Development and function of myeloid subsets:
Gespeichert in:
Weitere Verfasser: | |
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Format: | Buch |
Sprache: | English |
Veröffentlicht: |
Amsterdam [u.a.]
Elsevier, Acad. Press
2013
|
Ausgabe: | 1. ed. |
Schriftenreihe: | Advances in immunology
120 |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | X, 323 S. Ill., graph. Darst. |
ISBN: | 9780124170285 |
Internformat
MARC
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245 | 1 | 0 | |a Development and function of myeloid subsets |c ed. by Kenneth M. Murphy ... |
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264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Acad. Press |c 2013 | |
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Datensatz im Suchindex
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adam_text | Titel: Development and function of myeloid subsets
Autor: Murphy, Kenneth M
Jahr: 2013
CONTENTS
Contributors /x
1. Ontogeny and Functional Specialization of Dendritic
Cells in Human and Mouse 1
Muzlifah Haniffa, Matthew Collin, and Florent Ginhoux
1. Introduction 2
2. History of DC Identification and Characterization 2
3. Recent Advances in Mouse DC Immunobiology: Lessons from a Rodent 9
4. Recent Advances in Human DC Immunobiology 18
5. Humanized Mice 27
6. Matching Mice and Men • 28
7. The Relationship of DCs to Monocytes and Macrophages 33
8. Next Steps Ahead 34
9. Disclosure Statement 35
Acknowledgments 35
References 35
2. Dendritic Cell Migration Through the Lymphatic
Vasculature to Lymph Nodes 51
Andrew M. Piatt and Gwendalyn J. Randolph
1. Structure and Function of the Lymphatic Vasculature 52
2. DC Migration into Lymphatics and the Requirement for Specialized Lymphatic
Capillaries 55
3. DC Mobilization to LNs: The Role of CCR7 58
4. DC Mobilization to LNs: The Machinery for Locomotion 59
5. Lymphangiogenesis and DC Trafficking During Inflammation 60
6. Concluding Remarks 63
References 63
3. A Close Encounter of the Third Kind: Monocyte-Derived Cells 69
Alexander Mildner, Simon Yona, and Steffen Jung
1. Dendritic Cell and Macrophages 70
2. Monocytes, the Mononuclear Phagocytes of the Blood Compartment 73
3. Monocytes, as Precursors of Tissue Mononuclear Phagocytes 76
4. Monocyte-Derived Cells in the Inflamed Peritoneum 80
vi
Contents
5. Monocyte-Derived Cells in the Inflamed Brain 83
6. Monocyte-Derived Cells in the Intestine 88
7. Development of Monocyte-Derived Cells 91
8. Perspective 93
Acknowledgments 94
References 94
4. Plasmacytoid Dendritic Cell Development 105
Ken Shortman, Priyanka Sathe, David Vremec, Shalin Naik, and
Meredith O Keeffe
1. Background 106
2. Markers for pDC Identification 107
3. Cytokines Promoting pDC Development 108
4. Transcription Factors Determining pDC Development 110
5. Early Investigation of the Myeloid Versus Lymphoid Origin of pDC 110
6. Markers of pDC of Lymphoid Origin? 111
7. CDP and the Consensus Myeloid Pathway to pDC 113
8. Reassessment of the Lymphoid Pathway to pDC 114
9. Implications of RAG-1 Expression and IgH Gene Rearrangements in pDC 116
10. Extension of the CDP Definition to Include New pDC Precursors 118
11. A Different Non-pDC but pDC-Like Product of the Myeloid Pathway 118
12. Tracking pDC Development Using Cellular Barcoding 120
13. Some Conclusions 121
References 122
5. Pathological Consequence of Misguided Dendritic Cell
Differentiation in Histiocytic Diseases 127
Marie-Luise Berres, Carl E. Allen, and Miriam Merad
1. The Mononuclear Phagocyte System 128
2. The DC Lineage 128
3. Origin and Regulation of DC Differentiation 130
4. DC Heterogeneity 132
5. Batf-IRF8-ID2-Dependent DC Lineage 132
6. Batf3-ID2-IRF8-lndependent DC Lineage 134
7. Monocyte-Derived DCs and Inflammatory DCs 135
8. The LC Exception 135
9. The Human DC Lineage 137
10. Human Histiocytoses as a Result of Dysregulated Differentiation
of the Human Myeloid Compartment 139
Contents vii
11. Conclusion and Perspective 150
Acknowledgments 150
References 151
6. Macrophage Activation and Polarization as an Adaptive
Component of Innate immunity 163
Massimo Locati, Alberto Mantovani, and Antonio Sica
1. Introduction 164
2. Activation, Priming, and Tolerance as Adaptive Responses
of Macrophages 165
3. Polarized Activation 168
4. Molecular Mechanisms Underlying Macrophage Polarization 170
5. Epigenetic Regulation of Macrophage Polarization 173
6. Posttanscriptional Regulation in Macrophage Activation and Polarization 174
7. Concluding Remarks 176
Acknowledgments 177
References 177
7. Terminal Differentiation of Dendritic Cells 185
Cyril Seillet and Gabrielle T. Belz
1. Introduction 186
2. Dendritic Cell Subsets 186
3. Transcriptional Regulation of Early DC Development: Cellular Differentiation
and Some of the Key Regulatory Molecules 188
4. Transcriptional Regulation of Late DC Development at Steady State 192
5. Alternative DC Generation: Emergency Hematopoiesis 202
6. Perspectives 203
Acknowledgments 204
References 204
8. Diversity of Pathogen Sensors in Dendritic Cells 211
Silvia Cerboni, Matteo Gentili, and Nicolas Manel
1. Introduction 212
2. Diversity of Pathogen Sensors in DCs 218
3. Interactions and Effectors 226
4. Perspectives 230
Acknowledgments 231
References 231
viii
Contents
9. Transcriptional Control of Dendritic Cell Development 239
Kenneth M. Murphy
1. Dendritic Cells Comprise Functionally Heterogeneous Subsets 240
2. DC Development 242
3. Zbtb46 and cDCs 248
4. Ongoing Issues in DC Development 250
Acknowledgments 258
References 258
10. Transcriptional Control of Macrophage Identity,
Self-Renewal, and Function 269
Kaaweh Molawi and Michael H. Sieweke
1. Creating Macrophage Identity 270
2. Controlling Macrophage Numbers and Proliferation 281
3. Transcriptional Control of Macrophage Specialization and Functional
Activation States 285
4. Concluding Remarks 291
Acknowledgments 291
References 292
Index
Contents of Recent Volumes
301
311
|
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isbn | 9780124170285 |
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spelling | Development and function of myeloid subsets ed. by Kenneth M. Murphy ... 1. ed. Amsterdam [u.a.] Elsevier, Acad. Press 2013 X, 323 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in immunology 120 Murphy, Kenneth M. (DE-588)1089816251 edt Advances in immunology 120 (DE-604)BV006681033 120 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027045717&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Development and function of myeloid subsets Advances in immunology |
title | Development and function of myeloid subsets |
title_auth | Development and function of myeloid subsets |
title_exact_search | Development and function of myeloid subsets |
title_full | Development and function of myeloid subsets ed. by Kenneth M. Murphy ... |
title_fullStr | Development and function of myeloid subsets ed. by Kenneth M. Murphy ... |
title_full_unstemmed | Development and function of myeloid subsets ed. by Kenneth M. Murphy ... |
title_short | Development and function of myeloid subsets |
title_sort | development and function of myeloid subsets |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027045717&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
volume_link | (DE-604)BV006681033 |
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