Holdings: Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction

Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction:

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Bibliographic Details
Main Author:	Mauritz, Verena Bernadette (Author)
Format:	Thesis Book
Language:	English
Published:	Aachen Shaker 2014
Series:	Berichte aus der Medizintechnik
Subjects:	Cytotoxizität Knochenersatz Herstellung Integration Keramischer Werkstoff Verbundwerkstoff Gefäßprothese Kunststoff Unterkieferplastik Biokompatibilität Hochschulschrift
Online Access:	Inhaltsverzeichnis
Physical Description:	132 S. Ill., graph. Darst.
ISBN:	9783844027051

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MARC


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Record in the Search Index

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adam_text	TABLE OF CONTENTS 1 INTRODUCTION 1 1.1 CLINICAL PROBLEM 1 1.2 OBJECTIVE AND STRUCTURE OF THE THESIS 3 2 STATE OF THE ART MEDICAL AND TECHNICAL KNOWLEDGE S 2.1 TREATMENT METHODS 5 2.1.1 ALLOPLASTIC MATERIALS 6 2.1.2 DISTRACTION OSTEOGENESIS 8 2.1.3 AUTOLOGOUS BONE 9 2.2 TREATMENT GAP ANALYSIS 10 2.3 BONE SCAFFOLDS FOR MANDIBULAR DEFECTS 14 2.3.1 APPLIED SCAFFOLD MATERIALS 14 2.3.2 CURRENT PROCESS TECHNOLOGIES 15 2.3.3 CHALLENGES 16 3 A NOVEL MANDIBULAR SCAFFOLD 18 3.1 REQUIREMENTS FOR THE DEVELOPMENT 18 3.1.1 FUNCTIONAL - & DESIGN REQUIREMENTS 18 3.1.2 BIOMATERIAL REQUIREMENTS 20 3.2 SELECTION OF BIOMATERIAL CARRIERS 22 3.2.1 CALCIUM ORTHOPHOSPHATE CERAMICS 23 3.2.2 BIODEGRADABLE POLYMERS 25 3.2.3 MATERIALS SELECTION 26 3.3 DETERMINATION OF SCAFFOLD DESIGN 28 3.3.1 EXTERNAL SCAFFOLD DESIGN 28 3.3.2 INTERNAL MICROSTRUCTURE DESIGN 29 3.4 MANUFACTURING PROCESS OF THE SCAFFOLD 31 3.4.1 SCAFFOLD DESIGN IMPLEMENTATION 33 3.4.2 MATERIALS PROCESSING 35 3.4.3 DETERMINATION OF PROCESS PARAMETERS 38 4 POLYCAPROLACTONE AS POTENTIAL POLYMER CARRIER 39 4.1 MATERIAL AND METHODS 39 HTTP://D-NB.INFO/1048581284 4.1.1 DEGRADATION OF PCL IN PBS AND HYDROCHLORIC ACID (HCI) 39 4.1.2 EFFECT OF GAMMA-STERILIZATION ON PCL 42 4.1.3 EFFECT OF MICROWAVE IRRADIATION ON PCL 42 4.2 RESULTS AND DISCUSSION 43 4.2.1 POLYMER DEGRADATION 43 4.2.2 PROCESSABILITY 46 4.3 CONCLUSION 48 5 ANALYSIS OF COMPOSITE MALLEABILITY DEPENDING UPON CERAMIC-POLYMER RATIO 49 5.1 PREPARATION OF THE SAMPLES 49 5.2 EVALUATION BASED ON ITERATIVE T.O.T.E.-METHOD 50 5.3 CONCLUSION 52 6 IN VITRO VALIDATION OF THE SCAFFOLD COMPOSITES 53 6.1 MATERIALS AND METHODS 53 6.1.1 MORPHOLOGICAL ANALYSIS 53 6.1.2 DEGRADATION ANALYSIS IN VITRO 54 6.1.3 MECHANICAL CHARACTERIZATION 55 6.1.4 POROSITY ANALYSIS 59 6.1.5 INHERENT VISCOSITY MEASUREMENTS 60 6.1.6 CELL - COMPOSITE INTERACTION VIA DIRECT CELL SEEDING 62 6.1.7 STATISTICAL ANALYSIS 63 6.2 RESULTS AND DISCUSSION 64 6.2.1 BIOCOMPATIBILITY 64 6.2.2 POROSITY CHARACTERIZATION 66 6.2.3 POLYMER DEGRADATION 70 6.2.4 MECHANICAL CHARACTERIZATION 75 6.3 SUMMARY 84 7 BONE HEALING PERFORMANCE IN AN OVINE BONE DEFECT MODEL (IN VIVO) 86 7.1 STUDY PURPOSE 86 7.2 MATERIALS AND METHODS 86 7.2.1 STUDY SET-UP 86 7.2.2 EXPERIMENTAL PROCEDURE 87 7.3 RESULTS AND DISCUSSION 89 7.3.1 BONE TO IMPLANT CONTACT 89 7.3.2 BONE AREA DENSITY 91 7.4 CONCLUSION 92 8 FUNCTIONALITY VALIDATION OF THE DEVELOPED MANDIBULAR SCAFFOLD 94 8.1 BIOMECHANICAL PRINCIPLES OF THE MANDIBLE 94 8.2 PERFUSION OF THE SCAFFOLD 95 8.2.1 EXPERIMENTAL PROCEDURE 96 8.2.2 RESULTS AND DISCUSSION 97 8.3 DYNAMIC MECHANICAL ANALYSIS OF THE SCAFFOLD 98 8.3.1 EXPERIMENTAL PROCEDURE 98 8.3.2 RESULTS AND DISCUSSION 99 9 CONCLUSION AND FUTURE WORK 101 10 SUMMARY 105 REFERENCES . 107 GLOSSARY 118 ABBREVIATIONS 120 ANNEX..... ............................... ........................................................................123
any_adam_object	1
author	Mauritz, Verena Bernadette
author_facet	Mauritz, Verena Bernadette
author_role	aut
author_sort	Mauritz, Verena Bernadette
author_variant	v b m vb vbm
building	Verbundindex
bvnumber	BV042004343
classification_rvk	ZM 7070
classification_tum	WER 430d WER 435d FEI 340d
ctrlnum	(OCoLC)887725368 (DE-599)DNB1048581284
dewey-full	681.761
dewey-hundreds	600 - Technology (Applied sciences)
dewey-ones	681 - Precision instruments and other devices
dewey-raw	681.761
dewey-search	681.761
dewey-sort	3681.761
dewey-tens	680 - Manufacture of products for specific uses
discipline	Handwerk und Gewerbe / Verschiedene Technologien Werkstoffwissenschaften Medizintechnik Werkstoffwissenschaften / Fertigungstechnik Feinwerktechnik
format	Thesis Book
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physical	132 S. Ill., graph. Darst.
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series2	Berichte aus der Medizintechnik
spelling	Mauritz, Verena Bernadette Verfasser aut Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction Verena Bernadette Mauritz Aachen Shaker 2014 132 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Berichte aus der Medizintechnik Zugl.: München, Techn. Univ., Diss., 2013 Cytotoxizität (DE-588)4193696-6 gnd rswk-swf Knochenersatz (DE-588)4164283-1 gnd rswk-swf Herstellung (DE-588)4159653-5 gnd rswk-swf Integration (DE-588)4027238-2 gnd rswk-swf Keramischer Werkstoff (DE-588)4030282-9 gnd rswk-swf Verbundwerkstoff (DE-588)4062670-2 gnd rswk-swf Gefäßprothese (DE-588)4140866-4 gnd rswk-swf Kunststoff (DE-588)4033676-1 gnd rswk-swf Unterkieferplastik (DE-588)4124358-4 gnd rswk-swf Biokompatibilität (DE-588)4221531-6 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Keramischer Werkstoff (DE-588)4030282-9 s Kunststoff (DE-588)4033676-1 s Verbundwerkstoff (DE-588)4062670-2 s Herstellung (DE-588)4159653-5 s Gefäßprothese (DE-588)4140866-4 s Integration (DE-588)4027238-2 s Knochenersatz (DE-588)4164283-1 s Biokompatibilität (DE-588)4221531-6 s Cytotoxizität (DE-588)4193696-6 s Unterkieferplastik (DE-588)4124358-4 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027446316&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Mauritz, Verena Bernadette Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction Cytotoxizität (DE-588)4193696-6 gnd Knochenersatz (DE-588)4164283-1 gnd Herstellung (DE-588)4159653-5 gnd Integration (DE-588)4027238-2 gnd Keramischer Werkstoff (DE-588)4030282-9 gnd Verbundwerkstoff (DE-588)4062670-2 gnd Gefäßprothese (DE-588)4140866-4 gnd Kunststoff (DE-588)4033676-1 gnd Unterkieferplastik (DE-588)4124358-4 gnd Biokompatibilität (DE-588)4221531-6 gnd
subject_GND	(DE-588)4193696-6 (DE-588)4164283-1 (DE-588)4159653-5 (DE-588)4027238-2 (DE-588)4030282-9 (DE-588)4062670-2 (DE-588)4140866-4 (DE-588)4033676-1 (DE-588)4124358-4 (DE-588)4221531-6 (DE-588)4113937-9
title	Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction
title_auth	Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction
title_exact_search	Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction
title_full	Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction Verena Bernadette Mauritz
title_fullStr	Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction Verena Bernadette Mauritz
title_full_unstemmed	Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction Verena Bernadette Mauritz
title_short	Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction
title_sort	biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction
topic	Cytotoxizität (DE-588)4193696-6 gnd Knochenersatz (DE-588)4164283-1 gnd Herstellung (DE-588)4159653-5 gnd Integration (DE-588)4027238-2 gnd Keramischer Werkstoff (DE-588)4030282-9 gnd Verbundwerkstoff (DE-588)4062670-2 gnd Gefäßprothese (DE-588)4140866-4 gnd Kunststoff (DE-588)4033676-1 gnd Unterkieferplastik (DE-588)4124358-4 gnd Biokompatibilität (DE-588)4221531-6 gnd
topic_facet	Cytotoxizität Knochenersatz Herstellung Integration Keramischer Werkstoff Verbundwerkstoff Gefäßprothese Kunststoff Unterkieferplastik Biokompatibilität Hochschulschrift
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027446316&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT mauritzverenabernadette biphasicosteoconductivepolymerscaffoldsformandibularbonereconstruction

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