I Domain Integrins:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Dordrecht [u.a.]
Springer
2014
|
| Schriftenreihe: | Advances in Experimental Medicine and Biology
819 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9789401791533 |
| DOI: | 10.1007/978-94-017-9153-3 |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | I DOMAIN INTEGRINS
/
: 2014
TABLE OF CONTENTS / INHALTSVERZEICHNIS
PREFACE
1 EVOLUTION OF INTEGRIN I DOMAINS
2 INTEGRIN A1B1
3 INTEGRIN A2B1
4 INTEGRIN A10B1- A COLLAGEN RECEPTOR CRITICAL IN SKELETAL DEVELOPMENT
5 INTEGRIN A11B1 – A MAJOR COLLAGEN RECEPTOR ON FIBROBLASTIC CELLS
6 REGULATION OF INTEGRIN ACTIVITY BY PHOSPHORYLATION
7 INTEGRIN AEB7:MOLECULAR FEATURES AND FUNCTIONAL SIGNIFICANCE IN THE
IMMUNE SYSTEM
8 STRUCTURAL ASPECTS OF INTEGRINS
9 INTEGRIN RECOGNITION MOTIFS IN THE HUMAN COLLAGENS
10 CELLULAR SIGNALLING BY COLLAGEN-BINDING INTEGRINS
11 THE THERAPEUTIC POTENTIAL OF I-DOMAIN INTEGRINS
INDEX
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
I DOMAIN INTEGRINS
/
: 2014
ABSTRACT / INHALTSTEXT
THE INTEGRIN FAMILY IS COMPOSED OF 24 MEMBERS AND APPROXIMATELY TEN
YEARS AGO (2003) WE PUBLISHED A BOOK DEVOTED TO THE NINE I DOMAIN
INTEGRIN SUBUNITS. IN THIS SECOND EDITION, I AM PLEASED THAT MOST OF THE
ORIGINAL AUTHORS HAVE BEEN ABLE TO CONTRIBUTE TO THE UPDATED VERSION. I
DOMAIN CONTAINING INTEGRINS INCLUDE COLLAGEN RECEPTORS AND LEUKOCYTE
RECEPTORS. IN 2003 THE KNOCKOUT MOUSE PHENOTYPES FOR ALL OF THE I DOMAIN
INTEGRINS HAD NOT YET BEEN PUBLISHED; THEY ARE NOW, AND ARE SUMMARIZED
AND DISCUSSED IN THIS EDITION. INTERESTINGLY, A RECENT 10 INTEGRIN
MUTATION IN DOGS HAS INDICATED THAT COLLAGEN-BINDING INTEGRINS IN THE
MUSCULOSKELETAL SYSTEM MIGHT HAVE MUCH MORE SEVERE PHENOTYPES IN LARGER
ANIMALS/HUMANS COMPARED TO THE MILD INTEGRIN PHENOTYPES OBSERVED IN
COLLAGEN-BINDING INTEGRIN DEFICIENT MICE. THIS FINDING IS FURTHER
DISCUSSED IN THE BOOK. IN THE CANCER FIELD, THE MICROENVIRONMENT IS
TAKING CENTER STAGE, AND HERE COLLAGEN RECEPTORS ON FIBROBLASTS ARE
PREDICTED TO PLAY IMPORTANT ROLES IN PARACRINE SIGNALING, IN REGULATING
TISSUE STIFFNESS AND MATRIX REMODELING. NEW TECHNOLOGIES, NEW MOUSE
MODELS IN COMBINATION WITH ANALYSES OF I INTEGRINS IN LARGER
ANIMALS/HUMANS ARE THUS PREDICTED TO INCREASE OUR KNOWLEDGE ABOUT THIS
GROUP OF RECEPTORS. WITH THIS IN MIND WE LOOK FORWARD TO ANOTHER 10
YEARS OF RESEARCH WITH I DOMAIN INTEGRINS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| spelling | I Domain Integrins Donald Gullberg, ed. Dordrecht [u.a.] Springer 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Advances in Experimental Medicine and Biology 819 Biowissenschaften Medizin Medicine Medical genetics Biochemistry Life sciences Biomedicine Gullberg, Donald E. Sonstige (DE-588)1056945982 oth Erscheint auch als Druckausgabe 978-94-017-9152-6 Advances in Experimental Medicine and Biology 819 (DE-604)BV023059251 819 https://doi.org/10.1007/978-94-017-9153-3 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027492654&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027492654&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | I Domain Integrins Advances in Experimental Medicine and Biology Biowissenschaften Medizin Medicine Medical genetics Biochemistry Life sciences Biomedicine |
| title | I Domain Integrins |
| title_auth | I Domain Integrins |
| title_exact_search | I Domain Integrins |
| title_full | I Domain Integrins Donald Gullberg, ed. |
| title_fullStr | I Domain Integrins Donald Gullberg, ed. |
| title_full_unstemmed | I Domain Integrins Donald Gullberg, ed. |
| title_short | I Domain Integrins |
| title_sort | i domain integrins |
| topic | Biowissenschaften Medizin Medicine Medical genetics Biochemistry Life sciences Biomedicine |
| topic_facet | Biowissenschaften Medizin Medicine Medical genetics Biochemistry Life sciences Biomedicine |
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