Impact of the genetic background on the development of diabetes-associated renal lesions in GIPRdn transgenic diabetic mice:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
München
Verl. Dr. Hut
2013
|
| Ausgabe: | 1. Aufl. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 155 S. Ill., graph. Darst. |
| ISBN: | 9783843912938 |
Internformat
MARC
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| 100 | 1 | |a Popper, Bastian |d 1985- |e Verfasser |0 (DE-588)105126488X |4 aut | |
| 245 | 1 | 0 | |a Impact of the genetic background on the development of diabetes-associated renal lesions in GIPRdn transgenic diabetic mice |c by Bastian Alexander Popper |
| 250 | |a 1. Aufl. | ||
| 264 | 1 | |a München |b Verl. Dr. Hut |c 2013 | |
| 300 | |a 155 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Zugl..: München, Univ., Diss., 2013 | ||
| 546 | |a Mit einer Zssfassung in dt. Sprache | ||
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| 650 | 0 | 7 | |a Phänotyp |0 (DE-588)4248244-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Transgene Tiere |0 (DE-588)4279021-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pathogenese |0 (DE-588)4115512-9 |2 gnd |9 rswk-swf |
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| 650 | 0 | 7 | |a Diabetes mellitus |0 (DE-588)4070446-4 |2 gnd |9 rswk-swf |
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| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-027296804 | ||
Datensatz im Suchindex
| _version_ | 1804152199476936704 |
|---|---|
| adam_text | TABLE OF CONTENTS
1. INTRODUCTION 9
2. SCIENTIFIC BACKGROUND 11
2.1 DIABETES MELLITUS 11
2.1.1 DESCRIPTION AND CLASSIFICATION 11
2.1.2 CLINICAL FEATURES, DIAGNOSIS AND RISK FACTORS OF DIABETES MELLITUS
13
2.1.3 COMMON DIABETES-ASSOCIATED ORGAN LESIONS 14
2.2 DIABETIC NEPHROPATHY IN MICE AND MEN 17
2.2.1 PATHOHISTOLOGICAL CLASSIFICATION OF DIABETIC NEPHROPATHY IN HUMANS
18
2.2.2 NEPHRON NUMBER AND GLOMERULAR HYPERTROPHY IN DIABETIC NEPHROPATHY
19
2.2.3 PODOCYTES IN HEALTH AND DISEASE 23
2.3 MOUSE MODELS IN DIABETES RESEARCH 27
2.3.1 MOUSE MODELS OF TYPE 1 DIABETES 27
2.3.2 MOUSE MODELS OF TYPE 2 DIABETES 29
2.4 MOUSE MODELS OF DIABETIC NEPHROPATHY 31
2.5 GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE AND ITS RECEPTOR 34
2.6 GIPR
DN
TRANSGENIC MICE IN DIABETES RESEARCH 36
3. MATERIAL AND METHODS 39
3.1 ANIMALS 39
3.1.1 GENOTYPING 40
3.1.2 PRIMER 40
3.1.3 DNA EXTRACTION 41
3.1.4 POLYMERASE CHAIN REACTION (PCR) 42
3.1.5 GEL ELECTROPHORESIS 42
3.1.6 BLOOD PRESSURE MEASUREMENT 43
3.1.7 BLOOD AND URINE GLUCOSE TESTING 43
3.1.8 SERUM PARAMETERS AND URINE ANALYSIS 44
3.1.9 DETERMINATION OF FOOD AND WATER CONSUMPTION
AND COLLECTION OF 24-HOUR URINE SAMPLES 44
3.1.10 DETERMINATION OF URINE ALBUMIN CONCENTRATIONS BY
ENZYME LINKED IMMUNO-SORBENT ASSAY (ELISA) 44
HTTP://D-NB.INFO/1045229180
3.2 KIDNEY PERFUSION AND TISSUE PROCESSING 47
3.2.1 KIDNEY PERFUSION 47
3.2.2 TISSUE PROCESSING FOR PLASTIC HISTOLOGY 50
3.2.3 EPON EMBEDDING AND TRANSMISSION ELECTRON
MICROSCOPY 52
3.3 QUANTITATIVE MORPHOLOGICAL ANALYSES 55
3.3.1 ESTIMATION OF KIDNEY VOLUME 55
3.3.2 TISSUE SHRINKAGE AND SECTION THICKNESS ESTIMATION 55
3.3.3 ESTIMATION OF THE TOTAL NEPHRON
NUMBER 62
3.3.4 ESTIMATION OF THE TOTAL GLOMERULAR VOLUME
PER KIDNEY 66
3.3.5 ESTIMATION OF THE MEAN GLOMERULAR VOLUME 66
3.3.6 ESTIMATION OF THE NUMBER OF PODOCYTES PER GLOMERULUS
AND THE MEAN PODOCYTE VOLUME 67
3.3.7 ESTIMATION OF THE MEAN GLOMERULAR MESANGIUM AND
CAPILLARY VOLUMES 70
3.3.8 ESTIMATION OF THE CAPILLARY LENGTH PER GLOMERULUS 71
3.3.9 DETERMINATION OF THE FILTRATION SLIT FREQUENCY (FSF) 72
3.3.10 ESTIMATION OF THE TRUE HARMONIC MEAN THICKNESS OF THE
GLOMERULAR BASEMENT MEMBRANE (GBM) 73
3.4 SEMIQUANTITATIVE EVALUATION OF GLOMERULOSCLEROSIS 76
3.5 IMMUNOHISTOCHEMISTRY 77
3.6 DATA PRESENTATION AND STATISTICAL ANALYSES 78
4. RESULTS 79
4.1 BODY WEIGHT OF GIPR
DN
TRANSGENIC AND WILD-TYPE MICE 79
4.2 BLOOD GLUCOSE LEVELS 80
4.3 DATA OF BLOOD PRESSURE MEASUREMENTS 81
4.3.1 SYSTOLIC BLOOD PRESSURE 81
4.3.2 SYSTOLIC BLOOD PRESSURE IN PERCENTAGE OF CONTROL 82
4.4 WATER AND FOOD CONSUMPTION OF GIPR
DN
TRANSGENIC
AND CONTROL MICE 83
4.5 SERUM PARAMETERS OF GIPR
DN
TRANSGENIC AND WILD-TYPE MICE 85
4.6 URINE ANALYSIS OF GIPR
DN
TRANSGENIC AND WILD-TYPE MICE 86
4.6.1 DAILY URINE VOLUME 86
4.6.2 CREATININE CONCENTRATION IN 24-HOUR URINE SAMPLES 87
4.6.3 URINE-ALBUMIN EXCRETION IN 24-HOUR URINE SAMPLES 88
4.6.4 ALBUMIN-TO-CREATININE RATIO (ACR) 89
4.7 QUALITATIVE HISTOLOGICAL KIDNEY FINDINGS 90
4.8 RESULTS OF QUANTITATIVE MORPHOLOGICAL INVESTIGATIONS 93
4.8.1 KIDNEY VOLUME OF GIPR
DN
TRANSGENIC AND WILD-TYPE MICE 93
4.8.2 TOTAL NUMBER OF GLOMERULI IN GIPR
DN
TRANSGENIC AND WILD-TYPE MICE 94
4.8.3 TOTAL GLOMERULAR VOLUME GIPR
DN
TRANSGENIC AND WILD-TYPE MICE 95
4.8.4 MEAN GLOMERULAR VOLUME OF GIPR
DN
TRANSGENIC AND WILD-TYPE MICE 96
4.8.5 MEAN GLOMERULAR VOLUME IN PERCENTAGE OF CONTROL 97
4.8.6 VOLUME FRACTION OF THE MESANGIUM IN THE GLOMERULI 98
4.8.7 MEAN GLOMERULAR MESANGIUM VOLUME 99
4.8.8 VOLUME FRACTION OF CAPILLARIES IN THE GLOMERULI 100
4.8.9 MEAN GLOMERULAR CAPILLARY VOLUME 101
4.8.10 LENGTH DENSITY OF THE CAPILLARIES IN THE GLOMERULI 102
4.8.11 CAPILLARY LENGTH PER GLOMERULUS 103
4.8.12 NUMERICAL VOLUME DENSITY OF PODOCYTES IN THE GLOMERULI 104
4.8.13 TOTAL NUMBER OF PODOCYTES PER GLOMERULUS 105
4.8.14 MEAN PODOCYTE VOLUME 106
4.8.15 MEAN PODOCYTE VOLUME IN PERCENTAGE OF CONTROL 107
4.8.16 THICKNESS OF THE GLOMERULAR BASEMENT MEMBRANE (GBM) 108
4.8.17 FILTRATION SLIT FREQUENCY (FSF) 109
4.9 QUALITATIVE ULTRASTRUCTURAL GLOMERULAR FINDINGS IN
GIPR
DN
TRANSGENIC AND WILD-TYPE MICE 109
4.10 DETERMINATION OF THE MEAN THICKNESS OF GMA/MMA SECTIONS 111
5. DISCUSSION 113
6. PERSPECTIVES 127
7. SUMMARY 129
8. ZUSAMMENFASSUNG 131
9. BIBLIOGRAPHY 133
10. APPENDIX 153
10.1 EXAMPLE FOR THE CALCULATION OF THE HARMONIC
MEAN THICKNESS OF THE GBM 153
10.2 ACKNOWLEDGMENT 155
|
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| indexdate | 2024-07-10T01:06:55Z |
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| isbn | 9783843912938 |
| language | English |
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| spelling | Popper, Bastian 1985- Verfasser (DE-588)105126488X aut Impact of the genetic background on the development of diabetes-associated renal lesions in GIPRdn transgenic diabetic mice by Bastian Alexander Popper 1. Aufl. München Verl. Dr. Hut 2013 155 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zugl..: München, Univ., Diss., 2013 Mit einer Zssfassung in dt. Sprache Glomerulopathie (DE-588)4157649-4 gnd rswk-swf Phänotyp (DE-588)4248244-6 gnd rswk-swf Transgene Tiere (DE-588)4279021-9 gnd rswk-swf Pathogenese (DE-588)4115512-9 gnd rswk-swf Nephropathia diabetica (DE-588)4136461-2 gnd rswk-swf Diabetes mellitus (DE-588)4070446-4 gnd rswk-swf Tiermodell (DE-588)4140660-6 gnd rswk-swf Maus (DE-588)4169148-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Nephropathia diabetica (DE-588)4136461-2 s Pathogenese (DE-588)4115512-9 s Glomerulopathie (DE-588)4157649-4 s Phänotyp (DE-588)4248244-6 s Tiermodell (DE-588)4140660-6 s Maus (DE-588)4169148-9 s Diabetes mellitus (DE-588)4070446-4 s Transgene Tiere (DE-588)4279021-9 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027296804&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Popper, Bastian 1985- Impact of the genetic background on the development of diabetes-associated renal lesions in GIPRdn transgenic diabetic mice Glomerulopathie (DE-588)4157649-4 gnd Phänotyp (DE-588)4248244-6 gnd Transgene Tiere (DE-588)4279021-9 gnd Pathogenese (DE-588)4115512-9 gnd Nephropathia diabetica (DE-588)4136461-2 gnd Diabetes mellitus (DE-588)4070446-4 gnd Tiermodell (DE-588)4140660-6 gnd Maus (DE-588)4169148-9 gnd |
| subject_GND | (DE-588)4157649-4 (DE-588)4248244-6 (DE-588)4279021-9 (DE-588)4115512-9 (DE-588)4136461-2 (DE-588)4070446-4 (DE-588)4140660-6 (DE-588)4169148-9 (DE-588)4113937-9 |
| title | Impact of the genetic background on the development of diabetes-associated renal lesions in GIPRdn transgenic diabetic mice |
| title_auth | Impact of the genetic background on the development of diabetes-associated renal lesions in GIPRdn transgenic diabetic mice |
| title_exact_search | Impact of the genetic background on the development of diabetes-associated renal lesions in GIPRdn transgenic diabetic mice |
| title_full | Impact of the genetic background on the development of diabetes-associated renal lesions in GIPRdn transgenic diabetic mice by Bastian Alexander Popper |
| title_fullStr | Impact of the genetic background on the development of diabetes-associated renal lesions in GIPRdn transgenic diabetic mice by Bastian Alexander Popper |
| title_full_unstemmed | Impact of the genetic background on the development of diabetes-associated renal lesions in GIPRdn transgenic diabetic mice by Bastian Alexander Popper |
| title_short | Impact of the genetic background on the development of diabetes-associated renal lesions in GIPRdn transgenic diabetic mice |
| title_sort | impact of the genetic background on the development of diabetes associated renal lesions in giprdn transgenic diabetic mice |
| topic | Glomerulopathie (DE-588)4157649-4 gnd Phänotyp (DE-588)4248244-6 gnd Transgene Tiere (DE-588)4279021-9 gnd Pathogenese (DE-588)4115512-9 gnd Nephropathia diabetica (DE-588)4136461-2 gnd Diabetes mellitus (DE-588)4070446-4 gnd Tiermodell (DE-588)4140660-6 gnd Maus (DE-588)4169148-9 gnd |
| topic_facet | Glomerulopathie Phänotyp Transgene Tiere Pathogenese Nephropathia diabetica Diabetes mellitus Tiermodell Maus Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027296804&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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