Heterogeneity in astrocyte responses after acute injury in vitro and in vivo:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | kostenfrei http://d-nb.info/1044236922/34 kostenfrei Inhaltsverzeichnis |
| Beschreibung: | 95 S. Ill., graph. Darst. |
| Format: | Langzeitarchivierung gewährleistet, LZA |
Internformat
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| 100 | 1 | |a Bardehle, Sophia |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Heterogeneity in astrocyte responses after acute injury in vitro and in vivo |c Sophia Bardehle |
| 264 | 1 | |c 2013 | |
| 300 | |a 95 S. |b Ill., graph. Darst. | ||
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| 502 | |a München, Univ., Diss., 2013 | ||
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Datensatz im Suchindex
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|---|---|
| adam_text | TABLE OF CONTENTS
1 INTRODUCTION 1
1.1 GLIAL CELLS IN THE CENTRAL NERVOUS SYSTEM 1
1.2 ASTROCYTE FUNCTIONS IN BRAIN PHYSIOLOGY 4
1.2.1 GLIOVASCULAR UNIT AND THE BLOOD-BRAIN BARRIER 6
1.3 ASTROCYTE FUNCTIONS UNDER PATHOLOGICAL CONDITIONS 7
1.3.1 RHOGTPASE CDC42: KEY REGULATOR OF CELL POLARITY 12
1.3.2 ASTROCYTE SUBPOPULATION WITH STEM CELL POTENTIAL 13
1.3.3 STAB WOUND INJURY - MODEL FOR TRAUMATIC BRAIN INJURY IN MICE 14
1.4 TRANSGENIC MOUSE LINES TO STUDY ASTROCYTE REACTION IN VITRO AND IN
VIVO 15
1.5 TWO-PHOTON LASER SCANNING MICROSCOPY FOR LIVE IMAGING IN THE MOUSE
BRAIN 16
2 AIM OF THE STUDY 19
3 RESULTS 20
3.1 THE ROLE OF RHOGTPASE CDC42 IN ASTROCYTE RECRUITMENT TO THE INJURY
SITE 20
3.2 LIVE IMAGING OF ASTROCYTE RESPONSES TO ACUTE BRAIN INJURY 34
4 DISCUSSION 57
4.1 HETEROGENEITY OF REACTIVE ASTROCYTES AFTER ACUTE INJURY IN VIVO 57
4.2 ASTROCYTE RECRUITMENT TO THE INJURY SITE 60
4.3 ASTROCYTE PROLIFERATION IN JUXTAVASCULAR POSITION 64
4.4 REVISED CONCEPT OF REACTIVE ASTROGLIOSIS AND SCAR FORMATION 66
4.5 INFLUENCE OF CDC42 ON ASTROCYTE RESPONSES TO INJURY IN VITRO AND IN
VIVO 67
4.6 COMPARISON OF ASTROCYTE RESPONSES TO INJURY IN VITRO AND IN VIVO 70
REFERENCES 75
ACKNOWLEDGEMENTS 90
APPENDIX 91
I. ABBREVIATIONS 91
II. LIST OF FIGURES 93
III. LISTOFTABLES 93
CURRICULUM VITAE 94
HTTP://D-NB.INFO/1044799455
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| spelling | Bardehle, Sophia Verfasser aut Heterogeneity in astrocyte responses after acute injury in vitro and in vivo Sophia Bardehle 2013 95 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Univ., Diss., 2013 Langzeitarchivierung gewährleistet, LZA (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-161529 https://nbn-resolving.org/urn:nbn:de:bvb:19-161529 Resolving-System kostenfrei Volltext http://d-nb.info/1044236922/34 Langzeitarchivierung Nationalbibliothek http://edoc.ub.uni-muenchen.de/16152/ Verlag kostenfrei DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026931907&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bardehle, Sophia Heterogeneity in astrocyte responses after acute injury in vitro and in vivo |
| subject_GND | (DE-588)4113937-9 |
| title | Heterogeneity in astrocyte responses after acute injury in vitro and in vivo |
| title_auth | Heterogeneity in astrocyte responses after acute injury in vitro and in vivo |
| title_exact_search | Heterogeneity in astrocyte responses after acute injury in vitro and in vivo |
| title_full | Heterogeneity in astrocyte responses after acute injury in vitro and in vivo Sophia Bardehle |
| title_fullStr | Heterogeneity in astrocyte responses after acute injury in vitro and in vivo Sophia Bardehle |
| title_full_unstemmed | Heterogeneity in astrocyte responses after acute injury in vitro and in vivo Sophia Bardehle |
| title_short | Heterogeneity in astrocyte responses after acute injury in vitro and in vivo |
| title_sort | heterogeneity in astrocyte responses after acute injury in vitro and in vivo |
| topic_facet | Hochschulschrift |
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