Metabolism-dependent regulation of the central mitochondrial preprotein import receptor Tom22:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Enth. Sonderabdr. |
| Beschreibung: | VI, 127 S. Ill., graph. Darst. 30 cm |
Internformat
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Datensatz im Suchindex
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| adam_text | METABOLISM-DEPENDENT REGULATION OF THE
CENTRAL MITOCHONDRIAL PREPROTEIN IMPORT
RECEPTOR TOM22
INAUGURAL-DISSERTATION
ZUR ERLANGUNG DER DOKTORWURDE
DER FAKULTAT FUR BIOLOGIE
DER ALBERT-LUDWIGS-UNIVERSITAT
FREIBURG IM BREISGAU
N
C
ES
^
AUSCH
VORGELEGT VON
CAROLIN GERBETH
AUS PLAUEN
IM FEBRUAR 2014
HTTP://D-NB.INFO/1052562116
TABLE OF CONTENTS
DANKSAGUNG IV
TABLE OF CONTENTS V
ABBREVIATIONS VI
1 SUMMARY 1
2 INTRODUCTION 2
2.1 MITOCHONDRIA
- VERSATILE ORGANELLES 2
2.2 OUTLINE OF PROTEIN
IMPORT INTO MITOCHONDRIA 4
2.3 THE TOM
COMPLEX - PROTEIN TRANSLOCATION ACROSS
THE OUTER MEMBRANE 7
2.4 BIOGENESIS OF (J-BARREL PROTEINS
IN THE
OUTER MEMBRANE 8
2.5 BIOGENESIS OF A-HELICAL
OUTER MEMBRANE PROTEINS 10
2.6 PROTEIN IMPORT
INTO THE
INNER MEMBRANE AND
MATRIX 12
2.7 REDOX-REGULATED IMPORT INTO
THE IMS 16
2.8 INTEGRATION OF MITOCHONDRIAL
FUNCTIONS INTO CELLULAR SIGNALLING
PATHWAYS 17
3 AIMS OF THE STUDY 24
4 RESULTS AND DISCUSSION 25
4.1 LOCALIZATION OF PROTEIN
KINASES AND PHOSPHATASES
IN MITOCHONDRIA 25
4.1.1 CASEIN KINASE 1 IS TETHERED TO THE OUTER MEMBRANE 25
4.1.1 MITOCHONDRIAL SUBLOCALIZATION OF PROTEIN PHOSPHATASE
PTC5 30
4.2 CK1 DEPENDENT REGULATION
OF MITOCHONDRIAL IMPORT 33
4.2.1 TOM22 IS A SUBSTRATE OF MITOCHONDRIAL
CK1 33
4.2.2 CK1 PHOSPHORYLATION
PROMOTES ASSEMBLY OF TOM22 INTO THE
TOM COMPLEX 37
4.2.3 PHOSPHORYLATION OF TOM22 AT THR57 STABILIZES ASSOCIATION OF TOM20
WITH THE
TOM COMPLEX 40
4.2.4 PKA-DEPENDENT PHOSPHORYLATION
OF TOM22 AT THR76
IMPAIRS ITS BIOGENESIS 44
4.2.5 DIFFERENTIAL METABOLIC REGULATION
OF TOM22 BIOGENESIS
BY CK1 AND
PKA 45
5 EXPERIMENTAL PROCEDURES 48
6 REFERENCES 57
7 SUPPLEMENT: PUBLICATIONS 75
V
|
| any_adam_object | 1 |
| author | Gerbeth, Carolin |
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| author_facet | Gerbeth, Carolin |
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| bvnumber | BV042060865 |
| ctrlnum | (OCoLC)891348710 (DE-599)DNB1052562116 |
| dewey-full | 572.64 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.64 |
| dewey-search | 572.64 |
| dewey-sort | 3572.64 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Thesis Book |
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| language | English |
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| spelling | Gerbeth, Carolin Verfasser (DE-588)1050956885 aut Metabolism-dependent regulation of the central mitochondrial preprotein import receptor Tom22 vorgelegt von Carolin Gerbeth 2014 VI, 127 S. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Enth. Sonderabdr. Freiburg (Breisgau), Univ., Diss., 2014 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027501740&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gerbeth, Carolin Metabolism-dependent regulation of the central mitochondrial preprotein import receptor Tom22 |
| subject_GND | (DE-588)4113937-9 |
| title | Metabolism-dependent regulation of the central mitochondrial preprotein import receptor Tom22 |
| title_auth | Metabolism-dependent regulation of the central mitochondrial preprotein import receptor Tom22 |
| title_exact_search | Metabolism-dependent regulation of the central mitochondrial preprotein import receptor Tom22 |
| title_full | Metabolism-dependent regulation of the central mitochondrial preprotein import receptor Tom22 vorgelegt von Carolin Gerbeth |
| title_fullStr | Metabolism-dependent regulation of the central mitochondrial preprotein import receptor Tom22 vorgelegt von Carolin Gerbeth |
| title_full_unstemmed | Metabolism-dependent regulation of the central mitochondrial preprotein import receptor Tom22 vorgelegt von Carolin Gerbeth |
| title_short | Metabolism-dependent regulation of the central mitochondrial preprotein import receptor Tom22 |
| title_sort | metabolism dependent regulation of the central mitochondrial preprotein import receptor tom22 |
| topic_facet | Hochschulschrift |
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