Bioinert polyglycerol nano- and microgels for the encapsulation and controlled release of proteins and living cells:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Volltext Inhaltsverzeichnis |
| Beschreibung: | Nebentitel: Bioinerte Polyglycerin Nano- und Mikrogele für die Verkapselung und kontrollierte Freisetzung von Proteinen und lebenden Zellen |
| Beschreibung: | 157 Bl. Ill., graph. Darst. |
Internformat
MARC
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| 245 | 1 | 0 | |a Bioinert polyglycerol nano- and microgels for the encapsulation and controlled release of proteins and living cells |c vorgelegt von Dirk Steinhilber |
| 246 | 1 | 3 | |a Bioinerte Polyglycerin Nano- und Mikrogele für die Verkapselung und kontrollierte Freisetzung von Proteinen und lebenden Zellen |
| 264 | 1 | |c 2013 | |
| 300 | |a 157 Bl. |b Ill., graph. Darst. | ||
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| 500 | |a Nebentitel: Bioinerte Polyglycerin Nano- und Mikrogele für die Verkapselung und kontrollierte Freisetzung von Proteinen und lebenden Zellen | ||
| 502 | |a Berlin, Freie Univ., Diss., 2013 | ||
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| 912 | |a ebook | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-027037045 | ||
Datensatz im Suchindex
| _version_ | 1804151785535832064 |
|---|---|
| adam_text | CONTENTS
1 INTRODUCTION 1
1.1 BIOTHERAPEUTICS 1
1.1.1 MICROENCAPSULATION OF LIVING CELLS FOR TISSUE ENGINEERING 1
1.1.2 MICROENCAPSULATION OF LIVING CELLS FOR THERAPEUTIC APPLICATIONS 2
1.1.3 NANOENCAPSULATION OF THERAPEUTIC PROTEINS 3
1.1.3.1 PROTEIN ENCAPSULATION INTO PLGA NANOPARTICLES 4
1.1.3.2 PROTEIN ENCAPSULATION INTO LIPOSOMES 5
1.1.3.3 PROTEIN ENCAPSULATION INTO NANOGELS 5
1.2 ENCAPSULATION STRATEGIES 6
1.3 BIOCOMPATIBLE POLYMERS AS HYDROGEL BUILDING BLOCKS 7
1.3.1.1 ALGINATES 8
1.3.1.2 HYALURONIC ACID 8
1.3.2 SYNTHETIC POLYMERS 9
1.3.2.1 POLY(ETHYLENE GLYCOL) 9
1.3.2.2 POLY(VINYL ALCOHOL) 9
1.3.2.3 POLYGLYCEROL 9
1.4 CROSSLINKING CHEMISTRY 10
1.4.1 BIOORTHOGONALITY IN CHEMISTRY 11
1.4.2 FREE RADICAL 11
1.4.3 THIO-MICHAEL ADDITION 13
HTTP://D-NB.INFO/104852972X
1.4.4 STAUDINGER LIGATION 14
1.4.5 CU-CATALYZED AZIDE-ALKYNE CYCLOADDITION 15
1.4.6 STRAIN PROMOTED AZIDE-ALKYNE CYCLOADDITION 16
1.4.7 TETRAZINE INVERSE ELECTRON DEMAND DIELS-ALDER CYCLOADDITION 17
1.5 PREPARATION OF NANO- AND MICROGELS BY GELATION IN NANO- AND
MICROREACTORS 17
1.5.1 MINI- AND MICROEMULSION DROPLET GELATION 18
1.5.2 SOFT LITHOGRAPHY 21
1.5.3 CROSS-LINKED MICELLES 21
1.5.4 NANOPRECIPITATION 22
1.5.5 MICROFLUIDIC DROPLET GELATION 23
1.6 DEGRADABLE GEL PARTICLES 24
1.6.1 ENZYMATIC DEGRADATION 25
1.6.2 PHOTOLYTIC DEGRADATION 27
1.6.3 REDUCTIVE DEGRADATION 27
1.6.4 PH-CONTROLLED DEGRADATION 28
2 SCIENTIFIC GOALS 29
3 PUBLICATIONS 31
3.1 BIOCOMPATIBLE FUNCTIONALIZED POLYGLYCEROL MICROGELS WITH CELL
PENETRATING PROPERTIES
31
3.2 SYNTHESIS, REDUCTIVE CLEAVAGE AND CELLULAR INTERACTION STUDIES OF
BIODEGRADABLE,
POLYGLYCEROL NANOGELS 90
3.3 SURFACTANT FREE PREPARATION OF BIODEGRADABLE DENDRITIC POLYGLYCEROL
NANOGELS BY
INVERSE NANOPRECIPITATION FOR ENCAPSULATION AND RELEASE OF
PHARMACEUTICAL ENZYMES 69
3.4 HYPERBRANCHED POLYGLYCEROLS ON THE NANOMETER AND MICROMETER SCALE 69
3.5 A MICROGEL CONSTRUCTION KIT FOR THE BIOORTHOGONAL ENCAPSULATION AND
PH-CONTROLLED
RELEASE OF LIVING CELLS 135
4 CONCLUSIONS AND OUTLOOK 135
5 KURZZUSAMMENFASSUNG 138
6 REFERENCES 140
7 PUBLICATIONS, PATENT APPLICATIONS AND CONFERENCE CONTRIBUTIONS 153
8 CURRICULUM VITAE 156
|
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| author | Steinhilber, Dirk 1983- |
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| dewey-full | 610 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| indexdate | 2024-07-10T01:00:20Z |
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| physical | 157 Bl. Ill., graph. Darst. |
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| spelling | Steinhilber, Dirk 1983- Verfasser (DE-588)104682029X aut Bioinert polyglycerol nano- and microgels for the encapsulation and controlled release of proteins and living cells vorgelegt von Dirk Steinhilber Bioinerte Polyglycerin Nano- und Mikrogele für die Verkapselung und kontrollierte Freisetzung von Proteinen und lebenden Zellen 2013 157 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nebentitel: Bioinerte Polyglycerin Nano- und Mikrogele für die Verkapselung und kontrollierte Freisetzung von Proteinen und lebenden Zellen Berlin, Freie Univ., Diss., 2013 (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:kobv:188-fudissthesis000000096051-6 http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000096051 kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027037045&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Steinhilber, Dirk 1983- Bioinert polyglycerol nano- and microgels for the encapsulation and controlled release of proteins and living cells |
| subject_GND | (DE-588)4113937-9 |
| title | Bioinert polyglycerol nano- and microgels for the encapsulation and controlled release of proteins and living cells |
| title_alt | Bioinerte Polyglycerin Nano- und Mikrogele für die Verkapselung und kontrollierte Freisetzung von Proteinen und lebenden Zellen |
| title_auth | Bioinert polyglycerol nano- and microgels for the encapsulation and controlled release of proteins and living cells |
| title_exact_search | Bioinert polyglycerol nano- and microgels for the encapsulation and controlled release of proteins and living cells |
| title_full | Bioinert polyglycerol nano- and microgels for the encapsulation and controlled release of proteins and living cells vorgelegt von Dirk Steinhilber |
| title_fullStr | Bioinert polyglycerol nano- and microgels for the encapsulation and controlled release of proteins and living cells vorgelegt von Dirk Steinhilber |
| title_full_unstemmed | Bioinert polyglycerol nano- and microgels for the encapsulation and controlled release of proteins and living cells vorgelegt von Dirk Steinhilber |
| title_short | Bioinert polyglycerol nano- and microgels for the encapsulation and controlled release of proteins and living cells |
| title_sort | bioinert polyglycerol nano and microgels for the encapsulation and controlled release of proteins and living cells |
| topic_facet | Hochschulschrift |
| url | http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000096051 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027037045&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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