The pancreatic beta cell:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2014
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Vitamins and hormones
95 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufn. für Zeitschr.-H. |
| Beschreibung: | XVIII, 482 S. Ill., graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a The pancreatic beta cell |c ed. Gerald Litwack |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2014 | |
| 300 | |a XVIII, 482 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Vitamins and hormones |v 95 | |
| 500 | |a Einzelaufn. für Zeitschr.-H. | ||
| 700 | 1 | |a Litwack, Gerald |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027169194&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-027169194 | ||
Datensatz im Suchindex
| _version_ | 1804152000939556864 |
|---|---|
| adam_text | Titel: The pancreatic beta cell
Autor: Litwack, Gerald
Jahr: 2014
CONTENTS
Contributors xiii
Preface xvii
1. Metabolie Regulation of Insulin Secretion 1
Kevin Keane and Philip Newsholme
1. Introduction 2
2. Glucose Metabolism and Insulin Secretion 5
3. Fatty Acid Metabolism and Insulin Secretion 12
4. Amino Acid Metabolism and Insulin Secretion 16
5. Association of Nutrient Metabolism with Pancreatic ß-Cell Dysfunction 22
6. Conclusions 26
References 27
2. Proinsulin Entry and Transit Through the Endoplasmic
Reticulum in Pancreatic Beta Cells 35
Ming Liu, Jordan Wright, Huan Guo, Yi Xiong, and Peter Arvan
1. Overview of Insulin Biosynthesis in Pancreatic Beta Cells 36
2. Proinsulin Entry into the ER 39
3. Proinsulin Transit Through the ER 49
4. Conclusion and Perspective 54
Acknowledgments 54
References 54
3. Metabolism-Secretion Coupling and Mitochondrial
Calcium Activities in Clonal Pancreatic ß-Cells 63
Lukas N. Groschner, Muhammad Rizwan Alam, and Wolfgang F. Graier
1. Introduction 64
2. The Importance of Mitochondria to ß-Cell Function 65
3. Oxidative Metabolism of ß-Cells 67
4. Mitochondrial Ca2+ and Energy Metabolism 71
5. Ca2+ Handling in ß-Cells 74
Acknowledgments 80
References 80
vii
viii
Contents
4. Metabolic Syndrome and Ionic Channels in Pancreatic Beta Cells 87
Marcia Hiriart, Myrian Velasco, Carlos Larqué, and Carlos Manilo Diaz-Garcla
1. Introduction 88
2. A Rapid Fly on Metabolie Syndrome 89
3. Physiology of Pancreatic Islets In Glucose Homeostasis 93
4. Physiology and Pathophysiology of Ionic Channels 96
5. Concluding Remarks 107
References 107
5. The Beta Celllmmunopeptidome 115
Nadine L. Dudek and Anthony W. Purcell
1. Introduction 116
2. Autoantlgens In T1D 117
3. Antigen Processing 121
4. Identifying T Cell Epitopes In T1D 125
5. Peptlde-Based Intervention and the Role of Small Molecules 132
6. Advances In Mass Spectrometry for the Identification of PTMs 135
7. Conclusions 138
References 139
6. Autophagy and Pancreatic ß-Cells 145
Simona Mazza and Tania Maffucci
1. Introduction 146
2. Autophagy 146
3. Autophagy and Pancreatic ß-Cell Homeostasis 151
4. Adaptive Autophagy In Pancreatic ß-Cell 154
5. Autophagy and Diabetes 157
6. Modulation of Autophagy as Therapeutic Strategy 158
7. Conclusions and Future Directions 160
Acknowledgments 160
References 160
7. The Somatostatin Receptor in Human Pancreatic ß-Cells 165
Matthias Braun
1. Introduction 166
2. SST in Pancreatic Islets 169
3. Regulation of SST Secretion from Pancreatic 5-Cells 170
4. Effects of Exogenous SST on Hormone Secretion from Pancreatic Islets 171
Contents
¡x
5. Cellular Mechanisms Underlying SST Inhibition of Pancreatic Hormone
Secretion 172
6. SSTRs In Pancreatic Islet Cells 175
7. Physiological Role of SST Signaling in Pancreatic Islets 178
8. SST and 5-Cells in Diabetes Mellitus 181
9. Clinical Uses of SSTR Agonists and Pancreatic Islets 182
10. Conclusions and Future Directions 184
Acknowledgments 185
References 185
8. Modulation of the Pancreatic Islet-Stress Axis as a Novel
Potential Therapeutic Target in Diabetes Mellitus 195
Barbara Ludwig, Andreas Barthel, Andreas Reichel, Norman L. Block,
Stefan Ludwig, Andrew V. Schally, and Stefan R. Bornstein
1. Introduction 196
2. Factors and Conditions Predisposing to the Development of
Diabetes Mellitus 198
3. Current Options and Concepts for the Prevention and Treatment
of Diabetes Mellitus 202
4. Implication of the Pancreatic islet-Stress Axis In Diabetes Mellitus:
A Potential Target for Prevention and Therapy 208
5. Conclusions and Future Directions 210
Acknowledgments 210
References 211
9. Regenerative Medicine for Diabetes: Differentiation
of Human Pluripotent Stem Cells into Functional ß-Cells
In Vitro and Their Proposed Journey to Clinical Translation 223
Bipasha Bose, Kishore Reddy Katikireddy, and Sudheer Shenoy P
1. Introduction 224
2. Diabetes and Its History 226
3. Differentiation Protocols for Human Pluripotent Stem Cells to ß-Cells 229
4. hESC/hPSC-Derlved Beta Islets-Based Cell Therapy for Diabetes 239
5. Conclusion 244
References 244
10. The Calcium-Sensing Receptor and ß-Cell Function 249
Paul E. Squires, Peter M. Jones, Mustafa Y.G. Younis, and Claire E. Hills
1. Introduction 250
X
Contents
2. The Calcium-Sensing Receptor (CaSR) 252
3. Effects of CaSR on ß-Cell Adhesion, Coupling, and Communication 254
4. Effects of the CaSR on Insulin Secretion 256
5. Effects of the CaSR on ß-Cell Proliferation 259
6. The CaSR and Diabetes Mellitus 261
7. Conclusion 262
Acknowledgment 263
References 263
11. Cellular Inhibitor of Apoptosis Protein-1 and Survival
of Beta Cells Undergoing Endoplasmic Reticulum Stress 269
Pu Xia and Yanfei Qi
1. Introduction 269
2. ER Stress in the Balance Between Cell Death and Survival 271
3. ER Stress and Lipotoxicity in Beta Cell Failure 277
4. Role of clAPI in Beta Cell Survival Under ER Stress 282
Acknowledgments 289
References 289
12. ß-Cell Responses to Nitric Oxide 299
Katarzyna A. Broniowska, Bryndon J. Oleson, and John A. Corbett
1. Introduction 299
2. Cytokine-lnduced Damage 300
3. Mechanisms of Nitric Oxide-Induced ß-Cell Death: Apoptosis or Necrosis? 309
4. Recovery from Nitric Oxide-Induced Damage 312
5. Conclusions 315
References 317
13. Activated Protein C and Its Potential Applications
in Prevention of Islet ß-Cell Damage and Diabetes 323
Meilang Xue and Christopher J. Jackson
1. Introduction 324
2. Protein C and Activated Protein C 325
3. Pancreas and Pancreatic Islet ß-Cell Function 339
4. APC and ß-Cell Preservation in Diabetes 345
5. Conclusions 349
References 351
Contents
xi
14. Zinc and Its Transporters, Pancreatic ß-Cells, and Insulin
Metabolism 365
Liping Huang
1. Introduction 366
2. Zinc and Its Transporters in Insulin Synthesis and Secretion In
Pancreatic ß-Cells 367
3. Zinc Transporters and their Physiological Roles and Contributions
to Insulin Metabolism and Glucose Homeostasis: Studies in Mouse
Knockout Models of Zinc Transporters 374
4. Zinc and Its Transporters In the Development of Diabetes In Humans 382
5. Conclusions and Future Directions 383
Acknowledgments 384
References 384
15. The NOTCH Pathway in ß-Cell Growth and Differentiation 391
Yael Bar and Shimon Efrat
1. Introduction 391
2. Role of the NOTCH Pathway in Pancreas Development 393
3. Evidence for Reactivation of the NOTCH Pathway In Adult Pancreatic Cells 395
4. Effect of the NOTCH Pathway on Proliferation, Dedifferentiation, and
Redifferentiatlon of Cultured Human ß-Cell-Derived Cells 396
Acknowledgments 403
References 403
16. Roles of HNF1a and HNF4a in Pancreatic ß-Cells: Lessons
from a Monogenic Form of Diabetes (MODY) 407
Kazuya Yamagata
1. Introduction 408
2. Clinical Features of HNF1 a Diabetes (MODY3) 408
3. Functional Regulation of ß-Cells by HNFla 410
4. HNFla Regulates ß-Cell Growth 411
5. HNF4a Gene and Diabetes 412
6. Functional Role of HNF4a in ß-Cells 414
7. Anks4b Is a Novel Target of HNF4a in ß-Cells 415
8. Concluding Remarks 416
Acknowledgments 417
References 417
x¡¡
Contents
17. Role of the Mammalian Target of Rapamycin (mTOR)
Complexes in Pancreatic ß-Cell Mass Regulation 425
Alberto Bartolome and Carlos Guillen
1. Introduction 426
2. Pancreatic ß-Cell Mass 427
3. Structure of mTORC1/mTORC2 Complexes 429
4. Insulin and mTORC2 Signaling in Pancreatic ß-Cells 433
5. Integration of Insulin, Energy, and Stress Signals by mTORG 439
6. Conclusions and Future Directions 455
References 455
Index 471
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| language | English |
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| series2 | Vitamins and hormones |
| spelling | The pancreatic beta cell ed. Gerald Litwack 1. ed. Amsterdam [u.a.] Elsevier 2014 XVIII, 482 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Vitamins and hormones 95 Einzelaufn. für Zeitschr.-H. Litwack, Gerald Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027169194&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The pancreatic beta cell |
| title | The pancreatic beta cell |
| title_auth | The pancreatic beta cell |
| title_exact_search | The pancreatic beta cell |
| title_full | The pancreatic beta cell ed. Gerald Litwack |
| title_fullStr | The pancreatic beta cell ed. Gerald Litwack |
| title_full_unstemmed | The pancreatic beta cell ed. Gerald Litwack |
| title_short | The pancreatic beta cell |
| title_sort | the pancreatic beta cell |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027169194&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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