In vivo two-photon calcium imaging of hippocampal neurons in a mouse model of Alzheimer's disease:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | kostenfrei https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131010-1182882-0-7 Inhaltsverzeichnis |
| Beschreibung: | 102 Bl. Ill., graph. Darst. |
Internformat
MARC
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| 100 | 1 | |a Busche, Marc Aurel |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a In vivo two-photon calcium imaging of hippocampal neurons in a mouse model of Alzheimer's disease |c Marc Aurel Busche |
| 264 | 1 | |c 2013 | |
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Datensatz im Suchindex
| _version_ | 1804151590751305728 |
|---|---|
| adam_text | CONTENTS
1 INTRODUCTION 7
1.1 THE HIPPOCAMPUS 7
1.1.1 ANATOMY 7
1.1.2 FUNCTIONAL ORGANIZATION 9
1.2 IN VIVO TWO-PHOTON CALCIUM IMAGING 11
1.2.1 TWO-PHOTON MICROSCOPY 12
1.2.2 TWO-PHOTON MICROSCOPE SETUP 13
1.2.3 FLUORESCENCE LABELING 14
1.3 ALZHEIMER S DISEASE 16
1.3.1 IN VIVO IMAGING 17
1.3.2 NEURONAL DYSFUNCTION 21
2 MATERIAL & METHODS 30
2.1 ANIMALS 30
2.2 SURGERY AND LABELING PROCEDURE FOR HIPPOCAMPAL IMAGING 30
2.3 TWO-PHOTON IMAGING 31
2.4 IMAGE ANALYSIS 32
2.5 CELL-ATTACHED RECORDINGS 32
2.6 TREATMENT WITH Y-SECRETASE INHIBITOR 33
2.7 DIMER APPLICATION 33
2.8 QUANTIFICATION OF AB 33
2
HTTP://D-NB.INFO/1049219449
CONTENTS 3
2.9 DETECTION OF AB PLAQUES 34
2.10 STATISTICAL ANALYSIS 35
3 RESULTS 36
3.1 IMAGING NEURONAL ACTIVITY IN THE HIPPOCAMPUS 36
3.2 PATTERNS OF NEURONAL ACTIVITY IN HIPPOCAMPUS AND CORTEX 41
3.3 IMAGING NEURONAL ACTIVITY IN THE HIPPOCAMPUS OF ALZHEIMER TRANSGENIC
MICE . . 44
3.3.1 ALTERED ACTIVITY OF CA1 NEURONS IN PLAQUE-BEARING MICE 46
3.3.2 EARLY HYPERACTIVITY OF CA1 NEURONS IN PLAQUE-FREE MICE 46
3.3.3 RESCUE OF NEURONAL HYPERACTIVITY BY ACUTE Y-SECRETASE INHIBITION
.... 56
3.3.4 SOLUBLE AB INDUCES NEURONAL HYPERACTIVITY 57
4 DISCUSSION 66
4.1 IN VIVO IMAGING OF HIPPOCAMPAL NEURONS 67
4.2 NEURONAL HYPERACTIVITY 69
4.3 REGIONAL FUNCTIONAL VULNERABILITY 71
4.4 CLINICAL IMPLICATIONS 72
5 PUBLICATIONS IN PEER REVIEWED JOURNALS 75
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| spelling | Busche, Marc Aurel Verfasser aut In vivo two-photon calcium imaging of hippocampal neurons in a mouse model of Alzheimer's disease Marc Aurel Busche 2013 102 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2013 (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20131010-1182882-0-7 http://mediatum.ub.tum.de/node?id=1182882 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131010-1182882-0-7 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026907257&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Busche, Marc Aurel In vivo two-photon calcium imaging of hippocampal neurons in a mouse model of Alzheimer's disease |
| subject_GND | (DE-588)4113937-9 |
| title | In vivo two-photon calcium imaging of hippocampal neurons in a mouse model of Alzheimer's disease |
| title_auth | In vivo two-photon calcium imaging of hippocampal neurons in a mouse model of Alzheimer's disease |
| title_exact_search | In vivo two-photon calcium imaging of hippocampal neurons in a mouse model of Alzheimer's disease |
| title_full | In vivo two-photon calcium imaging of hippocampal neurons in a mouse model of Alzheimer's disease Marc Aurel Busche |
| title_fullStr | In vivo two-photon calcium imaging of hippocampal neurons in a mouse model of Alzheimer's disease Marc Aurel Busche |
| title_full_unstemmed | In vivo two-photon calcium imaging of hippocampal neurons in a mouse model of Alzheimer's disease Marc Aurel Busche |
| title_short | In vivo two-photon calcium imaging of hippocampal neurons in a mouse model of Alzheimer's disease |
| title_sort | in vivo two photon calcium imaging of hippocampal neurons in a mouse model of alzheimer s disease |
| topic_facet | Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1182882 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131010-1182882-0-7 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026907257&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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