Autonomic neurology:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2014
|
| Schriftenreihe: | Contemporary neurology series
86 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references |
| Beschreibung: | XV, 295 S. Ill., graph. Darst. |
| ISBN: | 9780199920198 |
Internformat
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| 245 | 1 | 0 | |a Autonomic neurology |c Eduardo E. Benarroch |
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| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Contemporary neurology series |v 86 | |
| 500 | |a Includes bibliographical references | ||
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-027536364 | ||
Datensatz im Suchindex
| _version_ | 1804152556118605824 |
|---|---|
| adam_text | Titel: Autonomic neurology
Autor: Benarroch, Eduardo E
Jahr: 2014
Contents
Preface xv
PART 1 BASIC PRINCIPLES OF THE FUNCTIONAL
ORGANIZATION, PHARMACOLOGY, AND EVALUATION
OF THE AUTONOMIC NERVOUS SYSTEM
1. CENTRAL AUTONOMIC NETWORK 3
Eduardo E. Benarroch
ANTERIOR LIMBIC CIRCUIT: EMOTIONAL AND BEHAVIORAL
CONTROL OF AUTONOMIC FUNCTION 5
Insular Cortex • Anterior Cingulate Cortex • Amygdala
HYPOTHALAMUS: AUTONOMIC PATTERN GENERATOR FOR
HOMEOSTASIS AND ADAPTATION 6
Functional Anatomy • Autonomic Output • Integrative Function
AUTONOMIC BRAINSTEM AREAS: REFLEX STATE-DEPENDENT CONTROL
OF VISCERAL EFFECTORS 7
Periaqueductal Gray • Parabrachial Complex • Barrington Nucleus • Nucleus of the
Solitary Tract • Ventrolateral Medulla • Medullary Raphe • Brainstem Respiratory Network
CONNECTIONS OF THE CENTRAL AUTONOMIC NETWORK 9
Inputs • Outputs
2. ANATOMY AND FUNCTION OF THE PERIPHERAL AUTONOMIC SYSTEM 15
Eduardo E. Benarroch
FUNCTIONAL ANATOMY OF THE SYMPATHETIC SYSTEM 17
Preganglionic Sympathetic Units • Preganglionic Input to the Sympathetic Ganglia •
Sympathetic Ganglia • Sympathetic Neurotransmission
FUNCTIONAL ANATOMY OF THE PARASYMPATHETIC SYSTEM 21
Output to Cranial Effectors • Vagal Output • Sacral Parasympathetic Output to
Pelvic Organs • Parasympathetic Neurotransmission
PRIMARY AFFERENTS 22
Functional Anatomy • Primary Afférents as Sensorimotor Nerves
FUNCTIONAL INTEGRATION OF PERIPHERAL CONTROL
OF THE VISCERAL ORGANS 24
Sympathetic Vasoconstrictor Output and Maintenance of Arterial Blood Pressure • Sympathetic
Output to the Skin and Thermoregulation • Control of Cardiac Function • Control of Cranial
Effectors • Control of the Gastrointestinal Tract • Control of Pelvic Organs
vii
viii
Contents
3. AUTONOMIC NEUROTRANSMISSION 31
Eduardo E. Benarroch
CHOLINERGIC TRANSMISSION 32
Synthesis, Storage, Release, and Metabolism of Acetylcholine • Cholinergic Receptors
ADRENERGIC TRANSMISSION 34
Synthesis, Storage, and Release of Norepinephrine • Uptake and Metabolism of
Norepinephrine • Adrenergic Receptors
NON-ADRENERGIC NON-CHOLINERGIC AUTONOMIC
NEUROTRANSMITTERS 37
Neuropeptides • ATP and Other Purines • Nitric Oxide • Serotonin
FUNCTIONAL ASPECTS OF AUTONOMIC
NEUROTRANSMISSION 38
Cotransmission • Denervation Supersensitivity
4. AUTONOMIC PHARMACOLOGY 42
Eduardo E. Benarroch
CLINICAL PHARMACOLOGY OF THE CHOLINERGIC SYSTEM 42
Drugs Affecting Synaptic Availability of Acetylcholine • Drugs Acting on
Muscarinic Receptors
CLINICAL PHARMACOLOGY OF THE ADRENERGIC SYSTEM 44
Drugs Affecting Norepinephrine Synthesis, Release, and Uptake • Drugs Acting on Alpha-1
Adrenergic Receptors • Drugs Acting on Alpha-2 Adrenergic Receptors • Drugs Acting on Beta
Adrenergic Receptors
AUTONOMIC SIDE EFFECTS OF DRUGS USED FOR TREATMENT OF
NEUROLOGIC AND PSYCHIATRIC DISORDERS 46
5. EVALUATION OF AUTONOMIC DISORDERS 49
Wolfgang Singer, Michelle L. Mauermann, and Eduardo E. Benarroch
CLASSIFICATION OF AUTONOMIC DISORDERS 50
Main Questions for Classification and Evaluation • Clinical Manifestations of Autonomic
Failure • Clinical Manifestations of Autonomic Hyperactivity • Focal or Restricted
Autonomic Manifestations
CLINICAL EVALUATION 52
History • Relevant Features in the Clinical History • Physical Examination
LABORATORY TESTING 54
Basic Studies • Antibody Testing • Special Laboratory Tests • Fractionated Plasma
Catecholamines
AUTONOMIC LABORATORY TESTING: GENERAL PRINCIPLES 56
Indications • Potential Pitfalls
EVALUATION OF SUDOMOTOR FUNCTION 57
Thermoregulatory Sweat Test • Quantitative Sudomotor Axon Reflex Test •
Silastic Imprint Method • Quantitative Direct and Indirect Test of Sudomotor
Function • Sympathetic Skin Response
Contents ix
CARDIOVASCULAR FUNCTION TESTS 60
Physiological Principles • HR Response to Deep Breathing • Valsalva Maneuver •
Head-Up Tilt • Other Cardiovascular Function Tests
OTHER TESTS BASED ON THE CLINICAL SYNDROME 67
Imaging Studies • Electrophysiological Studies • Polysomonography • Urodynamic and
Gastrointestinal Motility Studies
TISSUE BIOPSY IN THE DIAGNOSIS OF AUTONOMIC DISORDERS 67
Diagnosis of Amyloidosis • Punch Skin Biopsy
TESTS OF AUTONOMIC FUNCTION IN CLINICAL RESEARCH
LABORATORIES 68
Power Spectrum Analysis • Sympathetic Microneurography • Cardiac Sympathetic Imaging
PART 2 PATHOPHYSIOLOGY AND MANAGEMENT
OF AUTONOMIC DISORDERS
6. NEUROGENIC ORTHOSTATIC HYPOTENSION 73
Eduardo E. Benarroch and Wolfgang Singer
Neurogenic Orthostatic Hypotension • Variants
REPRESENTATIVE CASE 74
PATHOPHYSIOLOGY 75
Responses to Orthostatic Stress • Arterial Baroreflex • Mechanism of Neurogenic OH
CLINICAL FEATURES 76
Manifestations of Hypoperfusion • Precipitating and Aggravating Factors
ETIOLOGY 77
Degenerative Synucleinopathies • Autoimmune Ganglionopathy • Small Fiber
Neuropathy • Other Causes
EVALUATION 78
Clinical History • Physical Examination • Laboratory Tests • Autonomic Laboratory
Testing • Other Studies
MANAGEMENT 80
Nonpharmacologic Approaches • Pharmacologic Therapy • Prevention of Supine Hypertension
7. POSTURAL TACHYCARDIA SYNDROME 89
Wolfgang Singer and Eduardo E. Benarroch
REPRESENTATIVE CASES 90
Case 1 • Case 2
PATHOPHYSIOLOGY 91
Neuropathic POTS • Hyperadrenergic POTS • POTS and Volume Dysregulation • POTS and
Physical Deconditioning
COMORBIDITIES IN POTS 93
Chronic Symptoms in Patients with POTS • Potential Mechanisms of Persistence of Symptoms
x Contents
EVALUATION 94
Clinical History and Examination • Laboratory
MANAGEMENT 94
Nonpharmacologic Approaches • Pharmacologic Therapy
8. BAROREFLEX FAILURE 99
Eduardo E. Benarroch
REPRESENTATIVE CASE 100
PATHOPHYSIOLOGY AND ETIOLOGY 101
Baroreceptor Reflex • Effects of Baroreceptor Afferent Denervation • Main Causes
of Baroreflex Failure
CLINICAL MANIFESTATIONS 103
Hypertensive Crisis • Fluctuating Hypertension • Orthostatic Tachycardia •
Malignant Vagotonia
DIAGNOSIS 104
History and Examination • Autonomic Testing • Measurements of Baroreflex Sensitivity
MANAGEMENT 106
General Principles • Management of Hypertension Episodes • Management of
Hypotension and Bradycardia
9. SYNCOPE AND OTHER CAUSES OF TRANSIENT LOSS
OF CONSCIOUSNESS 110
Jeffrey W. Britton, Brian Moseley, and Eduardo E. Benarroch
SYNCOPE 111
Representative Case • Reflex (Neurally Mediated) Syncope • Syncope Due to
Orthostatic Hypotension • Cardiac Syncope
SEIZURES IN THE DIFFERENTIAL DIAGNOSIS OF SYNCOPE 116
Representative Case • Differential Diagnosis between Seizures and Syncope • letal Bradycardia
and Asystole • Coexistence of Arrhythmias and Seizures in Channelopathies
FUNCTIONAL TLOC 119
EVALUATION OF PATIENTS WITH TLOC 119
Clinical History and Examination • Electrocardiogram • Further Cardiologie
Evaluations • Neurologic Evaluation
MANAGEMENT OF PATIENTS WITH REFLEX SYNCOPE 121
Patient Education • Physical Counterpressure Maneuvers • Tilt or Exercise
Training • Pharmacological Therapy • Cardiac Pacing • Syncope and Driving
10. DISORDERS OF SWEATING 126
Eduardo E. Benarroch
PHYSIOLOGY 127
Central Control of Sweating • Sympathetic Control of Sweating • Sweat Gland Physiology
Contents xi
ASSESSMENT OF SUDOMOTOR FUNCTION 128
Thermoregulatory Sweat Test • Sudomotor Axon Reflex Tests • Punch Skin Biopsy
ANHIDROSIS 130
General Concepts • Representative Case • Multiple System Atrophy • Autonomic
Ganglionopathy • Small Fiber Neuropathies • Ross Syndrome • Isolated Acquired Idiopathic
Anhidrosis • Focal Central Nervous System Disorders • Drug-Induced Anhidrosis • Management
HYPERHIDROSIS 136
Representative Case • Generalized Hyperhidrosis • Primary Focal Hyperhidrosis • Compensatory
Hyperhidrosis • Secondary Facial Hyperhidrosis • Focal Hyperhidrosis Associated with •
Intrathoracic Mass Lesions • Hyperhidrosis Associated with Focal Central Nervous System
Lesions • Drug-Induced Hyperhidrosis • Management
11. NEUROGENIC BLADDER AND SEXUAL DYSFUNCTION 144
Eduardo E. Benarroch and Michelle L. Mauermann
NEUROGENIC BLADDER 145
Representative Case • Physiology • Pathophysiology • Evaluation • Neurologic Disorders
Commonly Associated with Neurogenic • Bladder • Management
NEUROGENIC SEXUAL DYSFUNCTION 153
Physiology • Pathophysiology and Common Autonomic Causes • Evaluation • Management
12. GASTROINTESTINAL DYSMOTILITY 158
Eduardo E. Benarroch
REPRESENTATIVE CASE 159
PHYSIOLOGY 159
Enteric Nervous System • Dorsal Motor Nucleus of the Vagus • Sacral Parasympathetic
Nucleus • Prevertebral Sympathetic Ganglia and Reflexes
PATHOPHYSIOLOGY 161
Dysphagia • Upper Gastrointestinal Dysmotility • Constipation •
Defecatory Impairment • Diarrhea
EVALUATION 162
Dysphagia • Gastroparesis • Constipation • Defecatory Dysfunction
DISORDERS COMMONLY ASSOCIATED WITH GASTROINTESTINAL
DYSMOTILITY 163
Spinal Cord Injury • Diabetic Neuropathy • Amyloid Neuropathy • Immune Enteric
Neuropathies • Familial Enteric Neuronopathies • Parkinson Disease
MANAGEMENT 165
Gastroparesis • Constipation
13. AUTONOMIC HYPERACTIVITY 170
Eduardo E. Benarroch
GENERAL FEATURES OF AUTONOMIC HYPERACTIVITY 171
Pathophysiology • Complications • Principles of Management
xi i Contents
PAROXYSMAL SYMPATHETIC HYPERACTIVITY IN SEVERE HEAD INJURY 175
Typical Features • Representative Case • Differential Diagnosis • Management
SUBARACHNOID HEMORRHAGE 176
FOCAL DISORDERS 177
Insular Stroke • Seizures • Paroxysmal Hypothermia with Hyperhidrosis • Brainstem Lesions
AUTONOMIC HYPERACTIVITY ASSOCIATED WITH SUBACUTE
ENCEPHALOPATHY 178
Delirium Tremens • Fatal Insomnia • Autoimmune Encephalitis
AUTONOMIC HYPERACTIVITY IN SPINAL CORD DISORDERS 179
Autonomic Dysreflexia in Spinal Cord Injury
AUTONOMIC HYPERACTIVITY IN PERIPHERAL NERVE DISORDERS 180
Guillain-Barré Syndrome
IATROGENIC CAUSES OF AUTONOMIC HYPERACTIVITY 180
PART 3 COMMON NEUROLOGIC AUTONOMIC DISORDERS
14. NEURODEGENERATIVE AUTONOMIC DISORDERS 187
Eduardo E. Benarroch and Wolfgang Singer
MULTIPLE SYSTEM ATROPHY 188
Definition and Overview • Representative Case • Autonomic Manifestations
of MSA • Motor Features • Sleep Related Motor and Respiratory Manifestations
Natural History • Neuropathology
LEWY BODY DISORDERS 194
Definition and Overview • Parkinson Disease • Dementia with Lewy Bodies • Pure Autonomic Failure
EVALUATION AND DIFFERENTIAL DIAGNOSIS 197
Autonomic Testing • Neuroimaging • Cardiac Uptake of Norepinephrine Analogs or
Precursors • Urodynamic Studies and Anal Sphincter EMC • Polysomnography • Other Studies
MANAGEMENT 200
15. AUTONOMIC NEUROPATHIES 205
Michelle L. Mauermann, Jennifer A. Tracy, and Wolfgang Singer
AMYLOID NEUROPATHY 206
Definition and Overview • AL Amyloidosis • Familial Amyloid Polyneuropathy •
Representative Case • Neuropathy Patterns • Autonomic Manifestations • Other Organ
Involvement • Neuropathology • Evaluation
DIABETIC NEUROPATHY 210
Definition and Overview • Representative Case • Neuropathy Patterns or Types • Autonomic
Manifestations • Neuropathology • Evaluation and Differential Diagnosis
AUTONOMIC TESTING AND MANAGEMENT 214
Contents xiii
16. NEUROPATHIC PAIN DISORDERS WITH
AUTONOMIC COMPONENT 217
Michelle L. Mauermann and Wolfgang Singer
PAINFUL SMALL FIBER NEUROPATHIES: DIFFERENTIAL
DIAGNOSIS AND EVALUATION 218
Differential Diagnosis • Evaluation
HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY 219
HSAN I • Background • Neuropathy • Autonomic Manifestations • Genetics •
Representative Case • HSAN II-V
FABRY DISEASE 222
Clinical Features • Treatment • Representative Case
CHANNELOPATHIES 224
Sodium (Nav 1.7) • Potassium
17. AUTOIMMUNE AUTONOMIC DISORDERS 227
Andrew McKeon and Eduardo E. Benarroch
AUTOIMMUNE AUTONOMIC GANGLIONOPATHY 228
Clinical Manifestations • Ganglionic AChR Antibodies • Seronegative AAG • Evaluation
PARANEOPLASTIC AUTONOMIC DISORDERS 230
Subacute Autonomic Neuropathy • Other Paraneoplastic Disorders with
Autonomic Features
OTHER AUTONOMIC DISORDERS WITH OR WITHOUT
IDENTIFIED ANTIBODIES 233
Acute Autonomic and Sensory Neuropathy • Guillain-Barré Syndrome • Sjögren Syndrome
TREATMENT 234
Acute Therapy • Chronic Therapy
REPRESENTATIVE CASES 236
Case 17.1 • Case 17.2
18. FOCAL DISORDERS OF THE CEREBRAL HEMISPHERES
AND BRAINSTEM 240
Jeffrey W. Britton, Brian Moseley, and Eduardo E. Benarroch
DISORDERS OF THE CEREBRAL HEMISPHERES 241
Stroke • Seizures
DISORDERS OF THE DIENCEPHALON AND BRAINSTEM 244
Hypothalamic Disorders • Brainstem Disorders
LEUKOENCEPHALOPATHIES AND OTHER
INHERITED DISORDERS 247
Adult-Onset Autosomal Dominant Leukodystrophy • Alexander Disease •
Leukoencephalopathy with Neuroaxonal Spheroids • Fragile X-Tremor/Ataxia
Syndrome • Vitamin B12 Deficiency
xiv Contents
19. FOCAL DISORDERS OF THE SPINAL CORD 252
Eduardo E. Benarroch
PATHOPHYSIOLOGY AND LOCALIZING FEATURES 253
Cardiovascular Function • Micturition • Gastrointestinal Motility •
Thermoregulation • Representative Case
TRAUMATIC SPINAL CORD INJURY 254
Neurogenic Shock • Orthostatic Hypotension • Neurogenic Bladder • Gastrointestinal
Dysmotility • Sexual Dysfunction • Temperature Dysregulation
MULTIPLE SCLEROSIS 257
Bladder Dysfunction • Bowel Dysfunction • Sexual Dysfunction • Thermoregulatory
Dysfunction • Cardiovascular Abnormalities
OTHER SPINAL CORD DISORDERS 259
Neuromyelitis Optica • Syringomyelia • Stiff Man Syndrome
AUTONOMIC DYSREFLEXIA 259
Hypertensive Episodes • Triggering Factors
BACLOFEN WITHDRAWAL SYNDROME 260
MANAGEMENT ISSUES 261
Orthostatic Hypotension • Neurogenic Bladder • Bowel Dysfunction • Autonomic Dysreflexia
20. CHRONIC PAIN DISORDERS WITH AUTONOMIC FEATURES 265
Eduardo E. Benarroch
PHYSIOLOGY AND PATHOPHYSIOLOGY OF PAIN-AUTONOMIC
INTERACTIONS 266
Peripheral Nociceptors • Peripheral Sensitization by Inflammation • Central Sensitization •
Relay of Nociceptive Information to the Central Autonomic Network • Patterned Autonomic
Responses to Pain • Cortical Reorganization in Chronic Pain States
COMPLEX REGIONAL PAIN SYNDROME 270
Definition • Clinical Manifestations • Pathophysiology • Evaluation • Treatment
SYMPATHETIC IMPAIRMENT IN PAINFUL PERIPHERAL NEUROPATHIES 273
Effects of SCNA9 Mutations • Erythromelalgia (Erythermalgia)
PRIMARY HEADACHE DISORDERS 274
Clinical Manifestations • Pathophysiology • Autonomic Manifestations of Migraine •
Differential Features of Trigémino-Autonomic Cephalalgias
CHRONIC VISCERAL PAIN 277
Unique Features of Visceral Sensation • Manifestations of Chronical Visceral Pain
Index 281
|
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| indexdate | 2024-07-10T01:12:35Z |
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| isbn | 9780199920198 |
| language | English |
| lccn | 2013024733 |
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| series2 | Contemporary neurology series |
| spelling | Autonomic neurology Eduardo E. Benarroch Oxford [u.a.] Oxford Univ. Press 2014 XV, 295 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Contemporary neurology series 86 Includes bibliographical references Autonomic Nervous System physiology Autonomic Nervous System Diseases Vegetatives Nervensystem (DE-588)4062444-4 gnd rswk-swf Vegetatives Nervensystem (DE-588)4062444-4 s DE-604 Benarroch, Eduardo E. Sonstige (DE-588)173188702 oth Contemporary neurology series 86 (DE-604)BV000898796 86 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027536364&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Autonomic neurology Contemporary neurology series Autonomic Nervous System physiology Autonomic Nervous System Diseases Vegetatives Nervensystem (DE-588)4062444-4 gnd |
| subject_GND | (DE-588)4062444-4 |
| title | Autonomic neurology |
| title_auth | Autonomic neurology |
| title_exact_search | Autonomic neurology |
| title_full | Autonomic neurology Eduardo E. Benarroch |
| title_fullStr | Autonomic neurology Eduardo E. Benarroch |
| title_full_unstemmed | Autonomic neurology Eduardo E. Benarroch |
| title_short | Autonomic neurology |
| title_sort | autonomic neurology |
| topic | Autonomic Nervous System physiology Autonomic Nervous System Diseases Vegetatives Nervensystem (DE-588)4062444-4 gnd |
| topic_facet | Autonomic Nervous System physiology Autonomic Nervous System Diseases Vegetatives Nervensystem |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027536364&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000898796 |
| work_keys_str_mv | AT benarrocheduardoe autonomicneurology |