Chemokines and cysteine proteases in diabetic kidney disease:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Volltext kostenfrei Inhaltsverzeichnis |
| Beschreibung: | 111 Bl. Ill., graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a Chemokines and cysteine proteases in diabetic kidney disease |c von Venkata Surya Narayana Murthy |
| 264 | 1 | |c 2013 | |
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Datensatz im Suchindex
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|---|---|
| adam_text | TABLE OF CONTENTS
1. INTRODUCTION 1
1.1 CHRONIC KIDNEY DISEASE 1
1.2 DIABETIC NEPHROPATHY 3
1.2.1 PATHOPHYSIOLOGY 6
1.2.2 THE ROLE OF INFLAMMATION 8
1.3 CHEMOKINES AND CHEMOKINE RECEPTORS 9
1.3.1 CHEMOKINES 9
1.3.2 CHEMOKINE RECEPTORS 10
1.3.3 ROLE OF CHEMOKINES AND CHEMOKINE RECEPTORS 14
1.3.4 CCL2/MCP-1 14
1.3.5 CXCL12/SDF-1 16
1.4CATHEPSINS 18
1.4.1 CYSTEINE CATHEPSINS 19
1.4.2 PATHOPHYSIOLOGICAL ROLE OF CYSTEINE CATHEPSINS 20
1.4.3 ROLE OF CYSTEINE CATHEPSINS IN PROTEINURIC KIDNEY DISEASES 21
1.4.4 CATHEPSIN S 21
1.5 ANIMAL MODELS OF DIABETIC NEPHROPATHY 23
1.6 SPIEGELMERS-NEXT GENERATION APTAMERS 25
2. RESEARCH HYPOTHESIS 28
3. MATERIAL AND METHODS 29
3.1 MATERIALS 31
3.2 METHODS PART I 34
3.3 METHODS PART II 45
4. RESULTS 54
4.1 PART 1 54
4.1.1 PLASMA CCL2 AND CXCL12 LEVELS 54
4.1.2 BODY WEIGHT AND BLOOD GLUCOSE 55
4.1.3 GLOMERULOSCLEROSIS 56
4.1.4 RENAL FUNCTIONAL PARAMETERS IN DB/DB MICE 58
4.1.5 KI-67+ PROLIFERATING GLOMERULAR CELLS 59
4.1.6 LEUKOCYTE NUMBERS IN GLOMERULI 60
4.1.7 RENAL MRNA EXPRESSION OF PROINFLAMMATROY AND
PODOCYTE PARAMETERS IN DB/DB MICE 62
4.1.8 PODOCYTE NUMBERS IN DB/DB MICE 63
HTTP://D-NB.INFO/1058575317
4.1.9 CXCL12 SUPPRESSES NEPHRIN DE NOVO EXPRESSION
OF PODOCYTE PROGENITORS 63
4.2 PAN II 67
4.2.1 CATHEPSIN S EXPRESSION IN MURINE AND HUMAN TYPE 2
DIABETIC KIDNEY DISEASE 67
4.2.2 R05461111 INHIBITS CATHEPSIN S ACTIVITY 71
4.2.3 ROS461111 REDUCES GLOMERULOSCLEROSIS 73
4.2.4 ROS461111 TREATMENT REDUCES PODOCYTE LOSS 73
4.2.5 R05461111 TREATMENT REDUCES ALBUMINURIA 75
4.2.6 CATHEPSIN S DIRECTLY INJURES GLOMERULAR ENDOTHELIAL CELLS 76
4.2.7 ROS461111 REDUCES OXIDATIVE STRESS-INDUCED
VASCULAR PERMEABILITY IN VIVO 78
4.2.8 ROS461111 REDUCES GLOMERULAR LEUKOCYTE RECRUITMENT
AND INFLAMMATION 80
5. DISCUSSION 83
5.1 PART I- CHEMOKINE BLOCKADE IN DIABETIC NEPHROPATHY 83
5.2 PART II- CATHEPSIN S INHIBITION IN DIABETIC NEPHROPATHY 86
6. SUMMARY AND CONCLUSION 91
7. ZUSAMMENFASSUNG UND FAZIT 93
8. REFERENCES 95
9. ABBREVIATIONS 104
10. APPENDIX 106
11. CURRICULUM VITAE 108
|
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| spelling | Darisipudi, Venkata Surya Narayana Murthy 1981- Verfasser (DE-588)1055971785 aut Chemokines and cysteine proteases in diabetic kidney disease von Venkata Surya Narayana Murthy 2013 111 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Univ., Diss., 2013 (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-173379 http://edoc.ub.uni-muenchen.de/17337/ Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:19-173379 Resolving-System kostenfrei DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027471938&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Darisipudi, Venkata Surya Narayana Murthy 1981- Chemokines and cysteine proteases in diabetic kidney disease |
| subject_GND | (DE-588)4113937-9 |
| title | Chemokines and cysteine proteases in diabetic kidney disease |
| title_auth | Chemokines and cysteine proteases in diabetic kidney disease |
| title_exact_search | Chemokines and cysteine proteases in diabetic kidney disease |
| title_full | Chemokines and cysteine proteases in diabetic kidney disease von Venkata Surya Narayana Murthy |
| title_fullStr | Chemokines and cysteine proteases in diabetic kidney disease von Venkata Surya Narayana Murthy |
| title_full_unstemmed | Chemokines and cysteine proteases in diabetic kidney disease von Venkata Surya Narayana Murthy |
| title_short | Chemokines and cysteine proteases in diabetic kidney disease |
| title_sort | chemokines and cysteine proteases in diabetic kidney disease |
| topic_facet | Hochschulschrift |
| url | http://edoc.ub.uni-muenchen.de/17337/ https://nbn-resolving.org/urn:nbn:de:bvb:19-173379 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027471938&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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