Protein Conformational Dynamics:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer
2014
|
| Schriftenreihe: | Advances in Experimental Medicine and Biology
805 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9783319029702 |
| DOI: | 10.1007/978-3-319-02970-2 |
Internformat
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| 245 | 1 | 0 | |a Protein Conformational Dynamics |c Ke-li Han ; Xin Zhang ; Ming-jun Yang, ed. |
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Datensatz im Suchindex
| _version_ | 1804152002474672128 |
|---|---|
| adam_text | PROTEIN CONFORMATIONAL DYNAMICS
/
: 2014
TABLE OF CONTENTS / INHALTSVERZEICHNIS
PROTEIN FOLDING SIMULATIONS BY GENERALIZED-ENSEMBLE ALGORITHMS
APPLICATION OF MARKOV STATE MODELS TO SIMULATE LONG TIMESCALE DYNAMICS
OF BIOLOGICAL MACROMOLECULES
UNDERSTANDING PROTEIN DYNAMICS USING CONFORMATIONAL ENSEMBLES
GENERATIVE MODELS OF CONFORMATIONAL DYNAMICS
GENERALIZED SPRING TENSOR MODELS FOR PROTEIN FLUCTUATION DYNAMICS AND
CONFORMATION CHANGES
THE JOYS AND PERILS OF FLEXIBLE FITTING
COARSE-GRAINED MODELS OF THE PROTEINS BACKBONE CONFORMATIONAL DYNAMICS
SIMULATING PROTEIN FOLDING IN DIFFERENT ENVIRONMENTAL CONDITIONS
SIMULATING THE PEPTIDE FOLDING KINETIC RELATED SPECTRA BASED ON THE
MARKOV STATE MODEL
THE DILEMMA OF CONFORMATIONAL DYNAMICS IN ENZYME CATALYSIS: PERSPECTIVES
FROM THEORY AND EXPERIMENT
EXPLOITING PROTEIN INTRINSIC FLEXIBILITY IN DRUG DESIGN
NMR AND COMPUTATIONAL METHODS IN THE STRUCTURAL AND DYNAMIC
CHARACTERIZATION OF LIGAND-RECEPTOR INTERACTIONS
MOLECULAR DYNAMICS SIMULATION OF MEMBRANE PROTEINS
FREE-ENERGY LANDSCAPE OF INTRINSICALLY DISORDERED PROTEINS INVESTIGATED
BY ALL-ATOM MULTICANONICAL MOLECULAR DYNAMICS
COORDINATION AND CONTROL INSIDE SIMPLE BIOMOLECULAR MACHINES
MULTI-STATE TARGETING MACHINERY GOVERN THE FIDELITY AND EFFICIENCY OF
PROTEIN LOCALIZATION
MOLECULAR DYNAMICS SIMULATIONS OF F1-ATPASE
CHEMOSENSORIAL G-PROTEINS-COUPLED RECEPTORS: A PERSPECTIVE FROM
COMPUTATIONAL METHODS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
PROTEIN CONFORMATIONAL DYNAMICS
/
: 2014
ABSTRACT / INHALTSTEXT
THIS BOOK DISCUSSES HOW BIOLOGICAL MOLECULES EXERT THEIR FUNCTION AND
REGULATE BIOLOGICAL PROCESSES, WITH A CLEAR FOCUS ON HOW CONFORMATIONAL
DYNAMICS OF PROTEINS ARE CRITICAL INTHIS RESPECT. IN THE LAST DECADE,
THE ADVANCEMENTS IN COMPUTATIONAL BIOLOGY, NUCLEAR MAGNETIC RESONANCE
INCLUDING PARAMAGNETIC RELAXATION ENHANCEMENT, AND FLUORESCENCE-BASED
ENSEMBLE/SINGLE-MOLECULE TECHNIQUES HAVE SHOWN THAT BIOLOGICAL MOLECULES
(PROTEINS, DNAS AND RNAS) FLUCTUATE UNDER EQUILIBRIUM CONDITIONS. THE
CONFORMATIONAL AND ENERGETIC SPACES THAT THESE FLUCTUATIONS EXPLORE
LIKELY CONTAIN ACTIVE CONFORMATIONS THAT ARE CRITICAL FOR THEIR
FUNCTION. MORE INTERESTINGLY, THESE FLUCTUATIONS CAN RESPOND ACTIVELY TO
EXTERNAL CUES, WHICH INTRODUCES LAYERS OF TIGHT REGULATION ON THE
BIOLOGICAL PROCESSES THAT THEY DICTATE.A GROWING NUMBER OF STUDIES HAVE
SUGGESTED THAT CONFORMATIONAL DYNAMICS OF PROTEINS GOVERN THEIR ROLE IN
REGULATING BIOLOGICAL FUNCTIONS, EXAMPLES OF THIS REGULATION CAN BE
FOUND IN SIGNAL TRANSDUCTION, MOLECULAR RECOGNITION, APOPTOSIS, PROTEIN
/ ION / OTHER MOLECULES TRANSLOCATION AND GENE EXPRESSION. ON THE
EXPERIMENTAL SIDE, THE TECHNICAL ADVANCES HAVE OFFERED DEEP INSIGHTS
INTO THE CONFORMATIONAL MOTIONS OF A NUMBER OF PROTEINS. THESE STUDIES
GREATLY ENRICH OUR KNOWLEDGE OF THE INTERPLAY BETWEEN STRUCTURE AND
FUNCTION. ON THE THEORETICAL SIDE, NOVEL APPROACHES AND DETAILED
COMPUTATIONAL SIMULATIONS HAVE PROVIDED POWERFUL TOOLS IN THE STUDY OF
ENZYME CATALYSIS, PROTEIN / DRUG DESIGN, PROTEIN / ION / OTHER MOLECULE
TRANSLOCATION AND PROTEIN FOLDING/AGGREGATION, TO NAME BUT A FEW.THIS
WORK CONTAINS DETAILED INFORMATION, NOT ONLY ON THE CONFORMATIONAL
MOTIONS OF BIOLOGICAL SYSTEMS, BUT ALSO ON THE POTENTIAL GOVERNING
FORCES OF CONFORMATIONAL DYNAMICS (TRANSIENT INTERACTIONS, CHEMICAL AND
PHYSICAL ORIGINS, THERMODYNAMIC PROPERTIES). NEW DEVELOPMENTS IN
COMPUTATIONAL SIMULATIONS WILL GREATLY ENHANCE OUR UNDERSTANDING OF HOW
THESE MOLECULES FUNCTION IN VARIOUS BIOLOGICAL EVENTS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| indexdate | 2024-07-10T01:03:47Z |
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| series | Advances in Experimental Medicine and Biology |
| series2 | Advances in Experimental Medicine and Biology |
| spelling | Protein Conformational Dynamics Ke-li Han ; Xin Zhang ; Ming-jun Yang, ed. Cham [u.a.] Springer 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Advances in Experimental Medicine and Biology 805 Datenverarbeitung Medizin Medicine Biochemistry Biology / Data processing Biomedicine Han, Ke-Li Sonstige oth Zhang, Xin Sonstige (DE-588)1012579743 oth Yang, Ming-jun Sonstige oth Erscheint auch als Druckausgabe 978-3-319-02969-6 Advances in Experimental Medicine and Biology 805 (DE-604)BV023059251 805 https://doi.org/10.1007/978-3-319-02970-2 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027170171&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027170171&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Protein Conformational Dynamics Advances in Experimental Medicine and Biology Datenverarbeitung Medizin Medicine Biochemistry Biology / Data processing Biomedicine |
| title | Protein Conformational Dynamics |
| title_auth | Protein Conformational Dynamics |
| title_exact_search | Protein Conformational Dynamics |
| title_full | Protein Conformational Dynamics Ke-li Han ; Xin Zhang ; Ming-jun Yang, ed. |
| title_fullStr | Protein Conformational Dynamics Ke-li Han ; Xin Zhang ; Ming-jun Yang, ed. |
| title_full_unstemmed | Protein Conformational Dynamics Ke-li Han ; Xin Zhang ; Ming-jun Yang, ed. |
| title_short | Protein Conformational Dynamics |
| title_sort | protein conformational dynamics |
| topic | Datenverarbeitung Medizin Medicine Biochemistry Biology / Data processing Biomedicine |
| topic_facet | Datenverarbeitung Medizin Medicine Biochemistry Biology / Data processing Biomedicine |
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