Cascade biocatalysis: integrating stereoselective and environmentally friendly reactions
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| Sprache: | English |
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2014
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| Beschreibung: | XXII, 465 S. graph. Darst. |
| ISBN: | 3527335226 9783527335220 9783527682492 |
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CONTENTS
LIST OF CONTRIBUTORS XIII
PREFACE
XXI
1 DIRECTED EVOLUTION OF LIGNINOLYTIC OXIDOREDUCTASES: FROM FUNCTIONAL
EXPRESSION TO STABILIZATION AND BEYOND 1
EVA GARCIA-RUIZ, DIANA M. MATE, DAVID GONZALEZ-PEREZ, PATRICIA
MOLINA-ESPEJA, SUSANA CAMARERO, ANGEL T. MARTINEZ, ANTONIO O.
BALLESTEROS, AND MIGUEL
ALCALDE
1.1 INTRODUCTION 1
1.2 DIRECTED MOLECULAR EVOLUTION 1
1.3 THE LIGNINOLYTIC ENZYMATIC CONSORTIUM 3
1.4- DIIECTED EVOLUTION OF LACCASES 6
1.4.1 DIRECTED EVOLUTION OF LOW-REDOX POTENTIAL LACCASES 7
1.4.2 DIRECTED EVOLUTION OF MEDIUM-REDOX POTENTIAL LACCASES 7
1.4.3 DIRECTED EVOLUTION OF LIGNINOLYTIC HIGH-REDOX POTENTIAL LACCASES
(HRPLS) 8
1.5 DIRECTED EVOLUTION OF PEROXIDASES AND PEROXYGENASES 11
1.6 SACCHAROMYCES CEREVISIAE BIOMOLECULAR TOOL BOX 15
1.7 CONDUSIONS AND OUTLOOK 16
ACKNOWLEDGMENTS 17
ABBREVIATIONS 17
REFERENCES 18
2
NEW TRENDS IN THE
IN SITU
ENZYMATIC RECYCLING OF NAD(P)(H)
COFACTORS 23
ERICA ELISA
FERRANDI, DANIELA MONTI, AND SERGIO RIVA
2.1 INTRODUCTION 23
2.2 RECENT ADVANCEMENTS IN THE ENZYMATIC METHODS FOR THE RECYCLING OF
NAD(P)(H) COENZYMES AND NOVEL REGENERATION SYSTEMS 24
2.2.1 IN SITU REGENERATION OFREDUCED NAD(P)H COFACTORS 24
2.2.1.1 FORMATE DEHYDROGENASE AND GLUCOSE DEHYDROGENASE 24
2.2.1.2 PHOSPHITE DEHYDROGENASE 26
2.2.1.3 HYDROGENASE 27
HTTP://D-NB.INFO/1047121220
VI I
CONTENTS
2.2.1.4 GLUCOSE 6-PHOSPHATE DEHYDROGENASE 29
2.2.1.5 ALCOHOL DEHYDROGENASE 29
2.2.2 IN SITU REGENERATION OF OXIDIZED NAD(P)
+
COFACTORS 31
2.2.2.1 LACTATE DEHYDROGENASE 31
2.2.2.2 NAD(P)H OXIDASE 32
2.2.2.3 ALCOHOL DEHYDROGENASE 34
2.2.2.4 MEDIATOR-COUPLED ENZYME SYSTEMS 35
2.3 CONCLUSIONS 37
ACKNOWLEDGMENTS 38
REFERENCES 38
3 MONOOXYGENASE-CATALYZED REDOX CASCADE BIOTRANSFBRMATIONS 43
FLORIAN RUDROFF AND MARKO D. MIHOVILOVIC
3.1 INTRODUCTION 43
3.1.1 SCOPE OF THIS CHAPTER 43
3.1.2 ENZYMATIC OXYGENATION 43
3.1.3 EFFECTIVE COFACTOR RECYCLING 44
3.1.4 IN VITRO MULTISTEP BIOCATALYSIS 46
3.1.5 COMBINED IN VITRO AND IN VIVO MULTISTEP BIOCATALYSIS 48
3.1.6 IN VIVO MULTISTEP BIOCATALYSIS 51
3.1.7 CHEMO-ENZYMATIC CASCADE REACTIONS 56
3.1.8 CONCLUSION AND OUTLOOK 60
REFERENCES 61
4 BIOCATALYTIC REDOX CASCADES INVOLVING TO-TRANSAMINASES 65
ROBERT C. SIMON, NINA RICHTER, AND WOLJGANG KROUTIL
4.1 INTRODUCTION 65
4.2 GENERAL FEATURES OF OJ-TRANSAMINASES 66
4.2.1 CASCADES TO SHIFT THE EQUILIBRIUM FOR AMINATION 67
4.3 LINEAR CASCADE REACTIONS INVOLVING CO-TRANSAMINASES 69
4.3.1 REDOX AND REDOX-NEUTRAL CASCADE REACTIONS 70
4.3.2 CARBONYL AMINATION FOLLOWED BY SPONTANEOUS RING CLOSURE 75
4.3.3 DERACEMIZATION OF RACEMIC AMINES EMPLOYING TWO
CO-TRANSAMINASES 78
4.3.4 CASCADE REACTIONS OF W-TAS WITH LYASES AND C-C
HYDROLASES/LIPASES 80
4.4 CONCLUDING REMARKS 82
REFERENCES 83
5 MULTI-ENZYME SYSTEMS AND CASCADE REACTIONS INVOLVING CYTOCHROME
P450 MONOOXYGENASES 87
VLADA B. URIACHER AND SEBASTIAN SCHULZ
5.1 INTRODUCTION 87
5.1.1 MULTISTEP CASCADE REACTIONS 87
5.1.2 CYTOCHROME P450 MONOOXYGENASES 88
5.1.3 GENERAL OVERVIEW OF PRESENTED CASCADE TYPES 91
CONTENTS
I VII
5.2 PHYSIOLOGICAL CASCADE REACTIONS INVOLVING P450S 92
5.2.1 MULTISTEP OXIDATIONS CATALYZED BY A SINGLE P450 92
5.2.2 MULTISTEP OXIDATIONS CATALYZED BY MULTIPLE P450S 102
5.3 ARTIFICIAL CASCADE REACTIONS INVOLVING P450S 108
5.3.1 CASCADE REACTIONS INVOLVING P450S AND COFACTOR REGENERATING
ENZYMES 108
5.3.1.1 COFACTOR REGENERATION IN CELL-FREE SYSTEMS (IN VITRO)
108
5.3.2 COFACTOR REGENERATION IN WHOLE-CELL BIOCATALYSTS 114
5.3.3 ARTIFICIAL ENZYME CASCADES INVOLVING P450S AND OTHER ENZYMES 115
5.3.3.1 ARTIFICIAL MULTI-ENZYME CASCADES WITH ISOLATED ENZYMES 116
5.3.3.2 ARTIFICIAL MULTI-ENZYME CASCADES IN VIVO 120
5.4 CONCLUSIONS AND OUTLOOK 124
REFERENCES 125
6
CHEMO-ENZYMATIC CASCADE REACTIONS FOR THE SYNTHESIS OF
GLYCOCONJUGATES 133
RUEBEN R. ROSENCRANTZ, BASTIAN LANGE, AND LOTHAR ELLING
6.1 INTRODUCTION 133
6.1.1 IMPACT OF GLYCOCONJUGATES AND THEIR SYNTHESIS
6.1.2 BIOCATALYSTS FOR THE SYNTHESIS OF GLYCOCONJUGATES
6.1.2.1 GLYCOSYLTRANSFERASES 134
6.1.2.2 GLYCOSIDASES AND GLYCOSYNTHASES 136
6.1.3 DEFINITION OF CASCADE REACTIONS 137
6.2 SEQUENTIAL SYNTHESES 139
6.2.1 NUCLEOTIDE SUGARS 139
6.2.2 GLYCOCONJUGATES 141
6.3 ONE-POT SYNTHESES 146
6.3.1 NUCLEOTIDE SUGARS 146
6.3.2 GLYCAN STRUCTURES 148
6.4 CONVERGENT SYNTHESES 151
6.5 CONDUSION 153
ACKNOWLEDGMENT 153
REFERENCES 153
7 SYNERGIES OF CHEMISTRY AND BIOCHEMISTRY FOR THE PRODUCTION OF SS-AMINO
ACIDS 161
JOSEFA MARIA CLEMENTE-JIMINEZ, SERGIO MARTINEZ-RODRIGUEZ, FELIPE
RODRIGUEZ-VICO, AND FRANCISCO JAVIER LAS
HERAS-VDZQUEZ
7.1 INTRODUCTION 161
7.2 DIHYDROPYRIMIDINASE 163
7.3 N-CARBAMOYL-SS-ALANINE AMIDOHYDROLASE 166
7.4 BIENZYMATIC SYSTEM FOR SS-AMINO ACID PRODUCTION 173
7.5 CONCLUSIONS AND OUTLOOK 174
ACKNOWLEDGMENTS 174
REFERENCES 174
133
134
VIIII
CONTENTS
8 RACEMIZABLE ACYL DONORS FOR ENZYMATIC DYNAMIC KINETIC
RESOLUTION 179
DAVIDE TESSARO
8.1 INTRODUCTION 179
8.2 THE TOOLS 180
8.2.1 THE ENZYMES 180
8.2.2 THE RACEMIZATION OF ACYL COMPOUNDS 182
8.3 APPLICATIONS OFDKR TO ACYL COMPOUNDS 183
8.3.1 BASE-CATALYZED RACEMIZATION 183
8.3.2 DKR OF OXOESTERS 185
8.3.3 DKR OFTHIOESTERS 188
8.4 CONCLUSIONS 193
ACKNOWLEDGMENTS 194
REFERENCES 194
9
STEREOSELECTIVE HYDROLASE-CATALYZED PROCESSES IN CONTINUOUS-FLOW
MODE 199
ZOLTDN BOROS, GABOR HORNYDNSZKY, JOEZSEF NAGY, AND LDSZLOE POPPE
9.1 INTRODUCTION 199
9.1.1 GENERAL REMARKS ON REACTIONS IN CONTINUOUS-FLOW
SYSTEMS 199
9.1.1.1 STEREOSELECTIVE REACTIONS IN CONTINUOUS FLOW SYSTEMS 202
9.1.1.2 ANALYTICAL APPLICATIONS 203
9.1.2 NONSTEREOSELECTIVE ENZYMATIC PROCESSES 204
9.2 ENZYME-CATALYZED STEREOSELECTIVE REACTIONS IN CONTINUOUS-FLOW
SYSTEMS 204
9.2.1 STEREOSELECTIVE PROCESSES CATALYZED BY NONHYDROLYTIC
ENZYMES 204
9.2.2 STEREOSELECTIVE PROCESSES CATALYZED BY HYDROLASES 207
9.2.2.1 APPLICABLE TYPES OF SELECTIVITIES 207
9.2.2.2 STEREOSELECTIVE HYDROLYTIC REACTIONS 207
9.2.2.3 STEREOSELECTIVE ACYLATIONS 211
9.2.2.4 EFFECTS OF THE OPERATION CONDITIONS AND THE MODE OF ENZYME
IMMOBILIZATION 220
9.3 OUTLOOK AND PERSPECTIVES 222
REFERENCES 222
10 PERSPECTIVES ON MULTIENZYME PROCESS TECHNOLOGY 231
PALOMA A. SANTACOLOMA AND JOHN M. WOODLEY
10.1 INTRODUCTION 231
10.2 MULTIENZYME SYSTEM CLASSIFICATION 233
10.3 BIOCATALYST OPTIONS 233
10.3.1 TRANSPORT LIMITATIONS 235
10.3.2 COMPARTMENTALIZATION 237
10.4 REACTOR OPTIONS 237
CONTENTS I IX
10.5 PROCESS DEVELOPMENT 239
10.5.1 RECOMBINANT DNA TECHNOLOGY 240
10.5.2 PROCESS ENGINEERING 241
10.6 PROCESS MODELING 241
10.7 FUTURE 244
10.8 CONDUDING REMARKS 245
REFERENCES 245
11 NITRILE CONVERTING ENZYMES INVOLVED IN NATURAL AND SYNTHETIC CASCADE
REACTIONS 249
LUDMILA MARTINKOVD, ANDREAS STOLZ, FRED VAN RANTWIJK, NICOLA
D'ANTONA, DEAN BRADY, AND LINDA G. OTTEN
11.1 INTRODUCTION 249
11.2 NATURAL CASCADES 250
11.2.1 NITRILE HYDRATASE - AMIDASE 250
11.2.2 ALDOXIME DEHYDRATASE-NITRILE HYDRATASE-AMIDASE 255
11.2.3 OTHER NATURAL CASCADES 256
11.3 ARTIFICIAL CASCADES 257
11.3.1 NITRILE HYDRATASE-AMIDASE 257
11.3.2 NITRILASE-AMIDASE 258
11.3.3 HYDROXYNITRILE LYASE-NITRILASE 259
11.3.4 HYDROXYNITRILE LYASE-NITRILASE-AMIDASE 261
11.3.5 HYDROXYNITRILE LYASE-NITRILE HYDRATASE 261
11.3.6 OXYGENASE-NITRILASE 262
11.3.7 LIPASE-NITRILE HYDRATASE-AMIDASE 263
11.4 CONCLUSIONS AND FUTURE USE OF THESE ENZYMES 264
ACKNOWLEDGMENTS 265
REFERENCES 265
12 MINING CENOMES FOR NITRILASES 271
LUDMILA MARTINKOVD
12.1 STRATEGIES IN NITRILASE SEARCH 271
12.2 DIVERSITYOF NITRILASE SEQUENCES 272
12.2.1 NITRILASES IN BACTERIA 274
12.2.2 NITRILASES IN FUNGI 274
12.2.3 NITRILASES IN PLANTS 275
12.3 STRUCTURE-FUNCTION RELATIONSHIPS 275
12.3.1 SEQUENCE CLUSTERING 275
12.3.2 ANALYSIS OF SPECIFIC REGIONS 276
12.3.3 ANALYSIS OF ENZYME MUTANTS 276
12.4 ENZYME PROPERTIES AND APPLICATIONS 277
12.4.1 ARYLACETONITRILASES 277
12.4.2 AROMATIC NITRILASES 278
12.4.3 ALIPHATIC NITRILASES 278
12.4.4 CYANIDE-TRANSFORMING ENZYMES 279
X |
CONTENTS
12.5 CONCLUSIONS 279
ACKNOWLEDGMENT 279
REFERENCES 280
13 KEY-STUDY ON THE KINETIC ASPECTS OF THE
IN SITU
N HASE/AMASE CASCADE
SYSTEM OF
M. IMPERIALE
RESTING CELLS FOR NITRILE BIOCONVERSION 283
LAURA CANTARELLA, FABRIZIA PASQUARELLI, AGATA SPERA, LUDMILA
MARTINKOVD, AND MARIA CANTARELLA
13.1 INTRODUCTION 283
13.2 THE TEMPERATURE EFFECT ON THE NHASE-AMIDASE BI-ENZYMATIC
CASCADE SYSTEM 284
13.3 EFFECT OF NITRILE CONCENTRATION ON NHASE ACTIVITY AND STABILITY 287
13.4 EFFECT OF NITRILE ON THE AMASE ACTIVITY AND STABILITY 289
13.5 CONCLUDING REMARKS 293
ACKNOWLEDGMENTS 293
REFERENCES 293
14 ENZYMATIC STEREOSELECTIVE SYNTHESIS OF SS-AMINO ACIDS 297
VARSHA CHHIBA, MOIRA BODE, KGAMA MATHIBA, AND DEAN BRADY
14.1 INTRODUCTION 297
14.2 PREPARATION OF SS-AMINO ACIDS 298
14.2.1 CHEMICAL METHODS FOR GENERATING SS-AMINO ACIDS 298
14.2.2 BIOCATALYTIC PREPARATION OF ENANTIOPURE SS-AMINO ACIDS 299
14.2.2.1 LIPASES AND AMINOACYLASES 299
14.2.2.2 TRANSAMINASES 300
14.2.2.3 NITRILE CONVERTING BIOCATALYSTS 300
14.3 NITRILE HYDROLYSIS ENZYMES 301
14.3.1 NITRILASE 301
14.3.1.1 NITRILASE STRUCTURE AND MECHANISM 301
14.3.1.2 NITRILASE SUBSTRATE SELECTIVITY 302
14.3.2 NITRILE HYDRATASE 302
14.3.2.1 NITRILE HYDRATASE STRUCTURE AND MECHANISM 303
14.3.3 AMIDASES 304
14.3.3.1 AMIDASE STRUCTURE AND MECHANISM 304
14.3.4 NITRILE HYDRATASE AND AMIDASE CASCADE SUBSTRATE SELECTIVITY 304
14.4 CONCLUSION 308
ACKNOWLEDGMENTS 309
REFERENCES 309
15 NEW APPLICATIONS OF TRANSKETOLASE: CASCADE REACTIONS FOR ASSAY
DEVELOPMENT 315
LAWRENCE
HECQUET, WOLF-DIETER FESSNER, VIRGIL HAEAINE, AND FRANCK
CHARMANTRAY
15.1 INTRODUCTION 315
15.2 CASCADE REACTIONS FOR ASSAYING TRANSKETOLASE ACTIVITY IN VITRO 317
CONTENTS
I XI
15.2.1 COUPLING WITH OTHER ENZYMES AS AUXILIARY AGENTS 317
15.2.1.1 COUPLING WITH NAD(H)-DEPENDENT DEHYDROGENASES 317
15.2.1.2 COUPLING WITH BOVINE SERUM ALBUMIN 319
15.2.1.3 COUPLING WITH BSA AND POLYPHENOL OXIDASE 321
15.2.2 COUPLING WITH A NONPROTEIN AUXILIARY AGENT 325
15.2.2.1 CHEMOENZYMATIC CASCADE REACTION BASED ON REDOX
CHROMOPHORE 325
15.2.2.2 PHENOL RED AS PH INDICATOR 326
15.3 CASCADE REACTIONS FOR ASSAYING.TRANSKETOLASE ACTIVITY BY IN VIVO
SELECTION 329
15.3.1 BIOCATALYZED SYNTHESIS OF PROBES 16A,B 330
15.3.2 IN VITRO STUDIES WITH WILD-TYPE TK AND PROBES 16A,B BY LC/MS 330
15.3.3 DETECTION OF TK ACTIVITY IN E. COLI AUXOTROPHS FROM AMINO ACID
PRECURSORS 331
15.4 CONCLUSION 334
REFERENCES 335
16 ALDOLASES AS CATALYST FOR THE SYNTHESIS OF CARBOHYDRATES AND
ANALOGS 339
PERE CIAPDS,
JESUS JOGLAR,
AND JORDI BUJONS
16.1 INTRODUCTION 339
16.2 IMINOCYCLITOL AND AMINOCYDITOL SYNTHESIS 340
16.3 CARBOHYDRATES AND OTHER POLYHYDROXYLATED COMPOUNDS 351
16.4 CONCLUSIONS 355
ACKNOWLEDGMENTS 356
REFERENCES 356
17 ENZYMATIC GENERATION OF SIALOCONJUGATE DIVERSITY 361
WOLF-DIETER FESSNER, NING
HE, DONG YI, PETER UNRUH, AND MARION KNORST
17.1 INTRODUCTION 361
17.2 A GENERIC STRATEGY FOR THE SYNTHESIS OF SIALOCONJUGATE LIBRARIES
363
17.2.1 SYNTHESIS OF SIALIC ACID DIVERSITY 368
17.2.1.1 NEURAMINIC ACID ALDOLASE 368
17.2.1.2 NEURAMINIC ACID SYNTHASE 371
17.2.2 NUCLEOTIDE ACTIVATION OF SIALIC ACIDS 372
17.2.2.1 KINETICS OF SIALIC ACID ACTIVATION 373
17.2.2.2 SUBSTRATE BINDING MODEL 373
17.2.2.3 ENGINEERING OF PROMISCUOUS CSS VARIANTS 376
17.2.3 SIALIC ACID TRANSFER 377
17.3 CASCADE SYNTHESIS OF NEO-SIALOCONJUGATES 378
17.3.1 CHOICE OF SIALYL ACCEPTOR 378
17.3.2 ONE-POT TWO-STEP CASCADE REACTIONS 379
17.3.3 ONE-POT THREE-STEP CASCADE REACTIONS 383
17.3.4 METABOLIE DIVERSIFICATION 385
17.3.5 POST-SYNTHETIC DIVERSIFICATION 386
XII
|
CONTENTS
17.3.6 BIOMEDICAL APPLICATIONS OF SIALOCONJUGATE ARRAYS 388
17.4 CONCLUSIONS 388
ACKNOWLEDGMENTS 389
REFERENCES 389
18 METHYLTRANSFERASES IN BIOCATALYSIS 393
LUDGER WESSJOHANN, MARTIN DIPPE, MARTIN TENGG, AND MANDANA
GRUBER-KHADJAWI
18.1 INTRODUCTION 393
18.2 SAM-DEPENDENT METHYLTRANSFERASES 395
18.2.1 SUBSTRATES 396
18.2.2 COFACTORS 400
18.2.3 HIGHER HOMOLOGS AND DERIVATIVES OF SAM 403
18.2.4 COFACTOR (RE)GENERATION 406
18.2.5 CASCADE APPLICATIONS 410
18.3 CONCLUSION AND OUTLOOK 415
ABBREVIATIONS 417
ACKNOWLEDGEMENT 417
REFERENCES 418
19 CHEMOENZYMATIC MULTISTEP ONE-POT PROCESSES 427
HARALD GROEGER AND WERNER HUMMEL
19.1 INTRODUCTION: WHY CHEMOENZYMATIC CASCADES AND WHY ONE-POT
PROCESSES? 427
19.2 CONCEPTS OF CHEMOENZYMATIC PROCESSES 427
19.3 COMBINATION OF SUBSTRATE ISOMERIZATION AND THEIR DERIVATIZATION
WITH
CHEMO- AND BIOCATALYSTS RESULTING IN DYNAMIC KINETIC RESOLUTIONS
AND RELATED PROCESSES 429
19.4 COMBINATION OF SUBSTRATE SYNTHESIS (WITHOUT ISOMERIZATION) AND
DERIVATIZATION STEP(S) 438
19.4.1 ONE-POT PROCESSES WITH AN INITIAL BIOCATALYTIC STEP, FOLLOWED BY
CHEMOCATALYSIS OR A NONCATALYZED CHEMICAL PROCESS 439
19.4.2 ONE-POT PROCESS WITH AN INITIAL CHEMO PROCESS, FOLLOWED BY
BIOCATALYSIS 443
19.4.2.1 COMBINATION OF N ONCATALYZED ORGANIC REACTIONS AND
BIOCATALYSIS 443
19.4.2.2 COMBINATION OF METAL CATALYSIS AND BIOCATALYSIS 445
19.4.2.3 COMBINATION OF ORGANOCATALYSIS AND BIOCATALYSIS 449
19.5 CONCLUSION AND OUTLOOK 453
REFERENCES 453
INDEX 457 |
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| discipline | Chemie / Pharmazie Biologie |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV041983635 |
| illustrated | Illustrated |
| indexdate | 2024-08-03T01:39:30Z |
| institution | BVB |
| isbn | 3527335226 9783527335220 9783527682492 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027426035 |
| oclc_num | 887796142 |
| open_access_boolean | |
| owner | DE-29T DE-188 DE-11 DE-20 DE-703 |
| owner_facet | DE-29T DE-188 DE-11 DE-20 DE-703 |
| physical | XXII, 465 S. graph. Darst. |
| publishDate | 2014 |
| publishDateSearch | 2014 |
| publishDateSort | 2014 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Cascade biocatalysis integrating stereoselective and environmentally friendly reactions ed. by Sergio Riva ... Weinheim Wiley-VCH 2014 XXII, 465 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Katalyse (DE-588)4029921-1 gnd rswk-swf Tandem-Reaktion (DE-588)4306783-9 gnd rswk-swf Biotechnologie (DE-588)4069491-4 gnd rswk-swf Biokatalyse (DE-588)4393622-2 gnd rswk-swf Ökologische Chemie (DE-588)4135167-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Biokatalyse (DE-588)4393622-2 s Biotechnologie (DE-588)4069491-4 s Tandem-Reaktion (DE-588)4306783-9 s DE-604 Ökologische Chemie (DE-588)4135167-8 s Katalyse (DE-588)4029921-1 s Riva, Sergio edt Erscheint auch als Online-Ausgabe, EPUB 978-3-527-68251-5 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-68250-8 Erscheint auch als Online-Ausgabe, PDF 978-3-527-68248-5 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4583958&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027426035&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cascade biocatalysis integrating stereoselective and environmentally friendly reactions Katalyse (DE-588)4029921-1 gnd Tandem-Reaktion (DE-588)4306783-9 gnd Biotechnologie (DE-588)4069491-4 gnd Biokatalyse (DE-588)4393622-2 gnd Ökologische Chemie (DE-588)4135167-8 gnd |
| subject_GND | (DE-588)4029921-1 (DE-588)4306783-9 (DE-588)4069491-4 (DE-588)4393622-2 (DE-588)4135167-8 (DE-588)4143413-4 |
| title | Cascade biocatalysis integrating stereoselective and environmentally friendly reactions |
| title_auth | Cascade biocatalysis integrating stereoselective and environmentally friendly reactions |
| title_exact_search | Cascade biocatalysis integrating stereoselective and environmentally friendly reactions |
| title_full | Cascade biocatalysis integrating stereoselective and environmentally friendly reactions ed. by Sergio Riva ... |
| title_fullStr | Cascade biocatalysis integrating stereoselective and environmentally friendly reactions ed. by Sergio Riva ... |
| title_full_unstemmed | Cascade biocatalysis integrating stereoselective and environmentally friendly reactions ed. by Sergio Riva ... |
| title_short | Cascade biocatalysis |
| title_sort | cascade biocatalysis integrating stereoselective and environmentally friendly reactions |
| title_sub | integrating stereoselective and environmentally friendly reactions |
| topic | Katalyse (DE-588)4029921-1 gnd Tandem-Reaktion (DE-588)4306783-9 gnd Biotechnologie (DE-588)4069491-4 gnd Biokatalyse (DE-588)4393622-2 gnd Ökologische Chemie (DE-588)4135167-8 gnd |
| topic_facet | Katalyse Tandem-Reaktion Biotechnologie Biokatalyse Ökologische Chemie Aufsatzsammlung |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=4583958&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027426035&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT rivasergio cascadebiocatalysisintegratingstereoselectiveandenvironmentallyfriendlyreactions |