Homer has the Blues: Involvement of Homer1 in stress-induced psychopathology
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Volltext kostenfrei Inhaltsverzeichnis |
| Beschreibung: | IX, 179 S. Ill., graph. Darst. |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | HOMER
HAS THE BLUES
INVOLVEMENT OF HOMERL
IN STRESS-INDUCED PSYCHOPATHOLOGY
DISSERTATION
AN DER FAKULTAT FUR BIOLOGIE
DER LUDWIG-MAXIMILIANS-UNIVERSITAT MIINCHEN
VORGELEGT VON
KLAUS WAGNER
18. JULI 2013
HTTP://D-NB.INFO/1053270402
TABLE OF CONTENTS
TABLE OF CONTENTS
TABLE OF CONTENTS I
ABSTRACT IV
ZUSAMMENFASSUNG V
LIST OF ABBREVIATIONS VI
1. GENERAL INTRODUCTION 1
1.1. CONCEPTUAL AND MOLECULAR BASIS OF STRESS 1
THE CONCEPT OF STRESS 1
MOLECULAR PATHWAYS OF THE STRESS RESPONSE 2
PATHOLOGICAL IMPACT OF STRESS 4
1.2. DEPRESSION AND THE CURRENT STATE OF TREATMENT 5
1.3. THE GLUTAMATE SYSTEM 7
ORGANIZATION OF THE GLUTAMATE SYNAPSE 7
GLUTAMATE SIGNALING AND MOOD DISORDERS 8
1.4. THE POSTSYNAPTIC SCAFFOLD HOMERL 11
STRUCTURE AND FUNCTION OF HOMER FAMILY PROTEINS 11
BEHAVIORAL IMPLICATIONS OF HOMERL 12
1.5. MODELING MOOD DISORDERS IN RODENTS 14
CHRONIC STRESS MODELS 15
1.6. AIM OF THE THESIS 17
2. RESEARCH ARTICLES 19
2.1. DIFFERENCES IN FKBP51 REGULATION FOLLOWING CHRONIC SOCIAL DEFEAT
STRESS
CORRELATE WITH INDIVIDUAL STRESS SENSITIVITY: INFLUENCE OF PAROXETINE
TREATMENT
21
ABSTRACT 22
INTRODUCTION 23
MATERIALS AND METHODS 25
RESULTS 29
DISCUSSION 38
SUPPLEMENTAL MATERIAL 43
TABLE OF CONTENTS
2.2. HIPPOCAMPAL HOMERL IS REGULATED BY CHRONIC SOCIAL DEFEAT STRESS 49
ABSTRACT 50
INTRODUCTION 51
MATERIALS AND METHODS 53
RESULTS 59
DISCUSSION 64
2.3. HOMERL MEDIATES ACUTE STRESS-INDUCED COGNITIVE DEFICITS IN THE
DORSAL
HIPPOCAMPUS 69
ABSTRACT 70
INTRODUCTION 71
MATERIALS AND METHODS 73
RESULTS 79
DISCUSSION 86
*V
2.4. HIPPOCAMPAL HOMERL LEVELS INFLUENCE MOTIVATIONAL BEHAVIOR IN AN
OPERANT
CONDITIONING TASK 91
ABSTRACT 92
INTRODUCTION 93
MATERIALS AND METHODS 95
RESULTS 99
DISCUSSION 105
SUPPLEMENTAL MATERIAL 108
2.5. HOMERL/MGLUR5 SIGNALING MODERATES VULNERABILITY TO CHRONIC SOCIAL
STRESS
ILL
ABSTRACT 112
INTRODUCTION 113
MATERIALS AND METHODS 115
RESULTS 122
DISCUSSION 133
SUPPLEMENTAL MATERIAL 138
3. GENERAL DISCUSSION 143
3.1. SOCIAL DEFEAT STRESS 144
3.2. HOMERL IS INVOLVED IN THE STRESS RESPONSE 146
3.3. IMPLICATIONS FOR NOVEL TREATMENT OPTIONS 149
3.4. SUMMARY AND FUTURE PERSPECTIVES 151
TABLE OF CONTENTS
4. REFERENCES 153
5. CURRICULUM VITAE 172
6. PUBLICATIONS 173
7. ACKNOWLEDGMENTS 175
8. ASSERTION / EIDESSTATTLICHE VERSICHERUNG 177
IN
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| spelling | Wagner, Klaus Verfasser aut Homer has the Blues Involvement of Homer1 in stress-induced psychopathology von Klaus Wagner 2013 IX, 179 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Univ., Diss., 2013 Mit einer Zssfassung in dt. Sprache (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-170563 http://edoc.ub.uni-muenchen.de/17056/ Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:19-170563 Resolving-System kostenfrei DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027369617&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wagner, Klaus Homer has the Blues Involvement of Homer1 in stress-induced psychopathology |
| subject_GND | (DE-588)4113937-9 |
| title | Homer has the Blues Involvement of Homer1 in stress-induced psychopathology |
| title_auth | Homer has the Blues Involvement of Homer1 in stress-induced psychopathology |
| title_exact_search | Homer has the Blues Involvement of Homer1 in stress-induced psychopathology |
| title_full | Homer has the Blues Involvement of Homer1 in stress-induced psychopathology von Klaus Wagner |
| title_fullStr | Homer has the Blues Involvement of Homer1 in stress-induced psychopathology von Klaus Wagner |
| title_full_unstemmed | Homer has the Blues Involvement of Homer1 in stress-induced psychopathology von Klaus Wagner |
| title_short | Homer has the Blues |
| title_sort | homer has the blues involvement of homer1 in stress induced psychopathology |
| title_sub | Involvement of Homer1 in stress-induced psychopathology |
| topic_facet | Hochschulschrift |
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