Reductive deoxygenation of alcohols & Synthesis of novel natural products isolated from Ruscus aculeatus L.:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | kostenfrei https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-288069 Inhaltsverzeichnis |
| Beschreibung: | 145 S. Ill., graph. Darst. |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | TABLE OF CONTENTS
1 REDUCTIVE DEOXYGENATION OF ALCOHOLS - CATALYTIC
METHODS BEYOND BARTON MCCOMBIE DEOXYGENATION 3
1.1 INTRODUCTION 3
1.2 DEOXYGENATIONS EMPLOYING A TWO-STEP PROCEDURE 5
1.2.1 DEOXYGENATION OF ALCOHOL DERIVATIVES (ETHERS, ESTERS) 5
1.2.2 DEOXYGENATION OF ALCOHOLS VIA ELIMINATION-HYDROGENATION SEQUENCE
1S
1.3 DIRECT REDUCTIVE DEOXYGENATION OF ALCOHOLS 18
1.3.1 DIRECT DEOXYGENATION WITH HYDROGENATION CATALYSTS 18
1.3.2 (LEWIS) ACID CATALYZED DIRECT DEOXYGENATIONS 21
1.4 CONCLUSION 26
1.5 REFERENCES 27
2 REDUCTION OF BENZYLIC ALCOHOLS AND A-HYDROXYCARBONYL
COMPOUNDS BY HYDRIODIC ACID IN A BIPHASIC REACTION
MEDIUM 33
2.1 INTRODUCTION 33
2.2 RESULTS AND DISCUSSION 34
2.2.1 DEOXYGENATION OF BENZYLIC ALCOHOLS 34
2.2.2 DEOXYGENATION OF ALLYLIC AND PROPARGYLIC ALCOHOLS 36
2.2.3 CONVERSION OF ALIPHATIC ALCOHOLS WITHOUT JI-SYSTEM IN A-POSITION
37
2.2.4 MECHANISM OF THE DEOXYGENATION WITH HYDRIODIC ACID 38
2.2.5 DEOXYGENATION WITH CATALYTIC AMOUNTS OF HYDRIODIC ACID 39
2.3 CONCLUSIONS 41
2.4 EXPERIMENTAL 42
2.5 REFERENCES 46
HTTP://D-NB.INFO/1058713574
3 SYNTHESIS OF NOVEL NATURAL PRODUCTS ISOLATED FROM
BUTCHERS BROOM 51
3.1 BENZOXEPINES ISOLATED FROM BUTCHERS BROOM 51
3.2 SYNTHESIS OF THE RUSCOZEPINES AND ANALOGOUS BENZOXEPINES 53
3.2.1 RUSCOZEPINE A, B AND ANALOGOUS BENZOXEPINES 55
3.2.2 SYNTHESIS OF 8-METHOXY-2,3-DIHYDROBENZO[B]OXEPIN-7-OL 65
3.2.3 NITROGEN ANALOG OF RUSCOZEPINES - BENZAZEPINE 66
3.3 PHARMACOLOGY 67
3.3.1 RHIZOMA EXTRACT OF RUSCUS ACULEATUS L 67
3.3.2 MTT VIABILITY ASSAY - CYTOTOXICITY 67
3.3.3 ICAM-1 EXPRESSION INHIBITION ASSAY - ANTI-INFLAMMATORY ACTIVITY 68
3.3.4 ORAC-FLUORESCEIN ASSAY - ANTIOXIDANT ACTIVITY 70
3.4 CONCLUSION 72
3.5 EXPERIMENTAL 73
3.5.1 PREPARATION OF COMPOUNDS 73
3.5.2 PHARMACOLOGICAL TESTING 107
3.6 REFERENCES 109
4 SUMMARY ILL
5 ZUSAMMENFASSUNG 112
6 APPENDIX 115
6.1 ABBREVIATIONS 115
6.2 COPIES OF SELECTED NMR - SPECTRA 118
6.3 LIST OF PRESENTATIONS AND PUBLICATIONS 141
6.4 CURRICULUM VITAE 142
6.5 DANKSAGUNGEN 144
|
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| dewey-ones | 540 - Chemistry and allied sciences |
| dewey-raw | 540 |
| dewey-search | 540 |
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| discipline | Chemie / Pharmazie |
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| spelling | Herrmann, Josef Maximilian 1983- Verfasser (DE-588)1056945559 aut Reductive deoxygenation of alcohols & Synthesis of novel natural products isolated from Ruscus aculeatus L. vorgelegt von Josef Maximilian Herrmann 2013 145 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Regensburg, Univ., Diss., 2013 Naturstoff (DE-588)4041418-8 gnd rswk-swf Mäusedorn (DE-588)7518729-2 gnd rswk-swf Chemische Synthese (DE-588)4133806-6 gnd rswk-swf Alkohole (DE-588)4141899-2 gnd rswk-swf Desoxygenierung (DE-588)4149192-0 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Mäusedorn (DE-588)7518729-2 s Naturstoff (DE-588)4041418-8 s Chemische Synthese (DE-588)4133806-6 s DE-604 Alkohole (DE-588)4141899-2 s Desoxygenierung (DE-588)4149192-0 s Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:355-epub-288069 http://epub.uni-regensburg.de/28806/ Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-288069 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027485022&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Herrmann, Josef Maximilian 1983- Reductive deoxygenation of alcohols & Synthesis of novel natural products isolated from Ruscus aculeatus L. Naturstoff (DE-588)4041418-8 gnd Mäusedorn (DE-588)7518729-2 gnd Chemische Synthese (DE-588)4133806-6 gnd Alkohole (DE-588)4141899-2 gnd Desoxygenierung (DE-588)4149192-0 gnd |
| subject_GND | (DE-588)4041418-8 (DE-588)7518729-2 (DE-588)4133806-6 (DE-588)4141899-2 (DE-588)4149192-0 (DE-588)4113937-9 |
| title | Reductive deoxygenation of alcohols & Synthesis of novel natural products isolated from Ruscus aculeatus L. |
| title_auth | Reductive deoxygenation of alcohols & Synthesis of novel natural products isolated from Ruscus aculeatus L. |
| title_exact_search | Reductive deoxygenation of alcohols & Synthesis of novel natural products isolated from Ruscus aculeatus L. |
| title_full | Reductive deoxygenation of alcohols & Synthesis of novel natural products isolated from Ruscus aculeatus L. vorgelegt von Josef Maximilian Herrmann |
| title_fullStr | Reductive deoxygenation of alcohols & Synthesis of novel natural products isolated from Ruscus aculeatus L. vorgelegt von Josef Maximilian Herrmann |
| title_full_unstemmed | Reductive deoxygenation of alcohols & Synthesis of novel natural products isolated from Ruscus aculeatus L. vorgelegt von Josef Maximilian Herrmann |
| title_short | Reductive deoxygenation of alcohols & Synthesis of novel natural products isolated from Ruscus aculeatus L. |
| title_sort | reductive deoxygenation of alcohols synthesis of novel natural products isolated from ruscus aculeatus l |
| topic | Naturstoff (DE-588)4041418-8 gnd Mäusedorn (DE-588)7518729-2 gnd Chemische Synthese (DE-588)4133806-6 gnd Alkohole (DE-588)4141899-2 gnd Desoxygenierung (DE-588)4149192-0 gnd |
| topic_facet | Naturstoff Mäusedorn Chemische Synthese Alkohole Desoxygenierung Hochschulschrift |
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