Mitochondrial protein import targeted by cellular signalling cascades - TOM complex phosphorylation:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 214 S. Ill., graph. Darst. 30 cm |
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Datensatz im Suchindex
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| adam_text | MITOCHONDRIAL PROTEIN IMPORT
TARGETED BY
CELLULAR SIGNALLING CASCADES -
TOM COMPLEX PHOSPHORYLATION
INAUGURAL-DISSERTATION
ZUR ERLANGUNG DER DOKTORWURDE
DER FAKULTAT FUR BIOLOGIE UND DER FAKULTDT FUR MEDIZIN
DER ALBERT-LUDWIGS-UNIVERSITAT FREIBURG IM BREISGAU
DEN
AUSTA
VORGELEGT VON
ANGELIKA BETTINA HARBAUER
AUS AUGSBURG
IM FEBRUAR 2014
HTTP://D-NB.INFO/1052563562
TABLE OF CONTENTS
TABLE OF CONTENTS
1. SUMMARY 1
2. INTRODUCTION 2
2.1. MITOCHONDRIAL ORIGIN AND ARCHITECTURE 2
2.2. PROTEIN IMPORT INTO MITOCHONDRIA 3
2.2.1. PRINCIPLES OF MITOCHONDRIAL PROTEIN IMPORT 3
2.2.2. BIOGENESIS OF INNER MEMBRANE PROTEINS 5
2.2.3. BIOGENESIS OF OUTER MEMBRANE PROTEINS 8
2.2.4. ASSEMBLY OF THE TOM COMPLEX 11
2.3 INTERPLAY BETWEEN MITOCHONDRIA AND THE CYTOSOL 13
2.3.1. MITOCHONDRIA IN CELLULAR FUNCTIONS 13
2.3.2. METABOLIC SWITCHING MEDIATED BY PKA SIGNALLING 13
2.3.3. CROSSTALK BETWEEN MITOCHONDRIA AND THE CELL CYCLE 15
2.3.4. DYNAMICS, TRANSPORT AND INHERITANCE OF MITOCHONDRIA 20
3. AIMS OF THE STUDY 23
4. RESULTS AND DISCUSSION 24
4.1. METABOLIC REGULATION OF THE TOM COMPLEX BY PKA 25
4.1.1. TOM70 IS PHOSPHORYLATED BY CYTOSOLIC PKA 25
4.1.2. PHOSPHORYLATION OF TOM70 REGULATES IMPORT OF CARRIER PROTEINS 26
4.1.3. TOM40 AND TOM22 ARE FURTHER TARGETS OF PKA 28
4.2. CELL CYCLE DEPENDENT REGULATION OF THE TOM COMPLEX 32
4.2.1. TOM6 IS PHOSPHORYLATED IN M PHASE BY CDK 32
4.2.2. PHOSPHORYLATION OF TOM6 STIMULATES ITS IMPORT INTO MITOCHONDRIA
33
4.2.3. STRUCTURAL CHANGES IN THE TOM COMPLEX INFLUENCE PROTEIN IMPORT 34
4.2.4. MUTATION OF TOM6
SER16
AFFECTS GROWTH OF CELLS IN M PHASE 36
4.3. THE TOM COMPLEX AS CENTRAL SENSOR OF CELLULAR HOMEOSTASIS 39
4.3.1. ADAPTION OF PROTEIN IMPORT TO METABOLIC CUES 39
4.3.2. FUNCTIONALITY OF PROTEIN IMPORT AS SENSOR FOR MITOCHONDRIAL
FITNESS 40
5. MATERIALS AND METHODS 43
6. REFERENCES 54
7. PUBLICATIONS AND MANUSCRIPTS
75
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
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| language | English |
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| spelling | Harbauer, Angelika Bettina 1984- Verfasser (DE-588)1051262542 aut Mitochondrial protein import targeted by cellular signalling cascades - TOM complex phosphorylation vorgelegt von Angelika Bettina Harbauer 2014 214 S. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Freiburg (Breisgau), Univ., Diss., 2014 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027493121&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Harbauer, Angelika Bettina 1984- Mitochondrial protein import targeted by cellular signalling cascades - TOM complex phosphorylation |
| subject_GND | (DE-588)4113937-9 |
| title | Mitochondrial protein import targeted by cellular signalling cascades - TOM complex phosphorylation |
| title_auth | Mitochondrial protein import targeted by cellular signalling cascades - TOM complex phosphorylation |
| title_exact_search | Mitochondrial protein import targeted by cellular signalling cascades - TOM complex phosphorylation |
| title_full | Mitochondrial protein import targeted by cellular signalling cascades - TOM complex phosphorylation vorgelegt von Angelika Bettina Harbauer |
| title_fullStr | Mitochondrial protein import targeted by cellular signalling cascades - TOM complex phosphorylation vorgelegt von Angelika Bettina Harbauer |
| title_full_unstemmed | Mitochondrial protein import targeted by cellular signalling cascades - TOM complex phosphorylation vorgelegt von Angelika Bettina Harbauer |
| title_short | Mitochondrial protein import targeted by cellular signalling cascades - TOM complex phosphorylation |
| title_sort | mitochondrial protein import targeted by cellular signalling cascades tom complex phosphorylation |
| topic_facet | Hochschulschrift |
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