CLCA proteins in the airways: new insights into their expression patterns and role in innate immunity in pneumonia
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
Mensch und Buch Verl.
2014
|
| Schlagworte: | |
| Online-Zugang: | Volltext Inhaltsverzeichnis |
| Beschreibung: | Nebentitel: CLCA-Proteine in den Atemwegen |
| Beschreibung: | X, 86 S. Ill., graph. Darst. |
| ISBN: | 9783863875381 |
Internformat
MARC
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| 245 | 1 | 0 | |a CLCA proteins in the airways |b new insights into their expression patterns and role in innate immunity in pneumonia |c vorgelegt von Kristina Dietert geb. Siegert |
| 246 | 1 | 3 | |a CLCA-Proteine in den Atemwegen |
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| 300 | |a X, 86 S. |b Ill., graph. Darst. | ||
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| 650 | 7 | |a bacterial diseases |2 cabt | |
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Datensatz im Suchindex
| _version_ | 1805079634377703424 |
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| adam_text |
CONTENTS
LIST OF ABBREVIATIONS IX
1 INTRODUCTION 1
1.1 THE CLCA PROTEIN FAMILY 1
1.1.1 BACKGROUND 1
1.1.2 CLCA PROTEINS IN RESPIRATORY DISEASES 3
1.1.3 CLCA PROTEINS IN MUCUS CELL METAPLASIA 4
1.1.4 CLCA PROTEINS IN PNEUMONIA AND INNATE IMMUNITY 5
1.1.5 EXPRESSION OF CLCA FAMILY MEMBERS IN MURINE, HUMAN AND PORCINE
AIRWAYS 6
1.1.5.1 MURINE MCLCA3 AND ITS HUMAN AND PORCINE ORTHOLOGS, HCLCAL AND
PCLCAI. 8
1.1.5.2 MURINE MCLCA5 AND ITS HUMAN AND PORCINE ORTHOLOGS, HCLCA2 AND
PCLCA2. 8
1.2 SPECIES-SPECIFIC ANATOMIE AND HISTOLOGIE DIFFERENCES BETWEEN MURINE,
HUMAN
AND PORCINE AIRWAYS 9
1.2.1 COMPARATIVE ANATOMY 9
1.2.2 COMPARATIVE HISTOLOGY 10
1.2.2.1 TRACHEAL EPITHELIUM 10
1.2.2.2 INTRAPULMONARY AIRWAY EPITHELIUM 11
1.3 INNATE IMMUNITY OF THE LUNG 14
1.3.1 INNATE IMMUNE RESPONSE: ACTORS 14
1.3.2 INNATE IMMUNE RESPONSE: MEDIATORS 15
1.4 AIMS AND HYPOTHESES OF THIS STUDY 18
2 OWN RESEARCH PUBLICATIONS IN SCIENTIFIC JOURNALS 20
2.1 MURINE CLCA5 IS UNIQUELY EXPRESSED IN DISTINCT NICHES OF AIRWAY
EPITHELIAL
CELLS 20
2.2 MCLCA3 MODULATES IL-17 AND CXCL-1 INDUCTION AND LEUKOCYTE
RECRUITMENT
IN MURINE STAPHYLOCOCCUS AUREUS PNEUMONIA 33
3 CONCLUDING DISCUSSION 48
3.1 EXPRESSION OF MURINE CLCA5 IN THE RESPIRATORY TRACT AND ITS PUTATIVE
ROLE IN
MUCUS CELL DIFFERENTIATION 51
VII
HTTP://D-NB.INFO/1063389313
CONTENTS
3.1.1 CHARACTERIZATION OF THE EXPRESSION PATTERN AND CELLULAR
LOCALIZATION OF
MCLCA5 IN MURINE AIRWAYS 52
3.1.2 EXPRESSION OF THE MCLCA5 PROTEIN IN CHALLENGED LUNGS 53
3.1.3 SPECIES-SPECIFIC DIFFERENCES IN EXPRESSION PATTERNS OF MCLCA5
VERSUS ITS
HUMAN AND PORCINE ORTHOIOGS, HCLCA2 AND PCLCA2 54
3.2 MCLCA3 IN THE INNATE IMMUNE RESPONSE 56
3.3 NEW INSIGHTS FROM THIS STUDY IN CONTEXT OF CLCA RESEARCH 58
3.4 CONCLUSIONS 60
3.5 OUTLOOK 61
4 SUMMARY 64
5 ZUSAMMENFASSUNG 66
6 REFERENCES 69
7 LIST OF PUBLICATIONS 82
8 FUNDING 83
9 ACKNOWLEDGEMENTS I DANKSAGUNG 84
SELBSTSTAENDIGKEITSERKLAERUNG 86 |
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| format | Thesis Book |
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| indexdate | 2024-07-20T06:48:05Z |
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| isbn | 9783863875381 |
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| spelling | Dietert, Kristina Verfasser (DE-588)1060086751 aut CLCA proteins in the airways new insights into their expression patterns and role in innate immunity in pneumonia vorgelegt von Kristina Dietert geb. Siegert CLCA-Proteine in den Atemwegen Berlin Mensch und Buch Verl. 2014 X, 86 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nebentitel: CLCA-Proteine in den Atemwegen Berlin, Freie Univ., Diss., 2014 animal models cabt mice cabt mucus cabt cell differentiation cabt stem cells cabt immunity cabt respiratory diseases cabt bacterial diseases cabt immunohistochemistry cabt immunofluorescence cabt reverse transcriptase PCR cabt Tiermodell (DE-588)4140660-6 gnd rswk-swf Proteine (DE-588)4076388-2 gnd rswk-swf Angeborene Immunität (DE-588)4739713-5 gnd rswk-swf Lungenentzündung (DE-588)4036659-5 gnd rswk-swf Zelldifferenzierung (DE-588)4067536-1 gnd rswk-swf Immunmodulation (DE-588)4315157-7 gnd rswk-swf Chloridkanal (DE-588)4291189-8 gnd rswk-swf Genexpression (DE-588)4020136-3 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Lungenentzündung (DE-588)4036659-5 s Angeborene Immunität (DE-588)4739713-5 s Chloridkanal (DE-588)4291189-8 s Proteine (DE-588)4076388-2 s Zelldifferenzierung (DE-588)4067536-1 s Genexpression (DE-588)4020136-3 s Immunmodulation (DE-588)4315157-7 s Tiermodell (DE-588)4140660-6 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:kobv:188-fudissthesis000000097741-1 http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000097741 kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027595394&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dietert, Kristina CLCA proteins in the airways new insights into their expression patterns and role in innate immunity in pneumonia animal models cabt mice cabt mucus cabt cell differentiation cabt stem cells cabt immunity cabt respiratory diseases cabt bacterial diseases cabt immunohistochemistry cabt immunofluorescence cabt reverse transcriptase PCR cabt Tiermodell (DE-588)4140660-6 gnd Proteine (DE-588)4076388-2 gnd Angeborene Immunität (DE-588)4739713-5 gnd Lungenentzündung (DE-588)4036659-5 gnd Zelldifferenzierung (DE-588)4067536-1 gnd Immunmodulation (DE-588)4315157-7 gnd Chloridkanal (DE-588)4291189-8 gnd Genexpression (DE-588)4020136-3 gnd |
| subject_GND | (DE-588)4140660-6 (DE-588)4076388-2 (DE-588)4739713-5 (DE-588)4036659-5 (DE-588)4067536-1 (DE-588)4315157-7 (DE-588)4291189-8 (DE-588)4020136-3 (DE-588)4113937-9 |
| title | CLCA proteins in the airways new insights into their expression patterns and role in innate immunity in pneumonia |
| title_alt | CLCA-Proteine in den Atemwegen |
| title_auth | CLCA proteins in the airways new insights into their expression patterns and role in innate immunity in pneumonia |
| title_exact_search | CLCA proteins in the airways new insights into their expression patterns and role in innate immunity in pneumonia |
| title_full | CLCA proteins in the airways new insights into their expression patterns and role in innate immunity in pneumonia vorgelegt von Kristina Dietert geb. Siegert |
| title_fullStr | CLCA proteins in the airways new insights into their expression patterns and role in innate immunity in pneumonia vorgelegt von Kristina Dietert geb. Siegert |
| title_full_unstemmed | CLCA proteins in the airways new insights into their expression patterns and role in innate immunity in pneumonia vorgelegt von Kristina Dietert geb. Siegert |
| title_short | CLCA proteins in the airways |
| title_sort | clca proteins in the airways new insights into their expression patterns and role in innate immunity in pneumonia |
| title_sub | new insights into their expression patterns and role in innate immunity in pneumonia |
| topic | animal models cabt mice cabt mucus cabt cell differentiation cabt stem cells cabt immunity cabt respiratory diseases cabt bacterial diseases cabt immunohistochemistry cabt immunofluorescence cabt reverse transcriptase PCR cabt Tiermodell (DE-588)4140660-6 gnd Proteine (DE-588)4076388-2 gnd Angeborene Immunität (DE-588)4739713-5 gnd Lungenentzündung (DE-588)4036659-5 gnd Zelldifferenzierung (DE-588)4067536-1 gnd Immunmodulation (DE-588)4315157-7 gnd Chloridkanal (DE-588)4291189-8 gnd Genexpression (DE-588)4020136-3 gnd |
| topic_facet | animal models mice mucus cell differentiation stem cells immunity respiratory diseases bacterial diseases immunohistochemistry immunofluorescence reverse transcriptase PCR Tiermodell Proteine Angeborene Immunität Lungenentzündung Zelldifferenzierung Immunmodulation Chloridkanal Genexpression Hochschulschrift |
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