Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain:
ATP was naturally selected very early on as the main source of biological energy, and thus became an indispensable feature of life on the Earth. This was a critical evolutionary choice because it shaped enzymatic systems to utilize ATP in energy-dependent reactions and necessitated an appearance of...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer
2014
|
| Schriftenreihe: | Advances in Neurobiology
11 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext |
| Zusammenfassung: | ATP was naturally selected very early on as the main source of biological energy, and thus became an indispensable feature of life on the Earth. This was a critical evolutionary choice because it shaped enzymatic systems to utilize ATP in energy-dependent reactions and necessitated an appearance of the universal intracellular signaling system based on calcium ions; keeping cytosolic Ca2+ extremely low became vitally important, since otherwise insoluble Ca2+-phosphates would preclude the cell energetics. Thus, all living cells on the Earth, beginning from the most primitive ones, had high cytosolic concentrations of ATP and there is little surprise that ATP was soon utilized by nature for another fundamental function of sending information from one living cell to another. In summary, ATP acts as the main energy source and is pivotal for numerous signaling cascades both inside (by fueling various transport systems and donating phosphate groups) and between the cells (by chemical transmission). Similarly, glutamate acts as an important molecule for both intercellular signaling through glutamatergic transmission and cell energetics by contributing to ATP production. In this collection of chapters, written by the leading experts in the fields of cell metabolism and energetics, intracellular signaling and neurotransmission, we covered various aspects of the interfacing between these two fundamental molecules. This book will be particularly useful for researchers, students, physicians and psychotherapists working in the field of neurobiology, neurology and psychiatry |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9783319088945 |
| DOI: | 10.1007/978-3-319-08894-5 |
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| isbn | 9783319088945 |
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| spelling | Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain Vladimir Parpura ; Arne Schousboe ; Alexei Verkhratsky, ed. Cham [u.a.] Springer 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Advances in Neurobiology 11 ATP was naturally selected very early on as the main source of biological energy, and thus became an indispensable feature of life on the Earth. This was a critical evolutionary choice because it shaped enzymatic systems to utilize ATP in energy-dependent reactions and necessitated an appearance of the universal intracellular signaling system based on calcium ions; keeping cytosolic Ca2+ extremely low became vitally important, since otherwise insoluble Ca2+-phosphates would preclude the cell energetics. Thus, all living cells on the Earth, beginning from the most primitive ones, had high cytosolic concentrations of ATP and there is little surprise that ATP was soon utilized by nature for another fundamental function of sending information from one living cell to another. In summary, ATP acts as the main energy source and is pivotal for numerous signaling cascades both inside (by fueling various transport systems and donating phosphate groups) and between the cells (by chemical transmission). Similarly, glutamate acts as an important molecule for both intercellular signaling through glutamatergic transmission and cell energetics by contributing to ATP production. In this collection of chapters, written by the leading experts in the fields of cell metabolism and energetics, intracellular signaling and neurotransmission, we covered various aspects of the interfacing between these two fundamental molecules. This book will be particularly useful for researchers, students, physicians and psychotherapists working in the field of neurobiology, neurology and psychiatry Medizin Medicine Neurosciences Neurobiology Parpura, Vladimir 1964- Sonstige (DE-588)137167687 oth Schousboe, Arne Sonstige oth Verkhratsky, Alexei Sonstige oth Erscheint auch als Druckausgabe 978-3-319-08893-8 Advances in Neurobiology 11 (DE-604)BV041360191 11 https://doi.org/10.1007/978-3-319-08894-5 Verlag Volltext |
| spellingShingle | Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain Advances in Neurobiology Medizin Medicine Neurosciences Neurobiology |
| title | Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain |
| title_auth | Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain |
| title_exact_search | Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain |
| title_full | Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain Vladimir Parpura ; Arne Schousboe ; Alexei Verkhratsky, ed. |
| title_fullStr | Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain Vladimir Parpura ; Arne Schousboe ; Alexei Verkhratsky, ed. |
| title_full_unstemmed | Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain Vladimir Parpura ; Arne Schousboe ; Alexei Verkhratsky, ed. |
| title_short | Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain |
| title_sort | glutamate and atp at the interface of metabolism and signaling in the brain |
| topic | Medizin Medicine Neurosciences Neurobiology |
| topic_facet | Medizin Medicine Neurosciences Neurobiology |
| url | https://doi.org/10.1007/978-3-319-08894-5 |
| volume_link | (DE-604)BV041360191 |
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