Mutant p53 and MDM2 in Cancer:
This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Dordrecht [u.a.]
Springer
2014
|
| Schriftenreihe: | Subcellular Biochemistry
85 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Zusammenfassung: | This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer, and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer, and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9789401792110 |
| DOI: | 10.1007/978-94-017-9211-0 |
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Datensatz im Suchindex
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| adam_text | MUTANT P53 AND MDM2 IN CANCER
/
: 2014
TABLE OF CONTENTS / INHALTSVERZEICHNIS
P53 AND HEREDITARY CANCER.-ALTERATIONS OF P63 AND P73 IN HUMAN
CANCERS.-COOPERATION OF P53 MUTATIONS WITH OTHER ONCOGENIC ALTERATIONS
IN CANCER
P53 MUTATIONS AND HOW MUTATIONS AFFECT TRANSCRIPTION.-TRANSCRIPTIONAL
REGULATION BY MUTANT P53 AND ONCOGENESIS
P53 MUTATION IN THE GENESIS OF METASTASIS
STRUCTURAL STUDIES ON MECHANISMS TO ACTIVATE MUTANT P53
MUTANT P53 AND THE RESPONSE TO CHEMOTHERAPY AND RADIATION
THE P53-MDM2 LOOP: A CRITICAL JUNCTURE OF STRESS RESPONSE
MECHANISMS OF MUTANT P53 STABILIZATION IN CANCER
CROSSTALK BETWEEN MDM2, P53 AND HIF-1Α: DISTINCT RESPONSES TO OXYGEN
STRESS AND IMPLICATIONS FOR TUMOUR HYPOXIA
MDM2 OVEREXPRESSION, ACTIVATION OF SIGNALING NETWORKS, AND CELL
PROLIFERATION
P53-INDEPENDENT EFFECTS OF MDM2
SPLICE VARIANTS OF MDM2 IN ONCOGENESIS
MDM2 AND MDMX INVOLVEMENT IN HUMAN CANCER
TARGETING THE P53-MDM2- MDMX LOOP FOR CANCER THERAPY
INVOLVEMENT OF P53 IN THE REPAIR OF DNA DOUBLE STRAND BREAKS:
MULTIFACETED ROLES OF P53 IN HOMOLOGOUS RECOMBINATION REPAIR (HRR) AND
NON-HOMOLOGOUS END JOINING (NHEJ)
THE ROLE OF TUMOR SUPPRESSOR P53 IN THE ANTIOXIDANT DEFENSE AND
METABOLISM
LUNG CANCER STEM CELLS, P53 MUTATIONS AND MDM2
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
MUTANT P53 AND MDM2 IN CANCER
/
: 2014
ABSTRACT / INHALTSTEXT
THIS BOOK PROVIDES THE READERS WITH AN OVERVIEW OF RESEARCH ON P53,
WHICH HAS BEEN SHOWN TO PLAY A ROLE IN NUMEROUS CRUCIAL BIOLOGICAL
PATHWAYS IN NORMAL AND CANCER CELLS. LEADING SCIENTIST IN THE FIELD, WHO
HAVE ALL MADE DIRECT CONTRIBUTIONS TO THE UNDERSTANDING OF THE MOLECULAR
EVENTS UNDERPINNING P53 FUNCTION, HAVE BEEN INVITED TO CONTRIBUTE THE
VARIOUS CHAPTERS, WHICH DISCUSS THE CURRENT KNOWLEDGE OF THE SIGNALING
CASCADES THAT ARE ACTIVATED BY MUTATIONS IN P53 AND OVEREXPRESSION OF
MDM2, FREQUENTLY FOUND IN HUMAN CANCER, AND ARE MAJOR CAUSES OF
ONCOGENESIS. THIS BOOK FEATURES CHAPTERS ON THE MOLECULAR BASIS OF
ONCOGENESIS INDUCED BY GAIN OF FUNCTION MUTATION OF P53, SIGNALING
PATHWAYS INDUCED BY MDM2 OVEREXPRESSION, CONTROL OF MUTANT OR WILD-TYPE
P53 FUNCTION BY MDM2 AND MDMX, P53 MUTATION IN HEREDITARY CANCER, AND
STRUCTURAL ASPECTS THAT ACTIVATE MUTANT P53 WHICH CAN BE TARGETED BY
DRUG THERAPY. THIS BOOK SHOULD BE USEFUL FOR SCIENTISTS AT ALL LEVELS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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| spelling | Mutant p53 and MDM2 in Cancer Swati Palit Deb ; Sumitra Deb, ed. Dordrecht [u.a.] Springer 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Subcellular Biochemistry 85 This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer, and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer, and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels Medizin Medicine Oncology Cytology Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Protein p53 (DE-588)4176550-3 gnd rswk-swf Maligne Transformation (DE-588)4168713-9 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Krebs Medizin (DE-588)4073781-0 s Maligne Transformation (DE-588)4168713-9 s Protein p53 (DE-588)4176550-3 s 2\p DE-604 Deb, Swati Palit Sonstige oth Deb, Sumitra Sonstige oth Erscheint auch als Druckausgabe 978-94-017-9210-3 Subcellular Biochemistry 85 (DE-604)BV041437497 85 https://doi.org/10.1007/978-94-017-9211-0 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027554882&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027554882&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Mutant p53 and MDM2 in Cancer Subcellular Biochemistry Medizin Medicine Oncology Cytology Krebs Medizin (DE-588)4073781-0 gnd Protein p53 (DE-588)4176550-3 gnd Maligne Transformation (DE-588)4168713-9 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4176550-3 (DE-588)4168713-9 (DE-588)4143413-4 |
| title | Mutant p53 and MDM2 in Cancer |
| title_auth | Mutant p53 and MDM2 in Cancer |
| title_exact_search | Mutant p53 and MDM2 in Cancer |
| title_full | Mutant p53 and MDM2 in Cancer Swati Palit Deb ; Sumitra Deb, ed. |
| title_fullStr | Mutant p53 and MDM2 in Cancer Swati Palit Deb ; Sumitra Deb, ed. |
| title_full_unstemmed | Mutant p53 and MDM2 in Cancer Swati Palit Deb ; Sumitra Deb, ed. |
| title_short | Mutant p53 and MDM2 in Cancer |
| title_sort | mutant p53 and mdm2 in cancer |
| topic | Medizin Medicine Oncology Cytology Krebs Medizin (DE-588)4073781-0 gnd Protein p53 (DE-588)4176550-3 gnd Maligne Transformation (DE-588)4168713-9 gnd |
| topic_facet | Medizin Medicine Oncology Cytology Krebs Medizin Protein p53 Maligne Transformation Aufsatzsammlung |
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