Verfügbarkeit: The biochemistry of retinoic acid receptors

The biochemistry of retinoic acid receptors: 1 Structure, activation, and function at the molecular level

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Bibliographische Detailangaben
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	Dordrecht [u.a.] Springer
Schriftenreihe:	Subcellular biochemistry 70
Schlagworte:	Molekularbiologie Rezeptor Retinoesäure Aufsatzsammlung
Online-Zugang:	TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract
Beschreibung:	1 Online-Ressource
ISBN:	9789401790505
DOI:	10.1007/978-94-017-9050-5

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Datensatz im Suchindex

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adam_text	THE BIOCHEMISTRY OF RETINOIC ACID RECEPTORS I: STRUCTURE, ACTIVATION, AND FUNCTION AT THE MOLECULAR LEVEL / : 2014 TABLE OF CONTENTS / INHALTSVERZEICHNIS FORWARD HISTORY OF RETINOIC ACID RECEPTORS ARCHITECTURE OF DNA BOUND RAR HETERODIMERS RETINOIC ACID RECEPTORS: STRUCTURAL BASIS FOR COREGULATOR INTERACTION AND EXCHANGE EVOLUTION OF RETINOIC ACID RECEPTORS AND RETINOIC ACID SIGNALING RXRS: COLLEGIAL PARTNERS NUCLEAR AND EXTRA-NUCLEAR EFFECTS OF RETINOIC ACID RECEPTORS: HOW THEY ARE INTERCONNECTED- THE ROLES OF RETINOIC ACID AND RETINOIC ACID RECEPTORS IN INDUCING EPIGENETIC CHANGES RARS AND MICRO RNAS INTEGRATIVE GENOMICS TO DISSECT RETINOIDS FUNCTIONS COMPLEXITY OF THE RAR‐MEDIATED TRANSCRIPTIONAL REGULATORY PROGRAMS INDEX DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. THE BIOCHEMISTRY OF RETINOIC ACID RECEPTORS I: STRUCTURE, ACTIVATION, AND FUNCTION AT THE MOLECULAR LEVEL / : 2014 ABSTRACT / INHALTSTEXT A ROLE FOR VITAMIN A IN LIVING ORGANISMS HAS BEEN KNOWN THROUGHOUT HUMAN HISTORY. IN THE LAST 100 YEARS, THE BIOCHEMICAL NATURE OF VITAMIN A AND ITS ACTIVE DERIVATIVE, RETINOIC ACID, ITS PHYSIOLOGICAL IMPACT ON GROWTH PROCESSES AND THE ESSENTIAL DETAILS OF ITS MECHANISM OF ACTION HAVE BEEN REVEALED BY INVESTIGATIONS CARRIED OUT BY RESEARCHERS USING VERTEBRATE AND MORE RECENTLY INVERTEBRATE MODELS TO STUDY A MULTIPLICITY OF PROCESSES AND CONDITIONS, ENCOMPASSING EMBRYOGENESIS, POSTNATAL DEVELOPMENT TO OLD AGE. A WEALTH OF INTERCELLULAR INTERACTIONS, INTRACELLULAR SIGNALING SYSTEMS AND MOLECULAR MECHANISMS HAVE BEEN DESCRIBED AND THE OVERALL CONCLUSION IS THAT RETINOIC ACID IS ESSENTIAL FOR LIFE. THIS BOOK SERIES, WITH CHAPTERS AUTHORED BY EXPERTS IN EVERY ASPECT OF THIS COMPLEX FIELD, UNIFIES THE KNOWLEDGE BASE AND MECHANISMS CURRENTLY KNOWN IN DETAILED, ENGAGING, WELL-ILLUSTRATED, FOCUSED CHAPTERS THAT SYNTHESIZE INFORMATION FOR EACH SPECIFIC AREA.IN VIEW OF THE RECENT EXPLOSION IN THIS FIELD, IT IS TIMELY TO PUBLISH A CONTEMPORARY, COMPREHENSIVE, BOOK SERIES RECAPITULATING THE MOST EXCITING DEVELOPMENTS IN THE FIELD AND COVERING FUNDAMENTAL RESEARCH IN MOLECULAR MECHANISMS OF VITAMIN A ACTION, ITS ROLE IN PHYSIOLOGY, DEVELOPMENT AND CONTINUED WELL-BEING AND THE POTENTIAL OF VITAMIN A DERIVATIVES AND SYNTHETIC MIMETICS TO SERVE AS THERAPEUTIC TREATMENTS FOR CANCERS AND OTHER DEBILITATING HUMAN DISEASES. VOLUME I: HERE, WE PRESENT THE FIRST VOLUME OF A MULTI-VOLUME SERIES ON RETINOIC ACID SIGNALING THAT WILL COVER ALL ASPECTS OF THIS BROAD AND DIVERSE FIELD. ONE AIM OF VOLUME I IS TO PRESENT A COMPILATION OF TOPICS RELATED TO THE BIOCHEMISTRY OF NUCLEAR RETINOIC ACID RECEPTORS, FROM THEIR ARCHITECTURE WHEN BOUND TO DNA AND ASSOCIATED WITH THEIR COREGULATORS TO THEIR ABILITY TO REGULATE TARGET GENE TRANSCRIPTION.A SECOND AIM IS TO PROVIDE INSIGHT INTO RECENT ADVANCES THAT HAVE BEEN MADE IN IDENTIFYING NOVEL TARGETS AND NON-GENOMIC EFFECTS OF RETINOIC ACID. VOLUME I IS DIVIDED INTO TEN CHAPTERS CONTRIBUTED BY PROMINENT EXPERTS IN THEIR RESPECTIVE FIELDS. EACH CHAPTER STARTS WITH THE HISTORY OF THE AREA OF RESEARCH. THEN, THE KEY FINDINGS THAT CONTRIBUTED TO DEVELOPMENT OF THE FIELD ARE DESCRIBED, FOLLOWED BY A DETAILED LOOK AT KEY FINDINGS AND PROGRESS THAT ARE BEING MADE IN CURRENT, ONGOING RESEARCH. EACH CHAPTER IS CONCLUDED WITH A DISCUSSION OF THE RELEVANCE OF THE RESEARCH AND A PERSPECTIVE ON MISSING PIECES AND LINGERING GAPS THAT THE AUTHOR RECOMMENDS WILL BE IMPORTANT IN DEFINING FUTURE DIRECTIONS IN VITAMIN A RESEARCH DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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series	Subcellular biochemistry
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spelling	The biochemistry of retinoic acid receptors 1 Structure, activation, and function at the molecular level Mary Ann Asson-Batres ; Cécile Rochette-Egly, ed. Dordrecht [u.a.] Springer 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Subcellular biochemistry 70 Subcellular biochemistry ... Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Rezeptor (DE-588)4049722-7 gnd rswk-swf Retinoesäure (DE-588)4274949-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Retinoesäure (DE-588)4274949-9 s Rezeptor (DE-588)4049722-7 s Molekularbiologie (DE-588)4039983-7 s DE-604 Asson-Batres, Mary Ann Sonstige oth Rochette-Egly, Cécile Sonstige oth (DE-604)BV041997702 1 Erscheint auch als Druckausgabe 978-94-017-9049-9 Subcellular biochemistry 70 (DE-604)BV041437497 70 https://doi.org/10.1007/978-94-017-9050-5 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027439825&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027439825&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract
spellingShingle	The biochemistry of retinoic acid receptors Subcellular biochemistry Molekularbiologie (DE-588)4039983-7 gnd Rezeptor (DE-588)4049722-7 gnd Retinoesäure (DE-588)4274949-9 gnd
subject_GND	(DE-588)4039983-7 (DE-588)4049722-7 (DE-588)4274949-9 (DE-588)4143413-4
title	The biochemistry of retinoic acid receptors
title_auth	The biochemistry of retinoic acid receptors
title_exact_search	The biochemistry of retinoic acid receptors
title_full	The biochemistry of retinoic acid receptors 1 Structure, activation, and function at the molecular level Mary Ann Asson-Batres ; Cécile Rochette-Egly, ed.
title_fullStr	The biochemistry of retinoic acid receptors 1 Structure, activation, and function at the molecular level Mary Ann Asson-Batres ; Cécile Rochette-Egly, ed.
title_full_unstemmed	The biochemistry of retinoic acid receptors 1 Structure, activation, and function at the molecular level Mary Ann Asson-Batres ; Cécile Rochette-Egly, ed.
title_short	The biochemistry of retinoic acid receptors
title_sort	the biochemistry of retinoic acid receptors structure activation and function at the molecular level
topic	Molekularbiologie (DE-588)4039983-7 gnd Rezeptor (DE-588)4049722-7 gnd Retinoesäure (DE-588)4274949-9 gnd
topic_facet	Molekularbiologie Rezeptor Retinoesäure Aufsatzsammlung
url	https://doi.org/10.1007/978-94-017-9050-5 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027439825&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027439825&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
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