Magnetic nanoparticles - characterization and modeling for drug targeting applications:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | kostenfrei https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20140108-1171352-0-7 Inhaltsverzeichnis |
| Beschreibung: | II, 156 S. Ill., graph.Darst. |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1804151767481450496 |
|---|---|
| adam_text | CONTENTS
CONTENTS I
1 INTRODUCTION 1
2 THEORY 7
2.1 MAGNETIC NANOPARTICLES 7
2.1.1 NON-MAGNETIC PROPERTIES 11
2.1.2 MAGNETIC PROPERTIES 13
2.2 TARGETING MODEL 17
2.2.1 MAGNETOSTATICS 18
2.2.2 FLUID DYNAMICS 20
2.2.3 MINOR FORCES 23
2.2.4 PARTICLE TRAJECTORIES 29
2.3 OPTICS 30
2.3.1 BEER-LAMBERT-LAW 30
2.3.2 SCATTERING OF LIGHT 30
3 MATERIALS AND METHODS 33
3.1 MAGNETIC FIELD SOURCES 33
3.1.1 HALBACH CYLINDERS 33
3.1.2 OTHER MAGNETIC SET-UPS 38
3.2 NUMERICAL METHODS 39
3.2.1 FINITE ELEMENT METHOD 39
3.2.2 MONTE-CARLO METHOD 40
3.2.3 TRAJECTORY SIMULATION AND ANALYSIS 40
3.2.4 ERROR SOURCES 42
3.3 EXPERIMENTAL MATERIALS AND METHODS 44
3.3.1 TECHNICAL MATERIALS 44
3.3.2 EXPERIMENTAL MATERIALS 44
3.3.3 EXPERIMENTAL METHODS 45
HTTP://D-NB.INFO/1047975874
II CONTENTS
4 CHARACTERIZATION OF NANOPARTICLES 49
4.1 MAGNETIC MOMENT OF CELLS AND MICROBUBBLES 50
4.1.1 MAGNETIC SET-UP 50
4.1.2 MEASUREMENT AND EVALUATION 52
4.1.3 PERFORMANCE OF THE ALGORITHM 61
4.1.4 RESULTS 64
4.2 MAGNETIC MOMENT OF NANOPARTICLES 66
4.2.1 MAGNETIC SET-UP 67
4.2.2 MEASUREMENT AND EVALUATION 67
4.2.3 RESULTS 74
4.3 PARTICLE AGGREGATION 76
4.3.1 INFLUENCE OF IONIC STRENGTH AND VALENCE 77
4.3.2 INFLUENCE OF MAGNETIC FIELD 78
4.4 DISCUSSION 81
5 MODEL AND SIMULATION 91
5.1 TRAJECTORY SIMULATION 91
5.2 STATIC MODEL 94
5.2.1 LOCAL GENE TARGETING AND CELL POSITIONING 94
5.3 ARTERIAL MODEL 98
5.3.1 MULTIPLE PASSAGES 100
5.3.2
#
COMPARISON OF INPUT PARAMETERS 102
5.4 DISCUSSION 109
6 CONCLUSION AND OUTLOOK 117
A APPENDIX 121
A.L FITTING FUNCTIONS AND PARAMETERS 121
A.1.1 MAGNETIZATION CURVES 121
A. 1.2 DISTRIBUTIONS 122
A.1.3 CHI-SQUARE FITTING 124
A.2 ADDITIONAL NUMERICAL RESULTS 125
A.2.1 INFLUENCE OF INERTIA FORCES 125
A.2.2 DISREGARD OF ACCELERATION 125
A.3 REFERENCE LISTS 127
A.3.1 ORDERS OF MAGNITUDE FOR BIOLOGICAL COMPONENTS 127
A.3.2 GRADES OF PERMANENT MAGNETS 127
A.3.3 PROPERTIES OF SALT AND BUFFERED SOLUTIONS 127
A.3.4 LISTS OF SYMBOLS AND ABBREVIATIONS 129
LIST OF FIGURES 132
LIST OF TABLES 134
LIST OF MANUFACTURERS 135
BIBLIOGRAPHY 137
LIST OF PUBLICATIONS 153
|
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Technik Elektrotechnik Medizin |
| format | Thesis Book |
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| spelling | Heidsieck, Alexandra Verfasser aut Magnetic nanoparticles - characterization and modeling for drug targeting applications Alexandra Y. Heidsieck 2013 II, 156 S. Ill., graph.Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2013 Magnetteilchen (DE-588)4406122-5 gnd rswk-swf Nanopartikel (DE-588)4333369-2 gnd rswk-swf Targeted drug delivery (DE-588)4302415-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Magnetteilchen (DE-588)4406122-5 s Nanopartikel (DE-588)4333369-2 s Targeted drug delivery (DE-588)4302415-4 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20140108-1171352-0-7 http://mediatum.ub.tum.de/node?id=1171352 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20140108-1171352-0-7 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027024337&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Heidsieck, Alexandra Magnetic nanoparticles - characterization and modeling for drug targeting applications Magnetteilchen (DE-588)4406122-5 gnd Nanopartikel (DE-588)4333369-2 gnd Targeted drug delivery (DE-588)4302415-4 gnd |
| subject_GND | (DE-588)4406122-5 (DE-588)4333369-2 (DE-588)4302415-4 (DE-588)4113937-9 |
| title | Magnetic nanoparticles - characterization and modeling for drug targeting applications |
| title_auth | Magnetic nanoparticles - characterization and modeling for drug targeting applications |
| title_exact_search | Magnetic nanoparticles - characterization and modeling for drug targeting applications |
| title_full | Magnetic nanoparticles - characterization and modeling for drug targeting applications Alexandra Y. Heidsieck |
| title_fullStr | Magnetic nanoparticles - characterization and modeling for drug targeting applications Alexandra Y. Heidsieck |
| title_full_unstemmed | Magnetic nanoparticles - characterization and modeling for drug targeting applications Alexandra Y. Heidsieck |
| title_short | Magnetic nanoparticles - characterization and modeling for drug targeting applications |
| title_sort | magnetic nanoparticles characterization and modeling for drug targeting applications |
| topic | Magnetteilchen (DE-588)4406122-5 gnd Nanopartikel (DE-588)4333369-2 gnd Targeted drug delivery (DE-588)4302415-4 gnd |
| topic_facet | Magnetteilchen Nanopartikel Targeted drug delivery Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1171352 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20140108-1171352-0-7 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027024337&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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