Endogenous Stem Cell-Based Brain Remodeling in Mammals:
This book uses the juvenile mammalian brain as a starting point to describe how different injury mechanisms influence neuronal and glial progenitor response to injury, and how in certain circumstances, these cells might play adaptive or harmful roles in recovery. It also provides an overview of eme...
Gespeichert in:
Format: | Elektronisch E-Book |
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Sprache: | English |
Veröffentlicht: |
New York, NY [u.a.]
Springer / Humana Press
2014
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Schriftenreihe: | Stem Cell Biology and Regenerative Medicine
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Schlagworte: | |
Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
Zusammenfassung: | This book uses the juvenile mammalian brain as a starting point to describe how different injury mechanisms influence neuronal and glial progenitor response to injury, and how in certain circumstances, these cells might play adaptive or harmful roles in recovery. It also provides an overview of emerging concepts in progenitor biology and how current understanding of the processes regulating these cells has tempered some of the initial enthusiasm regarding their therapeutic potential. Only recently has significant effort been devoted to the study of late neurogenesis in mammals, though this interesting phenomenon was first described over fifty years ago. In many settings, injury accelerates the ongoing neurogenesis now known to occur, and recently described reservoirs of glial progenitors add to the pool of existing reparative possibilities. Dr. Steven G. Kernie is an Associate Professor of Pediatrics and Pathology & Cell Biology at Columbia University in New York and Chief of Critical Care Medicine at Morgan Stanley Children's Hospital at Columbia University Medical Center. His laboratory is interested in how the brain repairs itself following injury. The presence of adult neural stem and progenitor cells in the mammalian brain has awakened new interest and optimism in potential treatment for a variety of acquired brain disorders. The Kernie lab is investigating how adult neural stem and progenitor cells participate in injury-induced remodeling and in identifying genes and drugs that might be important in augmenting their contribution. In order to do this, they have generated a variety of transgenic mice that allow for temporally controlled alterations in the endogenous stem cell population in order to optimize the post-injury remodeling that occurs. Dr. Marie-Pierre Junier is Research Director at Inserm and co-PI of team Glial Plasticity for the Center of++ Research Neuroscience Paris Seine at the University Pierre et Marie Curie. Her team showed the permissiveness of astrocytes to re-programming into immature states akin to neural progenitors or neural stem cells. It further demonstrated that these plastic capabilities of astrocytes sensitize them to cancerous transformation. The team is now using cancer stem cells isolated from human adult and pediatric gliomas to understand their differences from normal human neural stem cells. Combining proteomic, metabolic and epigenetic approaches, the team aims at developing new therapeutic strategies agains ... |
Beschreibung: | 1 Online-Ressource |
ISBN: | 9781489973993 |
DOI: | 10.1007/978-1-4899-7399-3 |
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520 | 1 | |a This book uses the juvenile mammalian brain as a starting point to describe how different injury mechanisms influence neuronal and glial progenitor response to injury, and how in certain circumstances, these cells might play adaptive or harmful roles in recovery. It also provides an overview of emerging concepts in progenitor biology and how current understanding of the processes regulating these cells has tempered some of the initial enthusiasm regarding their therapeutic potential. Only recently has significant effort been devoted to the study of late neurogenesis in mammals, though this interesting phenomenon was first described over fifty years ago. In many settings, injury accelerates the ongoing neurogenesis now known to occur, and recently described reservoirs of glial progenitors add to the pool of existing reparative possibilities. Dr. Steven G. Kernie is an Associate Professor of Pediatrics and Pathology & Cell Biology at Columbia University in New York and Chief of Critical Care Medicine at Morgan Stanley Children's Hospital at Columbia University Medical Center. His laboratory is interested in how the brain repairs itself following injury. The presence of adult neural stem and progenitor cells in the mammalian brain has awakened new interest and optimism in potential treatment for a variety of acquired brain disorders. The Kernie lab is investigating how adult neural stem and progenitor cells participate in injury-induced remodeling and in identifying genes and drugs that might be important in augmenting their contribution. In order to do this, they have generated a variety of transgenic mice that allow for temporally controlled alterations in the endogenous stem cell population in order to optimize the post-injury remodeling that occurs. Dr. Marie-Pierre Junier is Research Director at Inserm and co-PI of team Glial Plasticity for the Center of++ | |
520 | 1 | |a Research Neuroscience Paris Seine at the University Pierre et Marie Curie. Her team showed the permissiveness of astrocytes to re-programming into immature states akin to neural progenitors or neural stem cells. It further demonstrated that these plastic capabilities of astrocytes sensitize them to cancerous transformation. The team is now using cancer stem cells isolated from human adult and pediatric gliomas to understand their differences from normal human neural stem cells. Combining proteomic, metabolic and epigenetic approaches, the team aims at developing new therapeutic strategies agains ... | |
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Datensatz im Suchindex
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adam_text | ENDOGENOUS STEM CELL-BASED BRAIN REMODELING IN MAMMALS
/
: 2014
TABLE OF CONTENTS / INHALTSVERZEICHNIS
INTRODUCTION
STRUCTURAL PLASTICITY IN ADULT NERVOUS SYSTEM: A HISTORIC PERSPECTIVE
IMPACT OF INJURED TISSUE ON STEM CELL FATE
ROLE OF NEURAL STEM AND PROGENITOR CELLS IN THE ADAPTATION OF THE BRAIN
TO INJURY
ROLE OF ADULT NEUROGENESIS IN SEIZURE-INDUCED HIPPOCAMPAL REMODELING AND
EPILEPSY
NEUROGENESIS AND GLIOGENESIS IN THE POSTNATAL HYPOTHALAMUS: A NEW LEVEL
OF PLASTICITY FOR THE REGULATION OF HYPOTHALAMIC FUNCTION?
REGENERATIVE POTENTIAL OF NG2 CELLS
OLIGODENDROCYTE PROGENITORS AND BRAIN REMODELING FOLLOWING BLOOD BRAIN
BARRIER RUPTURE
GENOMIC INTEGRITY OF EMBRYONIC AND NEURAL STEM CELLS
LINKS BETWEEN INJURY-INDUCED BRAIN REMODELING AND ONCOGENESIS?
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
ENDOGENOUS STEM CELL-BASED BRAIN REMODELING IN MAMMALS
/
: 2014
ABSTRACT / INHALTSTEXT
THIS BOOK USES THE JUVENILE MAMMALIAN BRAIN AS A STARTING POINT TO
DESCRIBE HOW DIFFERENT INJURY MECHANISMS INFLUENCE NEURONAL AND GLIAL
PROGENITOR RESPONSE TO INJURY, AND HOW IN CERTAIN CIRCUMSTANCES, THESE
CELLS MIGHT PLAY ADAPTIVE OR HARMFUL ROLES IN RECOVERY. IT ALSO
PROVIDES AN OVERVIEW OF EMERGING CONCEPTS IN PROGENITOR BIOLOGY AND HOW
CURRENT UNDERSTANDING OF THE PROCESSES REGULATING THESE CELLS HAS
TEMPERED SOME OF THE INITIAL ENTHUSIASM REGARDING THEIR THERAPEUTIC
POTENTIAL. ONLY RECENTLY HAS SIGNIFICANT EFFORT BEEN DEVOTED TO THE
STUDY OF LATE NEUROGENESIS IN MAMMALS, THOUGH THIS INTERESTING
PHENOMENON WAS FIRST DESCRIBED OVER FIFTY YEARS AGO. IN MANY SETTINGS,
INJURY ACCELERATES THE ONGOING NEUROGENESIS NOW KNOWN TO OCCUR,AND
RECENTLY DESCRIBED RESERVOIRS OF GLIAL PROGENITORS ADD TO THE POOL OF
EXISTING REPARATIVE POSSIBILITIES. DR. STEVEN G.KERNIE IS AN ASSOCIATE
PROFESSOR OF PEDIATRICS AND PATHOLOGY & CELL BIOLOGY AT COLUMBIA
UNIVERSITY IN NEW YORK AND CHIEF OF CRITICAL CARE MEDICINE AT MORGAN
STANLEY CHILDREN’S HOSPITAL AT COLUMBIA UNIVERSITY MEDICAL CENTER. HIS
LABORATORY IS INTERESTED IN HOW THE BRAIN REPAIRS ITSELF FOLLOWING
INJURY. THE PRESENCE OF ADULT NEURAL STEM AND PROGENITOR CELLS IN THE
MAMMALIAN BRAIN HAS AWAKENED NEW INTEREST AND OPTIMISM IN POTENTIAL
TREATMENT FOR A VARIETY OF ACQUIRED BRAIN DISORDERS. THE KERNIE LAB IS
INVESTIGATING HOW ADULT NEURAL STEM AND PROGENITOR CELLS PARTICIPATE IN
INJURY-INDUCED REMODELING AND IN IDENTIFYING GENES AND DRUGS THAT MIGHT
BE IMPORTANT IN AUGMENTING THEIR CONTRIBUTION. IN ORDER TO DO THIS, THEY
HAVE GENERATED A VARIETY OF TRANSGENIC MICE THAT ALLOW FOR TEMPORALLY
CONTROLLED ALTERATIONS IN THE ENDOGENOUS STEM CELL POPULATION IN ORDER
TO OPTIMIZE THE POST-INJURY REMODELING THAT OCCURS. DR.MARIE-PIERRE
JUNIER IS RESEARCH DIRECTOR AT INSERM AND CO-PI OF TEAM GLIAL PLASTICITY
FOR THE CENTER OF RESEARCH NEUROSCIENCE PARIS SEINE AT THE UNIVERSITY
PIERRE ET MARIE CURIE. HER TEAM SHOWED THE PERMISSIVENESS OF ASTROCYTES
TO RE-PROGRAMMING INTO IMMATURE STATES AKIN TO NEURAL PROGENITORS OR
NEURAL STEM CELLS. IT FURTHER DEMONSTRATED THAT THESE PLASTIC
CAPABILITIES OF ASTROCYTES SENSITIZE THEM TO CANCEROUS TRANSFORMATION.
THE TEAM IS NOW USING CANCER STEM CELLS ISOLATED FROM HUMAN ADULT AND
PEDIATRIC GLIOMAS TO UNDERSTAND THEIR DIFFERENCES FROM NORMAL HUMAN
NEURAL STEM CELLS. COMBINING PROTEOMIC, METABOLIC AND EPIGENETIC
APPROACHES, THE TEAM AIMS AT DEVELOPING NEW THERAPEUTIC STRATEGIES
AGAINST THESE DEVASTATING CANCERS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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spelling | Endogenous Stem Cell-Based Brain Remodeling in Mammals Marie-Pierre Junier ; Steven G. Kernie, ed. New York, NY [u.a.] Springer / Humana Press 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Stem Cell Biology and Regenerative Medicine This book uses the juvenile mammalian brain as a starting point to describe how different injury mechanisms influence neuronal and glial progenitor response to injury, and how in certain circumstances, these cells might play adaptive or harmful roles in recovery. It also provides an overview of emerging concepts in progenitor biology and how current understanding of the processes regulating these cells has tempered some of the initial enthusiasm regarding their therapeutic potential. Only recently has significant effort been devoted to the study of late neurogenesis in mammals, though this interesting phenomenon was first described over fifty years ago. In many settings, injury accelerates the ongoing neurogenesis now known to occur, and recently described reservoirs of glial progenitors add to the pool of existing reparative possibilities. Dr. Steven G. Kernie is an Associate Professor of Pediatrics and Pathology & Cell Biology at Columbia University in New York and Chief of Critical Care Medicine at Morgan Stanley Children's Hospital at Columbia University Medical Center. His laboratory is interested in how the brain repairs itself following injury. The presence of adult neural stem and progenitor cells in the mammalian brain has awakened new interest and optimism in potential treatment for a variety of acquired brain disorders. The Kernie lab is investigating how adult neural stem and progenitor cells participate in injury-induced remodeling and in identifying genes and drugs that might be important in augmenting their contribution. In order to do this, they have generated a variety of transgenic mice that allow for temporally controlled alterations in the endogenous stem cell population in order to optimize the post-injury remodeling that occurs. Dr. Marie-Pierre Junier is Research Director at Inserm and co-PI of team Glial Plasticity for the Center of++ Research Neuroscience Paris Seine at the University Pierre et Marie Curie. Her team showed the permissiveness of astrocytes to re-programming into immature states akin to neural progenitors or neural stem cells. It further demonstrated that these plastic capabilities of astrocytes sensitize them to cancerous transformation. The team is now using cancer stem cells isolated from human adult and pediatric gliomas to understand their differences from normal human neural stem cells. Combining proteomic, metabolic and epigenetic approaches, the team aims at developing new therapeutic strategies agains ... Biowissenschaften Life sciences Oncology Neurosciences Neurochemistry Cytology Stem cells Junier, Marie-Pierre Sonstige oth Kernie, Steven G. Sonstige oth Erscheint auch als Druckausgabe 978-1-4899-7398-6 https://doi.org/10.1007/978-1-4899-7399-3 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027180671&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027180671&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
spellingShingle | Endogenous Stem Cell-Based Brain Remodeling in Mammals Biowissenschaften Life sciences Oncology Neurosciences Neurochemistry Cytology Stem cells |
title | Endogenous Stem Cell-Based Brain Remodeling in Mammals |
title_auth | Endogenous Stem Cell-Based Brain Remodeling in Mammals |
title_exact_search | Endogenous Stem Cell-Based Brain Remodeling in Mammals |
title_full | Endogenous Stem Cell-Based Brain Remodeling in Mammals Marie-Pierre Junier ; Steven G. Kernie, ed. |
title_fullStr | Endogenous Stem Cell-Based Brain Remodeling in Mammals Marie-Pierre Junier ; Steven G. Kernie, ed. |
title_full_unstemmed | Endogenous Stem Cell-Based Brain Remodeling in Mammals Marie-Pierre Junier ; Steven G. Kernie, ed. |
title_short | Endogenous Stem Cell-Based Brain Remodeling in Mammals |
title_sort | endogenous stem cell based brain remodeling in mammals |
topic | Biowissenschaften Life sciences Oncology Neurosciences Neurochemistry Cytology Stem cells |
topic_facet | Biowissenschaften Life sciences Oncology Neurosciences Neurochemistry Cytology Stem cells |
url | https://doi.org/10.1007/978-1-4899-7399-3 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027180671&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027180671&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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