Intracellular calcium:
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| ISBN: | 9780470695111 |
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| 084 | |a WD 4750 |0 (DE-625)148182: |2 rvk | ||
| 100 | 1 | |a Campbell, Anthony K. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Intracellular calcium |c by Anthony K. Campbell |
| 264 | 1 | |a Chichester |b Wiley | |
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Intracellular calcium | |
| 650 | 4 | |a Calcium / Physiological transport | |
| 650 | 0 | 7 | |a Calciumkanal |0 (DE-588)4205050-9 |2 gnd |9 rswk-swf |
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| 650 | 0 | 7 | |a Biochemie |0 (DE-588)4006777-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Signaltransduktion |0 (DE-588)4318717-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Cytologie |0 (DE-588)4070177-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Calcium |0 (DE-588)4069806-3 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Intrazellulärraum |0 (DE-588)4330337-7 |D s |
| 689 | 0 | 1 | |a Calcium |0 (DE-588)4069806-3 |D s |
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| 689 | 0 | 4 | |a Cytologie |0 (DE-588)4070177-3 |D s |
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Datensatz im Suchindex
| _version_ | 1804152747725946880 |
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| adam_text | Contents
About the Author
Preface xix
About the Companion Website
ххщ
VOLUME ONE
1
Setting the Scene:
W
hat is So Special About Calcium?
1
1.1
Discovery of Calcium
2
1.2
A Natural History of Calcium
4
1
.2.1
Calcium by the Sea
4
1.2.2
Calcium in Your Wake-Up Call
6
1.3
Elements of Life
g
1.4
Natural Occurrence of Calcium
1 [
Ì
.4.1
Isotopes of Calcium
¡
[
1.4.2
Geology of Calcium
ц
1.4.3
Calcium Outside Cells
13
1.4.4
Calcium Inside Cells
{
g
1.5
Requirement of Cells for
Са2+
19
1.5.1
Calcium in External Fluids
20
1
.5.2
Requirement of Animal Cells for Calcium
21
1
.5.3
Requirement of Plant Cells for Calcium
22
1.5.4
Requirement of Microorganisms for Calcium
22
1.6
Four Biological Roles of Calcium
23
Ì
.6.1
Structural
23
1.6.2
Electrical
23
1.6.3
Cofactor
24
1.6.4
Intracellular Regulator
26
1.7
The Puzzle About Ca2+ Inside Cells
29
1.8 1983
and All That ^
30
1.9
Darwin and Intracellular Ca2+
33
1.10
The Scene Set
34
1.
1
1
Ίά
Kalzium, das ist alles! 36
2 Intracellular
Са2 1
-
Principles and Terminology
39
2.1 The Problem 41
2.2
Some Specific Questions
41
2.3
Types of Intracellular Ca2+ Signal
44
2.4
Rubicon Principle
48
2.4.1
Digital Versus Analogue Cell Events
48
2.4.2
Path to the Rubicon
51
viti
Contents
2.5
Key Experiments to Answer Key Questions
54
2.6
Nomenclature
-
How Things are Named
57
2.6.1
English and Etymology
58
2.6.2
Organisms
59
2.6.3
Cells and Biochemistry
60
2.6.4
Genes
61
2.6.5
Proteins and Protein Sequences
62
2.6.6
Enzymes
63
2.6.7
Ion Channels
64
2.6.8
Agonists and Antagonists
66
2.6.9
Chemicals
67
2.6.10
Toxins
68
2.6.11
Drugs
68
2.6.12
Ca2* Indicators
69
2.6.13
Units
72
2.7
Model Systems
73
2.8
Darwin and Intracellular Ca2+
73
2.9
Conclusions
79
3
One Hundred Years Plus of Intracellular Ca2+
81
3.1
Background
81
3.1.1
Pathway of Discovery and Invention for Intracellular Ca2
81
3.1.2
Model Systems
83
3.2
Why Study the History of Science?
85
3.3
Tale of Three Pioneers and What Followed
86
3.3.1
Experiments of Sydney Ringer
(1836-1910) 86
3.3.2
Vision of Lewis Victor
Heilbrunn (1892-1959) 90
3.3.3
Setsuro Ebashi
(1922-2006):
Pioneer of Intracellular Ca2+ in Muscle
Contraction
94
3.4
Ca2+ as an Intracellular Regulator
95
3.4.1
Cell Theory
97
3.4.2
Origin of the Use of Ca2+
97
3.4.3
Manipulation of Ca2+
98
3.4.4
Measurement and Location of Free Ca2+ in Live Cells
99
3.4.5
Identification of the Components Responsible for Regulating Free Ca24
Inside Cells
107
3.4.6
Discovery of Plasma Membrane Ca2+ Pumps and Transporters
107
3.4.7
Discovery of How Ca2+ is Released from the SR/ER
108
3.4.8
Discovery of IP3 and its Receptor
109
3.4.9
Discovery of the Ryanodine Receptor 111
3.4.10
Discovery of SOCE
113
3.4.11
Discovery of Ca2+ Channels in the Plasma Membrane
116
3.4.12
Discovery of
TRP
Channels
119
3.4.13
Discovery of G-Proteins
119
3.4.14
Identification of the Ca2+ Targets Inside Cells and How They Work
119
3.4.15
Intracellular Ca2+in Plants
122
3.4.16
Intracellular Ca2+in Bacteria
122
3.4.17
Pathology of Intracellular Ca2+
123
Contents h
3.5
Conceptual
Development
of Ca2 1
as an
Intracellular Regulator 124
3.6
Conclusions
127
4
How to Study Intracellular Ca2+ as Cell Regulator
129
4.1
Pathway to Discover the Role of Intracellular Ca2 1 in a Cell Event
130
4.2
Manipulation of Extra- and Intracellular Ca2 1
1 31
4.3
Measurement of Intracellular Free Ca2+
1 3 5
4.3.1
Absorbing Dyes
136
4.3.2
Fluorescent Ca2 1 Indicators
137
4.3.3
Calibration of
Fluors
144
4.3.4
Ca2+-Activated
Photoproteins 146
4.3.5
Calibration of Ca2+-Activated
Photoproteins 1 54
4.3.6
Ca2+ Indicators and GFP I
5 8
4.3.7
Other Free Ca2+ Indicators for Whole Organs and Organisms
166
4.4
Detecting and Imaging Photons
166
4.5
Measurement of Total Cell Ca2 1
174
4.6
Calcium Buffers
176
4.7
Measurement of Ca2+Fluxes
179
4.8
How to Study Ca2+ and Other Ion Channels
180
4.9
How to Discover How the Rise in Cytosolic Free Ca2 1 Occurs and Then Returns
to Rest
183
4.10
How to Discover the Intracellular
Са2+
Target and How it Works
184
4.11
Other Ions
185
4.12
Conclusions !85
5
How Ca2+ is Regulated inside Cells
187
5.1
Principles ^
187
5.2
How Resting Cells Maintain Their Ca2+ Balance
191
5.3
Electrophysiology of Intracellular Ca2+
194
5.4
Primary Stimuli Which Produce a Cytosolic Free Ca2+ Signal
200
5.5
Plasma Membrane Ca2 1 Channels
204
5.5.1
Voltage-Gated Ca2+ Channels
205
5.5.2
TRP
Channels
213
5.5.3
Recept
or-Activated Ca2+ Channels
215
5.5.4
Mechanosensitive Channels
216
5.5.5
Store-Operated Calcium Entry
-
SOCE
218
5.5.6
Ca2+Receptor ^
221
5.6
Regulation of Intracellular Ca2+ By, and Within,
Organdíes
222
5.6.1
Endo^sarco-plasmic Reticulum
(ER/SR)
223
5.6.2
Mitochondrial
Ca2 1 ^
234
5.6.3
Lysosomal and Endosomal Ca2+
243
5.6.4
Secretory Vesicle Ca2 1
246
5.6.5
Peroxisomal Ca2+
246
5.6.6
Control of Ca2+ by the Golgi
246
5.6.7
Nucleus and
Ca2*
248
5.6.8
Plant Organelles and Ca2+
249
5.6.9
Acidocalcisomes
251
5.7
Second Messengers and Regulation of Ca2 1 Signalling in the Cytosol
251
χ
Con tents
5.8
Pore Formers and Intracellular Ca24
5.9
Connexins and Gap Junctions
5.10
Other Ion Channels and Ca2+
5.11
Conclusions
6
How Ca2* Works Inside Cells
6.1
Biological Chemistry of Ca2+
6.1.1
Ca2+ Ligands
6.1.2
Solvation
6.1.3
Problem of Activity Coefficients
6.1.4
Fractional Ca2+ Binding After a Ca2+ Signal
6.1.5
Kinetics
6.1.6
Diffusion
6.1.7
Solubility
6.2
Ca^-Binding Proteins
6.2.1
Types of Ca2+-Binding Protein Inside Cells
6.2.2
Proteins with the EF-Hand Motif
6.2.3
Proteins with the C2 Motif
6.2.4
Proteins with a Cluster of Acidic Residues
6.2.5
Proteins Forming a Cluster of Oxygen Ligands From the Three-
Dimensional Structure
6.3
Ca2+ and Other Intracellular Signals
6.3.1
Cyclic Nucleotides and Ca2+
6.3.2
Ca2+ and PKC
6.3.3
NO and Ca2+
6.3.4
Ca2+, Inositol Phosphates and Other Intracellular Signals
6.4
Ca2+ and
Monovalent Ions
6.4.1
Intracellular Ca2+ and K+ Conductance
6.4.2
Intracellular Ca2+ and Na+ Conductance
6.4.3
Ca2+ and Chloride Channels
6.5
Transition Metals, Other Divalent Cations and
Lanthanides
6.6
Conclusions
7
How Ca2+ Regulates Animal Cell Physiology
7.1
Ca2+ and How Nerves Work
7.2
Ca2+ and Cell Movement
7.3
Muscle Contraction
7.3.1
How Intracellular Ca2+ Causes Skeletal Muscle to Contract
7.3.2
How Intracellular Ca2+ Causes the Heart to Beat
7.3.3
How Intracellular Ca2+ Causes Smooth Muscle to Contract
7.3.4
How Intracellular Ca2+ Works in Invertebrate Muscle
7.3.5
Special Case of Ca2+ and the Spasmoneme
7.4
Chemotaxis and Ca2+
7.5
Intracellular Ca2* and Secretion
7.5.1
Principles
7.5.2
Neurosecretion
7.5.3
Ca2+, the Endocrine Pancreas and Insulin Secretion
255
256
257
257
259
261
262
266
268
270
274
275
275
277
277
279
288
291
294
298
298
303
304
305
305
306
307
308
309
310
313
314
317
317
323
325
327
329
330
330
334
334
340
341
Contents xi
7.5.4 Ca2+
and the Salivary Gland
343
7.5.5
Са2 1
and the
Exocrine
Pancreas
343
7.5.6
Ca2+ and the Adrenal Medulla
344
7.5.7
Intracellular Ca2+ and Mast Cells
344
7.5.8
Ca2 1 and Neutrophils, and Other Phagocytes
345
7.5.9
Ca2+ and Platelets
348
7.5.10
Ca2+and Nematocysts
349
7.5.11
Ca2 1 and Coccolithophores
350
7.5.12
Conclusions about Secretion and Intracellular Ca2+
351
7.6
Ca2 1 and Endocytosis
351
7.6.1
Principles
351
7.6.2
Phagocytosis
352
7.7
Intracellular Ca2 1 and Intermediary Metabolism
354
7.7.1
Са2*
Activation of Glucose Metabolism
354
7.7.2
Ca2+ and Mitochondrial Intermediary Metabolism
357
7.7.3
Ca2+ and Lipolysis and Lipogenesis
360
7.8
Intracellular Ca2+ and Cell Growth
360
7.8.1
Principles
360
7.8.2
Cell Cycle and Ca2+
361
7.8.3
Fertilisation and Intracellular Ca2+
366
7.8.4
Differentiation and Intracellular Ca2+
371
7.9
Intracellular Ca2 1 and the Immune Response
371
7.10
Intracellular Ca2+and Vision
373
7.10.1
Ca2+ and Vertebrate Vision
374
7.10.2
Ca2+and Invertebrate Vision
376
7.
1
1
Intracellular Ca2+ and Other Senses
378
7.12
Ca2+and
Bioluminescence
378
7.13
Intracellular
Са2 1
and Gene Expression
386
7.14
Conclusions
386
VOLUME TWO
8
Intracellular Ca2+ and Microorganisms
389
8.1
The Puzzle
389
8.2
What Are Microorganisms?
391
8.3
What Do Microorganisms Do?
391
8.4
Indirect Evidence of a Role for Intracellular
Ca2+ in
Bacteria
393
8.5
Potential Role of Intracellular Ca2+ in Bacteria
394
8.6
How Much Ca2+ is There in Bacteria?
397
8.7
How Bacteria Regulate Their Intracellular Ca2
398
8.7.1
Ca2+Influx into Bacteria
401
8.7.2
Ca2+ Efflux in Bacteria
405
8.8
Ca2+-Binding Proteins in Bacteria
406
8.9
Regulation of Bacterial Events by Intracellular Ca2+
406
8.9.1
Ca2+ and Growth of Bacteria
406
8.9.2
Calcium and Bacterial Movement
410
8.9.3
Quorum Sensing and Gene Expression
415
8.9.4
Ca2+and Bacterial Metabolism
416
xi
j
Contents
8.9.5
Bacterial Defence Dormancy, Spore Formation and Germination
416
8.9.6
Bacterial Infection
-
Virulence, Competence and Defence
417
8.9.7
Development of Bacterial Structures
419
8.9.8
Ca2+ and Gene Expression
422
8.9.9
Bacterial Transformation
422
8.9.10
Bacterial Metabolic Toxin Hypothesis
423
8.9.11
Intracellular Ca2 1 in Bacteria
-
Conclusions
424
8.10
Role of Intracellular Ca2+in Archaea
426
8.11
Intracellular Ca2+ and Viruses
430
8.11.1
Eukaryotic Viruses
430
8.11.2
Bacterial Viruses Bacteriophages
432
8.12
Intracellular Ca2+and Eukaryotic Microorganisms
433
8.12.1
Yeast
434
8.12.2
Paramecium and Related Ciliates
436
8.12.3
Slime Moulds
438
8.12.4
Luminous Radiolarians
440
8.13
Conclusions
440
9
Role of Intracellular Ca2 1 in Plants and Fungi
443
9.1
Role of Ca2+ in Plants
443
9.2
What Stimulates Plants?
444
9.2.1
Examples of Plant Cell Stimuli
444
9.2.2
Plant Hormones
446
9.2.3
Intracellular Signals in Plants
447
9.3
Requirement of Plants for Ca2+
447
9.4
Where Ca2+ is Stored in Plants
449
9.5
Measurement of Cytosolic Free Ca2+ in Plants
449
9.6
Identification of the Components of the Ca2+ Signalling System in Plants
455
9.6.1
Ca2 1 Pumps and Exchangers
455
9.6.2
Ca2 1 Channels in the Plasma Membrane
455
9.6.3
Plant
Organelies
and Ca2+
456
9.6.4
Ca2+ Stores Inside Plant Cells
458
9.6.5
Ca2+-Binding Proteins in Plants
458
9.6.6
Ca2+ -Sensitive Genes in Plants
459
9.7
How Intracellular Ca2+Can Provoke Cellular Events in Plants
460
9.7.1
Light and Intracellular Ca2+ in Plants
460
9.7.2
Control of Opening and Closing of
Stoma/Stornata
460
9.7.3
Wind and Mechanical Stimulation of Plants
462
9.7.4
Gravity Sensing and Growth
462
9.7.5
Fertilisation and Germination
462
9.7.6
Legumes
463
9.7.7
Intermediary Metabolism
463
9.7.8
Transport by Phloem
464
9.7.9
Defence Against Stress
465
9.8
Fungal Elicitors
467
9.9
Apoptosis
467
9 10
Intracellular Ca2+ and Plant Pathology
467
9.11
Ca2+ in Mosses, Liverworts and Ferns
468
9.12
Darwin and Plants
469
Contents
x/iř
9.13
Ca2 *
in Fungi
4^
9.13.1
Biology of Fungi
4.^9
9.13.2
Intracellular Ca2+and Yeast
471
9.13.3
Lichens
47-»
9.14
Ca2+and Slime Moulds
472
9.15
Conclusions
472
10
Pathology of Intracellular Ca2 1
473
10.1
What is Pathology?
473
10.2
Types of Pathology
474
10.3
Intracellular Ca2+ Friend or Foe?
475
10.4
Intracellular
Ca2 1
and Cell Death
476
10.4.1
Necrosis
478
10.4.2
Apoptosis
47$
10.4.3
Autophagy
481
10.4.4
Lysis
481
10.4.5
Cell Death Conclusions
483
10.5
Genetic Abnormalities in Ca2+ Signalling Proteins
483
10.5.1
Ca2+Channelopathies
484
10.5.2
Ca2 1 Pumpopathies
483
10.5.3
Mutations in
ER
Ca2+ Release Proteins 48i
10.5.4
Mutations in Ca2 1 Target Proteins
487
10.5.5
Proteins Associated with Ca2+ Signalling
487
10.6
Oxygen and Cell Pathology
487
10.6.1
Ca2+Paradox
487
10.6.2
Oxidative Damage and Intracellular Ca2+
489
10.7
Inappropriate Ca2+Signalling
490
10.7.
1 Immune System and Other Organs in Disease
490
10.7.2
Bacterial Metabolic Toxin Hypothesis
492
10.8 ER
Stress Response
494
10.9
Conclusions
498
11
Pharmacology of Intracellular Ca2+
499
1
Ï.1
Background to Compounds That Interact With Intracellular Ca2+ and Ca2 1
Movement
499
11.2
Pharmacological Targets for Intracellular Ca2 1
504
11.3
Drugs Used Clinically That Interfere With Intracellular
Са2 1
505
11.4
Anaesthetics
506
11.4.1
General Anaesthetics
506
11.4.2
Local Anaesthetics
507
J
1.5
Ca2+ Channel Effectors
508
11.5.1
Classes of Ca2+ Channel
Blocker 508
11.5.2
Dihydropyridines
512
11.5.3
Phenylalkylamines
513
11.5.4
Benzothiazepines
515
11.6
Hypertension
516
11.7
Arrhythmia, Tachycardia and Bradycardia
517
11.8
Angina
517
xiv Contents
11.9
Heart Failure
518
11.10
Agents Which Inhibit or Activate Adrenergic Receptors
518
11.11
Cardiac Glycosides
520
1.12
Benzodiazapines
521
1.13
Anti-Psychotic Drugs
522
1.14
Stimulants and Drugs of Abuse
525
1.15
Analgesics
527
1.16
Ant i
-Depressants and Manic Depression
532
1.17
Diabetes
532
1.18
M uscle Relaxants
533
1.19
Anti-Allergies and Anti-Immune Compounds
535
1.20Xanthines
^
535
1 21
Substances Used Experimentally to Interfere with Intracellular Ca:+
536
11.21.1
Ca2+ Buffers and Ionophores
537
11.21.2
Ca2+Channels
537
11.21.3
Agents Which Open or Close Voltage-Gated Ca2+ Channels
537
ll.21.4IPj Receptor Activators and
Blockers 538
11.21.5
Ryanodine Receptor Agonists and Antagonists
541
11.21.6
Plasma Membrane Ca2+ Pump and Exchanger Inhibitors
541
11.21.7
SERCA Pump
Inhibitors
541
11.21.8
Compounds Which Affect Store-Operated Calcium Entry (SOCE)
542
11.21.9
Mitochondrial
Blockers 543
11.21.10
Ca2+ Target Inhibitors
544
11.22
Natural Toxins and Poisons
548
11.22.
1 Natural Stings. Bites and Other Toxin-Producing Events
548
11.22.2
Cone Snail Toxins: Conotoxins
549
11.22.3
Spider Toxins
552
1
1
.22.4
Scorpion Toxins
552
11.22.5
Pufferfish, Octopus, and frog Toxins
554
11.22.6
Jellyfish Sting Toxins
554
11.22.7
Hymenopteran Stings and Bites
556
11.22.8
Snake Venoms
557
11.23
Plant Toxins and Intracellular Ca2+
557
1
1.24
Drugs and the Ca2+ Receptor
558
1
1.25
Bacteria
559
11.26
Ions and Intracellular Ca2+
559
11.27
Antibodies and Intracellular Ca2+
561
11.28
Summary and Conclusions
562
Π
Darwin and
4000
Million Years of Intracellular
Сп2+
563
565
570
572
572
572
575
12.3.4
Ca2
and the Origin of Life
576
12.3.5
Ca2+ and the Origin of the Three Cell Types: Bacteria, Archaea aiui Eukaroyta
577
12.3.6
Timescale
580
12.1
Darwin
and Calcium
і.:
Evolution and Ca2 *
12.3
What is
Evolution?
12.3.1
The Word Evolution
12.3.2
Process
12.3.3
Sequence of Evolution
Con tenes
xv
12.4 Evolution
of Ca2 1
Signalling
581
12.4.1
Origin of Ca2+Signalling 5KI
12.4.2
Membrane Potential
581
12.4.3
Evolution of Ca2+ Signalling Based on Phylogenetic Comparisons
584
12.4.4
Evolution of Ca^-Binding Sites
589
12.4.5
Origin of the EF-Hand
590
12.5
Darwin and Knock-Outs
593
12.6
Conclusions
596
13
They Think It s All Over 5W
13.1
What We Know About the Details of Intracellular Ca2+
600
13.2
What We Don t Know About Intracellular Ca2+
603
13.3
Intracellular Ca2 1 at School and University
606
13.4
Inspiration of Intracellular Ca2+
607
13.5
Communicating the Story of Intracellular Ca:+ to Others
610
13.6
End of the Beginning
615
Bibliography
4
Π
Organism Index
739
Subject Index
145
INTRACELLULAR
CALCIUM
ANTHONY K.
CAMPBELL
School of Pharmacy and Pharmaceutical Sciences, Cardiff University, UK
and Wekton Court Science Centre, UK
Thousands of imaginative scientists, over more than a century, have revealed the fascinating story of intracellular
calcium, through a pathway of ingenious invention and discovery.
Intracellular Calcium, the definitive book on this topic, reveals:
The pathway of discovery and invention of intracellular calcium over more than
100
years
The evidence for intracellular calcium as a universal switch in all animal, plant, fungal and microbial cells
•
How the components required for calcium signalling are named and classified
•
The ingenious technology that has been developed to study intracellular calcium
-
How calcium is regulated inside cells and how it works to trigger an event
The role of intracellular calcium in disease, cell injury and cell death
•
How many drugs work through the calcium signalling system
•
How intracellular calcium is involved in the action of many natural toxins
•
How the intracellular calcium signalling system has evolved over
4000
million years, showing why it was
crucial to the origin of life
A key principle presented throughout the book is the molecular variation upon which the intracellular calcium
signalling system depends. This variation occurs within the same cell type and between cells with different functions,
providing the invisible matrix upon which Darwin and Wallace s Natural Selection depends.
Featuring more than
120
figures, including detailed chemical structures as well as pictures of bey pioneers in the
field, a bibliography of more than
2000
references, as well as detailed subject and organism indices, this definitive
work provide^ a unique source of scholarship for all students, teachers and researchers in the
biomedical
sciences
and beyond.
ANTHONY K. CAMPBELL is one of the leading scholars in intracellular calcium, having strafed the subject tor
over
40
years. He is a pioneer in the use of bioluminescent indicators to measure and image free calcium in all the
domains of life· animals, plants, bacteria and Archaea. This work led to an invention now used in several billion
clinical tests per year world-wide.
Also available
as an e-book
|
| any_adam_object | 1 |
| author | Campbell, Anthony K. |
| author_facet | Campbell, Anthony K. |
| author_role | aut |
| author_sort | Campbell, Anthony K. |
| author_variant | a k c ak akc |
| building | Verbundindex |
| bvnumber | BV042220407 |
| classification_rvk | WD 4750 |
| ctrlnum | (DE-599)BVBBV042220407 |
| discipline | Biologie |
| format | Book |
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| indexdate | 2024-07-10T01:15:38Z |
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| language | English |
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| spelling | Campbell, Anthony K. Verfasser aut Intracellular calcium by Anthony K. Campbell Chichester Wiley txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Intracellular calcium Calcium / Physiological transport Calciumkanal (DE-588)4205050-9 gnd rswk-swf Intrazellulärraum (DE-588)4330337-7 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Cytologie (DE-588)4070177-3 gnd rswk-swf Calcium (DE-588)4069806-3 gnd rswk-swf Intrazellulärraum (DE-588)4330337-7 s Calcium (DE-588)4069806-3 s Calciumkanal (DE-588)4205050-9 s Signaltransduktion (DE-588)4318717-1 s Cytologie (DE-588)4070177-3 s Biochemie (DE-588)4006777-4 s DE-604 Digitalisierung UB Bayreuth - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027658922&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Bayreuth - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027658922&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Campbell, Anthony K. Intracellular calcium Intracellular calcium Calcium / Physiological transport Calciumkanal (DE-588)4205050-9 gnd Intrazellulärraum (DE-588)4330337-7 gnd Biochemie (DE-588)4006777-4 gnd Signaltransduktion (DE-588)4318717-1 gnd Cytologie (DE-588)4070177-3 gnd Calcium (DE-588)4069806-3 gnd |
| subject_GND | (DE-588)4205050-9 (DE-588)4330337-7 (DE-588)4006777-4 (DE-588)4318717-1 (DE-588)4070177-3 (DE-588)4069806-3 |
| title | Intracellular calcium |
| title_auth | Intracellular calcium |
| title_exact_search | Intracellular calcium |
| title_full | Intracellular calcium by Anthony K. Campbell |
| title_fullStr | Intracellular calcium by Anthony K. Campbell |
| title_full_unstemmed | Intracellular calcium by Anthony K. Campbell |
| title_short | Intracellular calcium |
| title_sort | intracellular calcium |
| topic | Intracellular calcium Calcium / Physiological transport Calciumkanal (DE-588)4205050-9 gnd Intrazellulärraum (DE-588)4330337-7 gnd Biochemie (DE-588)4006777-4 gnd Signaltransduktion (DE-588)4318717-1 gnd Cytologie (DE-588)4070177-3 gnd Calcium (DE-588)4069806-3 gnd |
| topic_facet | Intracellular calcium Calcium / Physiological transport Calciumkanal Intrazellulärraum Biochemie Signaltransduktion Cytologie Calcium |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027658922&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027658922&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT campbellanthonyk intracellularcalcium |