G Protein Signaling Mechanisms in the Retina:
We have learned a great deal about the organization and function of GPCR pathways, and the role that they play in vision. The information gained from these studies has provided, and will continue to provide, critical insights to further our understanding of complex GPCR pathways in the central nervo...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer
2014
|
| Schriftenreihe: | Springer Series in Vision Research
3 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Zusammenfassung: | We have learned a great deal about the organization and function of GPCR pathways, and the role that they play in vision. The information gained from these studies has provided, and will continue to provide, critical insights to further our understanding of complex GPCR pathways in the central nervous and endocrine systems. In essence, the retina is the first "optogenetically"-driven circuit with clearly understood physiology. Thus, studying GPCR-driven pathways in the retina will likely guide the interpretation of optogenetic experiments, which are increasingly utilized to study central circuits. Collectively, these signaling pathways allow the retina to represent visual space over a wide range of light intensities and to synchronize its function to the day/night cycle. G protein Signaling Mechanisms in the Retina summarizes our current understanding of the organizational principles of GPCR pathways, using insights derived from the study of the retina. The book highlights several G protein signaling cascades, including phototransduction, ON bipolar cell signaling, dopaminergic pathways, and ipRGC signaling |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9781493912186 |
| DOI: | 10.1007/978-1-4939-1218-6 |
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Datensatz im Suchindex
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| adam_text | G PROTEIN SIGNALING MECHANISMS IN THE RETINA
/
: 2014
TABLE OF CONTENTS / INHALTSVERZEICHNIS
1. INTRODUCTION: G-PROTEIN SIGNALING IN THE RETINA
PART ONE- PHOTOTRANSDUCTION IN RODS AND CONES
2. G-PROTEIN DEACTIVATION MECHANISMS IN VERTEBRATE PHOTOTRANSDUCTION
3. SIGNALING BY ROD AND CONE PHOTORECEPTORS: OPSIN PROPERTIES, G-PROTEIN
ASSEMBLY AND MECHANISMS OF ACTIVATION
4. G-PROTEIN–EFFECTOR COUPLING IN THE VERTEBRATE PHOTOTRANSDUCTION
CASCADE
PART II- INNER RETINAL GPCR SIGNALING PATHWAYS
5. INTERDEPENDENCE AMONG MEMBERS OF THE MGLUR6 G-PROTEIN MEDIATED
SIGNALPLEX OF RETINAL DEPOLARIZING BIPOLAR CELLS
6. MECHANISTIC BASIS FOR G-PROTEIN FUNCTION IN ON BIPOLAR CELLS
7. MODULATION OF TRPM1 AND THE MGLUR6 CASCADE IN ON BIPOLAR CELLS
8. THE ROLE OF DOPAMINE IN FINE-TUNING CONE- AND ROD-DRIVEN VISION
9. REGULATION OF ELECTRICAL SYNAPTIC PLASTICITY IN THE RETINA BY
G-PROTEIN COUPLED RECEPTORS
PART III- SIGNALING BY PHOTOSENSITIVE GANGLION CELLS
10. THE FUNCTIONAL PROPERTIES OF THE G-PROTEIN-COUPLED RECEPTOR
MELANOPSIN IN INTRINSICALLY PHOTOSENSITIVE RETINAL GANGLION CELLS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
G PROTEIN SIGNALING MECHANISMS IN THE RETINA
/
: 2014
ABSTRACT / INHALTSTEXT
WE HAVE LEARNED A GREAT DEAL ABOUT THE ORGANIZATION AND FUNCTION OF GPCR
PATHWAYS, AND THE ROLE THAT THEY PLAY IN VISION. THE INFORMATION GAINED
FROM THESE STUDIES HAS PROVIDED, AND WILL CONTINUE TO PROVIDE, CRITICAL
INSIGHTS TO FURTHER OUR UNDERSTANDING OF COMPLEX GPCR PATHWAYS IN THE
CENTRAL NERVOUS AND ENDOCRINE SYSTEMS. IN ESSENCE, THE RETINA IS THE
FIRST ‘OPTOGENETICALLY’-DRIVEN CIRCUIT WITH CLEARLY UNDERSTOOD
PHYSIOLOGY. THUS, STUDYING GPCR-DRIVEN PATHWAYS IN THE RETINA WILL
LIKELY GUIDE THE INTERPRETATION OF OPTOGENETIC EXPERIMENTS, WHICH ARE
INCREASINGLY UTILIZED TO STUDY CENTRAL CIRCUITS. COLLECTIVELY, THESE
SIGNALING PATHWAYS ALLOW THE RETINA TO REPRESENT VISUAL SPACE OVER A
WIDE RANGE OF LIGHT INTENSITIES AND TO SYNCHRONIZE ITS FUNCTION TO THE
DAY/NIGHT CYCLE. G PROTEIN SIGNALING MECHANISMS IN THE RETINA SUMMARIZES
OUR CURRENT UNDERSTANDING OF THE ORGANIZATIONAL PRINCIPLES OF GPCR
PATHWAYS, USING INSIGHTS DERIVED FROM THE STUDY OF THE RETINA. THE BOOK
HIGHLIGHTS SEVERAL G PROTEIN SIGNALING CASCADES, INCLUDING
PHOTOTRANSDUCTION, ON BIPOLAR CELL SIGNALING, DOPAMINERGIC PATHWAYS, AND
IPRGC SIGNALING
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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| indexdate | 2024-07-10T01:13:03Z |
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| language | English |
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| spelling | G Protein Signaling Mechanisms in the Retina Kirill A. Martemyanov ; Alapakkam P. Sampath, ed. New York, NY [u.a.] Springer 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Springer Series in Vision Research 3 We have learned a great deal about the organization and function of GPCR pathways, and the role that they play in vision. The information gained from these studies has provided, and will continue to provide, critical insights to further our understanding of complex GPCR pathways in the central nervous and endocrine systems. In essence, the retina is the first "optogenetically"-driven circuit with clearly understood physiology. Thus, studying GPCR-driven pathways in the retina will likely guide the interpretation of optogenetic experiments, which are increasingly utilized to study central circuits. Collectively, these signaling pathways allow the retina to represent visual space over a wide range of light intensities and to synchronize its function to the day/night cycle. G protein Signaling Mechanisms in the Retina summarizes our current understanding of the organizational principles of GPCR pathways, using insights derived from the study of the retina. The book highlights several G protein signaling cascades, including phototransduction, ON bipolar cell signaling, dopaminergic pathways, and ipRGC signaling Medizin Medicine Neurosciences Cell receptors Neurobiology Martemyanov, Kirill A. Sonstige oth Sampath, Alapakkam P. Sonstige oth Erscheint auch als Druckausgabe 978-1-4939-1217-9 Springer Series in Vision Research 3 (DE-604)BV041723082 3 https://doi.org/10.1007/978-1-4939-1218-6 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027554517&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027554517&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | G Protein Signaling Mechanisms in the Retina Springer Series in Vision Research Medizin Medicine Neurosciences Cell receptors Neurobiology |
| title | G Protein Signaling Mechanisms in the Retina |
| title_auth | G Protein Signaling Mechanisms in the Retina |
| title_exact_search | G Protein Signaling Mechanisms in the Retina |
| title_full | G Protein Signaling Mechanisms in the Retina Kirill A. Martemyanov ; Alapakkam P. Sampath, ed. |
| title_fullStr | G Protein Signaling Mechanisms in the Retina Kirill A. Martemyanov ; Alapakkam P. Sampath, ed. |
| title_full_unstemmed | G Protein Signaling Mechanisms in the Retina Kirill A. Martemyanov ; Alapakkam P. Sampath, ed. |
| title_short | G Protein Signaling Mechanisms in the Retina |
| title_sort | g protein signaling mechanisms in the retina |
| topic | Medizin Medicine Neurosciences Cell receptors Neurobiology |
| topic_facet | Medizin Medicine Neurosciences Cell receptors Neurobiology |
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