology Approach to Blood Seth Joel Corey, Marek Kimmel, Joshua N. Leonard, ed. |
| title_short | A Systems Biology Approach to Blood |
| title_sort | a systems biology approach to blood |
| topic | Medizin Medicine Hematology Biological models Biomedicine |
| topic_facet | Medizin Medicine Hematology Biological models Biomedicine |
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