How genes influence behavior:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2010
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XII, 249 S. Ill., graph. Darst., Kt. |
| ISBN: | 0199559902 9780199559909 |
Internformat
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| 245 | 1 | 0 | |a How genes influence behavior |c Jonathan Flint ; Ralph J. Greenspan ; Kenneth S. Kendler |
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Datensatz im Suchindex
| _version_ | 1804151563701190656 |
|---|---|
| adam_text | Titel: How genes influence behavior
Autor: Flint, Jonathan
Jahr: 2010
Contents
1 Introduction 1
Genetics: the universal research language 1
What will you get in the subsequent pages? 3
Learning through hard experience 4
The role of animal models 5
What makes for a good explanation? 6
References 7
2 Schizophrenia?All in the family? 8
Does schizophrenia run in families? 9
Traditional assumptions about heredity, mental illness, and behavior 13
What exactly is schizophrenia? 14
Adoption, heredity, and environment 16
Twins 21
Challenging the assumptions 29
Should we rely on twin and adoption studies? 31
References 33
3 Molecular genetics?Linkage analysis 34
Genes for psychosis? 34
When more than one gene may be the culprit, we call it complex 39
Psychiatry goes molecular 42
References 51
4 Other human phenotypes?Genetic influences on alcoholism,
depression, and personality 53
Alcoholism 53
Major depression 59
Personality 60
Genes for what? 62
Genes and sex 66
Genes and the environment 67
Genes and development 71
References 73
X
Contents
5 Genetic association analysis and candidate genes 76
Linkage versus association: candidate genes 77
Gauging probabilities and biases 82
Why reviewing association studies induces headaches 88
Endophenotypes : getting closer to 5-HTT 89
Is there a way out of the quagmire? 92
References 94
6 Genome-wide association studies 96
How the idea of GWAS came about 97
Predicting success: study power 98
Cataloging human DNA sequence diversity 100
Reading human history in our DNA 100
Where in the genome are the SNPs and how many are necessary? 102
The first GWAS results 104
Are GWAS results valid? 106
GWAS results for (some) psychiatric diseases 108
The missing variance: dark matter in the genome 111
Copy number variants (CNVs): a new kind of variation 112
References 114
7 Rodents 116
Behaviorism and fixed action patterns 117
The heritability of mouse behavior 118
Mapping behavior to a single chromosome 123
Mapping behavior to a chromosomal region 125
Anxious mice 126
Mice versus humans 128
Mapping at higher resolution 130
Effect of environment 134
The genetic architecture of mouse behavior 136
References 138
8 Many versus one?Genetic variation in flies and worms
(and some people) 139
Evolving behavior in the laboratory: Drosophila 139
Finding the genes 142
Genes for geotaxis? 144
Aggression, or Who you calling fruit fly? 145
Genes for aggression? 147
Contents
XI
Behavior, the single gene, and the mind of a worm
The first complete anatomy and developmental history
The first complete animal genome
Worm rudiments of social behavior
Wanderlust in fly larvae
Just plain lust in prairie voles
How a gene made me aggressive: 1. Chromosomal abnormalities
How a gene made me aggressive: 2. Single genes with large effects
So which is it? Pluribus or unum?
References
148
149
150
152
154
155
157
158
160
161
9 Model systems?Circadian rhythms
Mutagenesis
Molecular clockworks
More clock genes
The mouse s clock
Variation in the period gene
Variation in the timeless gene
Human clock genes and unquiet sleep
Lessons from fly rhythms
References
162
164
170
172
175
176
178
179
180
182
10 Model systems and the elements of behavior?Neural
mechanisms of learning and memory
Marine invertebrates: using a sea snail to learn about memory
Fruit flies remember things using the same cellular machinery
discovered in sea snails
The origins of genetic engineering as a tool for mammalian neurobiology
Synaptic plasticity: a cellular model of how memory works
Long-term potentiation: a cellular correlate of memory
Different forms of memory in the mammalian hippocampus
Knocking out memory in the mouse
Mutant mysteries
References
183
183
188
191
192
193
195
198
200
202
11 How genes influence behavior
The work of the behavioral geneticist
Two ways of explaining genetic effects
The single-gene perspective ignores background effects
Small-effect genes will tell us little about mechanism
204
204
206
207
208
Xll
Contents
Single genes in genetic architecture terms 209
Genetic architecture in single-gene terms 210
How genes influence behavior 211
The relative contributions of genes differ 212
How to understand an explanation 213
Ethics: should I write back to the prisoners? 214
References 216
Appendix Molecular methods 218
Nucleic acid biology 218
DNA sequencing 221
Polymerase chain reaction 226
Genotyping microsatellites 229
Genotyping SNPs 231
Cloning and sequencing: methods to find disease mutations 233
Genetic engineering 235
The first ingredient: embryonic stem cells 236
The second ingredient: homologous recombination 238
The third ingredient: homologous recombination in ES cells 239
Mutagenizing flies 241
References 241
Index 243
|
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| indexdate | 2024-07-10T00:56:49Z |
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| isbn | 0199559902 9780199559909 |
| language | English |
| lccn | 2009042123 |
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| spelling | Flint, Jonathan Verfasser aut How genes influence behavior Jonathan Flint ; Ralph J. Greenspan ; Kenneth S. Kendler 1. publ. Oxford [u.a.] Oxford Univ. Press 2010 XII, 249 S. Ill., graph. Darst., Kt. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Verhaltensgenetik (DE-588)4187763-9 gnd rswk-swf Verhaltensgenetik (DE-588)4187763-9 s DE-604 Greenspan, Ralph J. Verfasser (DE-588)1045182656 aut Kendler, Kenneth S. 1950- Verfasser (DE-588)13725718X aut DE-601 pdf/application http://www.gbv.de/dms/bowker/toc/9780199559909.pdf Inhaltsverzeichnis HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026890235&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Flint, Jonathan Greenspan, Ralph J. Kendler, Kenneth S. 1950- How genes influence behavior Verhaltensgenetik (DE-588)4187763-9 gnd |
| subject_GND | (DE-588)4187763-9 |
| title | How genes influence behavior |
| title_auth | How genes influence behavior |
| title_exact_search | How genes influence behavior |
| title_full | How genes influence behavior Jonathan Flint ; Ralph J. Greenspan ; Kenneth S. Kendler |
| title_fullStr | How genes influence behavior Jonathan Flint ; Ralph J. Greenspan ; Kenneth S. Kendler |
| title_full_unstemmed | How genes influence behavior Jonathan Flint ; Ralph J. Greenspan ; Kenneth S. Kendler |
| title_short | How genes influence behavior |
| title_sort | how genes influence behavior |
| topic | Verhaltensgenetik (DE-588)4187763-9 gnd |
| topic_facet | Verhaltensgenetik |
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