Transcriptional regulation of cancer genes in the Xiphophorus melanoma system:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
|
| Schlagworte: | |
| Online-Zugang: | Volltext Inhaltsverzeichnis |
| Beschreibung: | Zsfassung in dt. und engl. Sprache |
| Beschreibung: | 104 Bl. Ill., graph. Darst. |
Internformat
MARC
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| 245 | 1 | 0 | |a Transcriptional regulation of cancer genes in the Xiphophorus melanoma system |c von Janine Regneri |
| 246 | 1 | 3 | |a Transkriptionelle Regulation von Krebsgenen im Xiphophorus-Melanommodell |
| 264 | 1 | |c 2013 | |
| 300 | |a 104 Bl. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
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|---|---|
| adam_text | TABLE OF CONTENTS
ABSTRACT 1
ZUSAMMENFASSUNG 3
INTRODUCTION 5
THE
XIPHOPHORUS
MELANOMA MODEL 5
THE
XMRK
ONCOGENE 7
ACTIVATING MUTATIONS IN THE XMRK RECEPTOR 7
ONCOGENIC SIGNALING OF XMRK 8
CONTROL OF
XMRK
EXPRESSION 9
GENOMIC ORGANIZATION OF THE
TU
LOCUS 11
DIFFERENT
MDL-XMRK
ALLELE COMBINATIONS 12
THE
R
LOCUS 14
AIM OF THE THESIS 16
MATERIALS AND METHODS 17
CELL CULTURE 17
EXPERIMENTAL ANIMALS 17
RNA ISOLATION, REVERSE TRANSCRIPTION AND EXPRESSION ANALYSIS 19
PROTEIN ISOLATION AND WESTERN BLOT ANALYSIS 21
GENERATION OF BAC REPORTER CONSTRUCTS 22
LUCIFERASE ASSAY 25
PREPARATION OF GDNA, PCR AND SEQUENCING 25
PHYLOGENETIC ANALYSIS 27
COMPARATIVE ANALYSIS OF GENOMIC
SEQUENCES 27
RESULTS 28
ANALYSIS OF THE TRANSCRIPTIONAL REGULATION OF DIFFERENT
MDL-XMRK
ALLELE COMBINATIONS 28
EXPRESSION OF THE PROTO-ONCOGENE
EGFRB
IN ADULT TISSUES OF
X.
MACULATUS
AND
X. HELLERII
28
EXPRESSION OF THE TUMORIGENIC
MDF^-XMRLP
ALLELE 30
EXPRESSION OF THE PROTO-ONCOGENE
EGFRB
IN
XMRK^
-EXPRESSING TISSUES OF THE BLACK PIGMENT
CELL LINEAGE 35
HTTP://D-NB.INFO/1044050306
EXPRESSION OF THE NON-TUMORIGENIC
MDF
R
-XMRLF
ALLELE 36
EXPRESSION OF SR AND DRLI (MUT) MUTANT ALLELES 39
COMPARISON OF
MDF
R
-XMRLF
AND
MDF
D
-XMRLF
EXPRESSION IN GILLS OF
X.
MACULATUS
AND
BACKCROSS HYBRIDS 41
STRUCTURAL ANALYSIS OF THE PROXIMAL 5 REGION OF DIFFERENT
MDL-XMRK
ALLELES 42
COMPARATIVE STRUCTURAL ANALYSIS OF THE
MDF
R
-XMR D
AND
MDF
D
-XMRLP
GENOMIC REGIONS .. 43
TRANSCRIPTIONAL ACTIVITY OF
MDF
R
-XMRLD
AND
MDF
D
-XMR P
REPORTER CONSTRUCTS 48
ANALYSIS OF A DELETION SERIES
OF THE
MDF
D
-XMRLP
REPORTER CONSTRUCT 51
ANALYSIS OF CANDIDATES FOR THE
R
LOCUS-ENCODED GENE 54
MTAP
55
PDCD4A
57
CXXC4 58
CDKN2AB
59
DISCUSSION 63
TRANSCRIPTIONAL REGULATION OF
MDL-XMRK
ALLELE COMBINATIONS 63
FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF THE PUTATIVE
XMRK
PROMOTER REGION 70
ANALYSIS OF
R
LOCUS CANDIDATE GENES 75
PERSPECTIVES 80
APPENDIX 81
BIBLIOGRAPHY 94
ACKNOWLEDGMENTS 104
|
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| ctrlnum | (OCoLC)862848041 (DE-599)BVBBV041382471 |
| discipline | Medizin |
| format | Thesis Book |
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| spelling | Regneri, Janine Verfasser (DE-588)1043446079 aut Transcriptional regulation of cancer genes in the Xiphophorus melanoma system von Janine Regneri Transkriptionelle Regulation von Krebsgenen im Xiphophorus-Melanommodell 2013 104 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zsfassung in dt. und engl. Sprache Würzburg, Univ., Diss., 2013 Chromatophor (DE-588)4147957-9 gnd rswk-swf Epidermaler Wachstumsfaktor (DE-588)4271160-5 gnd rswk-swf Melanom (DE-588)4074707-4 gnd rswk-swf Schwertkärpfling (DE-588)4190386-9 gnd rswk-swf Onkogen (DE-588)4131118-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Melanom (DE-588)4074707-4 s Schwertkärpfling (DE-588)4190386-9 s Chromatophor (DE-588)4147957-9 s Epidermaler Wachstumsfaktor (DE-588)4271160-5 s Onkogen (DE-588)4131118-8 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-82319 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-82319 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026830421&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Regneri, Janine Transcriptional regulation of cancer genes in the Xiphophorus melanoma system Chromatophor (DE-588)4147957-9 gnd Epidermaler Wachstumsfaktor (DE-588)4271160-5 gnd Melanom (DE-588)4074707-4 gnd Schwertkärpfling (DE-588)4190386-9 gnd Onkogen (DE-588)4131118-8 gnd |
| subject_GND | (DE-588)4147957-9 (DE-588)4271160-5 (DE-588)4074707-4 (DE-588)4190386-9 (DE-588)4131118-8 (DE-588)4113937-9 |
| title | Transcriptional regulation of cancer genes in the Xiphophorus melanoma system |
| title_alt | Transkriptionelle Regulation von Krebsgenen im Xiphophorus-Melanommodell |
| title_auth | Transcriptional regulation of cancer genes in the Xiphophorus melanoma system |
| title_exact_search | Transcriptional regulation of cancer genes in the Xiphophorus melanoma system |
| title_full | Transcriptional regulation of cancer genes in the Xiphophorus melanoma system von Janine Regneri |
| title_fullStr | Transcriptional regulation of cancer genes in the Xiphophorus melanoma system von Janine Regneri |
| title_full_unstemmed | Transcriptional regulation of cancer genes in the Xiphophorus melanoma system von Janine Regneri |
| title_short | Transcriptional regulation of cancer genes in the Xiphophorus melanoma system |
| title_sort | transcriptional regulation of cancer genes in the xiphophorus melanoma system |
| topic | Chromatophor (DE-588)4147957-9 gnd Epidermaler Wachstumsfaktor (DE-588)4271160-5 gnd Melanom (DE-588)4074707-4 gnd Schwertkärpfling (DE-588)4190386-9 gnd Onkogen (DE-588)4131118-8 gnd |
| topic_facet | Chromatophor Epidermaler Wachstumsfaktor Melanom Schwertkärpfling Onkogen Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-82319 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026830421&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT regnerijanine transcriptionalregulationofcancergenesinthexiphophorusmelanomasystem AT regnerijanine transkriptionelleregulationvonkrebsgenenimxiphophorusmelanommodell |