Assessing the physiological and pathological functions of mast cells by the use of novel mouse models:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online-Zugang: | Volltext http://d-nb.info/1054914753/34 Inhaltsverzeichnis |
| Beschreibung: | Getr. Zähl. Ill., graph. Darst. |
| Format: | Langzeitarchivierung gewährleistet, LZA |
Internformat
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Datensatz im Suchindex
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| adam_text | *****. T.DAWFC
ASSESSING THE PHYSIOLOGICAL AND PATHOLOGICAL
FUNCTIONS OF MAST CELLS BY THE USE OF NOVEL
MOUSE MODELS
DISSERTATION ZUR ERLANGUNG DES DOKTORGRADES
DER FAKULTAT FUR BIOLOGIE
DER LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN
VORGELEGT VON
KLAUS-DIETER HEGER
FEBRUAR 2014
HTTP://D-NB.INFO/1058491725
TABLE OF CONTENTS
TABLE OF CONTENTS
1. ABBREVIATIONS 3
2. LIST OF PUBLICATIONS 5
3. SUMMARY 7
4. INTRODUCTION 9
4.1. MAST CELL BIOLOGY 9
4.1.1. MAST CELL DEVELOPMENT 9
4.1.2. MAST CELL SUBSETS AND THEIR HOMEOSTASIS 10
4.1.3. MAST CELL ACTIVATION AND SIGNALING PATHWAYS 12
4.1.4. GENETIC MOUSE MODELS TO STUDY MAST CELL IN VIVO FUNCTIONS 14
4.1.5. MAST CELLS IN PATHOLOGIES 17
4.2. REGULATION OF NF-KB ACTIVATION BY THE UBIQUITIN-EDITING ENZYME A20
21
4.2.1. THE UBIQUITIN SYSTEM 21
4.2.2. THE NF-KB FAMILY OF TRANSCRIPTION FACTORS 23
4.2.3. CANONICAL AND ALTERNATIVE NF-KB ACTIVATION 24
4.2.4. ACTIVATION OF THE IKK COMPLEX IS REGULATED BY UBIQUITINATION 25
4.2.5. TERMINATION OF NF-KB RESPONSES 26
4.2.6. A20 IS A KEY NEGATIVE REGULATOR OF CELLULAR ACTIVATION 27
4.2.7. CELL TYPE-SPECIFIC FUNCTIONS OF A20 30
4.2.8. A20/TNFAIP3 IN HUMAN DISEASES 31
5. AIMS OF THE THESIS 33
6. ABSTRACTS OF PUBLICATIONS 35
6.1. PUBLICATION I 36
6.2. PUBLICATION II 37
6.3. PUBLICATION III 38
7. DISCUSSION 39
7.1. GENERATION OF AN IN VIVO MOUSE MODEL FOR HYPERACTIVE MAST CELLS 39
7.1.1. A20 SELECTIVELY REGULATES INFLAMMATORY BUT NOT ANAPHYLACTIC MAST
CELL
RESPONSES 39
7.1.2. DESPITE THEIR PRONOUNCED HYPERACTIVITY, A20-DEFICIENT MAST CELLS
DO
NOT CAUSE OVERT SPONTANEOUS INFLAMMATION 42
7.1.3. DISSECTING THE ROLE OF MAST CELLS IN MOUSE MODELS FOR HUMAN
INFLAMMATORY AND AUTOIMMUNE DISEASES THROUGH AN IN VIVO GAIN-OF-FUNCTION
APPROACH 45
7.2. INDUCIBLE CONDITIONAL GENE TARGETING IN MAST CELLS ALLOWS STUDYING
THEIR
DIFFERENTIATION AND CELLULAR MAINTENANCE 48
8. REFERENCES 51
9. DECLARATION OF INDIVIDUAL CONTRIBUTION 65
10. ACKNOWLEDGEMENTS 67
11. CURRICULUM VITAE 69
12. REPRINTS OF PUBLICATIONS 71
1
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| spelling | Heger, Klaus-Dieter Verfasser aut Assessing the physiological and pathological functions of mast cells by the use of novel mouse models Klaus-Dieter Heger 2014 Getr. Zähl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Univ., Diss., 2014 Langzeitarchivierung gewährleistet, LZA (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-172404 https://nbn-resolving.org/urn:nbn:de:bvb:19-172404 Resolving-System kostenfrei Volltext http://d-nb.info/1054914753/34 Langzeitarchivierung Nationalbibliothek DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027527222&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Heger, Klaus-Dieter Assessing the physiological and pathological functions of mast cells by the use of novel mouse models |
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| title | Assessing the physiological and pathological functions of mast cells by the use of novel mouse models |
| title_auth | Assessing the physiological and pathological functions of mast cells by the use of novel mouse models |
| title_exact_search | Assessing the physiological and pathological functions of mast cells by the use of novel mouse models |
| title_full | Assessing the physiological and pathological functions of mast cells by the use of novel mouse models Klaus-Dieter Heger |
| title_fullStr | Assessing the physiological and pathological functions of mast cells by the use of novel mouse models Klaus-Dieter Heger |
| title_full_unstemmed | Assessing the physiological and pathological functions of mast cells by the use of novel mouse models Klaus-Dieter Heger |
| title_short | Assessing the physiological and pathological functions of mast cells by the use of novel mouse models |
| title_sort | assessing the physiological and pathological functions of mast cells by the use of novel mouse models |
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