Systems Biology of RNA Binding Proteins:
After transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes. Similarly to DNA binding proteins such as transcription factors that regulate gene expression by binding to DNA elements in the promot...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer
2014
|
| Schriftenreihe: | Advances in Experimental Medicine and Biology
825 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Zusammenfassung: | After transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes. Similarly to DNA binding proteins such as transcription factors that regulate gene expression by binding to DNA elements in the promoters of genes, RBPs regulate the fate of target RNAs by interacting with specific sequences or RNA secondary structural features within the transcribed RNA molecule. The set of functional RNA elements recognized by RBPs within target RNAs and which control the temporal, functional and spatial dynamics of the target RNA define a putative "mRNP code". These cis-regulatory RNA elements can be found in the 5' and 3' untranslated regions (UTRs), introns, and exons of all protein-coding genes. RNA elements in 5' and 3' UTRs are frequently involved in targeting RNA to specific cellular compartments, affecting 3' end formation, controlling RNA stability and regulating mRNA translation. RNA elements in introns and exons are known to function as splicing enhancers or silencers during the splicing process from pre-mRNA to mature mRNA. This book provides case studies of RNA binding proteins that regulate aspects of RNA processing that are important for fundamental understanding of diseases and development. Chapters include systems-level perspectives, mechanistic insights into RNA processing and RNA Binding proteins in genetic variation, development and disease. The content focuses on systems biology and genomics of RNA Binding proteins and their relation to human diseases |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9781493912216 |
| DOI: | 10.1007/978-1-4939-1221-6 |
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Datensatz im Suchindex
| _version_ | 1804152586236854272 |
|---|---|
| adam_text | SYSTEMS BIOLOGY OF RNA BINDING PROTEINS
/
: 2014
TABLE OF CONTENTS / INHALTSVERZEICHNIS
ENCYCLOPEDIA OF RNA BINDING PROTEIN EXPRESSION AND DOMAIN ANNOTATIONS
RNA LOCALIZATION AND RNA BINDING PROTEINS THAT CONTROL LOCALIZATION
GENOME-WIDE APPROACHES TO STUDYING ALTERNATIVE POLYADENYLATION EVENTS
AND THE RBPS THAT CONTROL THEM
RNA BINDING PROTEINS, PRC COMPLEX AND LONG NCRNAS
GENE AND GENOME REGULATION BY PIWI PROTEINS
ENGINEERING ARTIFICIAL RBP INTERACTIONS
QUERYING FUNCTIONAL POLYMORPHISMS BY HIGH THROUGHPUT BINDING AND
FUNCTIONAL ASSAYS
RNA BINDING PROTEIN NETWORKS IN EMT/MET
THERAPIES AGAINST DISEASES ASSOCIATED WITH RNA PROCESSING DEFECTS AND
RNA BINDING PROTEINS
REPEAT-DISORDERS AND THE RNA BINDING PROTEINS IMPLICATED IN THEM
RNA BINDING PROTEINS IN HEART DEVELOPMENT
IDENTIFICATION OF MIRNAS AND THEIR TARGETS IN C ELEGANS
SPLICING CODE
INDEX
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
SYSTEMS BIOLOGY OF RNA BINDING PROTEINS
/
: 2014
ABSTRACT / INHALTSTEXT
AFTER TRANSCRIPTION IN THE NUCLEUS, RNA BINDING PROTEINS (RBPS)
RECOGNIZE CIS-REGULATORY RNA ELEMENTS WITHIN PRE-MRNA SEQUENCE TO FORM
MRNA-PROTEIN (MRNP) COMPLEXES. SIMILARLY TO DNA BINDING PROTEINS SUCH AS
TRANSCRIPTION FACTORS THAT REGULATE GENE EXPRESSION BY BINDING TO DNA
ELEMENTS IN THE PROMOTERS OF GENES, RBPS REGULATE THE FATE OF TARGET
RNAS BY INTERACTING WITH SPECIFIC SEQUENCES OR RNA SECONDARY STRUCTURAL
FEATURES WITHIN THE TRANSCRIBED RNA MOLECULE. THE SET OF FUNCTIONAL RNA
ELEMENTS RECOGNIZED BY RBPS WITHIN TARGET RNAS AND WHICH CONTROL THE
TEMPORAL, FUNCTIONAL AND SPATIAL DYNAMICS OF THE TARGET RNA DEFINE A
PUTATIVE “MRNP CODE”. THESE CIS-REGULATORY RNA ELEMENTS CAN BE FOUND
IN THE 5’ AND 3’ UNTRANSLATED REGIONS (UTRS), INTRONS, AND EXONS OF
ALL PROTEIN-CODING GENES. RNA ELEMENTS IN 5’ AND 3’ UTRS ARE
FREQUENTLY INVOLVED IN TARGETING RNA TO SPECIFIC CELLULAR COMPARTMENTS,
AFFECTING 3’ END FORMATION, CONTROLLING RNA STABILITY AND REGULATING
MRNA TRANSLATION. RNA ELEMENTS IN INTRONS AND EXONS ARE KNOWN TO
FUNCTION AS SPLICING ENHANCERS OR SILENCERS DURING THE SPLICING PROCESS
FROM PRE-MRNA TO MATURE MRNA. THIS BOOK PROVIDES CASE STUDIES OF RNA
BINDING PROTEINS THAT REGULATE ASPECTS OF RNA PROCESSING THAT ARE
IMPORTANT FOR FUNDAMENTAL UNDERSTANDING OF DISEASES AND DEVELOPMENT.
CHAPTERS INCLUDE SYSTEMS-LEVEL PERSPECTIVES, MECHANISTIC INSIGHTS INTO
RNA PROCESSING AND RNA BINDING PROTEINS IN GENETIC VARIATION,
DEVELOPMENT AND DISEASE. THE CONTENT FOCUSES ON SYSTEMS BIOLOGY AND
GENOMICS OF RNA BINDING PROTEINS AND THEIR RELATION TO HUMAN DISEASES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| spelling | Systems Biology of RNA Binding Proteins Gene W. Yeo, ed. New York, NY [u.a.] Springer 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Advances in Experimental Medicine and Biology 825 After transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes. Similarly to DNA binding proteins such as transcription factors that regulate gene expression by binding to DNA elements in the promoters of genes, RBPs regulate the fate of target RNAs by interacting with specific sequences or RNA secondary structural features within the transcribed RNA molecule. The set of functional RNA elements recognized by RBPs within target RNAs and which control the temporal, functional and spatial dynamics of the target RNA define a putative "mRNP code". These cis-regulatory RNA elements can be found in the 5' and 3' untranslated regions (UTRs), introns, and exons of all protein-coding genes. RNA elements in 5' and 3' UTRs are frequently involved in targeting RNA to specific cellular compartments, affecting 3' end formation, controlling RNA stability and regulating mRNA translation. RNA elements in introns and exons are known to function as splicing enhancers or silencers during the splicing process from pre-mRNA to mature mRNA. This book provides case studies of RNA binding proteins that regulate aspects of RNA processing that are important for fundamental understanding of diseases and development. Chapters include systems-level perspectives, mechanistic insights into RNA processing and RNA Binding proteins in genetic variation, development and disease. The content focuses on systems biology and genomics of RNA Binding proteins and their relation to human diseases Biowissenschaften Life sciences Gene expression Biochemistry Biological models RNS-Bindungsproteine (DE-588)4178253-7 gnd rswk-swf Systembiologie (DE-588)4809615-5 gnd rswk-swf RNS-Bindungsproteine (DE-588)4178253-7 s Systembiologie (DE-588)4809615-5 s b DE-604 Yeo, Gene W. Sonstige oth Erscheint auch als Druckausgabe 978-1-4939-1220-9 Advances in Experimental Medicine and Biology 825 (DE-604)BV023059251 825 https://doi.org/10.1007/978-1-4939-1221-6 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027554873&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027554873&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Systems Biology of RNA Binding Proteins Advances in Experimental Medicine and Biology Biowissenschaften Life sciences Gene expression Biochemistry Biological models RNS-Bindungsproteine (DE-588)4178253-7 gnd Systembiologie (DE-588)4809615-5 gnd |
| subject_GND | (DE-588)4178253-7 (DE-588)4809615-5 |
| title | Systems Biology of RNA Binding Proteins |
| title_auth | Systems Biology of RNA Binding Proteins |
| title_exact_search | Systems Biology of RNA Binding Proteins |
| title_full | Systems Biology of RNA Binding Proteins Gene W. Yeo, ed. |
| title_fullStr | Systems Biology of RNA Binding Proteins Gene W. Yeo, ed. |
| title_full_unstemmed | Systems Biology of RNA Binding Proteins Gene W. Yeo, ed. |
| title_short | Systems Biology of RNA Binding Proteins |
| title_sort | systems biology of rna binding proteins |
| topic | Biowissenschaften Life sciences Gene expression Biochemistry Biological models RNS-Bindungsproteine (DE-588)4178253-7 gnd Systembiologie (DE-588)4809615-5 gnd |
| topic_facet | Biowissenschaften Life sciences Gene expression Biochemistry Biological models RNS-Bindungsproteine Systembiologie |
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