The human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131017-1170163-0-5 Inhaltsverzeichnis |
| Beschreibung: | V, 100 Bl. |
Internformat
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| 100 | 1 | |a Krug, Susanne |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a The human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2 |c Susanne Gabriele Krug |
| 264 | 1 | |c 2013 | |
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Datensatz im Suchindex
| _version_ | 1804151513470205952 |
|---|---|
| adam_text | CONTENTS
ACKNOWLEDGEMENT I
ABSTRACT II
ZUSAMMENFASSUNG ILL
CONTENTS IV
1 INTRODUCTION 1
2 DYNAMICS OF THE HUMAN METABOLOME 5
2.1 INTRODUCTION 5
2.2 RESEARCH DESIGN AND METHODS 7
2.2.1 STUDY PARTICIPANTS AND STUDY DESIGN 7
2.2.2 SAMPLE COLLECTION 10
2.2.3 STANDARD BIOCHEMISTRY PARAMETERS 11
2.2.4 METABOLOMICS ANALYSES 12
2.2.5 STATISTICAL ANALYSIS 14
2.2.6 MATHEMATICAL MODELING OF FATTY ACID P-OXIDATION 15
2.3 RESULTS 17
2.3.1 TIME DEPENDENT METABOLITE CHANGES REFLECT THE METABOLIC CONDITIONS
INDUCED BY THE
CHALLENGES 17
2.3.2 METABOLITE CORRELATIONS 29
2.3.3 METABOLITES TO CLASSIFY THE METABOLIC CONDITION 31
2.3.4 INTER-INDIVIDUAL METABOLITE VARIATION DURING CHALLENGES 32
2.3.5 READ-OUTS FROM A IS-OXIDATION MODEL PROVIDE STRONGER ASSOCIATIONS
WITH PHENOTYPIC
DATA THAN ABSOLUTE METABOLITE CONCENTRATIONS 35
2.4 DISCUSSION 38
2.5 CONCLUSION 42
IV
HTTP://D-NB.INFO/1047561670
3 THE IMPACT OF TWO COMMON GENETIC VARIANTS ON METABOLITE RESPONSE TO
NUTRITIONAL INTERVENTIONS 44
3.1 INTRODUCTION I 44
3.2 RESEARCH DESIGN AND METHODS 45
3.2.1 STUDY PARTICIPANTS AND STUDY DESIGN 45
3.2.2 BIOCHEMICAL ANALYSES 49
3.2.3 METABOLOMICS ANALYSES 49
3.2.4 STATISTICAL ANALYSIS 50
3.3 THE IMPACT OF A COMMON FTO GENE VARIANT ON PLASMA METABOLITE
PROFILES DURING
NUTRITIONAL CHALLENGES 51
3.3.1 FTO
- FAT MASS AND OBESITY ASSOCIATED GENE 51
3.3.2 RESULTS 53
3.3.2.1 GENOTYPE-SPECIFIC DIFFERENCES IN BASELINE MEASURES 53
3.3.2.2 GENOTYPE-SPECIFIC DIFFERENCES IN CHALLENGE-INDUCED METABOLITE
DYNAMICS 54
3.3.3 DISCUSSION 59
3.3.4 CONCLUSION 64
3.4 THE IMPACT OF THE T RISK VARIANT IN RS7903146 OF THE TCF7L2 GENE ON
PLASMA METABOLITE
PROFILES DURING NUTRITIONAL CHALLENGES 65
3.4.1 TRANSCRIPTION FACTOR 7 LIKE 2 - TCF7L2 65
3.4.2 RESULTS 67
3.4.2.1 GENOTYPE-SPECIFIC DIFFERENCES IN BASELINE MEASURES 67
3.4.2.2 GENOTYPE-SPECIFIC DIFFERENCES IN CHALLENGE-INDUCED METABOLITE
DYNAMICS 70
3.4.3 DISCUSSION 75
3.4.4 CONCLUSION 81
LIST OF FIGURES 82
LIST OF TABLES 84
ABBREVIATIONS 85
REFERENCES 88
PUBLICATIONS AND PRESENTATIONS 98
CURRICULUM VITAE 100
V
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| any_adam_object | 1 |
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| discipline | Biologie Chemie Medizin Ökotrophologie |
| format | Thesis Book |
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| spelling | Krug, Susanne Verfasser aut The human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2 Susanne Gabriele Krug 2013 V, 100 Bl. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2013 Zsfassung in dt. Sprache (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20131017-1170163-0-5 http://mediatum.ub.tum.de/node?id=1170163 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131017-1170163-0-5 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026852986&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Krug, Susanne The human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2 |
| subject_GND | (DE-588)4113937-9 |
| title | The human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2 |
| title_auth | The human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2 |
| title_exact_search | The human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2 |
| title_full | The human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2 Susanne Gabriele Krug |
| title_fullStr | The human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2 Susanne Gabriele Krug |
| title_full_unstemmed | The human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2 Susanne Gabriele Krug |
| title_short | The human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2 |
| title_sort | the human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2 |
| topic_facet | Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1170163 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131017-1170163-0-5 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026852986&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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