Holdings: Essentials of stem cell biology

Essentials of stem cell biology:

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Bibliographic Details
Format:	Book
Language:	English
Published:	Amsterdam [u.a.] Elsevier 2014
Edition:	3. ed.
Subjects:	Biomedical Research Embryo Research Stem Cells Stem cells Tissue Engineering Stammzelle Aufsatzsammlung
Online Access:	Inhaltsverzeichnis
Physical Description:	XXVIII, 680 S. Ill., graph. Darst.
ISBN:	9780124095038 0124095038

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adam_text	Contents FOREWORD .............................................................................................xix PREFACE ..................................................................................................xxi UST OF CONTRIBUTORS .....................................................................xxiii Part I Introduction to Stem Cells CHAPTER 1 Why Stem Cell Research? Advances in the Field ...........3 Alan Trounson 1.1 The Origins of Stem Cell Technology .................................3 1.2 Organizations that Advocate and Support the Growth of the Stem Cell Sector ........................................................4 1.3 Applications of Stem Cells in Medicine .............................5 1.4 Challenges to the Use of Stem Cells ..................................5 For Further Study ..........................................................................6 CHAPTER 2 Sternness1: Definitions, Criteria, and Standards ............7 Douglas Melton 2.1 What is a Stem Cell? ............................................................7 2.2 Self-Renewal .........................................................................7 2.3 Potency .................................................................................8 2.4 Clonality ................................................................................8 2.5 Definition ..............................................................................9 2.6 Where do Stem Cells Come from? ......................................9 2.7 Stem Cells of the Early Embryo ..........................................9 2.8 Ontogeny of Adult Stem Cells ..........................................11 2.9 How are Stem Cells Identified, Isolated, and Characterized? ...................................................................13 2.10 Embryonic Stem Cells ........................................................14 2.11 Adult Stem Cells ................................................................14 2.12 Sternness; Progress Toward a Molecular Definition of Stem Cells ...........................................................................15 Acknowledgments ......................................................................16 For Further Study ........................................................................17 Contests CHAPTER 3 CHAPTER 4 CHAPTER 5 Pluripotent Stem Cells from Vertebrate Embryos: Pres¬ ent Perspective and Future Challenges .........................19 Richard L. Gardner 3.1 Introduction ........................................................................19 3.2 Biology of ES and ESL Colls ..............................................27 3.3 Stem Cell Therapy .............................................................32 3.4 Summary .............................................................................34 For Further Study ........................................................................34 Embryonic Stem Cells in Perspective ............................35 Janet Rossant 4.1 Embryonic Stem Cells m Perspective ..............................35 For Further Study ........................................................................38 The Development of Epithelial Stem Cell Concepts .....39 Cłmstopher S. Potten and James W. Wilson 5.1 Introduction ........................................................................39 5.2 A Definition of Stem Cells .................................................40 5.3 Hierarchically Organized Stem Cell Populations ............42 5.4 Skm Stem Cells ...................................................................45 5.5 The Intestinal Stem Cell System .......................................49 5.6 Stem Cell Organization on the Tongue ............................51 5.7 Generalized Scheme ..........................................................53 5.8 Summary .............................................................................55 For Further Study ........................................................................56 Part II Basic Biology and Mechanisms CHAPTER 6 Stem Cell Niches ..............................................................59 D. Leanne Jones and Margaret T. Fuller 6.1 Stem Cell Niche Hypothesis ..............................................59 6.2 Stem Cell Niches in the Drosophila Germ-Line ...............60 6.3 The Germ-Line Stem Cell Niche in the Diosophila Ovaiy ...............................................................60 6.4 Germ-Line Stem Cell Niche in the Drosophila Testis..... 63 6.5 Coordmate Control of Germ-Line Stem Cell and Somatic Stem Cell Maintenance and Proliferation ..........64 6.6 Structural Components of the Niche ................................66 6.7 Stem Cell Niches Withm Mammahan Tissues .................67 6.8 Summary .............................................................................77 Acknowledgments ......................................................................78 For Further Study ........................................................................78 Contente CHAPTER 7 Mechanisms of Stem Cell Self-Renewal .........................81 Hitoshi Niwa 7.1 Self-Renewal of Plunpotent Stem Cells ............................81 7.2 Prevention of Differentiation .............................................90 7.3 Maintenance of Stem Cell Proliferation ...........................91 7.4 Maintenance of Telomere Length ....................................92 7.5 X Chromosome Inactivation ..............................................92 7.6 Summary .............................................................................93 For Further Study. .93 CHAPTER 8 Cell Cycle Regulators in Stem Cells ...............................95 Tao Cheng and David Τ Scaddon 8.1 Introduction ........................................................................95 8.2 8.3 8.4 Cell Cycle Kinetics of Stem Cells In Vivo .........................95 Stem Cell Expansion Ex Vivo ............................................97 Mammalian CeD Cycle Regulation and Cyclm- Dependent Kinase Inhibitors ............................................98 8.5 Roles of Cyclm-Dependent Kinase Inhibitors in Stem Cell Regulation .........................................................99 8.6 Roles of p21 m Stem СеБ Regulation .............................100 8.7 Roles of p27 in Stem Cell Regulation .............................101 8.8 Other Cyclm-Dependent Kinase Inhibitors and the Retinoblastoma Pathway in Stem Cell Regulation ........102 8.9 Relation Between Cyclm-Dependent Kinase Inhibitors and Transforming Growth Factor ß-1...........103 8.10 CKIs and Notch ................................................................104 8.11 Summary and Future Directions .....................................105 Acknowledgments ....................................................................105 For Further Study ......................................................................105 CHAPTER 9 How Cells Change Then Phenotype ............................107 David Tosh and Marko E. Horb 9.1 Metaplasia and Transdifferentiation..............................107 9.2 Examples of Transdrfferentiation ...................................108 9.3 Barrett s Metaplasia ........................................................112 9.4 Regeneration ....................................................................112 9.5 Bone Marrow to Other Cell Types ..................................113 9.6 Dedifferentiation as a Prerequisite for Trans differentiation .........................................................114 9.7 How to Change a Cell s Phenotype Experimentally .....115 9.8 Summary ...........................................................................117 Acknowledgments ....................................................................117 For Further Study ......................................................................117 Coateats Part III Tissue and Organ Development CHAPTER 10 Differentiation m Early Development ..........................121 Susana M. Chuva de Sousa Lopes and Cìmstme L Mummery 10.1 Preimplantation Development ......................................121 10.2 Cell Polarization Occurs During Compaction ..............121 10.3 Axis Specification During Preimplantation in the Mouse .............................................................................125 10.4 Developmental Potency of the Early Mouse Embryo ...........................................................................126 10.5 Genes Important During Preimplantation Mouse Development ..................................................................127 10.6 From Implantation to Gastrulation ..............................132 10.7 The Mouse Tropnectoderm and Primitive Endodermi Cells ................................................................................132 10.8 Development of the Mouse Inner Cell Mass to the Epiblast ..........................................................................133 10.9 The Human Embryo ......................................................135 10.10 Implantation: Maternal Versus Embryonic Factors ... 137 10.11 The Role of Extra-Embryonic Tissues in Patterning the Mouse Embryo ........................................................138 For Further Study ......................................................................139 CHAPTER 11 Stem Cells Derived from Amniotic Fluid ......................141 Mara Cananzi, Anthony Alala and Paolo de Coppi 11.1 Amniotic Fluid - Function, Origin, and Composition .....141 11.2 Ammotic Fluid Mesenchyrnal Stem Cells ....................142 11.3 Amniotic Fluid Stem Cells ............................................146 11.4 Conclusions ....................................................................154 For Further Study ......................................................................155 CHAPTER 12 Stem and Progenitor Cells Isolated from Cord Blood ...............................................................................157 Hal E. Bioxmeyer 12.1 Addressing Delayed Time to Engraftment and Graft Failure With CB .............................................................157 12.2 Cryopreservation of CB Cells .......................................159 12.3 Induced Plunpotent Stem Cells Generated from CB .. 160 12.4 Concluding Comments ..................................................160 For Further Study ......................................................................160 CHAPTER 13 The Nervous System ......................................................163 Lorenz Stu der 13.1 Introduction ...................................................................163 13.2 Nemal Development .....................................................164 Contests 13.3 Neural Stem Cells ..........................................................166 13.4 Neural Differentiation of Mouse ES Cells ....................167 13.5 Neural Differentiation of Human and Nonhuman Primate ES Cells ............................................................177 13.6 Developmental Perspectives ........................................178 13.7 Therapeutic Perspectives .............................................179 13.8 Parkinson s Disease .......................................................179 13.9 Huntington s Disease ....................................................181 13.10 Stroke ..............................................................................182 13.11 Demyelmation ................................................................182 13.12 Summary ........................................................................183 For Further Study ......................................................................184 CHAPTER 14 Sensory Epithelium of the Eye and Ear .......................185 Constance Cepko, Donna M. Fekete 14.1 Introduction ...................................................................185 14.2 Introduction to Progenitor and Stem Cells m the Retma .............................................................................185 14.3 The Optic Vesicle Generates Diverse Cell Types that can Undergo Transdifferentiation................................186 14.4 In Vivo Neurogenesis m the Posthatch Clucken ........188 14. b Growth of Retinal Neurospheres from the Ciliary Margin of Mammals ......................................................191 14.6 Prospects for Stem Cell Therapy m the Retma ...........193 14.7 Development and Regeneration of Tissues Derived from the Inner Ear ...........................................194 14.8 In Vivo Neurogenesis in Postembryonic Animals ......196 14.9 In Vitro Expansion of Otic Piogenitors ........................199 14.10 Prospects for Therapy ...................................................201 Acknowledgments ....................................................................201 For Further Study ......................................................................202 CHAPTER 15 Epithelial Skin Stem Cells .............................................203 Tiiőonta Tumbar, Elame Fuchs 15.1 A Brief Introduction to Mouse Skin Organization .......203 15.2 The Bulge as a Residence of Epithelial Skin Stem Cells ................................................................................206 15.3 Models of Epithelial Stem Cell Activation ...................209 15.4 Molecular Fingerprint of the Bulge - Putative Stem Cell Markers ...................................................................212 15.5 Cell Signaling m Multipotent Epithelial Skin Stem Cells .................................................................................214 15.6 Commentary and Future Directions ............................217 For Further Study ......................................................................218 CHAPTER 16 Hematopoietic Stem Ceüs .............................................219 George Q. Daley 16.1 Embryonic Stem Cells and Embryonic Hematopoiesis ...............................................................219 16.2 Blood Formation in Embryoid Bodies ..........................220 16.3 Transformation of an EB-Denved HSC by BCR/ABL..221 16.4 Promoting Hematopoietic Engraftmcnt with STAT5 andHOXB4 ....................................................................222 16.5 Promoting Blood Formation in Vitio with Embryonic Morphogens ...................................................................225 For Further Study ......................................................................226 CHAPTER 17 Peripheral Blood Stem Cells ..........................................227 Zhan Wang, Gunter Schuch, J Koudy Williams and Stiay Sokei 17.1 Introduction ...................................................................227 17.2 Types and Source of Stem Cells in the Peripheral Blood ...............................................................................228 17.3 Endothelial Progenitor Cells .........................................229 17.4 Mcsenchymal Stem СеДѕ ..............................................236 17.5 Therapeutic Applications of Peripheral Blood Stem Cells ......................................................................237 17.6 Conclusions and Future Directions ..............................243 For Further Study ......................................................................244 CHAPTER 18 Multipotent Adult Progenitor Cells ..............................245 РпШр R. Roelandt, Valené D. Roobrouck and Catherine M. Verfailhe 18.1 Plunpotent Stem Cells - Embryonic Stem Cells .........245 18.2 Postnatal Tissue-Specific Stem Cells - Aie Some More than Multipotent?................................................246 18.3 Can Pluiipotency Be Acquired? ...................................247 18.4 Isolation of Rodent MAPCs ...........................................248 18.5 Isolation of Human MAPCs ..........................................249 18.6 Recent Developments ...................................................251 Acknowledgments ....................................................................252 For Further Study ......................................................................253 CHAPTER 19 Mesenchymal Stem Cells ..............................................255 Zulma Gazit, Gadi Felled, Dima Sheyn, Nadav Kunelman and Dan Gazit 19.1 The Definition of MSCs .................................................255 19.2 The Stem Cell Nature of MSCs .....................................256 19.3 Which Tissues Contain MSCs? .....................................256 19.4 MSC Isolation Techniques ............................................257 19.5 Immunomodulatory Effects of MSCs ...........................258 19.6 Skeletal Tissue Regeneration by MSCs .......................259 19.7 Non-Skeletal Tissue Regeneration by MSCs ...............263 19.8 Conclusions ....................................................................265 Acknowledgments ....................................................................266 For Further Study ......................................................................266 CHAPTER 20 Skeletal Muscle Stem Cells ...........................................267 Mark A. LaBaige, Helen M. Blau 20.1 Introduction ...................................................................267 20.2 The Original Muscle Stem Cell: The Satellite Cell .....268 20.3 Functional and Biochemical Heterogeneity Among Muscle Stem Cells .........................................................271 20.4 Unorthodox Origins of Skeletal Muscle .......................273 20.5 The Muscle Stem Cell NICHE .......................................275 20.6 Conclusion ......................................................................277 Acknowledgments ....................................................................278 For Further Study ......................................................................278 CHAPTER 21 Stem Cells and the Regenerating Heart ......................281 Nadja Rosenthal and Mana Paola Santini 21.1 Introduction ...................................................................281 21.2 Recruiting Circulating Stem Cell Reserves .................282 21.3 The Elusive Caidiac Stem Cell .....................................284 21.4 Evolving Concepts of Regeneration .............................286 For Further Study ......................................................................289 CHAPTER 22 Cell Lineages and Stem Cells in the Embryonic Kidney .............................................................................291 Gregory R. Dressier 22.1 The Anatomy of Kidney Development .........................291 22.2 Genes that Control Early Kidney Development ..........296 22.3 The Establishment of Additional Cell Lineages .........301 22.4 What Constitutes a Renal Stem Cell? ..........................305 Acknowledgments ....................................................................307 For Further Study ......................................................................307 CHAPTER 23 Adult Liver Stem Cells ...................................................309 Markus Grompe 23.1 Organization and Functions of Adult Mammalian Liver ................................................................................309 23.2 Liver Stem Cells .............................................................311 For Further Study ......................................................................327 Contents CHAPTER 24 Pancreatic Stem Cells ....................................................329 Yuval Dor and Douglas A. Melton 24.1 Introduction ...................................................................329 24.2 Definition of Stem Cells and of Progenitor Cells .........329 24.3 Progenitor Cells During Embryonic Development of the Pancreas ..................................................................330 24.4 Progenitor Cells m the Adult Pancreas .......................333 24.5 Forcing Other Tissues to Adopt a Pancreatic Phenotype ......................................................................338 24.6 In Vitro Studies ..............................................................340 24.7 Summary ........................................................................341 For Further Study ......................................................................342 CHAPTER 25 Stem Cells in the Gastrointestinal Tract ......................343 Scan Preston, Nicholas A. Wright, Natalie Direkzc and Mam Bullan 25.1 Introduction ...................................................................343 25.2 Gastrointestinal Mucosa Contains Multiple Lineages .........................................................................344 25.3 Epithelial Cell Lineages Originate from a Common Precursor Cell .................................................................346 25.4 Single Intestinal Stem Cells Regenerate Whole Crypts Containing all Epithelial Lineages ..................346 25.5 Mouse Aggregation Chimeras Show that Intestinal Crypts are Clonal Populations ......................................347 25.6 Somatic Mutations m Stem Cells Reveal Stem Cell Hierarchy and Clonal Succession .................................349 25.7 Human Intestinal Crypts Contain Multiple Epithelial Cell Lineages Derived from a Single Stem СеД ...........351 25.8 Bone Marrow Stem Cells Contribute to Gut Repopulation After Damage .........................................353 25.9 Gastrointestinal Stem Cells Occupy a Niche Maintained by ISEMFs in the Lamina Propria ............358 25.10 Multiple Molecules Regulate Gastrointestinal Development, Proliferation, and Differentiation .........360 25.11 Wnt/ß-Catenin Signaimg Pathway Controls Intestinal Stem Cell Function .......................................361 25.12 Transcription Factors Define Regional Gut Specification and Intestinal Stem Cell Fate .................363 25.13 Gastrointestinal Neoplasms Originate in Stem Cell Populations ....................................................................366 25.14 Summary ........................................................................370 For Further Study ......................................................................371 Contents Part IV Methods CHAPTER 26 Induced Plunpotent Stem Cells ....................................375 Keisuke Okíťd and Shinya Yamanaka 26.1 Generation of iPS Cells ..................................................375 26.2 Molecular Mechanisms in iPS Cell Induction ..............379 26.3 Recapitulation of Disease Ontology and Drug Screening ........................................................................381 26.4 iPS Cell Banking ............................................................382 26.5 Safety Concerns for Medical Application ....................382 26.6 Medical Application ......................................................383 26.7 Direct Fate Switch .........................................................384 26.8 Conclusion ......................................................................384 For Further Study ......................................................................385 CHAPTER 27 Embryonic Stem Cells: Derivation and Properties ......387 Junymg Yu and James A. Thomson 27.1 Derivation of Embryonic Stem Cells ............................387 27.2 Culture of Embryonic Stem Cells .................................390 27.3 Developmental Potential of Embryonic Stem Cells ...393 27.4 Conclusion ......................................................................397 For Further Study ......................................................................398 CHAPTER 28 Isolation and Maintenance of Murine Embryonic Stem Cells ...................................................399 Martin Evans 28.1 Introduction ...................................................................399 28.2 Maintenance of Embryonic Stem Cells ........................399 28.3 Media ..............................................................................401 28.4 Sera .................................................................................401 28.5 Colony-Forming Assay for Testmg Culture Conditions ......................................................................401 28.6 Embryonic Stem Cell Passage Culture ........................403 28.7 Isolation of New Embryonic STEM Cell Lines ............403 28.8 Method for Deriving Embryonic Stem Cells ................405 28.9 Summary ........................................................................407 For Further Study ......................................................................407 CHAPTER 29 Approaches for Denvation and Maintenance of Human Embryonic Stem Cells: Detailed Procedures and Alternatives ............................................................409 Inna Khmanskaya and Ш McMahon 29.1 Introduction ...................................................................409 29.2 Setting Up the Lab .........................................................410 29.3 Preparing and Screening Reagents ..............................412 29.4 Mechanical Passaging of hES Cell Colonies ...............418 29.5 Derivation of hES Cells ..................................................421 29.6 Maintenance of Established hES CeU Cultures ..........424 29.7 Freezing liES Cells .........................................................430 29.8 Thawing hES Cells ........................................................431 29.9 hES Cell Quality Control ...............................................433 For Further Study ......................................................................434 CHAPTER 30 Derivation and Differentiation of Human Embryonic Germ Cells ......................................................................435 Michael J. Shamblott, Candace L. Ken, Joyce AxeLman, Jolin W. Littlefìcìd, Gregory 0. Clark, Ethan S. Patterson, Russell C. Addis, Jennifer N. Kraszewski, Kathleen C. Kent and Jolm D. Gearhart 30.1 Introduction ...................................................................435 30.2 Human Embryonic Germ Cell Derivation ....................437 30.3 Embryoid Body-Derived Cells ......................................446 For Further Study ......................................................................451 CHAPTER 31 Genomic Reprogiamrning .............................................453 M. Azun Surani 31.1 Introduction ...................................................................453 31.2 Genomic Reprogramming in Germ Cells .....................454 31.3 Reprogrammmg Somatic Nuclei ...................................460 31.4 Conclusions ....................................................................462 For Further Study ......................................................................462 Part V Applications CHAPTER 32 Neural Stem Cells - Therapeutic Applications m Neurodegenerative Diseases ........................................467 Rodolfo Gonzalez, Yang D. Teng, Kook I. Park, Jean Pyo Lee, Jitka Ouxednik, Vaclav Ouiedmk, Jaimie Imitóla, Franz-Josef Mueller, Richard L. Sidrnan and Evan Y. Snyder 32.1 Introduction ...................................................................467 32.2 Definition of Neural Stem Cells ....................................468 32.3 Therapeutic Potential of Neural Stem Cells ................470 32.4 Gene Therapy Using Neural Stem Cells ......................475 32.5 Cell Replacement Using Neural Stem Cells ................476 32.6 Global Cell Replacement Usmg Neuial Stem Cells ..478 32.7 Neuial Stem Cells Display an Inherent Mechanism for Rescuing Dysfunctional Neurons ...........................481 32.8 Neural Stern Cells as the Glue That Holds Multiple Therapies Together .......................................................484 32.9 Summary ........................................................................485 For Further Study ......................................................................489 CHAPTER 33 Adult Progenitor Cells as a Potential Treatment for Diabetes ..........................................................................491 Susan Boniiei-Weir and Gordon C. Wen 33.1 Importance of (З-Сеїі Replacement Therapy for Diabetes and the Shortage of Insulin-Producing Cells ................................................................................491 33.2 Potential of Adult Stem-Progenitor Cells as a Source of Insulin-Producing Cells ................................491 33.3 Defining ß-Cells, Stem Cells, and Progenitor Cells .....492 33.4 New ß-Cells are Formed Throughout Adult Life ........493 33.5 What is the Cellular Origin of Adult Islet Neogenesis? ...................................................................493 33.6 Transdifferentiation of Nomslet Cells to Islet Cells.. ..496 33.7 Pancreatic Acmar Cell Transdifferentiation................497 33.8 Bone Mairow Cells as a Source of Insulin-Producing Cells ................................................................................497 33.9 Liver as a Source of Insulin-Producing Cells ...............497 33.10 Engineering Other Non-ß-Cells to Produce Insulin ....498 33.11 Attempts to Deliver Insulin Through Constitutive Rather Than Regulated Secretion ................................499 33.12 Summary ........................................................................499 For Further Study ......................................................................499 CHAPTER 34 Bums and Skm Ulcers ...................................................501 Holger Schlüter, Edwaid Upjoim, George Vangos and Pntmder Каш 34.1 Introduction ...................................................................501 34.2 Burns and Skin Ulcers - The Problem .........................501 34.3 Epidermal Stem Cells ....................................................502 34.4 Stem Cells m Burns and Skin Ulcers - Current Use ... 503 34.5 Recent and Future Developments ................................509 Acknowledgments ....................................................................513 For Further Study ......................................................................513 CHAPTER 35 Stem Cells and Heart Disease .......................................515 Piero Ал versa, Алпатѕа Leń, Bernardo Nadal-Gmaid and Jan Kajstuia 35.1 Heart: A Self-renewing Organ .....................................515 35.2 Distribution of CSCs m the Heart .................................517 35.3 Repair of Myocaidial Damage by Nonresident Primitive Cells ................................................................520 35.4 Repair of Myocaidial Damage by Resident Primitive Cells ................................................................523 35.5 Myocardial Regeneration in Humans ..........................526 For Further Study ......................................................................527 CHAPTER 36 Stem Cells for the Treatment of Muscular Dystrophy .......................................................................529 Francesco Saveno Tedesco, Maunlio Sampaolesi and Giulio Cossu 36.1 Introduction ...................................................................529 36.2 Myoblast Transplantation - Past Failure and New Hope ......................................................................531 36.3 Unconventional Myogenic Progenitors ........................533 36.4 Pluripotent Stem Cells for Future Cell-Based Therapies .......................................................................539 36.5 Future Perspectives ......................................................540 Acknowledgments ....................................................................541 For Further Study ......................................................................541 CHAPTER 37 CeU Therapy for Liver Disease .....................................543 Stephen C. Strom and Ewa C.S. ЕШѕ 37.1 Introduction ...................................................................543 37.2 Background Studies ......................................................545 37.3 Integration of Hepatocytes Following Transplantation .............................................................546 37.4 Clinical Hepatocyte Transplantation ...........................548 37.5 Hepatocyte Bridge .........................................................549 37.6 Hepatocyte Transplantation in Acute Liver Failure... 550 37.7 Hepatocyte Transplantation for Metabolic Liver Disease ...........................................................................552 37.8 Hepatocyte Transplantation - Novel Uses, Challenges, and Future Directions ..............................556 37.9 Conclusion ......................................................................562 For Further Study ......................................................................564 CHAPTER 38 Orthopedic Applications of Stem Cells ........................565 Jerry I. Huang, Jung U. Yoo and Victor M. Goldberg 38.1 Introduction ...................................................................565 38.2 Bone ................................................................................566 38.3 Cartilage .........................................................................569 38.4 Meniscus ........................................................................573 38.5 Ligaments and Tendons ...............................................575 38.6 Spine............................................................................... 578 38.7 Summary ........................................................................579 For Further Study ......................................................................580 CHAPTER 39 Embryonic Stem Cells m Tissue Engineering .............581 Sh tirami t Levenberg, M Khademhosseini and Robert Langer 39.1 Introduction ...................................................................581 39.2 Tissue Engineering Principles and Perspectives ........581 39.3 Limitations and Hurdles of Using ES Cells in Tissue Engineering .......................................................587 39.4 Summary ........................................................................591 For Further Study ......................................................................591 Part VI Regulation and Ethics CHAPTER 40 Ethical Considerations ..................................................595 Ronald M. Green 40.1 Introduction ...................................................................595 40.2 Is it Morally Permissible to Destroy a Human Embryo? .........................................................................595 40.3 Should we Postpone hES Cell Research ? ....................596 40.4 Can We Benefit from Others Destruction of Embryos? ........................................................................597 40.5 Can We Create an Embryo to Destroy it? ....................599 40.6 Should We Clone Hinnan Embryos? ............................599 40.7 What Ethical Guidelines Should Govern hES Cell and Therapeutic Cloning Research? ...................................602 40.8 Summary ........................................................................603 For Further Study ......................................................................604 CHAPTER 41 Overview of the FDA Regulatory Process ...................605 MaikH. Lee, Kevin J. Whittlesey, JjyoungM. Dang, Maegen Colehoiu, Judrth Aiddiacono, Eilen La2anis, David S. Kaplan, Donald Fink, Charles N. Duifor, Ashok Batía, Stephen L. Hubert, Deborah Lavoie Grayeski, Richaid McFailand and Celia Witten 41.1 Introduction and Chapter Overview ............................605 41.2 Brief Legislative History of FDA ..................................606 41.3 Laws, Regulations, and Guidance ...............................607 41.4 FDA Organization and Jurisdictional Issues ...............609 41.5 Approval Mechanisms and Clinical Studies ................611 41.6 Meetings with Industry, Professional Groups, and Sponsors ..................................................................613 41.7 Regulations and Guidance of Special Interest for Regenerative Medicine .................................................614 41.8 FDA s Standards Development Program .....................624 41.9 Advisory Committee Meetmgs ....................................627 41.10 FDA Research and Critical Path Science .....................628 41.11 Other Communication Efforts ......................................630 41.12 Conclusion ......................................................................632 For Further Study ......................................................................632 CHAPTER 42 It s Not about Curiosity, It s about Cures .....................635 Maiy Tylei Moow and S. Robert Levine 42.1 Choosing Life .................................................................635 42.2 Size of the Promise ........................................................636 42.3 Personal Promises Fuel Progress .................................637 42.4 Hope Versus Hype .........................................................640 42.5 Giving Life ......................................................................640 42.6 People Drive Progress ...................................................641 42.7 Better Health for All ......................................................642 Glossary ................................................................................................................645 Index .....................................................................................................................661
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institution	BVB
isbn	9780124095038 0124095038
language	English
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spelling	Essentials of stem cell biology ed. by Robert Lanza ... Stem cell biology 3. ed. Amsterdam [u.a.] Elsevier 2014 XXVIII, 680 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biomedical Research Embryo Research Stem Cells Stem cells Tissue Engineering Stammzelle (DE-588)4665329-6 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Stammzelle (DE-588)4665329-6 s DE-604 Lanza, Robert P. 1956- Sonstige (DE-588)136341640 oth Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026929239&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk
spellingShingle	Essentials of stem cell biology Biomedical Research Embryo Research Stem Cells Stem cells Tissue Engineering Stammzelle (DE-588)4665329-6 gnd
subject_GND	(DE-588)4665329-6 (DE-588)4143413-4
title	Essentials of stem cell biology
title_alt	Stem cell biology
title_auth	Essentials of stem cell biology
title_exact_search	Essentials of stem cell biology
title_full	Essentials of stem cell biology ed. by Robert Lanza ...
title_fullStr	Essentials of stem cell biology ed. by Robert Lanza ...
title_full_unstemmed	Essentials of stem cell biology ed. by Robert Lanza ...
title_short	Essentials of stem cell biology
title_sort	essentials of stem cell biology
topic	Biomedical Research Embryo Research Stem Cells Stem cells Tissue Engineering Stammzelle (DE-588)4665329-6 gnd
topic_facet	Biomedical Research Embryo Research Stem Cells Stem cells Tissue Engineering Stammzelle Aufsatzsammlung
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work_keys_str_mv	AT lanzarobertp essentialsofstemcellbiology AT lanzarobertp stemcellbiology

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