4D offline PET-based treatment verification in ion beam therapy: experimental and clinical evaluation
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
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2014
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| Beschreibung: | 129 S. Ill., graph. Darst. |
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Datensatz im Suchindex
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| adam_text | 4D OFFLINE PET-BASED TREATMENT
VERIFICATION IN ION BEAM THERAPY:
EXPERIMENTAL AND CLINICAL EVALUATION
CHRISTOPHER KURZ
DISSERTATION
AN DER FAKULTAT FUR PHYSIK
DER LUDWIG-MAXIMILIANS-UNIVERSITAT
MUNCHEN
VORGELEGT VON
CHRISTOPHER KURZ
AUS NEUWIED
MUNCHEN, DEN 12.06.2014
HTTP://D-NB.INFO/1059600943
CONTENTS
1 INTRODUCTION 1
2 FUNDAMENTALS OF ION BEAM THERAPY 3
2.1 A BRIEF INTRODUCTION TO ION BEAM THERAPY 3
2.2 PHYSICAL PROPERTIES OF ION BEAMS 4
2.2.1 ENERGY-LOSS OF IONS IN MATTER 5
2.2.2 LATERAL SCATTERING 8
2.2.3 NUCLEAR INTERACTIONS 8
2.3 BIOLOGICAL ASPECTS OF HEAVY ION BEAMS 10
2.4 CLINICAL IMPLEMENTATION OF ION BEAM THERAPY 12
2.4.1 ION BEAM DELIVERY 12
2.4.2 THE HEIDELBERG ION-BEAM THERAPY CENTER 13
2.4.3 TREATMENT PLANNING 14
2.5 UNCERTAINTIES IN ION BEAM THERAPY 16
2.6 ORGAN MOTION IN ION BEAM THERAPY 18
2.6.1 INTRODUCTION TO ORGAN MOTION 18
2.6.2 IMPLICATIONS OF ORGAN MOTION FOR ION BEAM THERAPY 19
2.6.3 ORGAN MOTION MANAGEMENT IN ION BEAM THERAPY 19
2.6.4 MOTION MONITORING 22
2.6.5 TREATMENT OF MOVING TARGETS AT HIT 23
2.7 SUMMARY 23
3 PET-BASED TREATMENT VERIFICATION IN ION BEAM THERAPY 25
3.1 PRODUCTION OF /3
+
-EMITTER 25
3.2 POSITRON EMISSION TOMOGRAPHY IMAGING 26
3.3 CLINICAL IMPLEMENTATION OF PET-BASED TREATMENT VERIFICATION 29
3.4 IMPLEMENTATION OF OFFLINE PET-BASED TREATMENT VERIFICATION AT HIT
.... 31
3.4.1 MC SIMULATION OF THE /3
+
-EMITTER DISTRIBUTION 32
3.4.2 CALCULATION OF THE IRRADIATION-INDUCED ACTIVITY 32
3.4.3 DATA ACQUISITION AND THE BIOGRAPH MCT SCANNER 33
3.4.4 THE SIMLNTERFACE 35
4 MOVING PHANTOM STUDIES 37
4.1 STUDIES ON POST-IRRADIATION 4D PET MONITORING 37
4.1.1 MATERIAL AND METHODS 37
4.1.2 IRRADIATION SPECIFIC DATA ANALYSIS AND RESULTS 41
4.1.3 DISCUSSION AND CONCLUSION 57
4.2 US-BASED 4D PET IMAGING 59
4.2.1 MATERIAL AND METHODS 59
4.2.2 RESULTS 62
4.2.3 DISCUSSION AND CONCLUSION 66
5 PERFORMANCE OF THE BIOGRAPH MCT SCANNER AT VERY LOW TRUE COUNT RATES
69
5.1 MATERIAL AND METHODS 70
5.1.1 PHANTOM IMAGING AND SIMULATION STUDY 70
5.1.2 APPLICATION TO CLINICAL CASES 72
5.2 RESULTS 73
5.2.1 PHANTOM DATA: ACTIVITY QUANTIFICATION, NOISE AND GEOMETRICAL
FIDELITY 73
5.2.2 IMPACT OF THE LSO RANDOM BACKGROUND 75
5.2.3 PATIENT DATA: ACTIVITY QUANTIFICATION, NOISE AND RANGE
VERIFICATION . . 79
5.3 DISCUSSION AND CONCLUSION 82
6 CLINICAL FEASIBILITY OF 4D OFFLINE PET-BASED TREATMENT VERIFICATION 85
6.1 MATERIAL AND METHODS 85
6.1.1 PATIENT COHORT AND DATA ACQUISITION 85
6.1.2 PET IMAGE RECONSTRUCTION 86
6.1.3 4D DOSE AND ACTIVITY CALCULATION 87
6.2 RESULTS 89
6.2.1 PATIENT LI 89
6.2.2 PATIENT L2 91
6.2.3 PATIENT L3 95
6.2.4 PATIENT L4 97
6.3 DISCUSSION AND CONCLUSION 101
7 CONCLUSION AND OUTLOOK 105
A ADDITIONAL RESULTS OF THE MOVING PHANTOM STUDIES 109
A.L LINE MONO IRRADIATION STUDY 109
A.2 LINE MULT IRRADIATION STUDY 110
B ADDITIONAL RESULTS OF THE 4D PATIENT DATA ANALYSIS 111
B.L PATIENT L4 ILL
BIBLIOGRAPHY
113
|
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| spelling | Kurz, Christopher 1986- Verfasser (DE-588)1059754401 aut 4D offline PET-based treatment verification in ion beam therapy experimental and clinical evaluation vorgelegt von 2014 129 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Univ., Diss., 2014 Mit einer Zssfassung in dt. Sprache (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-174437 https://nbn-resolving.org/urn:nbn:de:bvb:19-174437 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027576690&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kurz, Christopher 1986- 4D offline PET-based treatment verification in ion beam therapy experimental and clinical evaluation |
| subject_GND | (DE-588)4113937-9 |
| title | 4D offline PET-based treatment verification in ion beam therapy experimental and clinical evaluation |
| title_auth | 4D offline PET-based treatment verification in ion beam therapy experimental and clinical evaluation |
| title_exact_search | 4D offline PET-based treatment verification in ion beam therapy experimental and clinical evaluation |
| title_full | 4D offline PET-based treatment verification in ion beam therapy experimental and clinical evaluation vorgelegt von |
| title_fullStr | 4D offline PET-based treatment verification in ion beam therapy experimental and clinical evaluation vorgelegt von |
| title_full_unstemmed | 4D offline PET-based treatment verification in ion beam therapy experimental and clinical evaluation vorgelegt von |
| title_short | 4D offline PET-based treatment verification in ion beam therapy |
| title_sort | 4d offline pet based treatment verification in ion beam therapy experimental and clinical evaluation |
| title_sub | experimental and clinical evaluation |
| topic_facet | Hochschulschrift |
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