Genetic predispositions to atopic eczema and psoriasis: survey, meta-analyses and comparison
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131204-1118210-0-9 Inhaltsverzeichnis |
| Beschreibung: | III, 331 S. graph. Darst. |
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| 245 | 1 | 0 | |a Genetic predispositions to atopic eczema and psoriasis |b survey, meta-analyses and comparison |c Melanie Schneider |
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Datensatz im Suchindex
| _version_ | 1804151859130138624 |
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| adam_text | TECHNISCHE UNIVERSITAT MUNCHEN
INSTITUT FIIR MEDIZINISCHE STATISTIK UND EPIDEMIOLOGIE
GENETIC PREDISPOSITIONS
TO ATOPIC ECZEMA AND PSORIASIS:
SURVEY, META-ANALYSES AND COMPARISON
MELANIE SCHNEIDER
VOLLSTANDIGER ABDRUCK DER VON DER FAKULTAT FIIR MEDIZIN DER
TECHNISCHEN UNIVERSITAT MIINCHEN ZUR ERLANGUNG DES
AKADEMISCHEN GRADES EINES
DOKTORS DER MEDIZIN
GENEHMIGTEN DISSERTATION.
VORSITZENDER: UNIV.-PROF. DR. E. J. RUMMENY
PRLIFER DER DISSERTATION:
1. UNIV.-PROF. DR. ST. WAGENPFEIL
2. UNIV.-PROF. DR. DR. J. RING
DIE DISSERTATION WURDE AM 22.10.2012 BEI DER TECHNISCHEN
UNIVERSITAT MIINCHEN EINGEREICHT UND DURCH DIE FAKULTAT FIIR
MEDIZIN AM 18.09.2013 ANGENOMMEN.
HTTP://D-NB.INFO/1048191818
CONTENTS
1. INTRODUCTION 1
1.1. SPECIFICATION OF ATOPIC ECZEMA 1
1.1.1. CLINICAL, HISTOLOGICAL AND EPIDEMIOLOGICAL FEATURES OF ATOPIC
ECZEMA 1
1.1.2. PATHOGENESIS AND ETIOLOGY OF ATOPIC ECZEMA 4
1.2. SPECIFICATION OF PSORIASIS 7
1.2.1. CLINICAL, HISTOLOGICAL AND EPIDEMIOLOGICAL FEATURES OF PSORIASIS
... 7
1.2.2. PATHOGENESIS AND ETIOLOGY OF PSORIASIS 11
1.3. SIMILARITIES - IS A SHARED GENETIC BACKGROUND CONCEIVABLE? 13
2. METHODS 17
2.1. SURVEY OF GENETIC PREDISPOSITIONS 17
2.1.1. IDENTIFICATION OF ELIGIBLE STUDIES FOR THE SURVEY 17
2.1.2. INCLUSION CRITERIA FOR THE SURVEY 18
2.1.3. DATA EXTRACTION FOR THE SURVEY 19
2.2. META-ANALYSES OF WELL-STUDIED GENETIC VARIANTS 19
2.2.1. IDENTIFICATION OF ELIGIBLE STUDIES FOR THE META-ANALYSES 20
2.2.2. INCLUSION CRITERIA FOR THE META-ANALYSES 20
2.2.3. DATA EXTRACTION FOR THE META-ANALYSES 21
2.2.4. STATISTICAL ANALYSIS OF THE META-ANALYSES 21
2.3. COMPARISON OF GENETIC PREDISPOSITIONS 22
3. GENETIC PREDISPOSITIONS TO ATOPIC ECZEMA 23
3.1. SURVEY OF GENETIC PREDISPOSITIONS TO ATOPIC ECZEMA 23
3.1.1. GENETIC LINKAGE STUDIES ON ATOPIC ECZEMA 24
3.1.2. CANDIDATE GENE STUDIES ON ATOPIC ECZEMA 28
3.1.3. GENOME-WIDE ASSOCIATION STUDIES ON ATOPIC ECZEMA 33
3.2. META-ANALYSES OF WELL-STUDIED GENETIC VARIANTS FOR ATOPIC ECZEMA 36
3.2.1. SPINK5 VARIANT RS2303067 (GLU420LYS) 37
3.2.2. CMA1 VARIANT -1903G (BSTXI) 41
3.2.3. FLG VARIANTS R501X AND 2282DEL4 45
3.3. RELEVANCE OF GENETIC PREDISPOSITIONS TO ATOPIC ECZEMA 49
4. GENETIC PREDISPOSITIONS TO PSORIASIS 53
4.1. SURVEY OF GENETIC PREDISPOSITIONS TO PSORIASIS 53
4.1.1. GENETIC LINKAGE STUDIES ON PSORIASIS 54
4.1.2. CANDIDATE GENE STUDIES ON PSORIASIS 61
CONTENTS
4.1.3. GENOME-WIDE ASSOCIATION STUDIES ON PSORIASIS 66
4.2. META-ANALYSES OF WELL-STUDIED GENETIC VARIANTS FOR PSORIASIS 72
4.2.1. IL1RN VARIABLE NUMBER TANDEM REPEAT 73
4.2.2. IL10 VARIANT -1082G 77
4.2.3. PTPN22 VARIANT RS2476601 (R620W) 81
4.2.4. VDR VARIANTS APAL, TAQI AND BSMI 85
4.2.5. ACE INSERTION/DELETION 92
4.2.6. VEGFA VARIANT +405G 97
4.2.7. LCE VARIANTS LCE3C-LCE3B DELETION AND RS4112788 98
4.2.8. IL13 VARIANT RS20541 101
4.2.9. IL12B VARIANTS RS3212227 AND RS6887695 105
4.2.10. IL23R VARIANTS RSLL209026 AND RS7530511 115
4.2.11. MICA TRIPLET REPEAT (GCT)
N
121
4.2.12. CDSN VARIANTS +1243C/+619T AND HAPLOTYPES *5/*TTC .... 129
4.2.13. TNF VARIANTS -308A. -238A AND -857T 148
4.2.14. SNP N.9 INTERGENIC VARIANT RSL0456057 174
4.2.15. CCHCR1 HAPLOTYPE HCR*WWCC 179
4.2.16. HLA-B ALLELE B*57 183
4.2.17. HLA-C ALLELE CW*0602 187
4.3. RELEVANCE OF GENETIC PREDISPOSITIONS TO PSORIASIS 200
5. COMPARISON OF GENETIC PREDISPOSITIONS TO ATOPIC ECZEMA AND PSORIASIS
205
5.1. OVERLAP OF SUSCEPTIBILITY LOCI 205
5.2. SHARED POSITIVE REPORTS ON GENETIC PREDISPOSITIONS 207
5.2.1. DIVERGENT CANDIDATE GENES IN SHARED CHROMOSOMAL LOCATIONS ....
208
5.2.2. SHARED CANDIDATE GENES 211
5.3. SHARED NEGATIVE REPORTS ON GENETIC PREDISPOSITIONS 215
5.4. CONTRASTING REPORTS ON GENETIC PREDISPOSITIONS 216
6. CONCLUSIONS 217
6.1. INSIGHTS INTO THE GENETICS OF ATOPIC ECZEMA 217
6.2. INSIGHTS INTO THE GENETICS OF PSORIASIS 218
6.3. IS THERE A SHARED GENETIC BACKGROUND? 220
7. SUMMARY 223
A. ASSOCIATION STUDIES ON GENETIC PREDISPOSITIONS TO ATOPIC ECZEMA 225
A.L. POSITIVE REPORTS FOR ATOPIC
ECZEMA 225
A.2. NEGATIVE REPORTS FOR ATOPIC ECZEMA 230
B. ASSOCIATION STUDIES ON GENETIC PREDISPOSITIONS TO PSORIASIS 235
B.L. POSITIVE REPORTS FOR PSORIASIS 235
B.2. NEGATIVE REPORTS FOR PSORIASIS 243
C. LIST OF GENES 247
II
LIST OF FIGURES
LIST OF TABLES
BIBLIOGRAPHY
CONTENTS
263
267
269
III
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| spelling | Schneider, Melanie Verfasser aut Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison Melanie Schneider 2013 III, 331 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2013 (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20131204-1118210-0-9 http://mediatum.ub.tum.de/node?id=1118210 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131204-1118210-0-9 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027078958&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schneider, Melanie Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison |
| subject_GND | (DE-588)4113937-9 |
| title | Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison |
| title_auth | Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison |
| title_exact_search | Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison |
| title_full | Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison Melanie Schneider |
| title_fullStr | Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison Melanie Schneider |
| title_full_unstemmed | Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison Melanie Schneider |
| title_short | Genetic predispositions to atopic eczema and psoriasis |
| title_sort | genetic predispositions to atopic eczema and psoriasis survey meta analyses and comparison |
| title_sub | survey, meta-analyses and comparison |
| topic_facet | Hochschulschrift |
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