SCF and APC E3 Ubiquitin Ligases in Tumorigenesis:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer
2014
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| Schriftenreihe: | SpringerBriefs in Cancer Research
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| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9783319050263 |
| DOI: | 10.1007/978-3-319-05026-3 |
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Datensatz im Suchindex
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|---|---|
| adam_text | SCF AND APC E3 UBIQUITIN LIGASES IN TUMORIGENESIS
/ INUZUKA, HIROYUKI
: 2014
TABLE OF CONTENTS / INHALTSVERZEICHNIS
1. INTRODUCTION
2. THE FBXW SUBCLASS OF SCF E3 UBIQUITIN LIGASES
3. THE FBXL SUBCLASS OF SCF E3 UBIQUITIN LIGASES
4. THE FBXO SUBCLASS OF SCF E3 UBIQUITIN LIGASES
5. APC/CDC20 AND APC/CDH1 E3 UBIQUITIN LIGASES
6. CONCLUSIONS AND FUTURE PERSPECTIVES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
SCF AND APC E3 UBIQUITIN LIGASES IN TUMORIGENESIS
/ INUZUKA, HIROYUKI
: 2014
ABSTRACT / INHALTSTEXT
THIS SPRINGERBRIEF EXPLORES THE PHYSIOLOGICAL ROLES OF
SKP1-CULLIN1-F-BOX COMPLEX (SCF) AND ANAPHASE PROMOTING COMPLEX (APC) IN
NORMAL CELLS AND IN TUMOR FORMATION. THESE TWO RELATED, MULTI-SUBUNIT E3
UBIQUITIN LIGASE ENZYMES, APC AND SCF ARE THOUGHT TO BE THE MAJOR
DRIVING FORCES GOVERNING PROPER CELL CYCLE PROGRESSION. DEFECTIVE CELL
CYCLE REGULATION LEADS TO GENOMIC INSTABILITY AND ULTIMATELY, CANCER
DEVELOPMENT. SELECTIVE DEGRADATION OF KEY CELL CYCLE REGULATORS BY THE
UBIQUITIN-PROTEASOME SYSTEM HAS BEEN PROVEN TO BE A MAJOR REGULATORY
MECHANISM FOR ENSURING ORDERED AND COORDINATED CELL CYCLE PROGRESSION.
THE SCF AND APC E3 LIGASES HAVE BEEN CHARACTERIZED TO PLAY PIVOTAL ROLES
IN REGULATING THE CELL CYCLE PROGRESSION BY TIMELY DEGRADING VARIOUS
CRITICAL CELL CYCLE REGULATORS. THIS BRIEF REVIEWS RECENT STUDIES THAT
HAVE SHOWN THAT DEREGULATION OF SIGNALING PATHWAYS IN WHICH THE TWO
UBIQUITIN LIGASES ARE INVOLVED CAUSES ABERRANT CELL CYCLE REGULATION, IN
TURN LEADING TO TUMORIGENESIS. THE TEXT ALSO DISCUSSES HOW SCF AND APC
MAY PRESENT PROMISING THERAPEUTIC TARGETS TO TREAT VARIOUS CANCERS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| spelling | Inuzuka, Hiroyuki Verfasser aut SCF and APC E3 Ubiquitin Ligases in Tumorigenesis Hiroyuki Inuzuka ; Wenyi Wei Cham [u.a.] Springer 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier SpringerBriefs in Cancer Research Medizin Medicine Oncology Biochemistry Cell cycle Biomedicine Wei, Wenyi Verfasser aut Erscheint auch als Druckausgabe 978-3-319-05025-6 https://doi.org/10.1007/978-3-319-05026-3 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027271279&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027271279&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Inuzuka, Hiroyuki Wei, Wenyi SCF and APC E3 Ubiquitin Ligases in Tumorigenesis Medizin Medicine Oncology Biochemistry Cell cycle Biomedicine |
| title | SCF and APC E3 Ubiquitin Ligases in Tumorigenesis |
| title_auth | SCF and APC E3 Ubiquitin Ligases in Tumorigenesis |
| title_exact_search | SCF and APC E3 Ubiquitin Ligases in Tumorigenesis |
| title_full | SCF and APC E3 Ubiquitin Ligases in Tumorigenesis Hiroyuki Inuzuka ; Wenyi Wei |
| title_fullStr | SCF and APC E3 Ubiquitin Ligases in Tumorigenesis Hiroyuki Inuzuka ; Wenyi Wei |
| title_full_unstemmed | SCF and APC E3 Ubiquitin Ligases in Tumorigenesis Hiroyuki Inuzuka ; Wenyi Wei |
| title_short | SCF and APC E3 Ubiquitin Ligases in Tumorigenesis |
| title_sort | scf and apc e3 ubiquitin ligases in tumorigenesis |
| topic | Medizin Medicine Oncology Biochemistry Cell cycle Biomedicine |
| topic_facet | Medizin Medicine Oncology Biochemistry Cell cycle Biomedicine |
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