Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction:
Gespeichert in:
1. Verfasser: | |
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Format: | Abschlussarbeit Buch |
Sprache: | English |
Veröffentlicht: |
Aachen
Shaker
2014
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Schriftenreihe: | Berichte aus der Medizintechnik
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Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | 132 S. Ill., graph. Darst. |
ISBN: | 9783844027051 |
Internformat
MARC
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245 | 1 | 0 | |a Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction |c Verena Bernadette Mauritz |
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Datensatz im Suchindex
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adam_text | TABLE OF CONTENTS
1 INTRODUCTION 1
1.1 CLINICAL PROBLEM 1
1.2 OBJECTIVE AND STRUCTURE OF THE THESIS 3
2 STATE OF THE ART MEDICAL AND TECHNICAL KNOWLEDGE S
2.1 TREATMENT METHODS 5
2.1.1 ALLOPLASTIC MATERIALS 6
2.1.2 DISTRACTION OSTEOGENESIS 8
2.1.3 AUTOLOGOUS BONE 9
2.2 TREATMENT GAP ANALYSIS 10
2.3 BONE SCAFFOLDS FOR MANDIBULAR DEFECTS 14
2.3.1 APPLIED SCAFFOLD MATERIALS 14
2.3.2 CURRENT PROCESS TECHNOLOGIES 15
2.3.3 CHALLENGES 16
3 A NOVEL MANDIBULAR SCAFFOLD 18
3.1 REQUIREMENTS FOR THE DEVELOPMENT 18
3.1.1 FUNCTIONAL - & DESIGN REQUIREMENTS 18
3.1.2 BIOMATERIAL REQUIREMENTS 20
3.2 SELECTION OF BIOMATERIAL CARRIERS 22
3.2.1 CALCIUM ORTHOPHOSPHATE CERAMICS 23
3.2.2 BIODEGRADABLE POLYMERS 25
3.2.3 MATERIALS SELECTION 26
3.3 DETERMINATION OF SCAFFOLD DESIGN 28
3.3.1 EXTERNAL SCAFFOLD DESIGN 28
3.3.2 INTERNAL MICROSTRUCTURE DESIGN 29
3.4 MANUFACTURING PROCESS OF THE SCAFFOLD 31
3.4.1 SCAFFOLD DESIGN IMPLEMENTATION 33
3.4.2 MATERIALS PROCESSING 35
3.4.3 DETERMINATION OF PROCESS PARAMETERS 38
4 POLYCAPROLACTONE AS POTENTIAL POLYMER CARRIER 39
4.1 MATERIAL AND METHODS 39
HTTP://D-NB.INFO/1048581284
4.1.1 DEGRADATION OF PCL IN PBS AND HYDROCHLORIC ACID (HCI) 39
4.1.2 EFFECT OF GAMMA-STERILIZATION ON PCL 42
4.1.3 EFFECT OF MICROWAVE IRRADIATION ON PCL 42
4.2 RESULTS AND DISCUSSION 43
4.2.1 POLYMER DEGRADATION 43
4.2.2 PROCESSABILITY 46
4.3 CONCLUSION 48
5 ANALYSIS OF COMPOSITE MALLEABILITY DEPENDING UPON CERAMIC-POLYMER
RATIO 49
5.1 PREPARATION OF THE SAMPLES 49
5.2 EVALUATION BASED ON ITERATIVE T.O.T.E.-METHOD 50
5.3 CONCLUSION 52
6 IN VITRO VALIDATION OF THE SCAFFOLD COMPOSITES 53
6.1 MATERIALS AND METHODS 53
6.1.1 MORPHOLOGICAL ANALYSIS 53
6.1.2 DEGRADATION ANALYSIS IN VITRO 54
6.1.3 MECHANICAL CHARACTERIZATION 55
6.1.4 POROSITY ANALYSIS 59
6.1.5 INHERENT VISCOSITY MEASUREMENTS 60
6.1.6 CELL - COMPOSITE INTERACTION VIA DIRECT CELL SEEDING 62
6.1.7 STATISTICAL ANALYSIS 63
6.2 RESULTS AND DISCUSSION 64
6.2.1 BIOCOMPATIBILITY 64
6.2.2 POROSITY CHARACTERIZATION 66
6.2.3 POLYMER DEGRADATION 70
6.2.4 MECHANICAL CHARACTERIZATION 75
6.3 SUMMARY 84
7 BONE HEALING PERFORMANCE IN AN OVINE BONE DEFECT MODEL (IN VIVO) 86
7.1 STUDY PURPOSE 86
7.2 MATERIALS AND METHODS 86
7.2.1 STUDY SET-UP 86
7.2.2 EXPERIMENTAL PROCEDURE 87
7.3 RESULTS AND DISCUSSION 89
7.3.1 BONE TO IMPLANT CONTACT 89
7.3.2 BONE AREA DENSITY 91
7.4 CONCLUSION 92
8 FUNCTIONALITY VALIDATION OF THE DEVELOPED MANDIBULAR SCAFFOLD 94
8.1 BIOMECHANICAL PRINCIPLES OF THE MANDIBLE 94
8.2 PERFUSION OF THE SCAFFOLD 95
8.2.1 EXPERIMENTAL PROCEDURE 96
8.2.2 RESULTS AND DISCUSSION 97
8.3 DYNAMIC MECHANICAL ANALYSIS OF THE SCAFFOLD 98
8.3.1 EXPERIMENTAL PROCEDURE 98
8.3.2 RESULTS AND DISCUSSION 99
9 CONCLUSION AND FUTURE WORK 101
10 SUMMARY 105
REFERENCES . 107
GLOSSARY 118
ABBREVIATIONS 120
ANNEX..... ...............................
........................................................................123
|
any_adam_object | 1 |
author | Mauritz, Verena Bernadette |
author_facet | Mauritz, Verena Bernadette |
author_role | aut |
author_sort | Mauritz, Verena Bernadette |
author_variant | v b m vb vbm |
building | Verbundindex |
bvnumber | BV042004343 |
classification_rvk | ZM 7070 |
classification_tum | WER 430d WER 435d FEI 340d |
ctrlnum | (OCoLC)887725368 (DE-599)DNB1048581284 |
dewey-full | 681.761 |
dewey-hundreds | 600 - Technology (Applied sciences) |
dewey-ones | 681 - Precision instruments and other devices |
dewey-raw | 681.761 |
dewey-search | 681.761 |
dewey-sort | 3681.761 |
dewey-tens | 680 - Manufacture of products for specific uses |
discipline | Handwerk und Gewerbe / Verschiedene Technologien Werkstoffwissenschaften Medizintechnik Werkstoffwissenschaften / Fertigungstechnik Feinwerktechnik |
format | Thesis Book |
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genre_facet | Hochschulschrift |
id | DE-604.BV042004343 |
illustrated | Illustrated |
indexdate | 2024-07-10T01:10:22Z |
institution | BVB |
isbn | 9783844027051 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027446316 |
oclc_num | 887725368 |
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owner | DE-91 DE-BY-TUM DE-91G DE-BY-TUM DE-12 DE-83 |
owner_facet | DE-91 DE-BY-TUM DE-91G DE-BY-TUM DE-12 DE-83 |
physical | 132 S. Ill., graph. Darst. |
publishDate | 2014 |
publishDateSearch | 2014 |
publishDateSort | 2014 |
publisher | Shaker |
record_format | marc |
series2 | Berichte aus der Medizintechnik |
spelling | Mauritz, Verena Bernadette Verfasser aut Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction Verena Bernadette Mauritz Aachen Shaker 2014 132 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Berichte aus der Medizintechnik Zugl.: München, Techn. Univ., Diss., 2013 Cytotoxizität (DE-588)4193696-6 gnd rswk-swf Knochenersatz (DE-588)4164283-1 gnd rswk-swf Herstellung (DE-588)4159653-5 gnd rswk-swf Integration (DE-588)4027238-2 gnd rswk-swf Keramischer Werkstoff (DE-588)4030282-9 gnd rswk-swf Verbundwerkstoff (DE-588)4062670-2 gnd rswk-swf Gefäßprothese (DE-588)4140866-4 gnd rswk-swf Kunststoff (DE-588)4033676-1 gnd rswk-swf Unterkieferplastik (DE-588)4124358-4 gnd rswk-swf Biokompatibilität (DE-588)4221531-6 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Keramischer Werkstoff (DE-588)4030282-9 s Kunststoff (DE-588)4033676-1 s Verbundwerkstoff (DE-588)4062670-2 s Herstellung (DE-588)4159653-5 s Gefäßprothese (DE-588)4140866-4 s Integration (DE-588)4027238-2 s Knochenersatz (DE-588)4164283-1 s Biokompatibilität (DE-588)4221531-6 s Cytotoxizität (DE-588)4193696-6 s Unterkieferplastik (DE-588)4124358-4 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027446316&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Mauritz, Verena Bernadette Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction Cytotoxizität (DE-588)4193696-6 gnd Knochenersatz (DE-588)4164283-1 gnd Herstellung (DE-588)4159653-5 gnd Integration (DE-588)4027238-2 gnd Keramischer Werkstoff (DE-588)4030282-9 gnd Verbundwerkstoff (DE-588)4062670-2 gnd Gefäßprothese (DE-588)4140866-4 gnd Kunststoff (DE-588)4033676-1 gnd Unterkieferplastik (DE-588)4124358-4 gnd Biokompatibilität (DE-588)4221531-6 gnd |
subject_GND | (DE-588)4193696-6 (DE-588)4164283-1 (DE-588)4159653-5 (DE-588)4027238-2 (DE-588)4030282-9 (DE-588)4062670-2 (DE-588)4140866-4 (DE-588)4033676-1 (DE-588)4124358-4 (DE-588)4221531-6 (DE-588)4113937-9 |
title | Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction |
title_auth | Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction |
title_exact_search | Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction |
title_full | Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction Verena Bernadette Mauritz |
title_fullStr | Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction Verena Bernadette Mauritz |
title_full_unstemmed | Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction Verena Bernadette Mauritz |
title_short | Biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction |
title_sort | biphasic osteoconductive polymer scaffolds for mandibular bone reconstruction |
topic | Cytotoxizität (DE-588)4193696-6 gnd Knochenersatz (DE-588)4164283-1 gnd Herstellung (DE-588)4159653-5 gnd Integration (DE-588)4027238-2 gnd Keramischer Werkstoff (DE-588)4030282-9 gnd Verbundwerkstoff (DE-588)4062670-2 gnd Gefäßprothese (DE-588)4140866-4 gnd Kunststoff (DE-588)4033676-1 gnd Unterkieferplastik (DE-588)4124358-4 gnd Biokompatibilität (DE-588)4221531-6 gnd |
topic_facet | Cytotoxizität Knochenersatz Herstellung Integration Keramischer Werkstoff Verbundwerkstoff Gefäßprothese Kunststoff Unterkieferplastik Biokompatibilität Hochschulschrift |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027446316&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
work_keys_str_mv | AT mauritzverenabernadette biphasicosteoconductivepolymerscaffoldsformandibularbonereconstruction |