Hormones:
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| Hauptverfasser: | , |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier, Acad. Press
2015
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| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 413 S. Ill., graph. Darst. |
| ISBN: | 9780123694447 |
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| 240 | 1 | 0 | |a Hormones |
| 245 | 1 | 0 | |a Hormones |c Anthony W. Norman ; Helen L. Henry |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Acad. Press |c 2015 | |
| 300 | |a XV, 413 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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Datensatz im Suchindex
| _version_ | 1804152629308162048 |
|---|---|
| adam_text | Titel: Hormones
Autor: Norman, Anthony W
Jahr: 2015
Contents
Preface xiii
About the Cover xv
Chapter 1 Hormones: An Introduction
I. OVERVIEW OF HORMONES 1
A. Introduction 1
B. Review of Animal Cell Structure 2
C. Hormones and Their Communication
Systems 5
D. Biosynthesis of Peptide and Protein
Hormones 6
E. Regulation of Hormone Synthesis,
Secretion, and Serum Levels 8
II. HORMONE RECEPTORS 9
A. Introduction 9
B. Membrane Receptors 10
C. The Nuclear Receptor Family 12
D. Measurement of Hormone-Receptor
Interactions 14
III. MECHANISMS OF HORMONE ACTION 16
A. Cell Signaling by Membrane Receptors 16
B. Regulation of Gene Transcription by
Steroid Hormones 20
C. Membrane-Initiated Actions by Steroid
Hormones 21
IV. CLINICAL ASPECTS 22
Further Reading 25
Chapter 2 Steroid Hormones: Chemistrv,
Biosynthesis, and Metabolism
I. INTRODUCTION 27
A. General Comments 27
B. Historical Perspective 27
C. Radioactive Steroids 28
D. Molecular Biology Contributions 28
II. CHEMISTRY OF STEROIDS 28
A. Basic Ring Structure 28
B. Classes of Steroids 28
C. Structural Modification 30
D. Asymmetrie Carbons 30
E. Conformational Flexibility of Steroids 32
F. Other Steroid Structures 35
III. BIOSYNTHESIS OF STEROIDS 36
A. Introduction 36
B. Properties Steroidogenic Enzymes 39
C. Biosynthesis of Pregnenolone and
Progestins 49
D. Biosynthesis of Adrenal Cortex
Mineralocorticoids, Glucocorticoids,
and Some Androgens 50
E. Biosynthesis of Androgens 50
F. Biosynthesis of Progesterone and
Estrogens 50
G. Biosynthesis of Vitamin D Metabolites 51
H. Biosynthesis of Bile Acids 51
IV. SERUM BINDING PROTEINS FOR
STEROID HORMONES 51
A. Introduction 51
B. Serum Binding Proteins for Steroid
Hormones 52
Further Reading 53
Chapter 3 The Hypothalamus and Anterior Pituirarv
I. INTRODUCTION 55
A. Overview and CNS Control of the
Hypothalamus 55
B. Hypothalamic Control of the Pituitary
Gland 55
C. Pituitary Control of Distal Endocrine
Glands 57
D. Neuroendocrine Axis Feedback 58
II. ANATOMICAL RELATIONSHIPS 58
A. Hypothalamic-Pituitary Anatomy 58
B. Hypothalamic Neural Connections 59
C. Hypothalamic-Pituitary Circulatory
System 60
III. STRUCTURE, SYNTHESIS, SECRETION, AND
TARGET CELLS OF THE HYPOTHALAMIC
RELEASING HORMONES 60
A. Thyrotropin-Releasing Hormone 61
B. Gonadotropin-Releasing Hormone 63
C. Corticotropin-Releasing Hormone 64
D. Hypothalamic Control of Growth
Hormone Secretion 65
E. Hypothalamic Control of Prolactin
Secretion 66
v
vi Contents
IV. CHEMISTRY OF THE ANTERIOR
Chapter 5 Thyroid Hormones
PITUITARY HORMONES
66
A. Glycoprotein Hormones
66
I. INTRODUCTION
89
B. Growth Hormone
67
A. The Thyroid Gland and Its Hormones
89
C. Prolactin
67
B. Iodine Metabolism
89
D. POMC Derivatives: ACTH, cc-MSH,
ß-Lipotropin, Endorphin
68
II. ANATOMY OF THE THYROID GLAND
90
V. REGULATION AND BIOLOGICAL
III. CHEMISTRY OF THE THYROID
ACTIONS OF GROWTH HORMONE
HORMONES
91
AND PROLACTIN
69
A. Growth Hormone
69
IV. SYNTHESIS AND SECRETION OF
B. Prolactin
74
THYROID HORMONES
91
A. The Thyroid Epithelial Cell
91
VI. THE HYPOTHALAMUS AND APPETITE
B. Thyroglobulin
92
REGULATION
76
C. Iodide Uptake: The Na+/U Symporter
93
D. Thyroid Peroxidase and DUOX:
VII. CLINICAL ASPECTS
77
Tyrosine Iodination and Coupling
94
A. Hypothalamus
77
E. Thyroglobulin Storage, Endocytosis,
B. Pituitary
77
and Breakdown
95
Further Reading
F. Secretion of T4 and T3 and Recycling
79
of I
96
G. Transport and Metabolism of Thyroid
Chapter 4 Posterior Pituitary Hormones
Hormones
96
H. Antithyroid Drugs
98
I. INTRODUCTION
81
V. REGULATION OF THYROID
II. ANATOMY OF THE POSTERIOR
HORMONE SECRETION
99
PITUITARY
81
A. The Hypothalamic-Pituitary-Thyroid
Axis
99
III. CHEMISTRY, BIOSYNTHESIS, AND
B. Autoregulation
100
SECRETION OF THE POSTERIOR
C. Effects of TSH on the Thyroid
PITUITARY HORMONES
81
Epithelial Cell
100
A. Structures of Oxytocin and
Vasopressin
81
VI. BIOLOGICAL ACTIONS OF T3
101
B. Synthesis and Secretion of Vasopressin
A. Thyroid Hormone Receptor
101
and Oxytocin
83
B. Membrane Mediated Actions of
Thyroid Hormone
103
IV. BIOLOGICAL ACTIONS OF ARGININE
C. Basal Metabolie Rate and
VASOPRESSIN (AVP)
84
Thermogenesis
103
A. AVP Receptors
84
D. Metabolie Actions
104
B. AVP Regulation of Water Handling
84
E. Neurodevelopment
104
C. Cardiovascular Effects of AVP
84
D. Effects of AVP on Glucose Homeostasis
85
VII. CLINICAL ASPECTS
104
E. Effects of AVP on ACTH Secretion
85
A. Clinical Features of Hyper- and
F. AVP and the Brain
86
Hypothyroidism
104
B. Hyperthyroidism: Etiology and
V. BIOLOGICAL ACTIONS OF OXYTOCIN
86
Treatment
106
A. The Oxytocin Receptor
86
C. Hypothyroidism: Etiology and
B. Oxytocin and Parturition
86
Treatment
106
C. Oxytocin and Lactation
87
Further Reading
D. Oxytocin and the Brain
87
107
VI. CLINICAL ASPECTS
87
Chapter 6 Pancreatic Hormones: Insulin and
A. Oxytocin
87
Glucagon
B. Diabetes Insipidus
88
I. INTRODUCTION
109
Further Reading
88
A. Background Information
109
Contents vii
B. Regulation of Blood Glucose 109
C. Nutritional and Metabolie
Interrelationships 111
II. ANATOMICAL, MORPHOLOGICAL,
AND PHYSIOLOGICAL
RELATION SHIPS 113
A. Anatomy of the Hepatopancreatic
Complex 113
III. CHEMISTRY, BIOCHEMISTRY, AND
BIOLOGICAL ACTIVITIES OF THE
PANCREATIC HORMONES 116
A. Insulin 116
B. Glucagon and Glucagon-like Peptides 124
C. Insulin and Glucagon Collaborations 128
D. Leptin 132
E. Other Pancreatic Hormones 135
IV. CLINICAL ASPECTS 136
A. Diabetes Mellitus 136
E. Bombesin and Related Peptides:
Gastrin Releasing Peptide and
Neuromedin C 157
F. Tachykinin Family: Substance P and
Neurokinins A and B 158
G. Neurotensin 159
H. Calcitonin Gene-Related Peptide
Family: Amylin 160
I. Enteroglucagon and Oxyntomodulin 160
J. Motilin 161
K. Somatostatin 162
L. Gastric Acid Secretion 162
M. Ghrelin, Leptin, and Energy Use 164
IV. CLINICAL ASPECTS 168
A. Peptic Ulcer Disease 168
B. Carcinoid Syndrome 168
C. Zollinger-Ellison Syndrome 169
Further Reading 169
Further Reading
Chapter 7 Gastrointestinal Hormones
138
Chapter 8 E icosanoids
I. INTRODUCTION
171
I. INTRODUCTION 141
A. Background 141
B. Resume of the Gastrointestinal
Hormones 141
C. Problems of Food Processing and
Digestion 143
II. ANATOMICAL AND PHYSIOLOGICAL
RELATION SHIPS 143
A. Gastroenteropancreatic System 143
B. Stomach 145
C. Small Intestine and Colon 147
D. Hormone-Secreting Cells: Their
Distribution in the
Gastroenteropancreatic Complex 148
E. Pancreatic, Biliary, and Intestinal
Secretions 149
F. Coordination of Gastroenteropancreatic
Hormone Release 151
G. Motor Functions of the Intestinal
Tract 152
H. Brain-Gut Axis 153
III. BIOCHEMICAL PROPERTIES AND
MOLECULAR ACTIONS 153
A. General Relationships 153
B. Cholecystokinin/Gastrin Family 154
C. Secretin Family: Secretin, Vasoactive
Intestinal Peptide 156
D. Pancreatic Polypeptide Family: Peptide
YY and Neuropeptide Y 157
II. STRUCTURE AND NOMENCLATURE
OF EICOSANOIDS
III. SYNTHESIS AND INACTIVATION OF
172
EICOSANOIDS
172
A.
Overview of Eicosanoid Synthesis
172
B.
Phospholipase A2
174
C.
Prostaglandin H Synthase/
Cyclooxygenase
177
D.
Cyclooxygenase Inhibitors
178
E.
Lipoxygenase
178
F.
Transport and Inactivation of
Prostanoids
180
IV. EICOSANOID RECEPTORS AND
SIGNALING
V. EXAMPLES OF BIOLOGICAL ACTIONS
OF PROSTAGLANDINS
A. Prostacyclin and Thromboxane in the
Vasculature
B. Prostaglandins in the Kidney
C. Prostaglandins and Pain Perception
D. Prostaglandins in Reproduction
VI. CLINICAL ASPECTS
A. Prostaglandins and Cancer
B. Leukotrienes in Human Disease
Further Reading
181
181
182
182
183
184
185
185
186
187
viii Contents
Chapter 9 Cal cium-Regulating Hormones: Vitamin
IX Parathyroid Hormone, Calcironin. and Fibroblast
Growth Factor 23
I. INTRODUCTION 189
A. Background Information 189
B. Calcium and Phosphorus Homeostasis 190
II. ANATOMICAL AND PHYSIOLOGICAL
RELATIONSHIPS 192
A. Intestine 192
B. Bone 192
C. Kidney 195
D. Parathyroid Gland 195
E. Calcitonin-Secreting Cells 195
III. CHEMISTRY AND BIOCHEMISTRY 196
A. Vitamin D and la,25(OH)2D3 196
B. Parathyroid Elormone 198
C. Parathyroid Hormone-Related Protein 200
D. Calcitonin 201
E. Fibroblast Growth Factor 23 202
IV. BIOLOGY AND MOLECULAR
ACTIONS 202
A. Parathyroid Hormone Receptor and
Biological Actions 202
B. Parathyroid Hormone-Related Protein
Receptor and Biological Actions 203
C. Calcitonin Receptor and Biological
Actions 205
D. Vitamin D Receptor and Biological
Actions 206
E. Fibroblast Growth Factor-23 213
F. Integrated Actions of loc,25(OH)2D3,
PTH, Calcitonin, and FGF23 on Bone
Remodeling and Calcium Homeostasis 215
V. CLINICAL ASPECTS 217
A. Vitamin D Nutrition 217
B. Osteoporosis 218
C. Tuberculosis 219
D. Parathyroid Hormone 219
E. Parathyroid Hormone-Related Protein 220
F. Calcitonin 220
G. FGF23 220
Further Reading 221
Chapter 10 Ad renal Corticoids
I. INTRODUCTION 223
A. Background 223
B. Glucocorticoids 223
C. Mineralocorticoids 223
II. ANATOMY 224
A. Adrenal Cortex 224
B. Liver 225
III. BIOCHEMISTRY AND BIOSYNTHESIS
OF ADRENAL STEROIDS AND
TESTOSTERONE STEROIDS 225
IV. BIOLOGICAL AND MOLECULAR
ACTIONS OF GLUCOCORTICOIDS 227
A. Hypothalamic-Pituitary-Adrenal Axis 227
B. Corticotropin-Releasing Hormone 227
C. Transport of Glucocorticoids in the
Blood (CBG) 227
D. ACTH Modes of Action 230
E. Glucocorticoids and Stress 231
F. Immunosuppression and Apoptosis
Induced by Glucocorticoids 233
G. Feedback Effects of Glucocorticoids 233
H. Glucocorticoid Receptor 234
I. Dehydroepiandrosterone and Zona
Reticularis 234
V. CLINICAL ASPECTS 234
A. Cushing s Disease 234
B. Addison s Disease 235
C. Congenital Adrenal Hyperplasia and
Others 236
D. Mifepristone (RU-486) 236
Further Reading 238
Chapter 11 Hormones of the Adrenal Medulla
I. INTRODUCTION 239
II. ANATOMICAL AND PHYSIOLOGICAL
RELATIONSHIPS 239
A. The Adrenal Gland 239
B. The Adrenal Medulla and the
Sympathetic Nervous System 240
C. Chromaffin Cells of the Adrenal 242
III. CHEMISTRY AND BIOCHEMISTRY
OF THE CATECHOLAMINES 242
A. Biosynthesis and Secretion of
Catecholamines 242
B. Regulation of Catecholamine Synthesis
and Secretion 243
C. Catabolism of Catecholamines 246
D. Pharmacology of Catecholamines 247
IV. BIOLOGICAL ACTIONS OF
CATECHOLAMINES 248
A. Adrenergic Receptors 248
B. Biological Responses to Epinephrine 248
Contents
V. CLINICAL ASPECTS 251
A. Pheochromocytoma 251
B. Chronic Stress 253
Further Reading 253
Chapter 12 Androgens
I. INTRODUCTION 255
II. ANATOMY OF THE MALE
REPRODUCTIVE SYSTEM 255
A. Testes, Ducts, and Accessory Structures 255
B. Seminiferous Tubules 257
C. Leydig/Interstitial Cells 257
III. CHEMISTRY AND METABOLISM OF
ANDROGENS 257
A. Androgens and Related Molecules 257
B. Androgen Biosynthesis 260
C. Modification of Testosterone in Target
Tissues 260
D. Sex Hormone-binding Globulin 262
E. Catabolism of Androgens 262
IV. REGULATION OF ANDROGEN
PRODUCTION 262
A. Hypothalamic-Pituitary-Testes Axis:
Hormonal Control of the Testis 262
B. Hypothalamic-Pituitary-Testis Axis:
Feedback Control 264
C. Prolactin 265
V. BIOLOGICAL RESPONSES TO
ANDROGENS 265
A. The Androgen Receptor 265
B. Sexual Differentiation 266
C. Puberty 268
D. Spermatogenesis 270
E. Estrogens in Males 271
F. Androgens in Females 271
VI. CLINICAL ASPECTS 272
A. 5oc-Reductase Deficiency 272
B. Androgen Insensitivity Syndrome 272
C. Androgen Abuse 272
D. Prostate Cancer 272
Further Reading 273
Chapter 13 Estrogens and Progestins
I. INTRODUCTION 275
II. ANATOMY OF THE FEMALE
REPRODU CTIVE SYSTEM 275
A. Components of the Female
Reproductive System 275
B. The Ovarian Follicle and Corpus
Luteum 277
III. CHEMISTRY AND METABOLISM OF
FEMALE STEROID HORMONES 281
A. Female Steroid Hormones 281
B. Synthesis of Progesterone and
Estrogens 281
C. Catabolism of Progesterone and
Estrogens 282
IV. HYPOTHALAMIC-PITUITARY-OVARY
AXIS 283
A. Introduction 283
B. Control of the Ovary by the
Hypothalamus and Pituitary 284
C. Feedback Effects on the Hypothalamus
and Pituitary 286
D. The Human Menstrual Cycle 286
E. Menopause 289
V. BIOLOGICAL RESPONSES TO FEMALE
SEX STEROIDS 289
A. Estrogen and Progesterone Receptors 289
B. Uterine Effects of Estrogen and
Progesterone 291
C. Effects of Estrogen on Bone 292
D. Estrogen and the Cardiovascular
System 293
VI. CLINICAL ASPECTS 293
A. Hormonal Contraception 293
B. Postmenopausal Hormone Replacement
Therapy 295
C. Polycystic Ovary Syndrome (PCOS) 295
Further Reading 296
Chapter 14 Hoi moncs of Pregnancy, Parturirion,
ancl Lactation
I. INTRODUCTION 297
II. ANATOMICAL RELATIONSHIPS AND
THE BEGINNING OF PREGNANCY 298
A. Fertilization 298
B. Implantation 299
C. Placental Development 300
D. Mammary Glands 302
III. CHEMISTRY, BIO CHEMISTRY, AND
ACTIVITY OF THE HORMONES OF
PREGNANCY 302
A. Human Chorionic Gonadotrophin 303
B. Placental Lactogen and Placental
Growth Hormone 304
C. Other Peptide Hormones 305
X
Contents
D. Steroid Hormones
306
E. Maternal Adaptations to Pregnancy
307
IV.
PARTURITION
308
A. Introduction
308
B. Progesterone and Estrogen
309
C. The Fetal Adrenal, Placenta, and
Posterior Pituitary
310
V.
LACTATION
311
A. Mammogenesis
311
B. Lactogenesis
312
C. Suckling
313
VI.
CLINICAL ASPECTS
314
A. Assisted Reproductive Technology
314
B. Breast Cancer
317
Further Reading
319
Chapter 1 5 Hormones Related to the Kidnet
/ and
Car
•d i ova sc u l a r System
I.
INTRODUCTION
321
A. Background
321
II.
ANATOMICAL, MORPHOLOGICAL, AND
PHYSIOLOGICAL RELATIONSHIPS
322
A. The Kidney
322
B. Cardiovascular System
326
III.
HOMEOSTASIS OF FLUID,
ELECTROLYTES, AND BLOOD
PRESSURE
326
A. Introduction
326
B. Renin-Angiotensin II
328
C. Angiotensins I and II
328
D. Aldosterone Biosynthesis and Actions
in Renal Tubulär Reabsorption
331
E. Atrial Natriuretic Protein System
331
F. Endothelins
336
G. Nitric Oxide System
339
H. Kallikreins and Kinins
341
I. Adrenomedullin
341
J. Summary
343
Further Reading
Chapter 16 T he Pineal Gland
I. INTRODUCTION
II. ANATOMICAL FEATURES OF THE
PINEAL GLAND
A. Anatomical Location and Cellular
Composition
B. Connection with the Visual System
III. SYNTHESIS AND SECRETION OF
MELATONIN
A. Melatonin Biosynthetic Pathway:
Catabolism
B. Patterns and Regulation of Melatonin
Secretion
IV. BIOLOGICAL ACTIONS OF
MELATONIN
A. The Melatonin Receptors
B. Sleep and Jet Lag
C. Adrenal Cortex
D. Reproduction
E. Cancer
F. Melatonin as an Antioxidant
V. CLINICAL ASPECTS
Further Reading
Chapter 17 Growth Factors
I. INTRODUCTION
II. EPIDERMAL GROWTH FACTOR
A. Structure and Synthesis
B. EGF Receptors and Signaling
III. FIBROBLAST GROWTH FACTOR
FAMILY
A. Members of the FGF Family
B. The FGF Receptors and Signaling
348
351
352
352
352
352
352
354
357
357
358
359
359
360
360
360
361
363
363
363
364
365
365
369
IV. HORMONES AND BLOOD CELL
IV. PLATELET DERIVED GROWTH
PRODUCTION
343
FACTORS
370
A. Introduction
343
A. Structure of PDGFs
370
B. Process of Erythropoiesis
344
B. PDGF Receptors and Signaling
371
C. Erythropoietin (the Protein)
344
D. Hemoglobin
346
V. INSULIN-LIKE GROWTH FACTORS
373
A. Structure of IGF1 and IGF2
373
V. CLINICAL ASPECTS
346
B. Insulin and IGF Receptors and
A. Anemia
346
Signaling
373
B. Cardiovascular Events in Hypertension
348
C. IGF Binding Proteins
375
Contents xi
VI. TRANSFORMING GROWTH FACTOR ß 376
A. Structure and Secretion of TGFß 376
B. TGFß Receptors and Signaling 376
VII. CLINICAL ASPECTS 378
Further Reading 379
Appendix A
381
Appendix B
387
Appendix C
391
Appendix D
393
Appendix E
395
Appendix F
397
Index
399
|
| any_adam_object | 1 |
| author | Norman, Anthony W. 1938- Henry, Helen L. 1944- |
| author_GND | (DE-588)133112853 (DE-588)173585876 |
| author_facet | Norman, Anthony W. 1938- Henry, Helen L. 1944- |
| author_role | aut aut |
| author_sort | Norman, Anthony W. 1938- |
| author_variant | a w n aw awn h l h hl hlh |
| building | Verbundindex |
| bvnumber | BV042143076 |
| classification_rvk | WD 5800 |
| ctrlnum | (OCoLC)895278016 (DE-599)BVBBV042143076 |
| discipline | Biologie |
| edition | 3. ed. |
| format | Book |
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| id | DE-604.BV042143076 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T01:13:45Z |
| institution | BVB |
| isbn | 9780123694447 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027583013 |
| oclc_num | 895278016 |
| open_access_boolean | |
| owner | DE-11 DE-19 DE-BY-UBM DE-703 |
| owner_facet | DE-11 DE-19 DE-BY-UBM DE-703 |
| physical | XV, 413 S. Ill., graph. Darst. |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Elsevier, Acad. Press |
| record_format | marc |
| spelling | Norman, Anthony W. 1938- Verfasser (DE-588)133112853 aut Hormones Hormones Anthony W. Norman ; Helen L. Henry 3. ed. Amsterdam [u.a.] Elsevier, Acad. Press 2015 XV, 413 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Hormon (DE-588)4025864-6 gnd rswk-swf Hormon (DE-588)4025864-6 s DE-604 Henry, Helen L. 1944- Verfasser (DE-588)173585876 aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027583013&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Norman, Anthony W. 1938- Henry, Helen L. 1944- Hormones Hormon (DE-588)4025864-6 gnd |
| subject_GND | (DE-588)4025864-6 |
| title | Hormones |
| title_alt | Hormones |
| title_auth | Hormones |
| title_exact_search | Hormones |
| title_full | Hormones Anthony W. Norman ; Helen L. Henry |
| title_fullStr | Hormones Anthony W. Norman ; Helen L. Henry |
| title_full_unstemmed | Hormones Anthony W. Norman ; Helen L. Henry |
| title_short | Hormones |
| title_sort | hormones |
| topic | Hormon (DE-588)4025864-6 gnd |
| topic_facet | Hormon |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027583013&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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