Study of seed-based microRNA targeting in mammals:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131122-1171181-0-3 Inhaltsverzeichnis |
| Beschreibung: | XVIII, 119 S. Ill., graph. Darst. |
Internformat
MARC
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| 264 | 1 | |c 2013 | |
| 300 | |a XVIII, 119 S. |b Ill., graph. Darst. | ||
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| 502 | |a München, Techn. Univ., Diss., 2013 | ||
| 546 | |a Zsfassung in dt. Sprache | ||
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Datensatz im Suchindex
| _version_ | 1804151660907331584 |
|---|---|
| adam_text | 2.1 LIN-4-LIN-14
DUPLEX 6
2.2 RELATIONSHIP BETWEEN MRNA
AND PROTEIN ABUNDANCE 9
2.3 EFFECT OF MIRNA-MEDIATED REGULATION
ON PROTEIN ABUNDANCE .... 11
2.4 CIRCULAR MRNA 18
2.5 TEMPORAL ORDER OF MIRNA-MEDIATED GENE SILENCING 20
3.1 SCHEMATIC REPRESENTATION OF A MIRNA TARGET SITE 24
3.2 SET OF CLASSICAL SEED
TYPES 26
3.3 CHARACTETISTICS OF CLASSICAL SEED TYPES 27
3.4 DIFFERENT EFFICACY
OF ORF AND 3 UTR TARGETING 31
3.5 CROSS-TALK BETWEEN
CERNAS 33
3.6 CLIP APPROACHES 35
3.7 POSITIONAL FREQUENCIES OF TARGET SITE STARTS WITHIN CCRS 40
3.8 MINIMAL AND SUFIICIENT
SET OF SEED TYPES ACCORDING TO [1] 44
3.9 TRANSCRIPT DESTABILIZATION THROUGH THE 3 UTR 46
3.10 PREDICTIVE POWER
OF SEED TYPES 47
3.11 TRANSCRIPT DESTABILIZATION THROUGH THE CODING REGION 49
3.12 SEED TYPE PREFERENCES OF MIRNAS (3 UTR) 51
3.13 SEED TYPE PREFERENCES OF MIRNAS (CODING
REGION) 52
3.14 CONSERVATION OF CCRS IN THE 3 UTR 54
3.15 CONSERVATION OF FUNCTIONAL SITES IN THE 3 UTR 55
3.16 PREDICTIVE POWER
AFTER REMOVING NON-CONSERVED SITES 57
3.17 CONSERVATION OF FUNCTIONAL SITES IN THE CODING REGION 58
3.18 OVERLAP BETWEEN SEED
TYPE SETS . 63
3.19 COMPARISON OF SEED TYPE DISTRIBUTIONS . . . 63
3.20 BACKGROUND CONSERVATION 64
4.1 LEVELS OF EVALUATION 68
4.2 SENSITIVITY OF 3 UTR PREDICTIONS PER SEED TYPE 79
4.3 SENSITIVITY OF ORF PREDICTIONS PER SEED TYPE 81
4.4 DIFFERENT SCORING SYSTEMS 83
4.5 PRECISION-SENSITIVITY CURVES 85
XIII
HTTP://D-NB.INFO/1048370682
LIST OF FIGURES
4.6 PRECISION GAIN 86
4.7 INTERSECTION OF PREDICTION RESULT SETS 88
4.8 SENSITIVITY OF THE NAIVE APPROACH PER SEED TYPE 92
4.9 TARGET SITE SCORE DISTRIBUTION PER SEED TYPE (3 UTR) 93
4.10 TARGET SITE SCORE DISTRIBUTION PER SEED TYPE (CODING REGION) 93
5.1 TARGET SITE STARTS DOWNSTREAM OF THE T/C MUTATION 96
5.2 FRAME-DEPENDENT SITE CONSERVATION WITHIN CCRS 97
5.3 REPRESSION OF LRRK2 MRNA
EXPRESSION 99
|
| any_adam_object | 1 |
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| discipline | Biologie Chemie |
| format | Thesis Book |
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| id | DE-604.BV041551547 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:58:21Z |
| institution | BVB |
| language | English |
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| physical | XVIII, 119 S. Ill., graph. Darst. |
| psigel | ebook |
| publishDate | 2013 |
| publishDateSearch | 2013 |
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| spelling | Büttner, Florian Verfasser aut Study of seed-based microRNA targeting in mammals Florian A. Büttner 2013 XVIII, 119 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2013 Zsfassung in dt. Sprache (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20131122-1171181-0-3 http://mediatum.ub.tum.de/node?id=1171181 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131122-1171181-0-3 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026997276&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Büttner, Florian Study of seed-based microRNA targeting in mammals |
| subject_GND | (DE-588)4113937-9 |
| title | Study of seed-based microRNA targeting in mammals |
| title_auth | Study of seed-based microRNA targeting in mammals |
| title_exact_search | Study of seed-based microRNA targeting in mammals |
| title_full | Study of seed-based microRNA targeting in mammals Florian A. Büttner |
| title_fullStr | Study of seed-based microRNA targeting in mammals Florian A. Büttner |
| title_full_unstemmed | Study of seed-based microRNA targeting in mammals Florian A. Büttner |
| title_short | Study of seed-based microRNA targeting in mammals |
| title_sort | study of seed based microrna targeting in mammals |
| topic_facet | Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1171181 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131122-1171181-0-3 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026997276&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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