Molecular characterization of human regulatory and conventional T cells:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online-Zugang: | kostenfrei https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-273481 Inhaltsverzeichnis |
| Beschreibung: | 198 Bl. Ill., graph. Darst. |
Internformat
MARC
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| 245 | 1 | 0 | |a Molecular characterization of human regulatory and conventional T cells |c von Christian Schmidl |
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Datensatz im Suchindex
| _version_ | 1804151737118883840 |
|---|---|
| adam_text | TABLE OF CONTENTS
1 SUMMARY 1
2 INTRODUCTION 3
2.1 EPIGENETICS 4
2.1.1 DNA METHYLATION 4
2.1.2 CHROMATIN 5
2.1.3 NON-CODING RNAS 7
2.1.4 C/5-REGULAT0RY MODULES 8
2.1.5 EPIGENETICS AT C/S-REGULATORY MODULES AND
THE IMPACT ON GENE REGULATION 11
2.2 T HELPER CELLS 14
2.2.1 EPIGENETICS IN TH DEVELOPMENT 15
2.2.2 REGULATORYT CELLS 16
2.3 OBJECTIVES 24
3 CHAPTERS IDENTICAL TO MANUSCRIPTS 26
3.1 LINEAGE-SPECIFIC DNA METHYLATION IN T
CELLS CORRELATES
WITH HISTONE METHYLATION AND
ENHANCERACTIVITY 27
3.2 ISOLATION OF INTACT GENOMIC
DNA FROM FOXP3-SORTED HUMAN REGULATORY
T CELLS FOR
EPIGENETICANALYSES 71
3.3
EPIGENETIC REPROGRAMMING OF THE
RORC
LOCUS
DUERING
IN VITRO
EXPANSION IS A DISTINCTIVE
FEATURE OF HUMAN MEMORY BUT NOT NALVE TREG CELLS 84
3.4 DOMINANT TH2
DIFFERENTIATION OF HUMAN REGULATORY
T
CELLS UPON LOSS OF FOXP3
EXPRESSION 106
3.5 THE ENHANCER AND PROMOTER LANDSCAPE OF
HUMAN REGULATORY AND CONVENTIONAL
T CELL
SUBPOPULATIONS 133
4 DISCUSSION 165
4.1 GENERAL INSIGHTS INTO CELL TYPE-SPECIFIC GENE REGULATION IN TREG
AND TCONV 165
4.1.1 DISTRIBUTION OF DIFFERENTIAL DNA METHYLATION IN
REGULATORY AND
CONVENTIONAL T
CELLS 165
4.1.2 DMRS ARE
ASSOCIATED WITH HISTONE MARKS, NOVEL PROMOTERS AND ENHANCER FUNCTION
166
4.1.3 ENHANCER PROFILING IDENTIFIES KEY REGULATORS IN T CELL
SUBPOPULATIONS 170
4.2
PLASTICITY, STABILITY
AND HETEROGENEITY OF HUMAN
T
CELL POPULATIONS
171
4.2.1 METHODOLOGYADVANCEMENTS 171
4.2.2 DNA METHYLATION ANALYSIS AND GENE EXPRESSION PROFILING OF T CELL
SUBPOPULATIONS
172
4.2.3 CAP ANALYSIS OF GENE EXPRESSION EXTENDS THE INFORMATION CONTENT OF
GENE
EXPRESSION ANALYSIS 174
4.3 TREG IN THE
CLINIC AND FUTURE PERSPECTIVES 175
5 REFERENCES 179
6 PUBLICATIONS 197
7 DANKSAGUNG 198
HTTP://D-NB.INFO/1047733056
|
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| format | Thesis Book |
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| spelling | Schmidl, Christian Verfasser aut Molecular characterization of human regulatory and conventional T cells von Christian Schmidl 2012 198 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Regensburg, Univ., Diss., 2012 Methylierung (DE-588)4123751-1 gnd rswk-swf Epigenetik (DE-588)7566079-9 gnd rswk-swf DNS (DE-588)4070512-2 gnd rswk-swf Genregulation (DE-588)4122166-7 gnd rswk-swf T-Lymphozyt (DE-588)4127387-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content T-Lymphozyt (DE-588)4127387-4 s Epigenetik (DE-588)7566079-9 s Genregulation (DE-588)4122166-7 s DNS (DE-588)4070512-2 s Methylierung (DE-588)4123751-1 s b DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:355-epub-273481 http://epub.uni-regensburg.de/27348/ Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-273481 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027000688&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schmidl, Christian Molecular characterization of human regulatory and conventional T cells Methylierung (DE-588)4123751-1 gnd Epigenetik (DE-588)7566079-9 gnd DNS (DE-588)4070512-2 gnd Genregulation (DE-588)4122166-7 gnd T-Lymphozyt (DE-588)4127387-4 gnd |
| subject_GND | (DE-588)4123751-1 (DE-588)7566079-9 (DE-588)4070512-2 (DE-588)4122166-7 (DE-588)4127387-4 (DE-588)4113937-9 |
| title | Molecular characterization of human regulatory and conventional T cells |
| title_auth | Molecular characterization of human regulatory and conventional T cells |
| title_exact_search | Molecular characterization of human regulatory and conventional T cells |
| title_full | Molecular characterization of human regulatory and conventional T cells von Christian Schmidl |
| title_fullStr | Molecular characterization of human regulatory and conventional T cells von Christian Schmidl |
| title_full_unstemmed | Molecular characterization of human regulatory and conventional T cells von Christian Schmidl |
| title_short | Molecular characterization of human regulatory and conventional T cells |
| title_sort | molecular characterization of human regulatory and conventional t cells |
| topic | Methylierung (DE-588)4123751-1 gnd Epigenetik (DE-588)7566079-9 gnd DNS (DE-588)4070512-2 gnd Genregulation (DE-588)4122166-7 gnd T-Lymphozyt (DE-588)4127387-4 gnd |
| topic_facet | Methylierung Epigenetik DNS Genregulation T-Lymphozyt Hochschulschrift |
| url | http://epub.uni-regensburg.de/27348/ https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-273481 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027000688&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT schmidlchristian molecularcharacterizationofhumanregulatoryandconventionaltcells |