Molecular biology: not only for bioinformaticians
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2013
|
| Schriftenreihe: | Lecture notes in computer science
8248 : Tutorial |
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XII, 153 S. graph. Darst. |
| ISBN: | 3642453600 9783642453601 |
Internformat
MARC
| LEADER | 00000nam a22000008cb4500 | ||
|---|---|---|---|
| 001 | BV041474229 | ||
| 003 | DE-604 | ||
| 005 | 20140108 | ||
| 007 | t| | ||
| 008 | 131211s2013 gw d||| |||| 00||| eng d | ||
| 015 | |a 13,N49 |2 dnb | ||
| 016 | 7 | |a 1044795190 |2 DE-101 | |
| 020 | |a 3642453600 |9 3-642-45360-0 | ||
| 020 | |a 9783642453601 |c Pb. : EUR 49.22 (DE) (freier Pr.), EUR 50.60 (AT) (freier Pr.), sfr 61.50 (freier Pr.) |9 978-3-642-45360-1 | ||
| 024 | 3 | |a 9783642453601 | |
| 028 | 5 | 2 | |a Best.-Nr.: 86355479 |
| 035 | |a (OCoLC)865143510 | ||
| 035 | |a (DE-599)DNB1044795190 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE-BE | ||
| 049 | |a DE-11 |a DE-83 |a DE-91G |a DE-188 | ||
| 082 | 0 | |a 572.8 |2 22/ger | |
| 100 | 1 | |a Widłak, Wiesława |e Verfasser |0 (DE-588)104615785X |4 aut | |
| 245 | 1 | 0 | |a Molecular biology |b not only for bioinformaticians |c Wiesława Widłak |
| 263 | |a 201312 | ||
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2013 | |
| 300 | |a XII, 153 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Lecture notes in computer science |v 8248 : Tutorial | |
| 650 | 0 | 7 | |a Molekularbiologie |0 (DE-588)4039983-7 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4151278-9 |a Einführung |2 gnd-content | |
| 689 | 0 | 0 | |a Molekularbiologie |0 (DE-588)4039983-7 |D s |
| 689 | 0 | |5 DE-604 | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |z 978-3-642-45361-8 |
| 830 | 0 | |a Lecture notes in computer science |v 8248 : Tutorial |w (DE-604)BV000000607 |9 8248 | |
| 856 | 4 | 2 | |m X:MVB |q text/html |u http://deposit.dnb.de/cgi-bin/dokserv?id=4528685&prov=M&dok_var=1&dok_ext=htm |3 Inhaltstext |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026920310&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-026920310 | |
Datensatz im Suchindex
| _version_ | 1820875549232332800 |
|---|---|
| adam_text |
CONTENTS
PREFACE V
1 CELLS AND VIRUSES 1
1.1 CELL STRUCTURE 1
1.1.1 PROKARYOTIC CELL STRUCTURE 2
1.1.2 EUKARYOTIC CELL STRUCTURE 3
1.2 BIOLOGICAL MEMBRANES AND THEIR LIPID COMPONENT 4
1.2.1 PHOSPHOLIPIDS 5
1.2.2 CHOLESTEROL AND STEROIDS 6
1.3 NUCLEUS 7
1.3.1 CHROMOSOMES AND KARYOTYPE 7
1.4 CYTOPLASMIC ORGANELLES 9
1.4.1 MITOCHONDRIA 9
1.4.2 CHLOROPLASTS 10
1.4.3 ENDOPLASMIC RETICULUM AND GOLGI COMPLEX 10
1.4.4 PEROXISOMES. LVSOSOMES, VACUOLES.
AND GLYOXYSOMES 10
1.5 VIRUSES. BACTERIOPHAGES, AND VIROPHAGES 11
1.5.1 CLASSIFICATION OF VIRUSES 12
REFERENCES 12
2 PROTEIN STRUCTURE AND FUNCTION 15
2.1 AMINO ACIDS 15
2.2 PEPTIDES AND PROTEINS 17
2.3 LEVELS OF PROTEIN STRUCTURE 18
2.3.1 HYDROGEN BONDS 19
2.3.2 SECONDARY STRUCTURE OF PROTEINS 20
2.3.2.1 ALPHA HELIX 20
2.3.2.2 BETA STRAND. BETA SHEET, AND BETA BARREL. 20
2.3.3 TERTIARY AND QUATERNARY STRUCTURE OF PROTEINS 21
HTTP://D-NB.INFO/1044795190
VIII
CONTENTS
2.4 PROTEINS FUNCTIONS 22
2.4.1 ENZYMES 23
2.4.2 MEMBRANE PROTEINS 25
2.4.2.1 PROTEINS INVOLVED IN IMMUNE RESPONSE 26
2.4.2.2 CELL SURFACE RECEPTORS 27
2.4.2.3 ION CHANNELS 27
2.4.3 STRUCTURAL PROTEINS 28
REFERENCES 28
3 NUCLEIC ACIDS 31
3.1 NUCLEOTIDES 31
3.1.1 PENTOSES 32
3.1.2 NITROGENOUS BASES OF NUCLEOTIDES 32
3.2 DNA PROPERTIES 34
3.2.1 NUCLEOTIDE CHAIN 34
3.2.2 DNA STRUCTURE 36
3.3 STRUCTURE AND FUNCTION OF RNA 37
3.3.1 MESSENGER RNA 38
3.3.2 TRANSFER RNA 39
3.3.3 RIBOSOMES AND RR.NA 39
3.3.4 NON CODING RNA 40
3.4 THE ORGANIZATION OF GENETIC MATERIAL IN THE NUCLEUS -
CHROMATIN 42
3.4.1 HISTONES AND NUCLEOSOMES 42
3.4.2 CHROMATIN STRUCTURE 43
3.5 GENETIC CODE 44
3.6 GENES AND GENOME 45
3.7 REPETITIVE SEQUENCES 46
REFERENCES 47
4 DNA REPLICATION, MUTATIONS, AND REPAIR 49
4.1 DNA REPLICATION MECHANISM 49
4.1.1 DNA POLYMERASES 50
4.1.2 POLYMERASE CHAIN REACTION (PCR.) 52
4.2 TELOMERASES AND CELLULAR SENESCENCE 53
4.3 TOPOISOMERASES 54
4.4 MUTATIONS AND THEIR CONSEQUENCES 56
4.4.1 SUBSTITUTION 57
4.4.2 DELETION AND INSERTION 58
4.4.3 EXON SKIPPING 58
4.4.4 THE RELATIONSHIP BETWEEN MUTATIONS
AND POLYMORPHISMS 59
4.5 MUTATION MECHANISMS 60
4.5.1 MUTATIONS CAUSED BY UV LIGHT 61
4.5.2 MUTATIONS CAUSED BY CHEMICAL AGENTS 62
('(INTENTS IX
4.5.3 MUTATIONS CAUSED BY REPLICATION ERRORS 63
4.5.4 DNA METHYLATION AND CPG (CG) ISLANDS 63
4.6 MECHANISMS OF DNA REPAIR 65
4.6.1 BASE EXCISION REPAIR (BER.) 66
4.6.2 NUCLEOTIDE EXCISION REPAIR (NER.) 67
4.6.3 DNA MISMATCH REPAIR (MMR.) 68
REFERENCES 69
5 TRANSCRIPTION AND POSTTRANSCRIPTIONAL PROCESSES 71
5.1 GENE EXPRESSION OVERVIEW 71
5.2 GENE TRANSCRIPTION AND RNA POLYMERASES 72
5.2.1 R.NA POLYMERASES 73
5.3 DNA REGULATORY ELEMENTS 75
*5.3.1 RESPONSE ELEMENTS 76
5.4 STRUCTURAL MOTIFS OF TRANSCRIPTION FACTORS 77
5.5 TRANSCRIPTION OF PROTEIN-CODING GENES 78
5.6 TRANSCRIPTION OF R.NA GENES 80
5.7 THE ROLE OF TRANSCRIPTION FACTORS AND CHROMATIN
STRUCTURE IN REGULATION OF TRANSCRIPTION 81
5.7.1 MECHANISM OF GENE BOOKNIARKING 82
5.7.2 INSULATORS 83
5.8 R.NA PROCESSING 84
5.8.1 CAPPING PROCESS 85
5.8.2 POLVADENYLATION 85
5.8.3 PROCESSING OF PRE-RR.NA AND PRE-TR,NA 87
5.8.4 R.NA SPLICING 87
5.8.5 R.NA EDITING 88
5.9 REVERSE TRANSCRIPTION 89
REFERENCES 91
6 SYNTHESIS AND POSTTRANSLATIONAL MODIFICATIONS
OF PROTEINS 93
6.1 PROTEIN SYNTHESIS 93
6.1.1 THE INITIATION SIGNAL FOR PROTEIN SYNTHESIS 93
6.1.2 ROLE OF TR.NA IN TRANSLATION 94
6.1.3 PROCESS OF PROTEIN SYNTHESIS 96
6.1.3.1 INITIATION 96
6.1.3.2 ELONGATION 97
6.1.3.3 TERMINATION 98
6.1.4 READING FRAME SHIFT 98
6.1.5 OVERLAPPING GENES 99
6.2 POSTTRANSLATIONAL MODIFICATIONS AND PROTEIN SORTING 99
6.2.1 TARGETING OF PROTEINS TO THE ROUGH ENDOPLASMIC
RETICULUM 100
X
CONTENTS
6.2.2 TRANSPORT OF PROTEINS INTO AND ACROSS THE GOLGI
APPARATUS 102
6.2.3 TRANSPORT OF PROTEINS INTO LYSOSOMES 103
6.2.4 NUCLEAR TRANSPORT 103
6.2.4.1 NUCLEAR LOCALIZATION SIGNAL AND NUCLEAR
EXPORT SIGNAL 103
6.2.4.2 MECHANISM OF IMPORTINS AND EXPORTINS
ACTION 104
6.3 PROTEIN DEGRADATION 105
REFERENCES 106
7 CELL DIVISION 109
7.1 CELL CYCLE 109
7.1.1 CDK AND CYCLINS 110
7.1.2 MECHANISM OF INITIATION AND TERMINATION OF THE S
PHASE ILL
7.2 MITOSIS ILL
7.2.1 INITIATION OF MITOSIS 113
7.2.2 MECHANISM OF MITOSIS TERMINATION 113
7.3 MEIOSIS 114
7.3.1 INDEPENDENT CHROMOSOME SEGREGATION 114
7.4 DNA RECOMBINATION 116
7.4.1 HOMOLOGOUS RECOMBINATION 116
7.4.2 SITE-SPECIFIC RECOMBINATION 117
7.4.3 TRANSPOSITION 118
REFERENCES 120
8 CELL SIGNALING PATHWAYS 121
8.1 SIGNALING THROUGH HYDROPHOBIC MOLECULES 121
8.2 SIGNALING THROUGH ION CHANNEL LINKED RECEPTORS 123
8.3 SIGNAL TRANSDUCTION VIA RECEPTORS ASSOCIATED WITH G
PROTEIN 125
8.3.1 G PROTEIN-COUPLED RECEPTORS 125
8.3.2 G PROTEINS 126
8.3.3 EFFECTORS AND SECONDARY MESSENGERS 128
8.4 SIGNAL TRANSDUCTION THROUGH ENZYME LINKED RECEPTORS . 130
8.4.1 RECEPTOR TYROSINE KINASES 130
8.4.2 RECEPTOR SERINE/THREONINE KINASES 132
8.5 INTRACELLULAR SIGNALING PATHWAYS 132
8.5.1 CAMP-DEPENDENT SIGNALING PATHWAY 132
8.5.2 NF-KAPPAB SIGNALING PATHWAY 133
8.5.3 JAK-STAT SIGNALING PATHWAY 134
8.5.4 MAPK SIGNALING PATHWAY 135
8.6 APOPTOSIS 136
REFERENCES 138
CONTENTS XI
9 HIGH-THROUGHPUT TECHNOLOGIES IN MOLECULAR BIOLOGY . 139
9.1 DNA SEQUENCING 139
9.1.1 CHAIN TERMINATION SEQUENCING 139
9.1.2 FULL GENOME SEQUENCING 141
9.2 ANALYSIS OF GENE EXPRESSION AT R.N A LEVEL 143
9.2.1 DNA MICROARRAYS 143
9.2.1.1 TWO-COLOR MICROARRAYS 145
9.2.1.2 ONE-COLOR MICROARRAYS 146
9.3 STUDIES OF GENE EXPRESSION REGULATION BY CHROMATIN
INIMUNOPRECIPITATION 147
9.4 ANALYSIS OF PROTEIN EXPRESSION 149
9.4.1 MALDI MASS SPECTROMETRY 149
REFERENCES 153 |
| any_adam_object | 1 |
| author | Widłak, Wiesława |
| author_GND | (DE-588)104615785X |
| author_facet | Widłak, Wiesława |
| author_role | aut |
| author_sort | Widłak, Wiesława |
| author_variant | w w ww |
| building | Verbundindex |
| bvnumber | BV041474229 |
| classification_rvk | SS 4800 |
| ctrlnum | (OCoLC)865143510 (DE-599)DNB1044795190 |
| dewey-full | 572.8 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.8 |
| dewey-search | 572.8 |
| dewey-sort | 3572.8 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>00000nam a22000008cb4500</leader><controlfield tag="001">BV041474229</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20140108</controlfield><controlfield tag="007">t|</controlfield><controlfield tag="008">131211s2013 gw d||| |||| 00||| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">13,N49</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1044795190</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3642453600</subfield><subfield code="9">3-642-45360-0</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783642453601</subfield><subfield code="c">Pb. : EUR 49.22 (DE) (freier Pr.), EUR 50.60 (AT) (freier Pr.), sfr 61.50 (freier Pr.)</subfield><subfield code="9">978-3-642-45360-1</subfield></datafield><datafield tag="024" ind1="3" ind2=" "><subfield code="a">9783642453601</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">Best.-Nr.: 86355479</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)865143510</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB1044795190</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-11</subfield><subfield code="a">DE-83</subfield><subfield code="a">DE-91G</subfield><subfield code="a">DE-188</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">572.8</subfield><subfield code="2">22/ger</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Widłak, Wiesława</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)104615785X</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Molecular biology</subfield><subfield code="b">not only for bioinformaticians</subfield><subfield code="c">Wiesława Widłak</subfield></datafield><datafield tag="263" ind1=" " ind2=" "><subfield code="a">201312</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">2013</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XII, 153 S.</subfield><subfield code="b">graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Lecture notes in computer science</subfield><subfield code="v">8248 : Tutorial</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Molekularbiologie</subfield><subfield code="0">(DE-588)4039983-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4151278-9</subfield><subfield code="a">Einführung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Molekularbiologie</subfield><subfield code="0">(DE-588)4039983-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe</subfield><subfield code="z">978-3-642-45361-8</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Lecture notes in computer science</subfield><subfield code="v">8248 : Tutorial</subfield><subfield code="w">(DE-604)BV000000607</subfield><subfield code="9">8248</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">X:MVB</subfield><subfield code="q">text/html</subfield><subfield code="u">http://deposit.dnb.de/cgi-bin/dokserv?id=4528685&prov=M&dok_var=1&dok_ext=htm</subfield><subfield code="3">Inhaltstext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026920310&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-026920310</subfield></datafield></record></collection> |
| genre | (DE-588)4151278-9 Einführung gnd-content |
| genre_facet | Einführung |
| id | DE-604.BV041474229 |
| illustrated | Illustrated |
| indexdate | 2025-01-10T15:17:24Z |
| institution | BVB |
| isbn | 3642453600 9783642453601 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-026920310 |
| oclc_num | 865143510 |
| open_access_boolean | |
| owner | DE-11 DE-83 DE-91G DE-BY-TUM DE-188 |
| owner_facet | DE-11 DE-83 DE-91G DE-BY-TUM DE-188 |
| physical | XII, 153 S. graph. Darst. |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | Springer |
| record_format | marc |
| series | Lecture notes in computer science |
| series2 | Lecture notes in computer science |
| spelling | Widłak, Wiesława Verfasser (DE-588)104615785X aut Molecular biology not only for bioinformaticians Wiesława Widłak 201312 Berlin [u.a.] Springer 2013 XII, 153 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lecture notes in computer science 8248 : Tutorial Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Molekularbiologie (DE-588)4039983-7 s DE-604 Erscheint auch als Online-Ausgabe 978-3-642-45361-8 Lecture notes in computer science 8248 : Tutorial (DE-604)BV000000607 8248 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4528685&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026920310&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Widłak, Wiesława Molecular biology not only for bioinformaticians Lecture notes in computer science Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4039983-7 (DE-588)4151278-9 |
| title | Molecular biology not only for bioinformaticians |
| title_auth | Molecular biology not only for bioinformaticians |
| title_exact_search | Molecular biology not only for bioinformaticians |
| title_full | Molecular biology not only for bioinformaticians Wiesława Widłak |
| title_fullStr | Molecular biology not only for bioinformaticians Wiesława Widłak |
| title_full_unstemmed | Molecular biology not only for bioinformaticians Wiesława Widłak |
| title_short | Molecular biology |
| title_sort | molecular biology not only for bioinformaticians |
| title_sub | not only for bioinformaticians |
| topic | Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Molekularbiologie Einführung |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=4528685&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026920310&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000000607 |
| work_keys_str_mv | AT widłakwiesława molecularbiologynotonlyforbioinformaticians |