Heterochromatin dynamics and functions:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
|
| Schlagworte: | |
| Online-Zugang: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:19-163207 Inhaltsverzeichnis |
| Beschreibung: | 210 S. Ill., graph. Darst. |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV041451701 | ||
| 003 | DE-604 | ||
| 005 | 20140107 | ||
| 007 | t | ||
| 008 | 131129s2013 ad|| m||| 00||| eng d | ||
| 035 | |a (OCoLC)864636843 | ||
| 035 | |a (DE-599)BVBBV041451701 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-384 |a DE-473 |a DE-703 |a DE-1051 |a DE-824 |a DE-29 |a DE-12 |a DE-91 |a DE-19 |a DE-1049 |a DE-92 |a DE-739 |a DE-898 |a DE-355 |a DE-706 |a DE-20 |a DE-1102 | ||
| 100 | 1 | |a Hahn, Matthias |d 1981- |e Verfasser |0 (DE-588)1044772107 |4 aut | |
| 245 | 1 | 0 | |a Heterochromatin dynamics and functions |c Matthias Ulrich Hahn |
| 264 | 1 | |c 2013 | |
| 300 | |a 210 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a München, Univ., Kumulative Diss., 2013 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |o urn:nbn:de:bvb:19-163207 |
| 856 | 4 | 1 | |u http://edoc.ub.uni-muenchen.de/16320/ |x Verlag |z kostenfrei |3 Volltext |
| 856 | 4 | |u https://nbn-resolving.org/urn:nbn:de:bvb:19-163207 |x Resolving-System | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026898258&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 912 | |a ebook | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-026898258 | ||
Datensatz im Suchindex
| _version_ | 1804151576236916736 |
|---|---|
| adam_text | INDEX
STATEMENT AND STATUATORY DECLARATION 4
INDEX 5
ABBREVIATIONS 6
LIST OF PUBLICATIONS 7
DECLARATION OF CONTRIBUTIONS 8
ZUSAMMENFASSUNG 10
SUMMARY 12
1. INTRODUCTION 14
1.1 EPIGENETIC GENE REGULATION 14
1.2 PERICENTRIC HETEROCHROMATIN 16
1.3 CHROMATIN CHANGES IN DEVELOPMENT 18
1.4 POLYCOMB GENE SILENCING VIA H3K27 METHYLATION 19
1.5 HIGHER ORDER CHROMATIN STRUCTURE 20
1.6 CENTROMERES AND HETEROCHROMATIN 21
1.7 AIMS OF THIS WORK 24
2. RESULTS 25
2.1 HETEROCHROMATIN DYSREGULATION IN HUMAN DISEASES 25
2.2 EPIGENETIC REGULATION OF DEVELOPMENT BY HISTONE LYSINE METHYLATION
37
2.3 SUV4-20H HISTONE METHYLTRANSFERASES PROMOTE NEUROECTODERMAL
DIFFERENTIATION BY
SILENCING THE PLURIPOTENCY-ASSOCIATED OCT-25 GENE 52
2.4 H3K56ME3 IS A NOVEL, CONSERVED HETEROCHROMATIC MARK THAT LARGELY BUT
NOT COMPLETELY
OVERLAPS WITH H3K9ME3 IN BOTH REGULATION AND LOCALIZATION 97
2.5 SUV4-20H2 MEDIATES CHROMATIN COMPACTION AND IS IMPORTANT FOR COHESIN
RECRUITMENT TO
HETEROCHROMATIN 111
2.6 CENP-C FACILITATES THE RECRUITMENT OF M18BP1 TO CENTROMERIC
CHROMATIN 167
3. DISCUSSION 189
3.1 SUV4-20H ENZYMES AND H4K20ME3 IN EMBRYONIC DEVELOPMENT 189
3.2 H3K56ME3: A NOVEL PERICENTRIC HETEROCHROMATIN MARK 190
3.3 SUV4-20H ENZYMES IN HETEROCHROMATIN ORGANIZATION 192
3.4 HETEROCHROMATIN IN CENTROMERE FORMATION 197
3.5 OUTLOOK 199
CURRICULUM VITAE 202
ACKNOWLEDGEMENTS 203
REFERENCES 204
5
HTTP://D-NB.INFO/104682614X
|
| any_adam_object | 1 |
| author | Hahn, Matthias 1981- |
| author_GND | (DE-588)1044772107 |
| author_facet | Hahn, Matthias 1981- |
| author_role | aut |
| author_sort | Hahn, Matthias 1981- |
| author_variant | m h mh |
| building | Verbundindex |
| bvnumber | BV041451701 |
| collection | ebook |
| ctrlnum | (OCoLC)864636843 (DE-599)BVBBV041451701 |
| format | Thesis Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01434nam a2200325 c 4500</leader><controlfield tag="001">BV041451701</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20140107 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">131129s2013 ad|| m||| 00||| eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)864636843</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV041451701</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-384</subfield><subfield code="a">DE-473</subfield><subfield code="a">DE-703</subfield><subfield code="a">DE-1051</subfield><subfield code="a">DE-824</subfield><subfield code="a">DE-29</subfield><subfield code="a">DE-12</subfield><subfield code="a">DE-91</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-1049</subfield><subfield code="a">DE-92</subfield><subfield code="a">DE-739</subfield><subfield code="a">DE-898</subfield><subfield code="a">DE-355</subfield><subfield code="a">DE-706</subfield><subfield code="a">DE-20</subfield><subfield code="a">DE-1102</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hahn, Matthias</subfield><subfield code="d">1981-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1044772107</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Heterochromatin dynamics and functions</subfield><subfield code="c">Matthias Ulrich Hahn</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2013</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">210 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="a">München, Univ., Kumulative Diss., 2013</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe</subfield><subfield code="o">urn:nbn:de:bvb:19-163207</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://edoc.ub.uni-muenchen.de/16320/</subfield><subfield code="x">Verlag</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2=" "><subfield code="u">https://nbn-resolving.org/urn:nbn:de:bvb:19-163207</subfield><subfield code="x">Resolving-System</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026898258&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ebook</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-026898258</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV041451701 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:57:01Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-026898258 |
| oclc_num | 864636843 |
| open_access_boolean | 1 |
| owner | DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 |
| owner_facet | DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 |
| physical | 210 S. Ill., graph. Darst. |
| psigel | ebook |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| record_format | marc |
| spelling | Hahn, Matthias 1981- Verfasser (DE-588)1044772107 aut Heterochromatin dynamics and functions Matthias Ulrich Hahn 2013 210 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Univ., Kumulative Diss., 2013 (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-163207 http://edoc.ub.uni-muenchen.de/16320/ Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:19-163207 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026898258&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hahn, Matthias 1981- Heterochromatin dynamics and functions |
| subject_GND | (DE-588)4113937-9 |
| title | Heterochromatin dynamics and functions |
| title_auth | Heterochromatin dynamics and functions |
| title_exact_search | Heterochromatin dynamics and functions |
| title_full | Heterochromatin dynamics and functions Matthias Ulrich Hahn |
| title_fullStr | Heterochromatin dynamics and functions Matthias Ulrich Hahn |
| title_full_unstemmed | Heterochromatin dynamics and functions Matthias Ulrich Hahn |
| title_short | Heterochromatin dynamics and functions |
| title_sort | heterochromatin dynamics and functions |
| topic_facet | Hochschulschrift |
| url | http://edoc.ub.uni-muenchen.de/16320/ https://nbn-resolving.org/urn:nbn:de:bvb:19-163207 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026898258&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT hahnmatthias heterochromatindynamicsandfunctions |