The PD-1/B7-H1 Pathway in a Transgenic Mouse Model for Spontaneous Autoimmune Neuroinflammation: Immunological Studies on Devic B7-H1-/- Mice:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Volltext Inhaltsverzeichnis |
| Beschreibung: | Zsfassung in dt. und engl. Sprache |
| Beschreibung: | 109 Bl. Ill. |
Internformat
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| 245 | 1 | 0 | |a The PD-1/B7-H1 Pathway in a Transgenic Mouse Model for Spontaneous Autoimmune Neuroinflammation: Immunological Studies on Devic B7-H1-/- Mice |c von Angela Dreykluft |
| 246 | 1 | 3 | |a Der PD-1/B7-H1 Signalweg in einem transgenen Mausmodell für spontane autoimmune Neuroinflammation: Immunologische Studien an Devic B7-H1-/- Mäusen |
| 264 | 1 | |c 2013 | |
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| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Zsfassung in dt. und engl. Sprache | ||
| 502 | |a Würzburg, Univ., Diss., 2013 | ||
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| 912 | |a ebook | ||
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Datensatz im Suchindex
| _version_ | 1804151479275094016 |
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| adam_text | TABLE OF CONTENT
TABLE OF CONTENT
1 SUMMARY 4
2 ZUSAMMENFASSUNG 7
3 INTRODUCTION 10
3.1 THE IMMUNE SYSTEM: PROTECTION AND MENACE 10
3.1.1 MULTIPLE SCLEROSIS: AUTOIMMUNE ATTACK OF THE CENTRAL NERVOUS
SYSTEM... 11
3.1.2 NEUROMYELITIS OPTICA/DEVIC S DISEASE: ANOTHER DEMYELINATING
DISORDER 12
3.1.3 EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS: STUDYING MULTIPLE
SCLEROSIS 13
3.1.4 THE DEVIC MOUSE: A TRANSGENIC MOUSE MODEL FOR SPONTANEOUS
AUTOIMMUNE NEUROINFLAMMATION 14
3.2 T-CELLS IN AUTOIMMUNITY 16
3.2.1 A REVISED T-CELL REPERTOIRE: FROM THE THYMUS TO THE PERIPHERY 16
* 3.2.2 CD4
+
T HELPER SUBSETS IN AUTOIMMUNITY 19
3.2.3 AUTOIMMUNE RESPONSES IN THE PATHOGENESIS OF MS AND EAE 22
3.3 CO-SIGNALING IN T-CELL ACTIVATION 26
3.3.1 CO-SIGNALING MOLECULES OF THE B7 AND CD28 FAMILIES 26
3.3.2 THE PROGRAMMED DEATH-1 RECEPTOR AND ITS LIGANDS 27
3.3.3 THE PD-1/B7-H1 PATHWAY IN AUTOIMMUNITY 30
4 OBJECTIVES 34
5 MATERIAL AND METHODS 35
5.1 MATERIAL 35
5.1.1 CHEMICAL 35
5.1.2 BIOCHEMICALS, MEDIA AND SUPPLEMENTS 36
5.1.3 KITS 36
5.1.4 CELL CULTURE MEDIA 37
5.1.5 BUFFERS AND SOLUTIONS 37
5.1.6 PCR PRIMERS FOR GENOTYPING 39
5.1.7 ANTIBODIES FOR FLOW CYTOMETRY 40
5.1.8 ANTIBODIES FOR HISTOLOGY 41
5.1.9 CONSUMABLES 41
5.1.10 LABORATORY EQUIPMENT AND INSTRUMENTS 42
5.1.11 SOFTWARE 44
5.2 ANIMALS AND BIOASSAYS 44
5.2.1 EXPERIMENTAL ANIMALS 44
5.2.2 GENOTYPING OF MICE 44
5.2.3 SERUM COLLECTION 46
5.2.4 SPONTANEOUS EAE MODEL: DEVIC MICE 46
5.2.5 ADOPTIVE TRANSFER EXPERIMENTS 46
5.3 CELL BIOLOGICAL METHODS 47
5.3.1 CELL CULTURE 47
5.3.2 CELL COUNTING 47
5.3.3 PREPARATION OF SINGLE-CELL SUSPENSIONS FROM PERIPHERAL ORGANS 47
5.3.4 ISOLATION OF MONONUCLEAR LEUKOCYTES FROM THE CNS 48
5.4 IN VITRO ASSAYS 48
HTTP://D-NB.INFO/1043948481
TABLE OF CONTENT
5.4.1 PROLIFERATION ASSAY 48
5.4.2 RESTIMULATION ASSAY: ANTIGEN-DEPENDENT CYTOKINE PRODUCTION 50
5.4.3 IN VITRO SURVIVAL ASSAY 50
5.4.4 IN VITRO MIGRATION ASSAY 51
5.5 FLOW CYTOMETRY 51
5.5.1 STAINING OF CELL SURFACE MOLECULES 51
5.5.2 STAINING OF INTRACELLULAR COMPONENTS 52
5.5.3 CYTOMETRIC BEAD ARRAY 53
5.6 ELISA (ENZYME-LINKED IMMUNOSORBENT ASSAY) 53
5.7 IMMUNOHISTOCHEMISTRY 54
5.8 STATISTICAL ANALYSIS 55
6 RESULTS 56
6.1 CLINICAL FEATURES OF DEVIC B7-H1
+/+
AND DEVIC B7-H1
7
MICE 56
6.1.1 ACCELERATED AND AGGRAVATED COURSE OF SPONTANEOUS EAE-LIKE DISEASE
IN DEVIC B7-H1 MICE 56
6.1.2 ENHANCED ACCUMULATION OF CD4
+
T CELLS AND MACROPHAGES IN SPINAL
CORD LESIONS OF SICK DEVIC B7-H1 MICE 57
6.2 IMMUNE RESPONSES IN DEVIC B7-H1
+/+
AND DEVIC
B7-HL~
/
~ MICE 59
6.2.1 ENHANCED ACCUMULATION AND ACTIVATION OF VA3.2
+
VPI 1
+
CD4
+
T CELLS
IN THE CNS OF SICK DEVIC B7-H1 MICE 59
6.2.2 ENHANCED ANTIGEN-SPECIFIC THL AND THL 7 RESPONSES OF CNS-
INFILTRATING CD4
+
T CELLS IN DEVIC B7-H1
7
MICE 61
6.2.3 UNAFFECTED PHENOTYPES OF PERIPHERAL LYMPHOCYTES IN DEVIC B7-H1
7
MICE AT DISEASE MAXIMUM 62
6.2.4 INDIFFERENT LEVELS OF MOG-SPECIFIC AUTOANTIBODIES IN DEVIC B7-H1
7
MICE 64
6.2.5 UNAFFECTED CYTOKINE SECRETION PATTERN OF DEVIC B7-H1
/
SPLENOCYTES 64
6.2.6 ENHANCED ACCUMULATION OF VA3.2
+
VPI 1
+
CD4
+
T CELLS IN SECONDARY
LYMPHOID ORGANS OF SICK DEVIC B7-HL
/
MICE 65
6.2.7 INCREASED THYMIC CELLULARITIES IN DEVIC B7-H1
/
MICE 66
6.2.8 ELEVATED ANTIGEN-INDUCED PROLIFERATION OF DEVIC B7-H1
SPLENOCYTES 67
6.2.9 HINT ON MODIFIED SURVIVAL CAPACITIES OF DEVIC B7-H1
7
LYMPHOCYTES 69
6.2.10 UNALTERED IN VITRO MIGRATORY BEHAVIOR OF VA3.2
+
VPI 1
+
B7-H1
7
T CELLS.. 70
6.2.11 UNALTERED IN VIVO MIGRATORY BEHAVIOR OF VA3.2
+
V(311
+
B7-H1
7
T CELLS... 71
6.2.12 AMPLIFIED THL RESPONSE OF DEVIC B7-H1 SPLENOCYTES IN THE
PRECLINICAL PHASE 75
6.2.13 HIGHER EXPRESSION OF LFA-1 ON PERIPHERAL CD4
+
T CELLS IN DEVIC B7-
HL
7
MICE IN THE PRECLINICAL PHASE 75
7 DISCUSSION 77
8 ABBREVIATION DIRECTORY 86
9 REFERENCES 89
10 DECLARATION 104
11 ACKNOWLEDGMENTS 105
12 CURRICULUM VITAE 107
13 PUBLICATIONS 108
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| spelling | Dreykluft, Angela 1980- Verfasser (DE-588)1043447423 aut The PD-1/B7-H1 Pathway in a Transgenic Mouse Model for Spontaneous Autoimmune Neuroinflammation: Immunological Studies on Devic B7-H1-/- Mice von Angela Dreykluft Der PD-1/B7-H1 Signalweg in einem transgenen Mausmodell für spontane autoimmune Neuroinflammation: Immunologische Studien an Devic B7-H1-/- Mäusen 2013 109 Bl. Ill. txt rdacontent n rdamedia nc rdacarrier Zsfassung in dt. und engl. Sprache Würzburg, Univ., Diss., 2013 Autoimmunität (DE-588)4319435-7 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Maus (DE-588)4169148-9 gnd rswk-swf Zentralnervensystem (DE-588)4067637-7 gnd rswk-swf Entzündung (DE-588)4014975-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Maus (DE-588)4169148-9 s Autoimmunität (DE-588)4319435-7 s Zentralnervensystem (DE-588)4067637-7 s Entzündung (DE-588)4014975-4 s Signaltransduktion (DE-588)4318717-1 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-83288 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-83288 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026830557&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dreykluft, Angela 1980- The PD-1/B7-H1 Pathway in a Transgenic Mouse Model for Spontaneous Autoimmune Neuroinflammation: Immunological Studies on Devic B7-H1-/- Mice Autoimmunität (DE-588)4319435-7 gnd Signaltransduktion (DE-588)4318717-1 gnd Maus (DE-588)4169148-9 gnd Zentralnervensystem (DE-588)4067637-7 gnd Entzündung (DE-588)4014975-4 gnd |
| subject_GND | (DE-588)4319435-7 (DE-588)4318717-1 (DE-588)4169148-9 (DE-588)4067637-7 (DE-588)4014975-4 (DE-588)4113937-9 |
| title | The PD-1/B7-H1 Pathway in a Transgenic Mouse Model for Spontaneous Autoimmune Neuroinflammation: Immunological Studies on Devic B7-H1-/- Mice |
| title_alt | Der PD-1/B7-H1 Signalweg in einem transgenen Mausmodell für spontane autoimmune Neuroinflammation: Immunologische Studien an Devic B7-H1-/- Mäusen |
| title_auth | The PD-1/B7-H1 Pathway in a Transgenic Mouse Model for Spontaneous Autoimmune Neuroinflammation: Immunological Studies on Devic B7-H1-/- Mice |
| title_exact_search | The PD-1/B7-H1 Pathway in a Transgenic Mouse Model for Spontaneous Autoimmune Neuroinflammation: Immunological Studies on Devic B7-H1-/- Mice |
| title_full | The PD-1/B7-H1 Pathway in a Transgenic Mouse Model for Spontaneous Autoimmune Neuroinflammation: Immunological Studies on Devic B7-H1-/- Mice von Angela Dreykluft |
| title_fullStr | The PD-1/B7-H1 Pathway in a Transgenic Mouse Model for Spontaneous Autoimmune Neuroinflammation: Immunological Studies on Devic B7-H1-/- Mice von Angela Dreykluft |
| title_full_unstemmed | The PD-1/B7-H1 Pathway in a Transgenic Mouse Model for Spontaneous Autoimmune Neuroinflammation: Immunological Studies on Devic B7-H1-/- Mice von Angela Dreykluft |
| title_short | The PD-1/B7-H1 Pathway in a Transgenic Mouse Model for Spontaneous Autoimmune Neuroinflammation: Immunological Studies on Devic B7-H1-/- Mice |
| title_sort | the pd 1 b7 h1 pathway in a transgenic mouse model for spontaneous autoimmune neuroinflammation immunological studies on devic b7 h1 mice |
| topic | Autoimmunität (DE-588)4319435-7 gnd Signaltransduktion (DE-588)4318717-1 gnd Maus (DE-588)4169148-9 gnd Zentralnervensystem (DE-588)4067637-7 gnd Entzündung (DE-588)4014975-4 gnd |
| topic_facet | Autoimmunität Signaltransduktion Maus Zentralnervensystem Entzündung Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-83288 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026830557&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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