Increased removal of protein bound uremic toxins through reversible modification of the ionic strength during hemodiafiltration:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
|
| Schlagworte: | |
| Online-Zugang: | kostenfrei Inhaltsverzeichnis |
| Beschreibung: | Zsfassung in dt. und engl. Sprache |
| Beschreibung: | 172 S. Ill., graph. Darst. |
Internformat
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| 041 | 0 | |a eng | |
| 049 | |a DE-384 |a DE-473 |a DE-703 |a DE-1051 |a DE-824 |a DE-29 |a DE-12 |a DE-91 |a DE-19 |a DE-1049 |a DE-92 |a DE-739 |a DE-898 |a DE-355 |a DE-706 |a DE-20 |a DE-1102 | ||
| 100 | 1 | |a Devine, Eric |d 1986- |e Verfasser |0 (DE-588)1044485906 |4 aut | |
| 245 | 1 | 0 | |a Increased removal of protein bound uremic toxins through reversible modification of the ionic strength during hemodiafiltration |c von Eric Devine |
| 246 | 1 | 3 | |a Erhöhte Elimination proteingebundener Urämietoxine durch reversible Modifikation der Ionenstärke während der Hämodiafiltration |
| 264 | 1 | |c 2013 | |
| 300 | |a 172 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Zsfassung in dt. und engl. Sprache | ||
| 502 | |a Würzburg, Univ., Diss., 2013 | ||
| 650 | 0 | 7 | |a Hämodiafiltration |0 (DE-588)7853783-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Toxin |0 (DE-588)4127018-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Ionenstärke |0 (DE-588)4273160-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Urämie |0 (DE-588)4062077-3 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Hämodiafiltration |0 (DE-588)7853783-6 |D s |
| 689 | 0 | 1 | |a Urämie |0 (DE-588)4062077-3 |D s |
| 689 | 0 | 2 | |a Toxin |0 (DE-588)4127018-6 |D s |
| 689 | 0 | 3 | |a Ionenstärke |0 (DE-588)4273160-4 |D s |
| 689 | 0 | |5 DE-604 | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |o urn:nbn:de:bvb:20-opus-83583 |
| 856 | 4 | 1 | |u https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-83583 |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026884849&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 912 | |a ebook | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-026884849 | ||
Datensatz im Suchindex
| _version_ | 1804151555482451968 |
|---|---|
| adam_text | TABLE OF CONTENTS
AFFIDAVIT 2
ACKNOWLEDGEMENTS 3
TABLE OF CONTENTS 4
LIST OF FIGURES 10
LIST OF TABLES 13
LIST OF EQUATIONS 14
SUMMARY 15
ZUSAMMENFASSUNG 16
ABBREVIATIONS 17
INTRODUCTION 19
I. RENAL
FAILURE
:
19
1) CKD STAGES 19
2) EPIDEMIOLOGY OF CHRONIC
RENAL FAILURE 20
II. UREMIC TOXINS 20
1) UREMIC TOXIN CLASSIFICATION 20
A. FREE WATER-SOLUBLE SMALL SOLUTES 21
B. PROTEIN BOUND SOLUTES 22
C. MIDDLE MOLECULES 23
2) UREMIC TOXICITY 24
A. INDOXYL SULFATE 24
B. P-CRESOL AND P-CRESYL SULFATE 24
C. PHENYL ACETIC ACID 25
III. RENAL REPLACEMENT THERAPIES 26
1) DIALYSIS THERAPIES
:
26
2) HEMODIALYZER AND HEMODIALYSIS MEMBRANES 26
3) HEMODIALYSIS IN PRACTICE 27
IV. CLINICAL CHALLENGES 27
1) INADEQUATE REMOVAL OF UREMIC TOXINS 27
2) WORSE CLINICAL OUTCOME
IN ESRD
VERSUS GENERAL POPULATION 28
3) ALBUMIN BINDING
AND IMPAIRED
DRUG BINDING
IN CKD 29
V. THE RECEPTOR-LIGAND BINDING THEORY 29
4
HTTP://D-NB.INFO/1044804440
VI. AIM OF THE STUDY 31
MATERIALS AND METHODS 32
I. MATERIALS 32
1) REAGENTS 32
A. UREMIC TOXINS 32
B. CHEMICALS 32
C. SOLUTIONS 33
D. SELF PREPARED SOLUTIONS 33
E. BIOLOGIC FLUIDS 34
2) LABORATORY EQUIPMENTS 35
3) ANALYSIS TOOLS 35
4) ANALYTICAL SOFTWARE 36
II. METHODS 37
1) STANDARD OPERATING PROCEDURES 37
A. FREE HEMOGLOBIN CONCENTRATION 37
B. HEMOLYSIS 38
C. THROMBIN-ANTITHROMBIN III 38
D. COMPLEMENT COMPONENT 5A 38
E. CELL COUNT 38
F. MEASUREMENT OF THE UREMIC TOXIN CONCENTRATION BY RP-HPLC 38
I. SAMPLE PREPARATION 38
II. MEASUREMENTS 39
G. DIALYSIS EXPERIMENTS 39
H. BLOOD SMEARS 40
2) STATISTICAL ANALYSIS 40
3) EXPERIMENTAL PART 40
A. IN VITRO UREMIC TOXIN BINDING EXPERIMENTS 40
I. EFFECT OF STORAGE CONDITIONS 40
II. UREMIC TOXIN BINDING AFFINITY IN UREMIC PLASMA 41
III. PILOT BINDING STUDIES OF IS, PCS, AND PAA IN NORMAL HUMAN PLASMA 41
IV. DETERMINATION OF THE BINDING CONSTANTS OF IS IN HSA SOLUTION 41
V. DETERMINATION OF THE BINDING CONSTANTS OF IS, PCS, AND PAA IN NORMAL
HUMAN PLASMA 41
VI. BINDING STUDIES OF IS AND
PCS IN UREMIC PLASMA 42
VII. EFFECT OF PLASMA DILUTION ON THE BINDING PROPERTIES 42
VIII. EFFECT OF THE TEMPERATURE ON THE PBF OF IS 43
IX. EFFECT OF DIFFERENT ION SPECIES ON THE PBF OF IS IN UREMIC PLASMA 43
B. DIALYSIS EXPERIMENTS IN AQUEOUS SOLUTION 44
I. STANDARD HDF - STABILITY OF IONIC STRENGTH 45
II. STANDARD HDF - EFFECT OF Q
(
*/ 45
III. STANDARD HDF - MODIFICATION OF THE DIALYSIS SETUP 45
IV. STANDARD HDF-EFFECT OF Q
B
AND Q
0
46
V. SERIAL DIALYZERS - STABILITY OF IONIC STRENGTH 46
VI. SERIAL DIALYZERS - INFLUENCE OF Q
EX
47
5
VII. SERIAL DIALYZERS WITH TRANSMEMBRANE PRE-DILUTION 48
C. EX VIVO HEMOCOMPATIBILITY OF INCREASED IONIC STRENGTH 49
I. CELL DAMAGE IN SINGLE PASS DIALYSIS 49
II. EFFECT OF BLOOD VOLUME ON HEMOLYSIS AND CELL COUNT 51
III. MAXIMIZING THE NACI CONCENTRATION IN BLOOD 51
IV. ROLE OF THE FIRST-CARTRIDGE MEMBRANE IN THE OSMOTIC SHOCK 52
V. COMPARISON BETWEEN STANDARD AND SERIAL DIALYZERS PRE-DILUTION HDF 53
VI. SERIAL DIALYZERS TRANSMEMBRANE PRE-DILUTION HDF 53
D. REMOVAL OF UREMIC TOXINS BY DIALYSIS 54
I. CLEARANCE MEASUREMENT IN A MINIATURIZED SETUP 54
II. COMPARISON OF HD, HDF, AND INCREASED IONIC STRENGTH HDF IN HEALTHY
PLASMA 55
III. REMOVAL RATES IN UREMIC AND NORMAL PLASMA USING THE MINI SETUP 56
IV. COMPLETE REMOVAL OF IS AND PCS WITH HDF 57
V. STANDARD VERSUS SERIAL HD 57
VI. TOXIN REMOVAL USING A STANDARD DIALYSIS MACHINE 58
E. EXPERIMENTAL TRANSFER INTO THE ANIMAL MODEL 60
I. RBC RESISTANCE TO INCREASED IONIC STRENGTH UNDER STATIC CONDITIONS 60
II. RBC RESISTANCE TO INCREASED IONIC STRENGTH UNDER DYNAMIC CONDITIONS
60
III. IN VIVO PRE-DILUTION HDF EXPERIMENTS 61
RESULTS S3
I. BINDING OF UREMIC TOXINS IN HUMAN BIOLOGICAL FLUIDS . 63
1) EFFECT OF STORAGE CONDITIONS 63
2) DETERMINATION OF THE UREMIC
TOXIN BINDING
AFFINITY IN UREMIC PLASMA 64
3) PILOT BINDING
STUDIES OF DIFFERENT
UREMIC TOXINS
IN NORMAL PLASMA 65
4) EFFECT OF SODIUM CHLORIDE
ON PLASMA PROTEINS 66
A. EFFECT OF NACI ON THE IS BINDING ABILITY OF HSA 66
B. EFFECT OF NACI ON THE BINDING ABILITY OF NORMAL PLASMA FOR IS, PCS,
AND PAA 67
C. EFFECT OF NACI ON THE PBF IN UREMIC PLASMA 69
5) INFLUENCE OF OTHER
PARAMETERS ON PLASMA BINDING ABILITY FOR
IS 70
A. PLASMA DILUTION 70
B. TEMPERATURE 72
C. INFLUENCE OF OTHER ION SPECIES 73
II. MODIFICATION OF THE IONIC STRENGTH IN AQUEOUS SOLUTION APPLIED ON A
DIALYSIS MACHINE 74
1) STANDARD PRE-DILUTION
HDF 75
A. IONIC STRENGTH STABILITY 75
B. INFLUENCE OF Q,*/ON THE IONIC STRENGTH _76
C. EFFECT OF Q
FL
AND Q
0
77
2) SERIAL DIALYZERS
SETUP 78
A. IONIC STRENGTH STABILITY IN PRE-DILUTION HDF 78
B. INFLUENCE OF Q
EX
78
3) SIMULATION OF THE
NACI CONCENTRATION 79
A. STANDARD PRE-DILUTION HDF 79
I. COMPARISON TO EXPERIMENTAL DATA 79
6
VII. SERIAL DIALYZERS WITH TRANSMEMBRANE PRE-DILUTION 48
C. EX VIVO HEMOCOMPATIBILITY OF INCREASED IONIC STRENGTH 49
I. CELL DAMAGE IN SINGLE PASS DIALYSIS 49
II. EFFECT OF BLOOD VOLUME ON HEMOLYSIS AND CELL COUNT 51
III. MAXIMIZING THE NACI CONCENTRATION IN BLOOD 51
IV. ROLE OF THE FIRST-CARTRIDGE MEMBRANE IN THE OSMOTIC SHOCK 52
V. COMPARISON BETWEEN STANDARD AND SERIAL DIALYZERS PRE-DILUTION HDF 53
VI. SERIAL DIALYZERS TRANSMEMBRANE PRE-DILUTION HDF 53
D. REMOVAL OF UREMIC TOXINS BY DIALYSIS 54
I. CLEARANCE MEASUREMENT IN A MINIATURIZED SETUP 54
II. COMPARISON OF HD, HDF, AND INCREASED IONIC STRENGTH HDF IN HEALTHY
PLASMA 55
III. REMOVAL RATES IN UREMIC AND NORMAL PLASMA USING THE MINI SETUP 56
IV. COMPLETE REMOVAL OF IS AND PCS WITH HDF 57
V. STANDARD VERSUS SERIAL HD , 57
VI. TOXIN REMOVAL USING A STANDARD DIALYSIS MACHINE 58
E. EXPERIMENTAL TRANSFER INTO THE ANIMAL MODEL 60
I. RBC RESISTANCE TO INCREASED IONIC STRENGTH UNDER STATIC CONDITIONS 60
II. RBC RESISTANCE TO INCREASED IONIC STRENGTH UNDER DYNAMIC CONDITIONS
60
III. IN VIVO PRE-DILUTION HDF EXPERIMENTS 61
RESULTS 63
I. BINDING OF UREMIC TOXINS IN HUMAN BIOLOGICAL FLUIDS 63
1) EFFECT OF STORAGE CONDITIONS 63
2) DETERMINATION OF THE
UREMIC TOXIN BINDING
AFFINITY IN UREMIC PLASMA 64
3) PILOT BINDING
STUDIES OF DIFFERENT UREMIC
TOXINS
IN NORMAL
PLASMA 65
4) EFFECT OF SODIUM CHLORIDE
ON PLASMA PROTEINS 66
A. EFFECT OF NACI ON THE IS BINDING ABILITY OF HSA 66
B. EFFECT OF NACI ON THE BINDING ABILITY OF NORMAL PLASMA FOR IS, PCS,
AND PAA 67
C. EFFECT OF NACI ON THE PBF IN UREMIC PLASMA 69
5) INFLUENCE OF OTHER PARAMETERS
ON PLASMA BINDING ABILITY
FOR IS 70
A. PLASMA DILUTION 70
B. TEMPERATURE 72
C. INFLUENCE OF OTHER ION SPECIES 73
II. MODIFICATION OF THE IONIC STRENGTH IN AQUEOUS SOLUTION APPLIED ON A
DIALYSIS MACHINE 74
1} STANDARD PRE-DILUTION
HDF 75
A. IONIC STRENGTH STABILITY 75
B. INFLUENCE OF Q
INF
ON THE IONIC STRENGTH 76
C. EFFECT OF Q
S
AND Q
0 77
2) SERIAL DIALYZERS SETUP 78
A. IONIC STRENGTH STABILITY IN PRE-DILUTION HDF _
7
8
B. INFLUENCE OF Q
EX 7
8
3) SIMULATION OF THE NACI CONCENTRATION 79
A. STANDARD PRE-DILUTION HDF
7
9
I. COMPARISON TO EXPERIMENTAL DATA 1
7
9
6
II. INFLUENCE OF KOA ON THE REMOVAL OF NACI EXCESS 80
B. SERIAL DIALYZERS SETUP 80
I. WITH PRE-DILUTION HDF 80
II. WITH TRANSMEMBRANE PRE-DILUTION HDF 81
III. SERIAL DIALYZERS PRE-HDF VERSUS SERIAL DIALYZERS TRANSMEMBRANE
PRE-HDF 81
III. EX VIVO HEMOCOMPATIBILITY OF INCREASED IONIC STRENGTH 82
1) CELL DAMAGE AFTER CONTACT
WITH NACI 82
A. EFFECT ON RED BLOOD CELLS 82
B. EFFECT ON WHITE BLOOD CELLS 85
2) EFFECT OF THE
BLOOD VOLUME ON THE EX VIVO RESULTS 85
3) MAXIMAL NACI
CONCENTRATION IN BLOOD 88
4) ROLE OF THE
SEMI-PERMEABLE MEMBRANE IN THE OSMOTIC SHOCK 89
5) COMPARATIVE EX VIVO HEMOCOMPATIBILITY 92
A. STANDARD VERSUS SERIAL DIALYZERS PRE-DILUTION HDF 92
B. SERIAL DIALYZERS PRE-DILUTION HDF VERSUS SERIAL DIALYZERS
TRANSMEMBRANE PRE-DILUTION HDF 97
IV. IN VITRO TOXIN REMOVAL WITH NACI DIALYSIS 99
1) MINI-DIALYZER MODEL 99
A. EFFECT OF PLASMA PROTEINS ON THE INSTANTANEOUS CLEARANCE 99
B. COMPARISON OF HD, HDF, AND HDF WITH NACI USING NORMAL PLASMA 100
C. REMOVAL RATES IN UREMIC AND NORMAL PLASMA 101
D. COMPLETE REMOVAL OF IS AND PCS WITH HDF 102
E. SINGLE- VERSUS SERIAL-HEMODIALYSIS 103
2) COMPARATIVE TOXIN
REMOVAL WITH
THE DIALYSIS
MACHINE 104
V. ANIMAL MODEL 105
1) OVINE RBC RESISTANCE TO INCREASED IONIC STRENGTH 105
A. RESISTANCE UNDER STATIC CONDITIONS 105
B. RESISTANCE UNDER DYNAMIC CONDITIONS 105
2) IN VIVO DIALYSIS EXPERIMENTS 106
DISCUSSION 114
I. REDUCING THE PROTEIN BINDING OF UREMIC TOXINS 115
1) VALIDATION OF FROZEN
PLASMA 115
2) NACI DECREASES THE
PROTEIN BINDING
OF UREMIC TOXINS 116
A. CONCEPT VALIDATION IN PILOT EXPERIMENTS 116
B. BINDING OF IS TO HSA 117
C. BINDING OF IS, PCS, AND PAA IN NORMAL HUMAN PLASMA 118
D. COMPARISON OF THE PBF IN NORMAL AND UREMIC PLASMA 119
E. ESTIMATION OF
K
0
IN UREMIC PLASMA 119
F. CUMULATIVE EFFECT OF PLASMA DILUTION 121
G. CUMULATIVE EFFECT OF THE TEMPERATURE 121
H. INFLUENCE OF IONS AND PH 121
7
II. MODIFICATION OF PRE-DILUTION HDF FOR INCREASED IONIC STRENGTH 122
1) PILOT EXPERIMENTATION OF INCREASED IONIC STRENGTH
DURING STANDARD
PRE-DILUTION
HDF 123
2) TOXIN REMOVAL
INCREASED WITH
HIGHER IONIC STRENGTH 124
3) EX VIVO HEMOCOMPATIBILITY OF INCREASED
IONIC STRENGTH 125
A. SINGLE CONTACT EXPERIMENTS 125
B. EXPERIMENTS ON A DIALYSIS MACHINE AND UNDER DYNAMIC CONDITIONS 127
III. ITERATED APPLICATION OF INCREASED IONIC STRENGTH BY SERIAL
DIALYZERS HD / HDF 129
1) CONTROL OF THE
NACI CONCENTRATION
IN AQUEOUS SOLUTION 130
2) EX VIVO HEMOCOMPATIBILITY IN DYNAMIC CONDITIONS 130
3) TOXIN REMOVAL
EFFICACY 132
IV. TRANSFER OF INCREASED IONIC STRENGTH HDF TO THE ANIMAL MODEL 135
1) VALIDATION OF THE
ANIMAL MODEL 135
2) FEASIBILITY OF INCREASED
IONIC STRENGTH HDF 135
CONCLUSION 139
APPENDIX 141
I. ADDITIONAL THEORETICAL ASPECTS 141
II. INTEREST OF CALCULATING THE BLOOD RUNS THROUGH THE DIALYZER 144
III. DETERMINATION OF THE BINDING CONSTANTS K
D
AND B
M
145
1) OF HEALTHY
PLASMA FOR PAA 145
2) OF UREMIC PLASMA FOR IS AND
PCS 146
3) EFFECT OF DILUTION
ON THE
BINDING ABILITY OF PLASMA FOR IS 147
IV. SIMULATION OF INCREASED IONIC STRENGTH IN AQUEOUS SOLUTION ON A
DIALYSIS MACHINE 147
1) DEFINITIONS AND NOTATIONS 147
2) ALGORITHM ; 148
A. STANDARD PRE-DILUTION HDF WITH THE BELLCO DIALYSIS MACHINE 148
I. WORKING HYPOTHESES 148
II. EQUATIONS_ 149
B. STANDARD PRE-DILUTION HDF WITH THE NIKKISO DIALYSIS MACHINE 150
I. WORKING HYPOTHESES . 150
II. EQUATIONS 151
C. SERIAL DIALYZERS SETUP IN PRE-DILUTION HDF 152
I. WORKING HYPOTHESES 152
II. EQUATIONS 153
D. SERIAL DIALYZERS SETUP WITH TRANSMEMBRANE PRE-DILUTION HDF 154
I. WORKING HYPOTHESES 154
II. EQUATIONS 155
8
REFERENCES 158
PUBLICATIONS 170
CURRICULUM VITAE 171
9
|
| any_adam_object | 1 |
| author | Devine, Eric 1986- |
| author_GND | (DE-588)1044485906 |
| author_facet | Devine, Eric 1986- |
| author_role | aut |
| author_sort | Devine, Eric 1986- |
| author_variant | e d ed |
| building | Verbundindex |
| bvnumber | BV041438029 |
| collection | ebook |
| ctrlnum | (OCoLC)864626699 (DE-599)BVBBV041438029 |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV041438029 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:56:41Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-026884849 |
| oclc_num | 864626699 |
| open_access_boolean | 1 |
| owner | DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 |
| owner_facet | DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 |
| physical | 172 S. Ill., graph. Darst. |
| psigel | ebook |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| record_format | marc |
| spelling | Devine, Eric 1986- Verfasser (DE-588)1044485906 aut Increased removal of protein bound uremic toxins through reversible modification of the ionic strength during hemodiafiltration von Eric Devine Erhöhte Elimination proteingebundener Urämietoxine durch reversible Modifikation der Ionenstärke während der Hämodiafiltration 2013 172 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zsfassung in dt. und engl. Sprache Würzburg, Univ., Diss., 2013 Hämodiafiltration (DE-588)7853783-6 gnd rswk-swf Toxin (DE-588)4127018-6 gnd rswk-swf Ionenstärke (DE-588)4273160-4 gnd rswk-swf Urämie (DE-588)4062077-3 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Hämodiafiltration (DE-588)7853783-6 s Urämie (DE-588)4062077-3 s Toxin (DE-588)4127018-6 s Ionenstärke (DE-588)4273160-4 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-83583 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-83583 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026884849&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Devine, Eric 1986- Increased removal of protein bound uremic toxins through reversible modification of the ionic strength during hemodiafiltration Hämodiafiltration (DE-588)7853783-6 gnd Toxin (DE-588)4127018-6 gnd Ionenstärke (DE-588)4273160-4 gnd Urämie (DE-588)4062077-3 gnd |
| subject_GND | (DE-588)7853783-6 (DE-588)4127018-6 (DE-588)4273160-4 (DE-588)4062077-3 (DE-588)4113937-9 |
| title | Increased removal of protein bound uremic toxins through reversible modification of the ionic strength during hemodiafiltration |
| title_alt | Erhöhte Elimination proteingebundener Urämietoxine durch reversible Modifikation der Ionenstärke während der Hämodiafiltration |
| title_auth | Increased removal of protein bound uremic toxins through reversible modification of the ionic strength during hemodiafiltration |
| title_exact_search | Increased removal of protein bound uremic toxins through reversible modification of the ionic strength during hemodiafiltration |
| title_full | Increased removal of protein bound uremic toxins through reversible modification of the ionic strength during hemodiafiltration von Eric Devine |
| title_fullStr | Increased removal of protein bound uremic toxins through reversible modification of the ionic strength during hemodiafiltration von Eric Devine |
| title_full_unstemmed | Increased removal of protein bound uremic toxins through reversible modification of the ionic strength during hemodiafiltration von Eric Devine |
| title_short | Increased removal of protein bound uremic toxins through reversible modification of the ionic strength during hemodiafiltration |
| title_sort | increased removal of protein bound uremic toxins through reversible modification of the ionic strength during hemodiafiltration |
| topic | Hämodiafiltration (DE-588)7853783-6 gnd Toxin (DE-588)4127018-6 gnd Ionenstärke (DE-588)4273160-4 gnd Urämie (DE-588)4062077-3 gnd |
| topic_facet | Hämodiafiltration Toxin Ionenstärke Urämie Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-83583 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026884849&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT devineeric increasedremovalofproteinbounduremictoxinsthroughreversiblemodificationoftheionicstrengthduringhemodiafiltration AT devineeric erhohteeliminationproteingebundeneruramietoxinedurchreversiblemodifikationderionenstarkewahrendderhamodiafiltration |