The conquest of cancer: a distant goal
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Dordrecht [u.a.]
Springer
2015
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 249 S. Ill., graph. Darst. |
| ISBN: | 9401791643 9789401791649 |
Internformat
MARC
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|---|---|---|---|
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| 020 | |a 9789401791649 |c hardcover |9 978-94-017-9164-9 | ||
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| 245 | 1 | 0 | |a The conquest of cancer |b a distant goal |c Guy Faguet |
| 264 | 1 | |a Dordrecht [u.a.] |b Springer |c 2015 | |
| 300 | |a XV, 249 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a Medizin | |
| 650 | 4 | |a Medicine | |
| 650 | 4 | |a Oncology | |
| 650 | 4 | |a Human genetics | |
| 650 | 4 | |a Biomedicine | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-027676237 | ||
Datensatz im Suchindex
| _version_ | 1804152776494678016 |
|---|---|
| adam_text | Contents
Part I An Historical Overview of the War on Cancer
1
The Four-Decade Journey to the National Cancer Act of
1971.......... 3
Part II Cancer Through the Ages
2
An Historical Overview: From Prehistory to WWII
........................... 13
2.1
From Prehistory to Ancient Egypt
.................................................. 13
2.2
From Ancient Egypt to Greece and Rome
...................................... 14
2.3
From Rome to the Middle Age
....................................................... 20
2.4
From Medieval Europe to World War II
......................................... 23
3
Our Current Knowledge
........................................................................ 35
3.1
The Genetic Bases of Cancer
......................................................... 35
3.1.1
First the Basics
................................................................. 35
3.L2 More Details
..................................................................... 38
3.2
How Does Cancer Arise?
................................................................ 54
3.2.1
First the Basics
................................................................. 54
3.2.2
More Details
..................................................................... 56
3.3
How Does Cancer Spread?
............................................................. 62
3.3.1
First the Basics
................................................................. 62
3.3.2
More Details: The Invasion-Metastasis Cascade
.............. 64
4
Environmental Carcinogens
.................................................................. 69
4.1
First the Basics
............................................................................... 69
4.2
More Details
...................................................-.............. ................ 71
4.2Л
Smoking
............................................................................ 72
4.2.2
Obesity
............................................................................. 73
4.23
Alcoholism
....................................................................... 76
xi¡ Contenes
Part
ΠΙ
Cancer Statistics
5
Assessing the Enormity of the Problem
................................................. 83
5.1
Origin, Purpose, and Data Collection
............................................. 84
5.2
Incidence and Mortality Statistics:
Reporting and Interpretation
........................................................... 85
5.3
Cancer Incidence and Mortality Rates, US
2013
Estimates
........... 85
5.4
Probability of Developing and Dying
of Advanced Cancer,
2007-2009.................................................... 87
5.5
Cancer Prevalence, US
2009.......................................................... 88
5.6
Trends
m
Cancer Incidence and Mortality, US
1975-2009........... 89
5.7
Historical Trends in Cancer Survival
.............................................. 91
6
An Uncontrolled Problem
....................................................................... 95
Part IV How Is Advanced Cancer Treated?
7
The Cancer Cell-Kill Paradigm and Beyond
........................................ 101
7.1
An Historical Overview
.................................................................. 101
7.2
Nitrogen Mustard: Cytotoxic Chemotherapy Is Born
.................... 107
7.3
Drug Discovery: Five Decades of Trial
&
Error
.............................
Ill
7.4
Attempts to Surmount Cancer Drug Inefficacy:
Five Decades
Los t
........................................................................... 1.1.3
7.5
The New Targeted Therapeutics
..................................................... 123
8
Complementary and Alternative Medicine
........................................... 1 29
9
The Cell-Kill Paradigm: Bleak Outcomes
............................................ 135
Part V Stakeholders Role in the Status Quo
10
The Role of the National Cancer Institute
............................................ 145
10.1
Current Organization, Role, and Influence
..................................... 145
10.2
NCI s Cancer Centers Program Network
....................................... 146
10.3
NCI s Clinical Trials Program Network
......................................... 147
10.4
Clinical Trials: Types, Phases, Design,
and Interpretation
............................................................................ 149
11
Factors that Impact Oncology Research and Practice
.......... ............. 155
11.1
Oncologists Qualifications
.............................................................. 155
11.1.1
Training and Board Certification
...................................... 155
11.1.2
Continuing Medical Education
......................................... 156
11.2
Factors that Influence Oncology Practice
....................................... 158
11.2.1
Standard of Care
............................................................... 159
11.2.2
Overutihzation of Services and the Chemotherapy
Concession
........................................................................ 161
11.2.3
Medical Malpractice
......................................................... 164
Contents xiii
11.2.4
Clinical Researchers and Publications
.............................. 166
11.2.5
Pharmaceutical Companies
.............................................. 168
11.2.6
The Media
......................................................................... 171
12
The Complex Physician-Patient Interaction:
Expectations vs. ReaJity
.......................................................................... 173
12.1
From the Patient s Perspective
........................................................ 173
12.1.1
First theBasics
................................................................. 173
12.1.2
More
Detaüs
..................................................................... 174
12.2
From the Caregiver s Perspective
................................................... 181
12.2.1
Facing
Difficult Decisions
................................................ 181
12.2.2
Managing Cancer Patients at the End of Life
................... 186
Part
VI
A Paradigm Shift in Cancer Management
13
Prevention and Early Detection
............................................................. 193
14
The Holistic Management of Advanced Cancer:
A Three-Stage Blueprint
......................................................................... 199
14.1
Redesigning the Search for New Cancer Agents
............................ 201
14.2
Restructuring the Treatment of Advanced-Stage Cancer
............... 202
1.4.3
Reviving the Art of End of Life Care
............................................. 205
Conclusions
...................................................................................................... 207
References
........................................................................................................ 211
Index
................................................................................................................. 241
|
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| discipline | Medizin |
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| id | DE-604.BV042238051 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T01:16:05Z |
| institution | BVB |
| isbn | 9401791643 9789401791649 |
| language | English |
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| physical | XV, 249 S. Ill., graph. Darst. |
| publishDate | 2015 |
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| publishDateSort | 2015 |
| publisher | Springer |
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| spelling | Faguet, Guy B. 1939- Verfasser (DE-588)1065011873 aut The conquest of cancer a distant goal Guy Faguet Dordrecht [u.a.] Springer 2015 XV, 249 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medizin Medicine Oncology Human genetics Biomedicine Krebsforschung (DE-588)4165564-3 gnd rswk-swf Epidemiologie (DE-588)4015016-1 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Epidemiologie (DE-588)4015016-1 s DE-604 Krebsforschung (DE-588)4165564-3 s Erscheint auch als Online-Ausgabe 978-94-017-9165-6 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027676237&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Faguet, Guy B. 1939- The conquest of cancer a distant goal Medizin Medicine Oncology Human genetics Biomedicine Krebsforschung (DE-588)4165564-3 gnd Epidemiologie (DE-588)4015016-1 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4165564-3 (DE-588)4015016-1 (DE-588)4073781-0 |
| title | The conquest of cancer a distant goal |
| title_auth | The conquest of cancer a distant goal |
| title_exact_search | The conquest of cancer a distant goal |
| title_full | The conquest of cancer a distant goal Guy Faguet |
| title_fullStr | The conquest of cancer a distant goal Guy Faguet |
| title_full_unstemmed | The conquest of cancer a distant goal Guy Faguet |
| title_short | The conquest of cancer |
| title_sort | the conquest of cancer a distant goal |
| title_sub | a distant goal |
| topic | Medizin Medicine Oncology Human genetics Biomedicine Krebsforschung (DE-588)4165564-3 gnd Epidemiologie (DE-588)4015016-1 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Medizin Medicine Oncology Human genetics Biomedicine Krebsforschung Epidemiologie Krebs Medizin |
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