Predictive toxicology in drug safety:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge [u.a.]
Cambridge Univ. Press
2011
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 389 S. Ill., graph. Darst. 26 cm |
| ISBN: | 9780521763646 0521763649 |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1804151534064238592 |
|---|---|
| adam_text | Titel: Predictive toxicology in drug safety
Autor: Xu, Jinghai J
Jahr: 2011
Contents
Contributors
page
vii
Prologue
-
Predictive
toxicology:
a
new
chapter
in
drug
safety
evaluation
xi
Jinghai
J.
Xu
and
Laszlo
Urban
I:
SPECIFIC
AREAS
OF
PREDICTIVE
TOXICOLOGY
1
The
human
predictive
value
of
combined
animal
toxicity
testing:
current
state
and
emerging
approaches
Harry
M.
Olson
and
Thomas
S.
Davies
2
Screening
approaches
for
genetic
toxicity
Jiri
Aubrecht
and
Jinghai
J.
Xu
3
Cardiac
safety
Martin
Traebert
and
Berengere
Dumotier
4
Predicting
drug-induced
liver
injury:
safer
patients
or
safer
drugs?
Jinghai
J.
Xu
5
In
vitro
evaluation
of
metabolic
drug-drug
interactions
Albert
P.
Li
6
Reliability
of
reactive
metabolite
and
covalent
binding
assessments
in
prediction
of
idiosyncratic
drug
toxicity
Amit
S.
Kalgutkar
7
Immunotoxicity:
technologies
for
predicting
immune
stimulation,
a
focus
on
nucleic
acids
and
haptens
Jbrg
Vollmer
8
Predictive
models
for
neurotoxicity
assessment
Lucio
C.
Costa,
Gennaro
Giordano,
and
Marina
Guizzetti
9
De-risking
developmental
toxicity-mediated
drug
attrition
in
the
pharmaceutical
industry
Terence
R.
S.
Ozolins
II:
INTEGRATED
APPROACHES
OF
PREDICTIVE
TOXICOLOGY
10
Integrated
approaches
to
lead
optimization:
improving
the
therapeutic
index
183
Laszlo
Urban,
Jianling
Wang,
Dejan
Bojanic,
and
Susan
Ward
v
1
18
34
54
76
102
124
135
153
vi
Contents
11
Predictive
toxicology
approaches
for
small
molecule
oncology
drugs
204
Timothy
J.
Maziasz,
Vivek
J.
Kadambi,
and
Carl
L.
Alden
12
Mechanism-based
toxicity
studies
for
drug
development
230
Monicah
A.
Otieno
and
Lois
D.
Lehman-McKeeman
13
Fish
embryos
as
alternative
models
for
drug
safety
evaluation
244
Stefan
Scholz,
Anita
Buttner,
Nils
Kluver,
and
Joaquin
Guinea
14
The
role
of
genetically
modified
mouse
models
in
predictive
toxicology
269
Glenn
H.
Cantor
15
Toxicogenomic
and
pathway
analysis
284
Bin
Lu,
Ying
Jiang,
and
Chester
Ni
16
Drug
safety
biomarkers
302
David
Gerhold
and
Frank
D.
Sistare
17
Application
of
TK/PD
modeling
in
predicting
dose-limiting
toxicity
314
Li
J.
Yu,
Lee
Silverman,
Carl
L.
Alden,
Guohui
Liu,
Shimoga
Prakash,
and
Frank
Lee
18
Prediction
of
therapeutic
index
of
antibody-based
therapeutics:
mathematical
modeling
approaches
330
Kapil
Mayawala
and
Bruce
Gomes
19
Vaccine
toxicology:
nonclinical
predictive
strategies
344
Sarah
Gould
and
Raymond
Oomen
Epilogue
371
Index
375
Color
plates
follow
page
370.
|
| any_adam_object | 1 |
| author_GND | (DE-588)14308058X |
| building | Verbundindex |
| bvnumber | BV041418511 |
| classification_rvk | VS 5360 |
| ctrlnum | (OCoLC)731645223 (DE-599)BVBBV041418511 |
| dewey-full | 615.704 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.704 |
| dewey-search | 615.704 |
| dewey-sort | 3615.704 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
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| id | DE-604.BV041418511 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:56:20Z |
| institution | BVB |
| isbn | 9780521763646 0521763649 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-026865639 |
| oclc_num | 731645223 |
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| physical | XII, 389 S. Ill., graph. Darst. 26 cm |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Cambridge Univ. Press |
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| spelling | Predictive toxicology in drug safety ed. by Jinghai J. Xu ; Laszlo Urban Cambridge [u.a.] Cambridge Univ. Press 2011 XII, 389 S. Ill., graph. Darst. 26 cm txt rdacontent n rdamedia nc rdacarrier Drug Toxicity Drug Discovery Toxicity Tests Toxikologische Bewertung (DE-588)4303356-8 gnd rswk-swf Arzneimittelsicherheit (DE-588)4143182-0 gnd rswk-swf Arzneimittelnebenwirkung (DE-588)4003134-2 gnd rswk-swf Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf Arzneimittelentwicklung (DE-588)4143176-5 s Arzneimittelsicherheit (DE-588)4143182-0 s Toxikologische Bewertung (DE-588)4303356-8 s Arzneimittelnebenwirkung (DE-588)4003134-2 s UBWSCK Xu, Jinghai J. Sonstige oth Urban, Laszlo 1951- Sonstige (DE-588)14308058X oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026865639&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Predictive toxicology in drug safety Drug Toxicity Drug Discovery Toxicity Tests Toxikologische Bewertung (DE-588)4303356-8 gnd Arzneimittelsicherheit (DE-588)4143182-0 gnd Arzneimittelnebenwirkung (DE-588)4003134-2 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| subject_GND | (DE-588)4303356-8 (DE-588)4143182-0 (DE-588)4003134-2 (DE-588)4143176-5 |
| title | Predictive toxicology in drug safety |
| title_auth | Predictive toxicology in drug safety |
| title_exact_search | Predictive toxicology in drug safety |
| title_full | Predictive toxicology in drug safety ed. by Jinghai J. Xu ; Laszlo Urban |
| title_fullStr | Predictive toxicology in drug safety ed. by Jinghai J. Xu ; Laszlo Urban |
| title_full_unstemmed | Predictive toxicology in drug safety ed. by Jinghai J. Xu ; Laszlo Urban |
| title_short | Predictive toxicology in drug safety |
| title_sort | predictive toxicology in drug safety |
| topic | Drug Toxicity Drug Discovery Toxicity Tests Toxikologische Bewertung (DE-588)4303356-8 gnd Arzneimittelsicherheit (DE-588)4143182-0 gnd Arzneimittelnebenwirkung (DE-588)4003134-2 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| topic_facet | Drug Toxicity Drug Discovery Toxicity Tests Toxikologische Bewertung Arzneimittelsicherheit Arzneimittelnebenwirkung Arzneimittelentwicklung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026865639&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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