Extrasynaptic GABAA Receptors:
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABAA receptors underlie classical "phasic" GABAA rec...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer / Humana Press
2014
|
| Schriftenreihe: | The Receptors
27 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext |
| Zusammenfassung: | GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9781493914265 |
| DOI: | 10.1007/978-1-4939-1426-5 |
Internformat
MARC
| LEADER | 00000nmm a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV042115443 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 141013s2014 |||| o||u| ||||||eng d | ||
| 020 | |a 9781493914265 |c Online |9 978-1-4939-1426-5 | ||
| 024 | 7 | |a 10.1007/978-1-4939-1426-5 |2 doi | |
| 035 | |a (OCoLC)894727033 | ||
| 035 | |a (DE-599)GBV797793739 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-703 |a DE-91 | ||
| 050 | 0 | |a RC321-580 | |
| 082 | 0 | |a 612.8 | |
| 084 | |a WW 4041 |0 (DE-625)152094:13425 |2 rvk | ||
| 084 | |a BIO 000 |2 stub | ||
| 245 | 1 | 0 | |a Extrasynaptic GABAA Receptors |c Adam C. Errington ; Giuseppe Di Giovanni ; Vincenzo Crunelli, ed. |
| 264 | 1 | |a New York, NY [u.a.] |b Springer / Humana Press |c 2014 | |
| 300 | |a 1 Online-Ressource | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 1 | |a The Receptors |v 27 | |
| 520 | 1 | |a GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes | |
| 650 | 4 | |a Medizin | |
| 650 | 4 | |a Medicine | |
| 650 | 4 | |a Neurosciences | |
| 650 | 4 | |a Toxicology | |
| 650 | 4 | |a Neurology | |
| 650 | 0 | 7 | |a Neurotransmitter |0 (DE-588)4041905-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Synapse |0 (DE-588)4184224-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a GABAA-Rezeptor |0 (DE-588)4287511-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Inhibition |0 (DE-588)4273127-6 |2 gnd |9 rswk-swf |
| 655 | 7 | |8 1\p |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Synapse |0 (DE-588)4184224-8 |D s |
| 689 | 0 | 1 | |a Neurotransmitter |0 (DE-588)4041905-8 |D s |
| 689 | 0 | 2 | |a Inhibition |0 (DE-588)4273127-6 |D s |
| 689 | 0 | 3 | |a GABAA-Rezeptor |0 (DE-588)4287511-0 |D s |
| 689 | 0 | |8 2\p |5 DE-604 | |
| 700 | 1 | |a Errington, Adam C. |e Sonstige |4 oth | |
| 700 | 1 | |a Di Giovanni, Giuseppe |e Sonstige |4 oth | |
| 700 | 1 | |a Crunelli, Vincenzo |e Sonstige |4 oth | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druckausgabe |z 978-1-4939-1425-8 |
| 830 | 0 | |a The Receptors |v 27 |w (DE-604)BV041917994 |9 27 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-1-4939-1426-5 |x Verlag |3 Volltext |
| 912 | |a ZDB-2-SBL | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-027555788 | ||
| 883 | 1 | |8 1\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
| 883 | 1 | |8 2\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
| 966 | e | |u https://doi.org/10.1007/978-1-4939-1426-5 |l TUM01 |p ZDB-2-SBL |x Verlag |3 Volltext | |
| 966 | e | |u https://doi.org/10.1007/978-1-4939-1426-5 |l UBT01 |p ZDB-2-SBL |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804152587698569216 |
|---|---|
| any_adam_object | |
| building | Verbundindex |
| bvnumber | BV042115443 |
| callnumber-first | R - Medicine |
| callnumber-label | RC321-580 |
| callnumber-raw | RC321-580 |
| callnumber-search | RC321-580 |
| callnumber-sort | RC 3321 3580 |
| callnumber-subject | RC - Internal Medicine |
| classification_rvk | WW 4041 |
| classification_tum | BIO 000 |
| collection | ZDB-2-SBL |
| ctrlnum | (OCoLC)894727033 (DE-599)GBV797793739 |
| dewey-full | 612.8 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.8 |
| dewey-search | 612.8 |
| dewey-sort | 3612.8 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-1-4939-1426-5 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03528nmm a2200637 cb4500</leader><controlfield tag="001">BV042115443</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">141013s2014 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781493914265</subfield><subfield code="c">Online</subfield><subfield code="9">978-1-4939-1426-5</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-1-4939-1426-5</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)894727033</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBV797793739</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-703</subfield><subfield code="a">DE-91</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC321-580</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">612.8</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WW 4041</subfield><subfield code="0">(DE-625)152094:13425</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIO 000</subfield><subfield code="2">stub</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Extrasynaptic GABAA Receptors</subfield><subfield code="c">Adam C. Errington ; Giuseppe Di Giovanni ; Vincenzo Crunelli, ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York, NY [u.a.]</subfield><subfield code="b">Springer / Humana Press</subfield><subfield code="c">2014</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">The Receptors</subfield><subfield code="v">27</subfield></datafield><datafield tag="520" ind1="1" ind2=" "><subfield code="a">GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medizin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medicine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neurosciences</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Toxicology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neurology</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Neurotransmitter</subfield><subfield code="0">(DE-588)4041905-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Synapse</subfield><subfield code="0">(DE-588)4184224-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">GABAA-Rezeptor</subfield><subfield code="0">(DE-588)4287511-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Inhibition</subfield><subfield code="0">(DE-588)4273127-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="8">1\p</subfield><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Synapse</subfield><subfield code="0">(DE-588)4184224-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Neurotransmitter</subfield><subfield code="0">(DE-588)4041905-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Inhibition</subfield><subfield code="0">(DE-588)4273127-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="3"><subfield code="a">GABAA-Rezeptor</subfield><subfield code="0">(DE-588)4287511-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="8">2\p</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Errington, Adam C.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Di Giovanni, Giuseppe</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Crunelli, Vincenzo</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druckausgabe</subfield><subfield code="z">978-1-4939-1425-8</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">The Receptors</subfield><subfield code="v">27</subfield><subfield code="w">(DE-604)BV041917994</subfield><subfield code="9">27</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-1-4939-1426-5</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SBL</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-027555788</subfield></datafield><datafield tag="883" ind1="1" ind2=" "><subfield code="8">1\p</subfield><subfield code="a">cgwrk</subfield><subfield code="d">20201028</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#cgwrk</subfield></datafield><datafield tag="883" ind1="1" ind2=" "><subfield code="8">2\p</subfield><subfield code="a">cgwrk</subfield><subfield code="d">20201028</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#cgwrk</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-1-4939-1426-5</subfield><subfield code="l">TUM01</subfield><subfield code="p">ZDB-2-SBL</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-1-4939-1426-5</subfield><subfield code="l">UBT01</subfield><subfield code="p">ZDB-2-SBL</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| genre | 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV042115443 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:13:05Z |
| institution | BVB |
| isbn | 9781493914265 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027555788 |
| oclc_num | 894727033 |
| open_access_boolean | |
| owner | DE-703 DE-91 DE-BY-TUM |
| owner_facet | DE-703 DE-91 DE-BY-TUM |
| physical | 1 Online-Ressource |
| psigel | ZDB-2-SBL |
| publishDate | 2014 |
| publishDateSearch | 2014 |
| publishDateSort | 2014 |
| publisher | Springer / Humana Press |
| record_format | marc |
| series | The Receptors |
| series2 | The Receptors |
| spelling | Extrasynaptic GABAA Receptors Adam C. Errington ; Giuseppe Di Giovanni ; Vincenzo Crunelli, ed. New York, NY [u.a.] Springer / Humana Press 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier The Receptors 27 GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes Medizin Medicine Neurosciences Toxicology Neurology Neurotransmitter (DE-588)4041905-8 gnd rswk-swf Synapse (DE-588)4184224-8 gnd rswk-swf GABAA-Rezeptor (DE-588)4287511-0 gnd rswk-swf Inhibition (DE-588)4273127-6 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Synapse (DE-588)4184224-8 s Neurotransmitter (DE-588)4041905-8 s Inhibition (DE-588)4273127-6 s GABAA-Rezeptor (DE-588)4287511-0 s 2\p DE-604 Errington, Adam C. Sonstige oth Di Giovanni, Giuseppe Sonstige oth Crunelli, Vincenzo Sonstige oth Erscheint auch als Druckausgabe 978-1-4939-1425-8 The Receptors 27 (DE-604)BV041917994 27 https://doi.org/10.1007/978-1-4939-1426-5 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Extrasynaptic GABAA Receptors The Receptors Medizin Medicine Neurosciences Toxicology Neurology Neurotransmitter (DE-588)4041905-8 gnd Synapse (DE-588)4184224-8 gnd GABAA-Rezeptor (DE-588)4287511-0 gnd Inhibition (DE-588)4273127-6 gnd |
| subject_GND | (DE-588)4041905-8 (DE-588)4184224-8 (DE-588)4287511-0 (DE-588)4273127-6 (DE-588)4143413-4 |
| title | Extrasynaptic GABAA Receptors |
| title_auth | Extrasynaptic GABAA Receptors |
| title_exact_search | Extrasynaptic GABAA Receptors |
| title_full | Extrasynaptic GABAA Receptors Adam C. Errington ; Giuseppe Di Giovanni ; Vincenzo Crunelli, ed. |
| title_fullStr | Extrasynaptic GABAA Receptors Adam C. Errington ; Giuseppe Di Giovanni ; Vincenzo Crunelli, ed. |
| title_full_unstemmed | Extrasynaptic GABAA Receptors Adam C. Errington ; Giuseppe Di Giovanni ; Vincenzo Crunelli, ed. |
| title_short | Extrasynaptic GABAA Receptors |
| title_sort | extrasynaptic gabaa receptors |
| topic | Medizin Medicine Neurosciences Toxicology Neurology Neurotransmitter (DE-588)4041905-8 gnd Synapse (DE-588)4184224-8 gnd GABAA-Rezeptor (DE-588)4287511-0 gnd Inhibition (DE-588)4273127-6 gnd |
| topic_facet | Medizin Medicine Neurosciences Toxicology Neurology Neurotransmitter Synapse GABAA-Rezeptor Inhibition Aufsatzsammlung |
| url | https://doi.org/10.1007/978-1-4939-1426-5 |
| volume_link | (DE-604)BV041917994 |
| work_keys_str_mv | AT erringtonadamc extrasynapticgabaareceptors AT digiovannigiuseppe extrasynapticgabaareceptors AT crunellivincenzo extrasynapticgabaareceptors |