Sequence defined oligo(amidoamines): synthesis, carbohydrate functionalization und biomedical applications
Gespeichert in:
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online-Zugang: | Sequence defined oligo(amidoamines) Inhaltsverzeichnis |
| Beschreibung: | VIII, 92 S., S. IX - LXVII Ill., graph. Darst. 30 cm |
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Datensatz im Suchindex
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| adam_text | SEQUENCE-DEFINED OLIGO(AMIDOAMINES): SYNTHESIS,
CARBOHYDRATE FUNCTIONALIZATION AND BIOMEDICAL APPLICATIONS
SUMMARY
ZUSAMMENFASSUNG
VL
1. INTRODUCTION
1
1.1 SOLID PHASE TECHNOLOGY 1
1.2 CARBOHYDRATES AND MULTIVALENCY IN BIOLOGY 7
1.3 CONJ UGATION CHEMI STRY 12
1.3.1 THIOL-ENE ADDITION 13
1.4 CONTINUOUS FLOW SYSTEMS 17
1.4.1 CONTINUOUS FLOW PHOTOREACTORS 17
2. AIMS AND OUTLINE OF THE THESIS
19
3. BUILDING BLOCK SYNTHESIS
2]
_
3.1 BUILDING BLOCK DESIGN 23
3.2 VERSATILE BUILDING BLOCK SYNTHESIS 24
4. SYNTHESIS OF ASYMMETRICALLY BRANCHED OLIGO(AMIDOAMINES) ^
4.1 PAA BACKBONE SYNTHESIS 31
4.2 MULTIPLE ALLOC CLEAVAGE ON SOLID SUPPORT 33
4.3 SYNTHESIS OF ASYMMETRICALLY BRANCHED PAAS 35
HTTP://D-NB.INFO/1048401464
5. SYNTHESIS OF CARBOHYDRATE-FUNCTIONALIZED OLIGO(AMIDOAMINES)
5.1 EXPERIMENTAL FLOW SET-UP FOR THIOL-ENE COUPLING 41
5.2 CONJUGATION ON BUILDING BLOCK LEVEL AND CHAIN ASSEMBLY 43
5.3 CONJUGATION TO ALIPHATIC PAAS AT 254 NM 50
5.4 CONJUGATION TO MULTICOMPONENT STRUCTURES 57
6. APPLICATIONS OF SEQUENCE-DEFINED OLIGO(AMIDOAMINES) IN ^
CHEMICAL BIOLOGY
6.1 PRECISION MACROMOLECULES AS MS STANDARDS IN GLYCOPROTEOMICS 66
6.2 ELECTROPHORESIS AND DIFFUSION NMR STUDIES OF SEQUENCE-DEFINED PAAS
70
6.3 LECTIN BINDING STUDIES OF MANNOSE-FUNCTIONALIZED PAAS 73
6.4 TARGETED GENE DELIVERY USING CARBOHYDRATE-FUNCTIONALIZED PAAS 77
6.5 IMMUNOLOGICAL STUDIES OF GLYCOSYLATED PAA-CONJUGATES 83
7. CONCLUSIONS AND OUTLOOK 89
8. APPENDIX
8.1 LIST OF ABBREVIATIONS IX
8.2 MATERIALS XIII
8.3 METHODS XIII
8.4 EXPERIMENTAL PROCEDURES XVI
8.4.1 EXPERIMENTAL PROCEDURES: 3. BUILDING BLOCK SYNTHESIS XVI
8.4.2 EXPERIMENTAL PROCEDURES: 4. ASYMMETRICALLY BRANCHED PAAS XXIV
8.4.3 EXPERIMENTAL PROCEDURES: 5. CARBOHYDRATE-FUNCTIONALIZED PAAS XXXV
8.4.3.1 EXPERIMENTAL PROCEDURES: 5.2 CONJUGATION ON BUILDING BLOCK LEVEL
XXXV
8.4.3.2 EXPERIMENTAL PROCEDURES: 5.3 CONJUGATION TO ALIPHATIC PAAS AT
254 NM XLV
8.4.3.3 EXPERIMENTAL PROCEDURES: 5.4 CONJUGATION TO MULTICOMPONENT
STRUCTURES LI
8.4.4 EXPERIMENTAL PROCEDURES: 6. APPLICATIONS IN CHEMICAL BIOLOGY LIV
9. REFERENCES
LIX
|
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| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie Medizin |
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| spelling | Wojcik, Felix Verfasser (DE-588)1047325314 aut Sequence defined oligo(amidoamines) synthesis, carbohydrate functionalization und biomedical applications by Felix Wojcik 2014 VIII, 92 S., S. IX - LXVII Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Berlin, Freie Univ., Diss., 2014 Oligomere (DE-588)4212195-4 gnd rswk-swf Amine (DE-588)4001705-9 gnd rswk-swf Amidoverbindungen (DE-588)4332036-3 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Amidoverbindungen (DE-588)4332036-3 s Amine (DE-588)4001705-9 s Oligomere (DE-588)4212195-4 s DE-604 http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=5746665&custom_att_2=simple_viewer Sequence defined oligo(amidoamines) Zusätzliche Angaben DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027643021&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wojcik, Felix Sequence defined oligo(amidoamines) synthesis, carbohydrate functionalization und biomedical applications Oligomere (DE-588)4212195-4 gnd Amine (DE-588)4001705-9 gnd Amidoverbindungen (DE-588)4332036-3 gnd |
| subject_GND | (DE-588)4212195-4 (DE-588)4001705-9 (DE-588)4332036-3 (DE-588)4113937-9 |
| title | Sequence defined oligo(amidoamines) synthesis, carbohydrate functionalization und biomedical applications |
| title_auth | Sequence defined oligo(amidoamines) synthesis, carbohydrate functionalization und biomedical applications |
| title_exact_search | Sequence defined oligo(amidoamines) synthesis, carbohydrate functionalization und biomedical applications |
| title_full | Sequence defined oligo(amidoamines) synthesis, carbohydrate functionalization und biomedical applications by Felix Wojcik |
| title_fullStr | Sequence defined oligo(amidoamines) synthesis, carbohydrate functionalization und biomedical applications by Felix Wojcik |
| title_full_unstemmed | Sequence defined oligo(amidoamines) synthesis, carbohydrate functionalization und biomedical applications by Felix Wojcik |
| title_short | Sequence defined oligo(amidoamines) |
| title_sort | sequence defined oligo amidoamines synthesis carbohydrate functionalization und biomedical applications |
| title_sub | synthesis, carbohydrate functionalization und biomedical applications |
| topic | Oligomere (DE-588)4212195-4 gnd Amine (DE-588)4001705-9 gnd Amidoverbindungen (DE-588)4332036-3 gnd |
| topic_facet | Oligomere Amine Amidoverbindungen Hochschulschrift |
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