Graded BMP signaling in Drosophila: from transcriptional regulation to molecular function
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 105 S. Ill., graph. Darst. 30 cm |
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Datensatz im Suchindex
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| adam_text | ALBERT-LUDWIGS-UNIVERSITAT FREIBURG
FACULTY OF BIOLOGY
GRADED BMP SIGNALING IN DROSOPHILA:
FROM TRANSCRIPTIONAL REGULATION TO MOLECULAR FUNCTION
DISSERTATION SUBMITTED
BY
MILICA JEVTIC
TO OBTAIN A DEGREE OF DOCTOR RERUM NATURALIUM
FROM THE FACULTY OF BIOLOGY,
ALBERT-LUDWIGS-UNIVERSITAT FREIBURG,
FREIBURG IM BREISGAU, GERMANY
N
UR BESCHRANWRI
DEN AUSTAUSCH
SUPERVISOR
DR. GEORGIOS PYROWOLAKIS
BIOSS CENTRE
FOR BIOLOGICAL SIGNALING STUDIES &
INSTITUTE FOR BIOLOGY I,
UNIVERSITY OF FREIBURG, GERMANY
FREIBURG IM BREISGAU, FEBRUARY 2014
HTTP://D-NB.INFO/1052563643
TABLE OF CONTENTS
I ABSTRACT 1
II INTRODUCTION 2
THE TGF-P SUPERFAMILY 2
BMP AND ACTIVIN SIGNALLING PATHWAYS IN DROSOPHILA 3
THE BMP SIGNALING PATHWAY 3
THE BMP LIGANDS 3
BMP-MEDIATED TRANSCRIPTIONAL CONTROL 5
THE ACTIVIN SIGNALING PATHWAY 7
DECAPENTAPLEGIC (DPP), A KEY SIGNALING FACTOR INVOLVED IN DROSOPHILA
DEVELOPMENT 7
DPP: A LONG RANGE MORPHOGEN IN WING DEVELOPMENT 8
DEVELOPMENT OF THE WING 8
DPP MORPHOGEN READOUT: GENE EXPRESSION PATTERNS IN THE DEVELOPING WING
IMAGINAL DISC 9
MOLECULAR MECHANISMS IN SPATIAL REGULATION OF DPP ACTIVITY 11
DPP SIGNALING ACTIVITY SCALES WITH THE TISSUE SIZE IN GROWING WING
IMAGINAL DISC 12
ROLE OF DPP SIGNALING DURING DROSOPHILA EGGSHELL MORPHOGENESIS 13
AIM OF THE STUDY 15
III
RESULTS 16
DPP SIGNALING IN THE WING IMAGINAL DISC 16
IDENTIFICATION OF NOVEL TARGETS OF DPP SIGNALING IN DROSOPHILA WING
IMAGINAL DISCS 16
RNA-SEQ BASED TRANSCRIPTIONAL PROFILING OF DPP RESPONSES IN THE WING
IMAGINAL DISC 16
ANALYSIS AND VALIDATION OF RNA-SEQ DATA 17
ANALYSIS OF DPP TARGET GENES 20
SHIFTED 20
CG5639 34
WISHFUL THINKING 41
IV DISCUSSION 52
T *
TRANSCRIPTIONAL RESPOVISE TO DPP IN THE WING IMAGINAL DISC 52
TRANSCRIPTIONAL REGULATION OF DPP TARGET GENES AND THEIR POTENTIAL ROLE
IN DPP SIGNALING DURING
WING DEVELOPMENT 53
SHIFTED - CIS-LOGIC OF SHF REPRESSION IN THE WING IMAGINAL DISC 53
SHIFTED - THE ROLE OF SHF IN REGULATION OF WING GROWTH 55
CG5639 : 57
WISHFUL THINKING - FUNCTION AND REGULATION OF WIT IN THE WING IMAGINAL
DISC 58
WISHFUL THINKING - CIS-LOGIC OF WIT ACTIVATION IN THE WING IMAGINAL DISC
58
WISHFUL THINKING - ROLE OF WIT DURING WING DEVELOPMENT 60
WISHFUL THINKING-WIT IS REQUIRED IN DPP SIGNALING DURING EGGSHELL
MORPHOGENESIS 61
V MATERIALS AND METHODS 62
DROSOPHILA TECHNIQUES 62
MOLECULAR BIOLOGY TECHNIQUES 70
IMMUNOHISTOCHEMISTRY 81
CELL CULTURE 83
PROTEIN TECHNIQUES 83
CHEMICALS AND REAGENTS 85
ANTIBODIES 87
SOLUTIONS, BUFFERS, AND MEDIA 88
VI SUPPLEMENTARY INFORMATION 92
VII ACKNOWLEDGMENTS 94
VIII REFERENCES 95
|
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| language | English |
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| spelling | Jevtić, Milica Verfasser (DE-588)1050988779 aut Graded BMP signaling in Drosophila from transcriptional regulation to molecular function submitted by Milica Jevtić 2014 105 S. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Freiburg (Breisgau), Univ., Diss., 2014 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027501777&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Jevtić, Milica Graded BMP signaling in Drosophila from transcriptional regulation to molecular function |
| subject_GND | (DE-588)4113937-9 |
| title | Graded BMP signaling in Drosophila from transcriptional regulation to molecular function |
| title_auth | Graded BMP signaling in Drosophila from transcriptional regulation to molecular function |
| title_exact_search | Graded BMP signaling in Drosophila from transcriptional regulation to molecular function |
| title_full | Graded BMP signaling in Drosophila from transcriptional regulation to molecular function submitted by Milica Jevtić |
| title_fullStr | Graded BMP signaling in Drosophila from transcriptional regulation to molecular function submitted by Milica Jevtić |
| title_full_unstemmed | Graded BMP signaling in Drosophila from transcriptional regulation to molecular function submitted by Milica Jevtić |
| title_short | Graded BMP signaling in Drosophila |
| title_sort | graded bmp signaling in drosophila from transcriptional regulation to molecular function |
| title_sub | from transcriptional regulation to molecular function |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027501777&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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