Natural products: discourse, diversity and design
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Ames, Iowa
Wiley Blackwell
2014
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XVI, 531 S. Ill., graph. Darst. |
| ISBN: | 9781118298060 |
Internformat
MARC
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| 245 | 1 | 0 | |a Natural products |b discourse, diversity and design |c ed. Anne Osbourn ... |
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Datensatz im Suchindex
| _version_ | 1804152230795804672 |
|---|---|
| adam_text | Contents
я
Contributors
ix
SECTION I NATURAL PRODUCTS IN THE
NATURAL WORLD
1
Part
1
Role and Reason
3
1
The Role of Phytochemicals in Relationships of Plants with
Other Organisms
5
Paweł Bednarek
2
Designer Microbial Ecosystems
-
Toward Biosynthesis with
Engineered Microbial
Consortia
23
David M. Babson, Mark Held, and Claudia Schmidt-Dannert
3
Marine Natural Products
-
Chemical Defense/Chemical
Communication in Sponges and Corals
39
Elodie Quévrain, Isabelle Domart-Coulon,
and
Marie-Lise
Bourguet-Kondracki
Part
2
Self-Protection
-
Avoiding Autotoxicity
- 67
4
How Plants Avoid the
Toxicity
of Self-Produced Defense
Bioactive Compounds
69
Supaart
Sirikantaramas,
Mami
Yamazaki, and Kazuki
Saito
Part
3
Fishing and Pharming
83
5
Marine Bioprospecting
85
Amanda M. Fenner and William H. Gerwick
6
Myxobacteria: Chemical Diversity and Screening Strategies
103
Alberto Plaza and
Rolf Müller
7
Fungal Endophytes of Grasses and Morning Glories, and Their
Bioprotective Alkaloids
125
Christopher L. Schardl, Li Chen, and Carolyn A. Young
VÍ
CONTENTS
8
Fungal-Actinomy
cete
Interactions
-
Wakening of Silent Fungal
Secondary Metabolism Gene Clusters via Interorganismic
Interactions
147
Volker Schroeckh, Hans-Wilhelm Nützmann, and Axel A. Brakhage
9
Secondary Metabolites Produced by Plant Pathogens
159
Barbara J. Howlett
SECTION II FROM GENES TO MOLECULES
171
Part
1
Reading the Genome
173
10
Analyzing Fungal Secondary Metabolite Genes and Gene
Clusters
175
Yi-Ming Chiang, Clay
С. С.
Wang, and
Beri R.
Oakley
Part
2
Biosynthesis and Hetenrfogous Expression
195
11
RiPPs: Ribosomally Synthesized and Posttranslationally
Modified Peptides
197
Noah A. Bindman and Wilfred A. Van
Der Donk
12
Polyketide Synthase: Sequence, Structure, and Function
219
Joel Braegger, Grace Caidara,
Joris
Beid,
Michael
D.
Burkart,
and Shiou-Chuan (Sheryl) Tsai
13
Manipulation of Fungal Natural Product Pathways
245
Russell J. Cox and
Katherine
Williams
14
Production of Therapeutic Products
261
Guojian Zhang and Blaine A.
Pfeifer
Part
3
Regulation: Waking Sleeping Pathways
277
15
Waking Sleeping Pathways in Filamentous Fungi
279
Joe Spraker and Nancy Keller
SECTION
Ш
EVOLVING ENZYMES, EVOLVING PATHWAYS:
SYNTHETIC BIOLOGY
293
Part
1
Chemical Diversification
295
16
The Oxidosqualene Cyctases: One Substrate, Diverse Products
297
Dcuro Abe
CONTENTS
VU
17
Harnessing Sugar Biosynthesis and Glycosylation to Redesign
Natural Products and to Increase Structural Diversity
317
Carlos
Olano,
Carmen
Méndez,
and
José A. Salas
Part
2
Evolving Pathways
341
18
Evolutionary Mechanisms Involved in Development of Fungal
Secondary Metabolite Gene Clusters
343
Geromy G. Moore, Jerome Collemare,
Marc-Henri Lebrun,
and
Rosie
E.
Bradshaw
Part
3
Synthetic Biology
357
19
Synthetic Biology of Natural Products
359
Rainer Breitling
and
Eriko Takáno
SECTION
IV
SCREENING FOR BIOACTIVITY
371
20
Image-Based Screening Approaches to Natural Products
Discovery
373
Christopher J.
Schulze
and Roger G. Linington
21
Making Sense of Structures by Utilizing Mother Nature s
Chemical Libraries as Leads to Potential Drugs
397
David J. Newman and Gordon M. Cragg
22
Is There an Ideal Database for Natural Products Research?
413
John W. Blunt and Murray H. G. Munro
SECTION V TO APPLICATION
433
Case Studies
435
23
Daptomycin and A54145: Structure-Activity Relationship
(SAR)
Studies Enabled by Combinatorial Biosynthesis
437
Richard
R
Baltz
24
Discovery and Development of NVB302, a Semisynthetic
Antibiotic for Treatment of Clostridium difficile Infection
455
Steven Boakes and Michael J. Dawson
25
ILS-920: A Rapamycin Analog for
Ischemie
Stroke
469
Edmund I.
Graziarli
26
BC265: A Nonquinone Ansamycin Hsp90 Inhibitor Developed
Using Biosynthetic
Medicina]
Chemistry
483
Matthew A. Gregory, Steven J. Moss, and Barrie Wilkinson
VÌii
CONTENTS
27 Discovery and Development
of Caspofungin
(
CANCIDAS):
Concept to Clinic
497
James M. Balkovec, David L. Hughes, Prakash S. Masurekar,
Carole A. Sable, Robert E. Schwartz, and Sheo B. Singh
Index
523
Natural Products:
Discourse, Diversity, and Design
Natterai
Products: Discourse, Direr^itu, and Design explores the natural products, or the secondary
metabolites, produced by microbes, fungi, and plants. Natural products can be used in the development
or
a
wide array of products such as drugs, herbicides, antioxidants, preservatives, pigments and dyes
for materials, rood, flavors, and fragrances. As science advances, it has become exceedingly clear that
the potential or biological organisms to synthesize diverse natural products is likely to be far greater
than ever previously imagined.
An accessible and informative overview of these natural products in the genomic era.
Natura!
Products: Discourse, Diversity, and
Dťs/y;i
delves into the discover)-, examination, and application of
natural products across different kingdoms. Chapters explore their genetics and synthetic biology,
methods for screening for bioactivity and their practical applications. Its wide scope guarantees its
appeal to piant scientists, fungal biologists, and microbioiogists, ¿is well as those who work with
industrial biotechnology, drug discovery, medicinal chemistry, agronomy, crop improvement, and
natural product chemistry.
The volume is comprehensive in its treatment oi biologically based products in the natural world.
iitural Products: Di^cour-v, Divtwtv.
лил
Oesvgn will
bea
vital resource for anyone working in this
rapidly developing field.
Covers a range of important natural products from microbes, piants, fungi, and marine organisms.
•
Explores the rote of various metabolites as well as the evolution of their unique
biochemical pathways.
•
Chapters cover topics including biosynthesis and heterologous expression, avoiding
autotoxicity, and chemical
¿ічегапсагіоп.
•
Includes case studies on the development
ai commercial
products from
naturai
products from indus¬
try experts.
•
Wide-ranging and in-depth coverage or
јп
expanding held.
The editors
Anne Osbourn is Professor
лі
the University oi East
Anglia,
ĽK.
and Director or the
Norwich Research Park Industrial Biotechnology and Bioenergy Alliance, and is based at the
lohn (nnes
Centre.
Rebecca J. Goss is Reader in Organic Biomolecular Chemistry at the School of Chemistry and also
at the
Biomedical
Sciences Research Complex at the
L
University ot St Andrews, UK.
Guy T. Carter has en
er 3
^ ot
expérience
working in Pharmaceutical R&D, primarily in the
discovery and development or microbiai products. He is currently CEO of
Carter-Beman
Consulting
and Chief Scientific Officer at Biosortia Pharmaceutical-,
L
SA.
|
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